Works (74)

Updated: April 22nd, 2024 05:35

2024 journal article

A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 752.

By: A. Pasqui*, V. Cicaloni*, L. Tinti*, A. Guiotto n, C. Tinti*, A. Mori*, M. Bruttini*, J. Hayek* ...

author keywords: Rett syndrome; MECP2 mutations; Precision medicine; Proteomics; Oxidative stress
TL;DR: By employing a multidisciplinary approach encompassing proteomics and bioinformatics analyses, as well as molecular biology assays, the study uncovered phenotypic responses linked to specific MECP2 gene mutations, contributing to a better understanding of the complexity of RTT molecular pathways. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 article

Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study

Ferrara, F., Yan, Xi, Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., … Valacchi, G. (2024, April 8). JOURNAL OF COSMETIC DERMATOLOGY, Vol. 4.

By: F. Ferrara*, . Yan*, A. Pecorelli*, A. Guiotto*, S. Colella*, A. Pasqui*, J. Ivarrson*, S. Lynch* ...

author keywords: 4HNE; inflammasome; inflammation; pollution; skin barrier
Sources: Web Of Science, NC State University Libraries
Added: April 15, 2024

2024 journal article

Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage

LIFE-BASEL, 14(1).

By: E. Esposito*, F. Ferrara*, M. Drechsler*, O. Bortolini*, D. Ragno*, S. Toldo*, A. Bondi*, A. Pecorelli* ...

author keywords: nutlin-3; ethosomes; transethosomes; skin damage; UV radiations
TL;DR: Ex vivo data suggest a better efficacy of transethosomes to promote nutlin-3 delivery within the skin, with respect to ethosomes, as well as in ex vivo skin explants exposed to UV radiations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2024 journal article

Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure

EXPERIMENTAL DERMATOLOGY, 33(1).

By: F. Ferrara*, A. Pecorelli*, E. Pambianchi*, S. White*, H. Choudhary*, A. Casoni*, G. Valacchi*

author keywords: 4HNE; COX2; inflammation; pollution; skin barrier
TL;DR: This study is among the first to investigate the combined effects of three of the most harmful outdoor stressors on human skin and confirms that daily topical of an antioxidant application may prevent pollution-induced skin damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 29, 2024

2023 journal article

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

FRONTIERS IN NUTRITION, 10.

By: D. Nieman*, J. Woo*, C. Sakaguchi*, A. Omar*, Y. Tang*, K. Davis*, A. Pecorelli n, G. Valacchi n, Q. Zhang*

author keywords: astaxanthin; exercise; proteomics; oxylipins; inflammation; cytokines
TL;DR: It is supported that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. (via Semantic Scholar)
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 17, 2023

2023 review

Blueberry Supplementation and Skin Health

[Review of ]. ANTIOXIDANTS, 12(6).

By: J. Ivarsson n, A. Pecorelli*, M. Lila n & G. Valacchi n

author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
TL;DR: The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 14, 2023

2023 article

CADMIUM EXPOSURE AFFECTS THE PROGRESSION OF HUMAN METASTATIC MELANOMA BY INDUCING A DEREGULATION OF ANTIOXIDANT CELL RESPONSE

Casoni, A., Benedusi, M., Cervellati, F., Pecorelli, A., Ferrara, F., Vallese, A., & Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 42–43.

By: A. Casoni*, M. Benedusi*, F. Cervellati*, A. Pecorelli*, F. Ferrara*, A. Vallese*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

CONSTITUTIVE ACTIVATION OF NLRP3 INFLAMMASOME MACHINERY IN EX-VIVO MODELS OF RETT SYNDROME: FROM PATHOGENETIC ROLE TO NEW POTENTIAL THERAPEUTIC TARGET

Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 12–12.

By: V. Cordone*, A. Pecorelli*, F. Ferrara*, A. Guiotto*, J. Hayek*, C. Cervellati*, F. Amicarelli*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(23).

By: J. Ivarsson*, F. Ferrara*, A. Vallese*, A. Guiotto*, S. Colella*, A. Pecorelli*, G. Valacchi*

author keywords: oxinflammation; inflammasome; pollutants; skin
TL;DR: Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2023 article

Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-kappa B p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients

Cordone, V., Vallese, A., Pecorelli, A., Guiotto, A., Ferrara, F., Benedusi, M., … Valacchi, G. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S21–S22.

By: V. Cordone*, A. Vallese*, A. Pecorelli n, A. Guiotto*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 journal article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

ANTIOXIDANTS, 12(7).

