@article{shaheen_montaser_li_2019, title={Effect of cellulose nanocrystals on scaffolds comprising chitosan, alginate and hydroxyapatite for bone tissue engineering}, volume={121}, ISSN={["1879-0003"]}, DOI={10.1016/j.ijbiomac.2018.10.081}, abstractNote={In this study, chitosan/alginate/hydroxyapatite/nanocrystalline cellulose scaffolds were successfully fabricated by the using of freeze-drying method, followed by dicationic crosslinking using CaCl2. The chemical structure and morphology along with mechanical properties of the formed scaffolds respecting to various CNC contents were studied by Fourier-transform infrared spectroscopy (FTIR), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and mechanical compression test. Chemical interaction and electrostatic attraction between chitosan (CS) and alginate with various CNC ratios were affirmed by FTIR spectroscopy. Results depicted that, scaffolds containing CNC exhibited remarkable improvement in both swelling ratio up to 110% compared without CNC (63%) and compressive strength when compared with other scaffolds. In addition, the average pore size increased, dramatically, with increasing of CNC up to 230 μm. Porosity was also obeyed the sequence and attainted a maximum value at 93.6%. The growth and cell attachment of fibroblast cells of the selected scaffold were examined prolonging to the cell viability by using Alamar Blue (AB) and then confirmed using SEM. The results indicated that the scaffold comprising CNC has a promising cell growth and cell adherence, and thus expected to have a potent possibility for applications in bone tissue culture.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, author={Shaheen, Th I and Montaser, A. S. and Li, Suming}, year={2019}, month={Jan}, pages={814–821} } @article{montaser_mahmoud_2019, title={Preparation of Chitosan-grafted-Polyvinyl acetate Metal Nanocomposite for producing Multifunctional Textile Cotton Fabrics}, volume={124}, ISSN={["1879-0003"]}, DOI={10.1016/j.ijbiomac.2018.11.254}, abstractNote={Chitosan-g-polyvinyl acetate (Cs-g-PVAc) was synthesized successfully using redox copolymerization using potassium persulfate as initiator. TiO2 and TiO2 doped ZnO which previously prepared by sol-gel technique added for preparing emulsion from polymer – metal oxide nanocomposites. Cotton fabrics were treated with prepared emulsions using citric acid and sodium hypophosphite. XRD measurements prove that the prepared TiO2 nanoparticles corresponded to anatase phase with average crystallite size d = 15.98 nm where the crystallinity and crystallite size decreased for Zn doped TiO2 where d = 11.7 nm. FTIR indicates that the exhibition of grafting process and formation polymer metal oxide nanocomposite. Samples treated with Copolymer showed the highest antibacterial properties. However, the copolymer doped with TiO2 and TiO2/ZnO showed lowest contact angle and affects positively on its photocatalytic performance. SEM and TEM micrographs confirmed that the prepared metal oxides are in nano scales, where TiO2 is smaller than TiO2/ZnO which effects on the band gap of TiO2/ZnO to be larger than TiO2 and consequently decreased on the photocatalytic properties TiO2/ZnO of samples compared to TiO2 sample under the halogen lamp.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, author={Montaser, Ahmed S. and Mahmoud, Fawzy A.}, year={2019}, month={Mar}, pages={659–666} } @article{montaser_wassel_al-shaye'a_2019, title={Synthesis, characterization and antimicrobial activity of Schiff bases from chitosan and salicylaldehyde/TiO2 nanocomposite membrane}, volume={124}, ISSN={["1879-0003"]}, DOI={10.1016/j.ijbiomac.2018.11.229}, abstractNote={Salicylaldehyde (SA) successfully used as a mono aldehyde crosslinker with chitosan forming hydrogel membrane in presence of TiO2 NPs through casting technique. FTIR, XRD, SEM-EDX and TGA used to characterized and examining membrane physical and thermal properties. Swelling percent was evaluated for the fabricated membranes to visualize the crosslinking effect of SA Antibacterial activity evaluated using CFU methods against S. aureus, P. aeruginosa. FTIR revealed the formation of Schiff based reaction, while XRD demonstrated the presence of Titanium NPs patterns and approved bond formation between of chitosan and TiO2 NPs. SEM-EDX approve the crosslinking and TiO2 NPs dispersity on membrane surface. Crosslinking was enhanced using SA and TiO2 until reaching 1 ml of SA and 0.5 mg of TiO2 inside membrane formulation. TGA confirmed the improvement of thermal behavior in presence either crosslinking or nanometals. Mechanical properties enhanced using both crosslinker and TiO2 nanoparticle at membrane formulation. The obtained findings validated that the nanoparticles affect strength properties while crosslinker affects plasticity. All formulated membranes showed an effective antimicrobial activity towards S. aureus and P. aeruginosa and exhibits full eradication of bacteria under investigation.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, author={Montaser, A. S. and Wassel, Ahmed. R. and Al-Shaye'a, Oqba N.}, year={2019}, month={Mar}, pages={802–809} } @article{montaser_rehan_el-naggar_2019, title={pH-Thermosensitive hydrogel based on polyvinyl alcohol/sodium alginate/N-isopropyl acrylamide composite for treating re-infected wounds}, volume={124}, ISSN={["1879-0003"]}, DOI={10.1016/j.ijbiomac.2018.11.252}, abstractNote={Skin re-infection problems and its correlation with inflammation, causes rising wound temperature resulting wound healing impairment. In this current study, polyvinyl alcohol (PVA) hydrogel blended with thermosensitive sodium alginate-g-N-isopropyl acrylamide (SA-g-NIPAM) producing thermosensitive hydrogel (PVA/SA-g-NIPAM) for controlled response to re-infected wounds. The thermosensitive SA-g-NIPAM was prepared using redox copolymerization with NIPAM. The fabricated (PVA/SA-g-NIPAM) grafted copolymer was investigated via FTIR technique. The physical properties (swelling ratios) and the morphological structure of the formed PVA/SA-g-NIPAM blend (50/50) were examined. The prepared hydrogel of PVA/SA-g-NIPAM immobilized with anti-inflammatory drug; diclofenac sodium (DS) was assessed via studying the in-vitro release of DS at acidic and neutral pH (5.5 and 7) respectively. The results obtained indicated that the swelling behavior of hydrogel strongly effected with modification process applied onto SA in addition to the carboxylic groups of SA which showed a positive effect on the physical properties at neutral and basic medium. Furthermore, studying the in-vitro release of DS loaded PVA/SA-g-NIPAM in correlation with temperature indicated that 65% of DS at room temperature and 35% at over body temperature were released. On the other hand, the DS loaded PVA/SA hydrogel was completely released within the first 60 min. The obtained results considered to supply the medical field with new pH-thermosensitive hydrogel can face re-infection skin wounds troubles.}, journal={INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES}, author={Montaser, A. S. and Rehan, Mohamed and El-Naggar, Mehrez E.}, year={2019}, month={Mar}, pages={1016–1024} }