Aoi Nakanishi-Hester
I am a dependable, passionate, and determined DVM/Ph.D. dual degree student studying neuroscience at NC State University College of Veterinary Medicine. One of my career goals is to improve animal and human welfare through translational research as a veterinarian. I study Alzheimer's Disease (AD) in the murine model. My project works as a bridge to fulfill the knowledge gap by defining the molecular mechanism of how protein kinase, known as TAK1, activation causes memory loss.
Works (9)
Updated: December 4th, 2024 05:01
2024 journal article
Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs
SCIENTIFIC REPORTS, 14(1).
open access via www.nature.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2024 journal article
Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain
FRONTIERS IN VETERINARY SCIENCE, 11.
author keywords: osteoarthritis; pain; dog; grapiprant; force plate; fish oil; exercise
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024
2024 article
The Mechanism and Roles of TAK1 hyperactivation in the Alzheimer's Disease Mouse Model
Nakanishi-Hester, A., Sai, K., & Ninomiya-Tsuji, J. (2024, March). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 300, pp. S556–S556.
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024
2023 journal article
Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer?s disease mouse models
JOURNAL OF CELL SCIENCE, 136(6).
author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
TL;DR:
It is reported that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models and provides a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 30, 2023
2022 journal article
A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain
FRONTIERS IN VETERINARY SCIENCE, 9.
author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR:
The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022
2022 magazine article
Prefarrow fat supplementation impact on piglet survival, reproduction
(2022, May 5). National Hog Farmer. https://www.nationalhogfarmer.com/nutrition/prefarrow-fat-supplementation-impact-piglet-survival-reproduction
Contributors: A. Hester
Source: ORCID
Added: February 1, 2024
2022 magazine article
Summer body condition at farrowing influences litter size
(2022, September 1). National Hog Farmer. https://www.nationalhogfarmer.com/livestock/summer-body-condition-farrowing-influences-litter-size
Contributors: A. Hester
Source: ORCID
Added: February 1, 2024
2021 journal article
2021 ADSA Undergraduate Scholarship Recognition Awards
Journal of Dairy Science. https://www.sciencedirect.com/science/article/pii/S0022030221010067
Contributors: A. Hester
Source: ORCID
Added: February 1, 2024
2021 journal article
Abstracts‐Posters
Veterinary and Comparative Oncology, 19(S1), 4–24.
Contributors: A. Hester
Source: ORCID
Added: February 1, 2024
Employment
Updated: April 21st, 2023 14:21
2022 - present
NC State University College of Veterinary Medicine Raleigh, NC, US
Ph.D./DVM student
Comparative Biomedical Sciences
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