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 17, 2023

2023 journal article

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

NUTRIENTS, 15(4).

author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 20, 2023

2023 article

INFLAMMASOMES REGULATION BY ENVIRONMENTAL POLLUTANTS IN HUMAN SKIN

Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 38–39.

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

MITOCHONDRIAL DYSFUNCTION AND NLRP3 INFLAMMASOME ACTIVATION IN AUTISM SPECTRUM DISORDER

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 20–20.

By: A. Vallese n, A. Pecorelli*, V. Cordone*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Mitochondria and inflammasome involvement in Autism Spectrum Disorder

Pecorelli, A. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S2–S2.

By: A. Pecorelli n

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Ox-inflammasome involvement in neuroinflammation

FREE RADICAL BIOLOGY AND MEDICINE, 207, 161–177.

By: A. Vallese*, V. Cordone*, A. Pecorelli* & G. Valacchi n

TL;DR: The current knowledge on the involvement of inflammasome in the main neuropathologies is provided, emphasizing the importance to further clarify the role of oxidative stress in its activation including therole of mitochondria in inflammaome-induced neuroinflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

Protective role of Ibuprofen-Curcumin co-load nanomicelles against oxidative stress and inflammasome activation mediated by indoor pollution exposure in A549 cells

Garces, M., Pecorelli, A., Moretton, M., Magnani, N., Chiapetta, D., Alvarez, S., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S151–S152.

By: M. Garces*, A. Pecorelli*, M. Moretton*, N. Magnani*, D. Chiapetta, S. Alvarez*, P. Evelson*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 article

ROLE OF COENZYME Q10 IN MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE DAMAGE IN RETT SYNDROME

Silvestri, S., Marcheggiani, F., Orlando, P., Cirilli, I., Mengarelli, F., Vallese, A., … Tiano, L. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 16–16.

By: S. Silvestri*, F. Marcheggiani*, P. Orlando*, I. Cirilli*, F. Mengarelli*, A. Vallese*, A. Pecorelli*, G. Valacchi*, L. Tiano*

UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

THE PROTECTIVE ROLE OF ENDOTHELIAL alpha 1AMPK IN AIRCRAFT NOISE-INDUCED VASCULAR DYSFUNCTION AND OXIDATIVE STRESS IS MEDIATED BY FASTING, EXERCISE AND PHARMACOLOGICAL TREATMENT

Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 11–12.

By: V. Cordone, A. Pecorelli, F. Ferrara, A. Guiotto, J. Hayek, C. Cervellati, F. Amicarelli, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Tension as a key factor in skin responses to pollution

SCIENTIFIC REPORTS, 13(1).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, A. Pasqui*, J. Therrien n & G. Valacchi n

TL;DR: The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 22, 2024

2023 article

The pathogenic axis between mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S49–S49.

By: A. Vallese*, A. Pecorelli*, V. Cordone*, F. Ferrara*, M. Benedusi*, F. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2022 article

Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder

Pecorelli, A., Francesca, F., Cordone, V., Guiotto, A., Cervellati, C., Hayek, J., & Valacchi, G. (2022, February 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 180, pp. 97–98.

By: A. Pecorelli n, F. Francesca n, V. Cordone*, A. Guiotto*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022

2022 article

Involvement Of Ferroptosis In Rett Syndrome

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Cervellati, C., Hayek, J., … Pecorelli, A. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Guiotto, V. Cordone, M. Benedusi, F. Cervellati, C. Cervellati, J. Hayek, G. Valacchi*, A. Pecorelli*

Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 article

Loss of Scavenger Receptor B1 (SR-B1) in Brain of a Rett Syndrome Mouse Model

Pecorelli, A., Ferrara, F., Guiotto, A., Vallese, A., Cordone, V., Belmonte, G., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Pecorelli*, F. Ferrara*, A. Guiotto, A. Vallese*, V. Cordone, G. Belmonte, J. Hayek, C. Cervellati, G. Valacchi*

Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 article

Mutations Specific Redox Regulation Pathway In Rett Syndrome By The Use Of Transcriptomics And Proteomics Approaches

Pasqui, A., Cicaloni, V., Tinti, L., Mori, A., Bruttini, M., Pecorelli, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Pasqui*, V. Cicaloni, L. Tinti, A. Mori, M. Bruttini, A. Pecorelli*, C. Tinti, F. Dotta, S. Laura, G. Valacchi*

Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 review

Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma

[Review of ]. CANCERS, 14(13).

