@article{oh_harman_koehl_huang_teixeira_occelli_storey_ying_komaromy_2024, title={Assessment of Early Glaucomatous Optic Neuropathy in the Dog by Spectral Domain Optical Coherence Tomography (SD-OCT)}, volume={15}, ISSN={["2072-666X"]}, url={https://doi.org/10.3390/mi15060780}, DOI={10.3390/mi15060780}, abstractNote={Background: Inherited primary open-angle glaucoma (POAG) in Beagle dogs is a well-established large animal model of glaucoma and is caused by a G661R missense mutation in the ADAMTS10 gene. Using this model, the study describes early clinical disease markers for canine glaucoma. Methods: Spectral-domain optical coherence tomography (SD-OCT) was used to assess nine adult, ADAMTS10-mutant (median age 45.6 months, range 28.8–52.8 months; mean diurnal intraocular pressure (IOP): 29.9 +/− SEM 0.44 mmHg) and three related age-matched control Beagles (mean diurnal IOP: 18.0 +/− SEM 0.53 mmHg). Results: Of all the optic nerve head (ONH) parameters evaluated, the loss of myelin peak height in the horizontal plane was most significant (from 154 +/− SEM 38.4 μm to 9.3 +/− SEM 22.1 μm; p < 0.01). There was a strong significant negative correlation between myelin peak height and IOP (Spearman correlation: −0.78; p < 0.003). There were no significant differences in the thickness of any retinal layers evaluated. Conclusions: SD-OCT is a useful tool to detect early glaucomatous damage to the ONH in dogs before vision loss. Loss in myelin peak height without inner retinal thinning was identified as an early clinical disease marker. This suggests that initial degenerative changes are mostly due to the loss of myelin.}, number={6}, journal={MICROMACHINES}, author={Oh, Annie and Harman, Christine D. and Koehl, Kristin L. and Huang, Jiayan and Teixeira, Leandro B. C. and Occelli, Laurence M. and Storey, Eric S. and Ying, Gui-Shuang and Komaromy, Andras M.}, year={2024}, month={Jun} }
 @article{smith_berglund_robertson_schnabel_mcmullen_gilger_oh_2023, title={Effect of gentamicin on <scp>CD3</scp>+ T‐lymphocyte proliferation for treatment of equine recurrent uveitis: An in vitro study}, volume={26}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/vop.13098}, DOI={10.1111/vop.13098}, abstractNote={Abstract}, number={4}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Smith, Hannah L. and Berglund, Alix K. and Robertson, James B. and Schnabel, Lauren V. and McMullen, Richard J., Jr and Gilger, Brian C. and Oh, Annie}, year={2023}, month={Apr}, pages={347–354} }
 @article{himebaugh_robertson_weninger_gilger_ekesten_oh_2023, title={Ex vivo analysis of ultraviolet radiation transmission through ocular media and retina in select species}, volume={233}, ISSN={0014-4835}, url={http://dx.doi.org/10.1016/j.exer.2023.109550}, DOI={10.1016/j.exer.2023.109550}, abstractNote={The aim of this study was to assess the transmission of the ultraviolet (UV) radiation (200–400 nm) through intact enucleated globes of different species (dogs, cats, pigs, rabbits, horses, and humans) using spectrophotometry. Globes of cats (n = 6), dogs (n = 18), pigs (n = 10), rabbits (n = 6), horses (n = 10), and humans (n = 4) were analyzed. A 5–10 mm circular area of sclera and choroid from the posterior aspect of the globe was removed under a surgical microscope, leaving the retina intact in all species except the horse. Glass coverslips were added in horses and rabbits due to retinal and globe fragility. The %T of wavelengths from 200 to 800 nm were measured through the ocular media (cornea, aqueous humor, lens, and vitreous humor) and retina, and compared between species. The globes of cats and dogs allowed the most amount of UV radiation transmission, while those of pigs and humans allowed the least amount of UV radiation transmission. A small amount of UV radiation transmission through the ocular media was detected in the rabbit and horse. Results from this study will support further vision research that may be used to train companion, working, and service animals.}, journal={Experimental Eye Research}, publisher={Elsevier BV}, author={Himebaugh, Nicole E. and Robertson, James B. and Weninger, Keith and Gilger, Brian C. and Ekesten, Bjorn and Oh, Annie}, year={2023}, month={Aug}, pages={109550} }
