Aoi Nakanishi-Hester

I am a dependable, passionate, and determined DVM/Ph.D. dual degree student studying neuroscience at NC State University College of Veterinary Medicine. One of my career goals is to improve animal and human welfare through translational research as a veterinarian. I study Alzheimer's Disease (AD) in the murine model. My project works as a bridge to fulfill the knowledge gap by defining the molecular mechanism of how protein kinase, known as TAK1, activation causes memory loss.

Works (9)

Updated: December 4th, 2024 05:01

2024 journal article

Prevalence of radiographic appendicular osteoarthritis and associated clinical signs in young dogs

SCIENTIFIC REPORTS, 14(1).

By: M. Enomoto n , N. Castro n, J. Hash n, A. Thomson n, A. Nakanishi-Hester n , E. Perry  n, S. Aker n, E. Haupt n ...

UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024

2024 journal article

Response to treatment with grapiprant as part of a standard multimodal regimen in young dogs with appendicular joint osteoarthritis associated pain

FRONTIERS IN VETERINARY SCIENCE, 11.

By: M. Enomoto n , J. Hash n, T. Cole n, M. Sanchez  n, A. Thomson n, E. Perry  n, S. Aker n, A. Nakanishi-Hester n  ...

author keywords: osteoarthritis; pain; dog; grapiprant; force plate; fish oil; exercise
Sources: Web Of Science, NC State University Libraries
Added: November 18, 2024

2024 article

The Mechanism and Roles of TAK1 hyperactivation in the Alzheimer's Disease Mouse Model

Nakanishi-Hester, A., Sai, K., & Ninomiya-Tsuji, J. (2024, March). JOURNAL OF BIOLOGICAL CHEMISTRY, Vol. 300, pp. S556–S556.

By: A. Nakanishi-Hester n , K. Sai n & J. Ninomiya-Tsuji n 

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2024

2023 journal article

Aberrantly activated TAK1 links neuroinflammation and neuronal loss in Alzheimer?s disease mouse models

JOURNAL OF CELL SCIENCE, 136(6).

By: K. Sai n, A. Nakanishi  n, K. Scofield n, D. Tokarz n, K. Linder n, T. Cohen *, J. Ninomiya-Tsuji n 

author keywords: Alzheimer?s disease; Cell death; Inflammation; TAK1
MeSH headings : Animals; Mice; Alzheimer Disease / genetics; Calcium; Cytokines / metabolism; Neuroinflammatory Diseases; Signal Transduction / physiology
TL;DR: It is reported that compound stimulation with the neurotoxic factors TNF and glutamate aberrantly activates neuronal TAK1 (also known as MAP3K7), which promotes the pathogenesis of AD in mouse models and provides a molecular mechanism linking cytokines, Ca2+ signaling and neuronal necroptosis in AD. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: May 30, 2023

2022 journal article

A Pilot, Open-Label Study to Evaluate the Efficacy of Intra-Articular Administration of a Caninized TNF Receptor Fc Fusion Protein as a Treatment for Osteoarthritis-Associated Joint Pain

FRONTIERS IN VETERINARY SCIENCE, 9.

By: A. Nakanishi  n, B. Lascelles  n, J. Allen n, B. Case n, D. Gearing* & M. Enomoto n 

author keywords: osteoarthritis; joint pain; TNF-alpha; force plate; limb use asymmetry test
TL;DR: The IA injection of caTNFR-Fc fusion protein provided no benefit in terms of objective limb use and activity data in dogs with OA in this pilot study, and data indicate TNF-α may not be a good therapeutic target in canine OA. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 27, 2022

2022 magazine article

Prefarrow fat supplementation impact on piglet survival, reproduction

(2022, May 5). National Hog Farmer. https://www.nationalhogfarmer.com/nutrition/prefarrow-fat-supplementation-impact-piglet-survival-reproduction

Contributors: A. Hester

www.nationalhogfarmer.com
Source: ORCID
Added: February 1, 2024

2022 magazine article

Summer body condition at farrowing influences litter size

(2022, September 1). National Hog Farmer. https://www.nationalhogfarmer.com/livestock/summer-body-condition-farrowing-influences-litter-size

Contributors: A. Hester

www.nationalhogfarmer.com
Source: ORCID
Added: February 1, 2024

2021 journal article

2021 ADSA Undergraduate Scholarship Recognition Awards

Journal of Dairy Science. https://www.sciencedirect.com/science/article/pii/S0022030221010067

Contributors: A. Hester

www.sciencedirect.com
Source: ORCID
Added: February 1, 2024

2021 journal article

Abstracts‐Posters

Veterinary and Comparative Oncology, 19(S1), 4–24.

Contributors: A. Hester

Source: ORCID
Added: February 1, 2024

Employment

Updated: April 21st, 2023 14:21

2022 - present

NC State University College of Veterinary Medicine Raleigh, NC, US
Ph.D./DVM student Comparative Biomedical Sciences

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