By: A. Pecorelli n & G. Valacchi n

author keywords: skin cancer; sunlight; redox imbalance; miRNome; mutations; epigenome
TL;DR: Current evidence suggests a complex interaction between UV-promoted deregulation of redox-sensitive miRNAs and known signal-transduction pathways underlying malignant transformation of melanocytes to melanoma, which could have relevant implications for future therapeutic approaches aimed at counteracting UV-induced redox and miRNome imbalances. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 26, 2022

2022 journal article

The constitutive activation of TLR4-IRAK1-NF kappa B axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients

FREE RADICAL BIOLOGY AND MEDICINE, 181, 1–13.

By: V. Cordone*, F. Ferrara*, A. Pecorelli n, A. Guiotto*, A. Vitale*, F. Amicarelli*, C. Cervellati*, J. Hayek*, G. Valacchi n

author keywords: MeCP2; p65; Oxinflammation; Interleukin-18; Interleukin-1 beta
MeSH headings : Humans; Inflammasomes / genetics; Inflammasomes / metabolism; Interleukin-1 Receptor-Associated Kinases / genetics; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Leukocytes, Mononuclear / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Toll-Like Receptor 4 / genetics
TL;DR: The deregulation of inflammasome components was even found in THP-1 cells silenced for MECP2 and importantly, in plasma compartment of RTT subjects, from the earliest stages of the pathology or in correlation with the severity of MeCP2 mutations. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 14, 2022

2022 journal article

Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation

REDOX BIOLOGY, 56.

Contributors: F. Ferrara*, V. Cordone*, A. Pecorelli*, M. Benedusi*, E. Pambianchi*, A. Guiotto*, A. Vallese*, F. Cervellati*, G. Valacchi*

author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
TL;DR: It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: F. Ferrara*, V. Cordone*, A. Pecorelli n, M. Benedusi*, E. Pambianchi n, A. Guiotto*, A. Vallese*, F. Cervellati*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2021 journal article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

COSMETICS, 8(4).

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2021

2021 article

Alteration of cellular defensive response and a possible involvement of ferroptosis cell death in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: A. Guiotto*, V. Cordone*, M. Benedusi*, F. Cervellati*, J. Hayek*, C. Cervellati*, G. Valacchi*, A. Pecorelli*

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

FREE RADICAL BIOLOGY AND MEDICINE, 166, 324–336.

By: M. Garces*, N. Magnani*, A. Pecorelli*, V. Calabro*, T. Marchini*, L. Caceres*, E. Pambianchi*, J. Galdoporpora* ...

author keywords: Nanoparticles; Lung epithelium; Nanotoxicology; Oxidative metabolism; NADPH oxidase; Mitochondria
MeSH headings : Animals; Hydrogen Peroxide; Lung; Metal Nanoparticles / toxicity; Mice; Oxygen; Silver
TL;DR: Results show that AgNP exposure alters O2 metabolism leading to a redox imbalance, which may be responsible for the impaired lung function observed due to alveolar epithelial injury. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 19, 2021

2021 review

Altered Bone Status in Rett Syndrome

[Review of ]. LIFE-BASEL, 11(6).

By: A. Pecorelli n, V. Cordone*, M. Schiavone n, C. Caffarelli*, C. Cervellati*, G. Cerbone*, S. Gonnelli*, J. Hayek*, G. Valacchi n

author keywords: MeCP2; bone mineral density; bone metabolism; osteoblast; WNT pathway
TL;DR: Evidence from human and animal studies supports the idea that MECP2 mutation could be associated with altered epigenetic regulation of bone-related factors and signaling pathways, including SFRP4/WNT/β-catenin axis and RANKL/RANK/OPG system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 12, 2021

2021 journal article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

ANTIOXIDANTS, 10(12).

By: E. Pambianchi n, F. Ferrara*, A. Pecorelli n, M. Benedusi*, H. Choudhary*, J. Therrien*, G. Valacchi n

author keywords: cosmeceuticals; pollution; iron-chelator
TL;DR: It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 24, 2022

2021 article

Deregulated inflammasome response in Rett syndrome

Cordone, V., Pecorelli, A., Falone, S., Hayek, J., Amicarelli, F., & Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.

By: V. Cordone*, A. Pecorelli*, S. Falone*, J. Hayek*, F. Amicarelli* & G. Valacchi*

UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 journal article

Impaired mitochondrial quality control in Rett Syndrome

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 700.