 @article{murillo_souza teixeira campos_oh_smith_watanabe_2023, title={Primary ocular hemangiosarcoma in a dog}, volume={10}, ISSN={["2052-6121"]}, DOI={10.1002/vrc2.751}, abstractNote={Abstract}, journal={VETERINARY RECORD CASE REPORTS}, author={Murillo, Daniel Felipe Barrantes and Souza Teixeira Campos, Maria Eduarda and Oh, Annie and Smith, Hannah and Watanabe, Tatiane Terumi Negrao}, year={2023}, month={Oct} }
 @article{stonex_zibura_andres_gilger_oh_2022, title={Polidocanol monotherapy for a superficial orbital venous malformation in a horse}, volume={25}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/vop.12997}, DOI={10.1111/vop.12997}, abstractNote={Abstract}, number={5}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Stonex, Tara M. and Zibura, Ashley E. and Andres, Michael and Gilger, Brian C. and Oh, Annie}, year={2022}, month={Jun}, pages={412–418} }
 @article{hack_crabtree_avila_sutton_grahn_oh_gilger_bellone_2021, title={Whole-genome sequencing identifies missense mutation inGRM6as the likely cause of congenital stationary night blindness in a Tennessee Walking Horse}, volume={53}, ISSN={["2042-3306"]}, DOI={10.1111/evj.13318}, abstractNote={Abstract}, number={2}, journal={EQUINE VETERINARY JOURNAL}, author={Hack, Yael L. and Crabtree, Elizabeth E. and Avila, Felipe and Sutton, Roger B. and Grahn, Robert and Oh, Annie and Gilger, Brian and Bellone, Rebecca R.}, year={2021}, month={Mar}, pages={316–323} }
 @article{oh_foster_lunn_mowat_2019, title={Circulating neurohormone imbalances in canine sudden acquired retinal degeneration syndrome and canine pituitary-dependent hypercortisolism}, volume={33}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.15646}, abstractNote={Abstract}, number={6}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Oh, Annie and Foster, Melanie L. and Lunn, Katharine F. and Mowat, Freya M.}, year={2019}, month={Nov}, pages={2587–2594} }
 @article{oh_foster_williams_zheng_ru_lunn_mowat_2019, title={Diagnostic utility of clinical and laboratory test parameters for differentiating between sudden acquired retinal degeneration syndrome and pituitary‐dependent hyperadrenocorticism in dogs}, volume={22}, ISSN={1463-5216 1463-5224}, url={http://dx.doi.org/10.1111/vop.12661}, DOI={10.1111/vop.12661}, abstractNote={Abstract}, number={6}, journal={Veterinary Ophthalmology}, publisher={Wiley}, author={Oh, Annie and Foster, Melanie L. and Williams, Jonathan G. and Zheng, Chaowen and Ru, Hongyu and Lunn, Katharine F. and Mowat, Freya M.}, year={2019}, month={Mar}, pages={842–858} }
 @article{mowat_wise_oh_foster_kremers_2019, title={In vivo electroretinographic differentiation of rod, short-wavelength and long/medium-wavelength cone responses in dogs using silent substitution stimuli}, volume={185}, ISSN={["1096-0007"]}, DOI={10.1016/j.exer.2019.05.013}, abstractNote={The canine species has dichromatic color vision comprising short-wavelength (S-) and long/medium (L/M-) wavelength-sensitive cones with peak spectral sensitivity of 429–435 nm and 555 nm respectively. Although differentiation of rod- and cone-mediated responses by electroretinogram (ERG) in dogs is commonly performed, and standards have been developed based on standards for human observers, methods to differentiate S- and L/M-cone responses in dogs have not been described. We developed flicker protocols derived from previously published rod and cone spectral sensitivities. We used a double silent substitution paradigm to isolate responses from each of the 3 photoreceptor subclasses. ERG responses were measured to sine-wave modulation of photoreceptor excitation at different temporal frequencies (between 4 and 56 Hz) and mean luminance (between 3.25 and 130 cd/m2) on 6 different normal dogs (3 adult female, and 3 adult male beagles) and one female beagle dog with suspected hereditary congenital stationary night blindness (CSNB). Peak rod driven response amplitudes were achieved with low frequency (4 Hz, maximal range 4–12 Hz) and low mean luminance (3.25 cd/m2). In contrast, peak L/M-cone driven response amplitudes were achieved with high frequency (32 Hz, maximal range 28–44 Hz) and high mean luminance (32.5–130 cd/m2). Maximal S-cone driven responses were obtained with low frequency stimuli (4 Hz, maximal range 4–12 Hz) and 32.5–130 cd/m2 mean luminance. The