By: I. Crivellari*, A. Pecorelli n, V. Cordone*, S. Marchi*, P. Pinton*, J. Hayek*, C. Cervellati*, G. Valacchi n

author keywords: RTT Syndrome; Oxidative stress; Mitochondrial quality control; Mitophagy; Apoptosis
MeSH headings : Adolescent; Adult; Apoptosis; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase 7 / genetics; Caspase 7 / metabolism; Child; Dynamins / genetics; Dynamins / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mitochondria / genetics; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitophagy; Oxidation-Reduction; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR: It is shown that RTT fibroblasts have networks of hyperfused mitochondria with morphological abnormalities and increased mitochondrial volume, shedding light on new aspects of mitochondrial dysfunction in RTT that are represented by defective mitochondrial QC pathways, providing new potential targets for a therapeutic intervention aimed at slowing down clinical course and manifestations in the affected patients. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: March 15, 2021

2021 article

Improper enzymatic defensive responses in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177.

By: A. Guiotto*, V. Cordone*, M. Benedusi*, F. Cervellati*, J. Hayek*, C. Cervellati*, G. Valacchi n, A. Pecorelli n

UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder

Pecorelli, A., Guiotto, A., Cordone, V., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 177, pp. S17–S18.

By: A. Pecorelli n, A. Guiotto*, V. Cordone*, F. Cervellati*, M. Benedusi*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: February 28, 2022

2021 article

Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder

Pecorelli, A., Cordone, V., Guiotto, A., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: A. Pecorelli n, V. Cordone*, A. Guiotto*, F. Cervellati*, M. Benedusi*, C. Cervellati*, J. Hayek*, G. Valacchi n

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

MOLECULES, 26(13).

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 23, 2021

2021 journal article

Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model

ARCHIVES OF DERMATOLOGICAL RESEARCH, 313(3), 139–146.

By: A. Pecorelli*, D. McDaniel, M. Wortzman & D. Nelson

author keywords: Antioxidants; Ozone; Oxidative damage; Cosmeceuticals; Free radicals; Reactive Oxygen Species (ROS)
MeSH headings : Administration, Cutaneous; Antioxidants / administration & dosage; Cell Culture Techniques; Cells, Cultured; Drug Evaluation, Preclinical; Epidermis / drug effects; Epidermis / pathology; Humans; Lipid Peroxidation / drug effects; Oxidative Stress / drug effects; Ozone / adverse effects; Reactive Oxygen Species / metabolism; Skin Aging / drug effects
TL;DR: A comprehensive topical antioxidant significantly diminished O 3 -induced oxidative damage in a human epidermal skin model and inhibited damage in tissues exposed to O 3 with no significant changes in epidermis structure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2021 journal article

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents

ACS CHEMICAL NEUROSCIENCE, 12(9), 1716–1736.

By: A. Grillo*, F. Fezza*, G. Chemi*, R. Colangeli*, S. Brogi*, D. Fazio*, S. Federico*, A. Papa* ...

author keywords: Endocannabinoid system; fatty acid amide hydrolase; enzyme inhibitors; selective inhibitors; epilepsy; temporal lobe epilepsy; seizures
MeSH headings : Amidohydrolases; Anticonvulsants / pharmacology; Endocannabinoids; Enzyme Inhibitors / pharmacology; Humans; Seizures
TL;DR: The discovery of selective anandamide catabolic enzyme fatty acid amide hydrolase (FAAH) inhibitors with promising antiepileptic efficacy are reported, starting from a further investigation of the authors' prototypical inhibitor 2a. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 10, 2021

2021 article

Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation

Ferrara, F., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 165.

By: F. Ferrara, A. Pecorelli, M. Benedusi, E. Pambianchi, A. Guiotto, F. Cervellati, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2020 journal article

A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 696.

By: V. Cicaloni*, A. Pecorelli n, V. Cordone*, L. Tinti*, M. Rossi*, J. Hayek*, L. Salvini*, C. Tinti*, G. Valacchi n

author keywords: Rare disease; Rett syndrome; Inflammatory status; NLRP3 inflammasome; Mass spectrometry-based proteomics
MeSH headings : Adult; Female; Fibroblasts / chemistry; Humans; Inflammation / complications; Inflammation / metabolism; Protein Interaction Maps; Proteome / analysis; Proteome / metabolism; Proteomics; Rett Syndrome / complications; Rett Syndrome / metabolism; Young Adult
TL;DR: Results provide a detailed insight into the molecular pathways involved in RTT immune dysfunction that, causing tissue and organ damage, can increase the vulnerability of affected patients to unknown endogenous factors or infections. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 journal article

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

FASEB JOURNAL, 34(5), 6521–6538.

By: A. Pecorelli*, F. Ferrara*, N. Messano*, V. Cordone*, M. Schiavone*, F. Cervellati*, B. Woodby*, C. Cervellati*, J. Hayek*, G. Valacchi*

author keywords: 4-hydroxynonenal; fission; fusion; mitophagy; nuclear factor erythroid 2-related factor 2
MeSH headings : Adolescent; Adult; Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Case-Control Studies; Child; Energy Metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Male; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Dynamics; Mitochondrial Proteins / metabolism; Oxidative Stress; Young Adult
TL;DR: It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2020 journal article

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation

REDOX BIOLOGY, 28.

By: A. Pecorelli*, V. Cordone*, N. Messano*, C. Zhang*, S. Falone*, F. Amicarelli*, J. Hayek*, G. Valacchi*

author keywords: NLRP3; ASC; Inflammatory status; Cytokines; MeCP2
MeSH headings : Biomarkers; Cytokines / metabolism; Disease Susceptibility; Fibroblasts / metabolism; Fluorescent Antibody Technique; Humans; Inflammasomes / metabolism; Inflammation Mediators / metabolism; Interleukin-1beta / metabolism; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Protein Transport; Rett Syndrome / etiology; Rett Syndrome / metabolism
TL;DR: It is suggested that RTT patients exhibited a challenged inflammasome machinery at cellular and systemic level, which may contribute to the subclinical inflammatory state feedback observed in this pathology. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 30, 2019

2020 journal article

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE, 1866(7).

By: D. Sbardella*, G. Tundo*, V. Cunsolo*, G. Grasso*, R. Cascella*, V. Caputo*, A. Santoro*, D. Milardi* ...

author keywords: Rett syndrome; Skin primary fibroblasts; Proteasome; alpha-Ring; PAC1; PAC2
MeSH headings : Codon, Nonsense / genetics; Dual Specificity Phosphatase 2 / genetics; Fibroblasts / metabolism; Gene Expression Regulation; Genetic Diseases, X-Linked / genetics; Genetic Diseases, X-Linked / pathology; Humans; Methyl-CpG-Binding Protein 2 / genetics; Neurodevelopmental Disorders / genetics; Neurodevelopmental Disorders / pathology; Primary Cell Culture; Proteasome Endopeptidase Complex / genetics; Proteolysis; Rett Syndrome / genetics; Rett Syndrome / pathology; Skin / metabolism; Skin / pathology; Ubiquitin / genetics
TL;DR: Molecular, transcription and proteomic analyses indicate that MeCP2 mutations down-regulate the expression of one proteasome subunit, α7, and of two chaperones, PAC1 and PAC2, which bind each other in the earliest step of proteAsome biogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020

2020 journal article

Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study

COLLOIDS AND SURFACES B-BIOINTERFACES, 185.

By: M. Sguizzato*, G. Valacchi*, A. Pecorelli*, P. Boldrini*, F. Simeliere*, N. Huang*, R. Cortesi*, E. Esposito*

author keywords: Biocompatible polymers; Polymer gels; In vitro diffusion; Polymer membranes; Gallic acid; Franz cell
MeSH headings : Adjuvants, Immunologic / pharmacology; Adjuvants, Immunologic / therapeutic use; Cell Line; Cell Movement / drug effects; Diffusion; Elasticity; Gallic Acid / pharmacology; Gallic Acid / therapeutic use; Gels / chemistry; Humans; Kinetics; Melanoma / drug therapy; Phase Transition; Poloxamer / chemistry; Rheology; Temperature; Viscosity; Wound Healing / drug effects
TL;DR: Scratch wound healing and migration assays conducted on human keratinocytes and melanoma cells demonstrated the ability of gallic acid loaded gel to inhibit cellular migration, suggesting its potential as adjuvant strategy for melanoma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2020

2020 journal article

Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery

ANTIOXIDANTS & REDOX SIGNALING, 33(3), 191–210.

By: C. Cervellati*, A. Trentini*, A. Pecorelli* & G. Valacchi*

author keywords: Alzheimer's disease; inflammation; multiple sclerosis; vascular dementia
MeSH headings : Animals; Biomarkers; Blood-Brain Barrier / metabolism; Brain / metabolism; Brain / pathology; Disease Susceptibility; Dysbiosis; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Nervous System Diseases / etiology; Nervous System Diseases / metabolism; Nervous System Diseases / pathology; Oxidative Stress; Peripheral Nerves / metabolism; Peripheral Nerves / pathology
TL;DR: Reaching a definitive clinical/epidemiological appreciation of the etiopathogenic significance of the connection between peripheral and brain inflammation in neurologic disorders is pivotal since it could open novel therapeutic avenues for these diseases. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2020 journal article

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 690.

author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
TL;DR: HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 19, 2021

2020 journal article

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(2), 112–119.