dog with CSNB had reduced rod- and S-cone-driven responses, but normal/supernormal L/M cone-driven responses. We have developed methods to differentiate rod, S- and L/M-cone function in dogs using silent substitution methods. The influence of temporal frequency and mean luminance on the ERGs originating in each photoreceptor type can now be studied independently. Dogs and humans have similar L/M cone responses, whereas mice have significantly different L/M responses. This work will facilitate a greater understanding of canine retinal electrophysiology and will complement the study of canine models of human hereditary photoreceptor disorders.}, journal={EXPERIMENTAL EYE RESEARCH}, author={Mowat, Freya M. and Wise, Elisabeth and Oh, Annie and Foster, Melanie L. and Kremers, Jan}, year={2019}, month={Aug} }
 @article{westermeyer_salmon_baynes_yeatts_khattab_oh_mowat_2019, title={Safety and efficacy of topically applied 0.5% and 1% pirfenidone in a canine model of subconjunctival fibrosis}, volume={22}, ISSN={["1463-5224"]}, url={https://doi.org/10.1111/vop.12619}, DOI={10.1111/vop.12619}, abstractNote={Abstract}, number={4}, journal={VETERINARY OPHTHALMOLOGY}, author={Westermeyer, Hans D. and Salmon, Beth and Baynes, Ronald and Yeatts, James and Khattab, Ahlam and Oh, Annie and Mowat, Freya}, year={2019}, month={Jul}, pages={502–509} }
 @article{young_oh_williams_foster_miller_lunn_mowat_2018, title={Clinical therapeutic efficacy of mycophenolate mofetil in the treatment of SARDS in dogs-a prospective open-label pilot study}, volume={21}, ISSN={["1463-5224"]}, DOI={10.1111/vop.12545}, abstractNote={Abstract}, number={6}, journal={VETERINARY OPHTHALMOLOGY}, author={Young, Whitney M. and Oh, Annie and Williams, Jonathan G. and Foster, Melanie L. and Miller, William W. and Lunn, Katharine F. and Mowat, Freya M.}, year={2018}, month={Nov}, pages={565–576} }
 @article{oh_loew_foster_davidson_english_gervais_herring_mowat_2018, title={Phenotypic characterization of complete CSNB in the inbred research beagle: how common is CSNB in research and companion dogs?}, volume={137}, ISSN={["1573-2622"]}, DOI={10.1007/s10633-018-9653-y}, abstractNote={{"Label"=>"PURPOSE"} Although congenital stationary night blindness (CSNB) has been described in a Japanese beagle dog research colony, certain clinical correlates with human CSNB have not yet been described, nor has an estimate of frequency of the condition been made in inbred and outbred beagle populations. {"Label"=>"METHODS"} A beagle with CSNB obtained from a commercial research dog supplier in the USA and matched control dogs (n = 3) underwent examination, refraction, ocular imaging, assessment of visual navigation ability and detailed electroretinography (ERG). Retrospective review of ERGs in two independent groups of inbred (n = 15 and 537, respectively) and one group of outbred dogs (n = 36) was used to estimate CSNB frequency in these populations. {"Label"=>"RESULTS"} In the affected dog, there were absent dark-adapted b-waves in response to dim-light flashes, severely reduced dark-adapted b-waves in response to bright-light flashes, and normal light-adapted b-waves with a-waves that had broadened troughs. Long-flash ERGs confirmed a markedly reduced b-wave with a preserved d-wave, consistent with cone ON-bipolar cell dysfunction. There was evidence of normal rod photoreceptor a-wave dark adaptation, and rapid light adaptation. In the wider beagle populations, five inbred beagles had a b/a wave ratio of < 1 in dark-adapted bright-flash ERG, whereas no outbred beagles had ERGs consistent with CSNB. {"Label"=>"CONCLUSIONS"} The identified dog had clinical findings consistent with complete type CSNB, similar to that described in the Japanese colony. CSNB appears to be a rare disorder in the wider beagle population, although its detection could confound studies that use retinal function as an outcome measure in research dogs, necessitating careful baseline studies to be performed prior to experimentation.}, number={2}, journal={DOCUMENTA OPHTHALMOLOGICA}, author={Oh, Annie and Loew, Ellis R. and Foster, Melanie L. and Davidson, Michael G. and English, Robert V and Gervais, Kristen J. and Herring, Ian P. and Mowat, Freya M.}, year={2018}, month={Oct}, pages={87–101} }