By: D. Nieman*, G. Valacchi*, L. Wentz*, F. Ferrara*, A. Pecorelli*, B. Woodby*, C. Sakaguchi*, A. Simonson*

author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
TL;DR: Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 journal article

Postexercise Inflammasome Activation and IL-1 beta Production Mitigated by Flavonoid Supplementation in Cyclists

INTERNATIONAL JOURNAL OF SPORT NUTRITION AND EXERCISE METABOLISM, 30(6), 396–404.

By: D. Nieman*, F. Ferrara*, A. Pecorelli*, B. Woodby*, A. Hoyle*, A. Simonson*, G. Valacchi*

author keywords: cytokines; gasdermin D; IL-18; inflammation
TL;DR: The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: November 9, 2020

2020 journal article

Proteomic pro fi ling reveals mitochondrial alterations in Rett syndrome

FREE RADICAL BIOLOGY AND MEDICINE, 155, 37–48.

By: V. Cicaloni*, A. Pecorelli n, L. Tinti*, M. Rossi*, M. Benedusi*, C. Cervellati*, O. Spiga*, A. Santucci* ...

MeSH headings : Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Proteome / genetics; Proteomics; Rett Syndrome / genetics
TL;DR: The proteomic analysis confirms the pathological relevance of mitochondrial dysfunction in RTT pathogenesis and progression and carries out the first comprehensive characterization of RTT cellular proteome, showing mainly changes in expression of proteins involved in the mitochondrial network. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2020

2020 journal article

Redox regulation of cutaneous inflammasome by ozone exposure

FREE RADICAL BIOLOGY AND MEDICINE, 152, 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: July 13, 2020

2020 article

Skin Health from the Inside Out

ANNUAL REVIEW OF FOOD SCIENCE AND TECHNOLOGY, VOL 11, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2019 journal article

13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation

FREE RADICAL BIOLOGY AND MEDICINE, 134, 598–603.

By: A. Pecorelli n, C. Cervellati*, V. Cordone n, F. Amicarelli*, J. Hayek* & G. Valacchi n

author keywords: Rett syndrome; Oxidative stress; Hydroxyoctadecadienoic acids; Inflammation; Omega-3 polyunsaturated fatty acids; Arachidonate 15-Lipoxygenase
MeSH headings : Adolescent; Adult; Arachidonate 15-Lipoxygenase / genetics; Arachidonate 15-Lipoxygenase / metabolism; Case-Control Studies; Child; Female; Humans; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Leukocytes, Mononuclear / metabolism; Linoleic Acids / metabolism; Linoleic Acids, Conjugated / metabolism; Male; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology; Young Adult
TL;DR: Statistically significant correlation was demonstrated between the increased plasma HODEs levels and the lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and the possible ability of omega-3 polyunsaturated fatty acids supplementation in improving the oxinflammation status in RTT. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: July 1, 2019

2019 journal article

Antiglycative Activity and RAGE Expression in Rett Syndrome

CELLS, 8(2).

By: V. Cordone*, A. Pecorelli n, M. Benedusi*, S. Santini*, S. Falone*, J. Hayek*, F. Amicarelli*, G. Valacchi n

author keywords: methylglyoxal; glyoxalases; advanced glycation end products; MeCP2; dicarbonyl stress; fibroblasts
MeSH headings : Adolescent; Adult; Antigens, Neoplasm / metabolism; Cell Survival / drug effects; Child; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosylation; Humans; Lactoylglutathione Lyase / metabolism; Mitogen-Activated Protein Kinases / metabolism; Pyruvaldehyde / pharmacology; Rett Syndrome / metabolism; Rett Syndrome / pathology; Thiolester Hydrolases / metabolism; Young Adult
TL;DR: Besides OxInflammation, RTT is associated with reshaping of the major defense systems against dicarbonyl stress, along with an altered cellular stress response towards pro-glycating insults. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: March 25, 2019

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 journal article

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 183.

By: A. Grillo*, G. Chemi*, S. Brogi*, M. Brindisi*, N. Relitti*, F. Fezza*, D. Fazio*, L. Castelletti* ...

author keywords: Endocannabinoid system; Fatty acid amide hydrolase; Enzyme inhibitors; Selective inhibitors; Dopamine ligands; Polypharmacology; Multitarget compounds; Dopamine receptor ligands
MeSH headings : Amidohydrolases / antagonists & inhibitors; Amidohydrolases / metabolism; Binding, Competitive; Cell Line; Cell Survival / drug effects; Dopamine / metabolism; Endocannabinoids / metabolism; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Humans; Ligands; Piperazines / chemistry; Piperazines / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
TL;DR: The synthesis and biological characterization of compounds 5a-j inspired by the structure of the authors' potent and selective fatty acid amide hydrolase (FAAH) inhibitors and ligands of dopamine D2 or D3 receptor subtypes are described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019

2019 article

HGA Induces Oxidative Damage in an Ostcoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms HGA Induces Oxidative Damage in an Osteoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Santucci, A., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S37–S38.

By: M. Schiavone, A. Pecorelli, B. Woodby, F. Ferrara, A. Santucci & G. Valacchi

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 review

Involvement of 4-hydroxy-2-nonenal in pollution-induced skin damage

[Review of ]. BIOFACTORS, 45(4), 536–547.

By: A. Pecorelli n, B. Woodby n, R. Prieux* & G. Valacchi n

author keywords: ozone; particulate matter; cigarette smoke; peroxidation
MeSH headings : Air Pollutants / metabolism; Air Pollutants / toxicity; Aldehydes / metabolism; Aldehydes / toxicity; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Oxidation-Reduction; Oxidative Stress; Ozone / metabolism; Ozone / toxicity; Particulate Matter / toxicity; Psoriasis / chemically induced; Psoriasis / genetics; Psoriasis / metabolism; Psoriasis / pathology; Reactive Oxygen Species / agonists; Reactive Oxygen Species / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Aging / drug effects; Skin Aging / genetics; Skin Aging / pathology; Tobacco Smoke Pollution / adverse effects; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR: Increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 20, 2020

2019 journal article

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

BIOFACTORS, 45(6), 920–929.

By: F. Ietta*, G. Valacchi*, L. Benincasa*, A. Pecorelli*, L. Cresti* & E. Maioli*

author keywords: apoptosis; ER stress; melanoma; mitochondria; protein synthesis; rottlerin
TL;DR: In this cell line, rottlerin exhibits its main and newest cytotoxic properties, that is, growth arrest, apoptosis induction, and translation shutoff, and the drug markedly inhibited cell proliferation through cyclin D1 downregulation and induced apoptotic cell death as early as after 18 h treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2019

2019 article

OxInflammation as a Aossible new Player in Rett Syndrome Pathophysiology

Pecorelli, A., Valacchi, G., Cordone, V., & Hayek, J. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S149–S149.

By: A. Pecorelli, G. Valacchi, V. Cordone & J. Hayek

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure

Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.

By: F. Ferrara, A. Pecorelli, B. Woodby, E. Pambianchi, N. Messano, J. Therrien, G. Valacchi

Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox-Regulation of Antimicrobial Peptides

Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S54–S55.

By: B. Woodby, E. Pambianchi, F. Francesca, N. Messano, A. Pecorelli, J. Therrien, G. Valacchii

UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2018 article

AtmO(3)spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, September). JOURNAL OF INVESTIGATIVE DERMATOLOGY, Vol. 138, pp. B15–B15.

By: G. Valacchi n, A. Pecorelli*, E. Pambianchi*, F. Ferrara n & M. Lila*

Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 article

Inflammasome involvement in Rett syndrome subclinical inflammation

Pecorelli, A., Cordone, V., Falone, S., Romani, A., Benedusi, M., Hayek, J., … Valacchi, G. (2018, November 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 128, pp. S108–S109.

By: A. Pecorelli n, V. Cordone*, S. Falone*, A. Romani*, M. Benedusi*, J. Hayek*, F. Amicarelli*, G. Valacchi n

TL;DR: The results suggest a possible basal activation of inflammasome in RTT cells that, on the other hand, appear to be unable to respond properly at the inflammatory stimulus. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018

2018 journal article

Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure

MECHANISMS OF AGEING AND DEVELOPMENT, 172, 86–95.

By: A. Romani*, C. Cervellati*, X. Muresan*, G. Belmonte*, A. Pecorelli n, F. Cervellati*, M. Benedusi*, P. Evelson*, G. Valacchi n

author keywords: Air pollution; Particulate matter; Oxidative damage; Inflammation
MeSH headings : Cell Line, Transformed; Humans; Interleukin-1alpha / metabolism; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; NF-kappa B / metabolism; Oxidation-Reduction / drug effects; Particulate Matter / toxicity
TL;DR: Overall these data, suggest lipid and protein oxidative damage, as well as an increase of inflammatory response after being challenged with CAPs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 review

OxInflammation: From Subclinical Condition to Pathological Biomarker

[Review of ]. FRONTIERS IN PHYSIOLOGY, 9.

By: G. Valacchi n, F. Virgili*, C. Cervellati* & A. Pecorelli n

author keywords: biomarkers; neurological disorders; oxidative stress; inflammation mediators; NF kappa B
TL;DR: The term “OxInflammation” is proposed as a novel operative term describing a permanent pro-oxidative feature that interact, in a positive feed-back manner, to a not yet clinically detectable inflammatory process, leading in a long run (chronically) to a systemic/local damage, as a consequence of the cross talk between inflammatory, and oxidative stress mediators. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells

FREE RADICAL BIOLOGY AND MEDICINE, 126, 287–295.

By: C. Sticozzi*, A. Pecorelli*, A. Romani*, G. Belmonte*, F. Cervellati*, E. Maioli*, M. Lila*, C. Gervellati, G. Valacchi*

MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
TL;DR: To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2018

2017 review

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

[Review of ]. FREE RADICAL BIOLOGY AND MEDICINE, 111, 270–280.

By: G. Valacchi n, A. Pecorelli n, C. Cervellati* & J. Hayek*

author keywords: Inflammation; Isoprostanes; Oxidative stress; Rare disease; Orphan disease; CDKL5; FOXG1; MecP2
MeSH headings : Aldehydes / metabolism; Brain / metabolism; Brain / pathology; Feedback, Physiological; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Humans; Inflammation; Isoprostanes / metabolism; Lipid Peroxidation / genetics; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mutation; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oxidative Stress; Proteasome Endopeptidase Complex / metabolism; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
TL;DR: Aiming 4HNE as a therapeutic target could represent a coadjuvant treatment with some beneficial impact in these patients, in a pathology completely orphan of any therapy, with special emphasis on 4-hydroxynonenal (4HNE). (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

First dual AK/GSK-3 beta inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 138, 438–457.

By: S. Brogi*, A. Ramunno*, L. Savi*, G. Chemi*, G. Alfano*, A. Pecorelli n, E. Pambianchi n, P. Galatello* ...

author keywords: Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3 beta); Adenosine kinase (AK); Dual inhibitors; Molecular docking
MeSH headings : Adenosine Kinase / antagonists & inhibitors; Adenosine Kinase / metabolism; Antioxidants / chemical synthesis; Antioxidants / chemistry; Antioxidants / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Humans; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Molecular Structure; Neuroblastoma / metabolism; Neuroblastoma / pathology; Neuroprotective Agents / chemical synthesis; Neuroprotective Agents / chemistry; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Protein Kinase Inhibitors / chemical synthesis; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Structure-Activity Relationship
TL;DR: The identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study

MOLECULES, 22(12).

author keywords: anti-inflammatory; artificial tears; corneal epithelium; cyclin D1; dry eye syndrome; HA; HA-CL; IL-8; re-epithelialization
MeSH headings : Analysis of Variance; Biomarkers; Cell Line; Cell Survival; Cyclin D1 / metabolism; Drug Stability; Dry Eye Syndromes; Epithelium, Corneal / drug effects; Humans; Hyaluronic Acid / analysis; Hyaluronic Acid / chemistry; Hydrogen-Ion Concentration; Lubricant Eye Drops / analysis; Lubricant Eye Drops / chemical synthesis; Lubricant Eye Drops / chemistry; Lubricant Eye Drops / pharmacology; Re-Epithelialization / drug effects; Viscosity; Wound Healing / drug effects
TL;DR: An in vitro evaluation of the re-epithelialization ability of two different preparations containing a recently synthetized HA cross-linked with urea showed no cellular toxicity, a slight decrease in IL-8 release, and restoration of epithelium integrity when the wounded 3D model was treated with S1 and S2. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 2017.

By: C. Cavicchio*, M. Benedusi*, E. Pambianchi n, A. Pecorelli n, F. Cervellati*, V. Savelli*, D. Calamandrei*, E. Maellaro* ...

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Ascorbic Acid / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Connexin 43 / genetics; Connexin 43 / metabolism; Humans; Melanoma / drug therapy; Melanoma / pathology; Microscopy, Electron, Scanning; Potassium / chemistry; Ribose / chemistry; Spheroids, Cellular / drug effects; Spheroids, Cellular / ultrastructure
TL;DR: The results suggest that PAR could be used as a safe adjuvant approach in support to conventional therapies for the treatment of melanoma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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