Works (99)

Updated: February 27th, 2026 04:15

2026 article

Oxysterol-induced oxidative disruption of skin junction integrity

Pecorelli, A., Guiotto, A., Casoni, A., Ruzza, M., Beltrami, L., Canepa, B., … Valacchi, G. (2026, January 29). Free Radical Biology and Medicine, Vol. 1.

By: A. Pecorelli*, A. Guiotto*, A. Casoni*, M. Ruzza*, L. Beltrami*, B. Canepa*, F. Biasi*, G. Poli*, G. Valacchi*

topics (OpenAlex): Dermatology and Skin Diseases; Acne and Rosacea Treatments and Effects; Cholesterol and Lipid Metabolism
Source: ORCID
Added: January 29, 2026

2026 article

Therapeutic Potential of Ozonized Glycerin in Skin Inflammation and Repair

Ivarsson, J., Guiotto, A., Trinchera, G., Pecorelli, A., Shiota, G., & Valacchi, G. (2026, February 12). Cosmetics.

By: J. Ivarsson*, A. Guiotto, G. Trinchera*, A. Pecorelli*, G. Shiota* & G. Valacchi*

topics (OpenAlex): Medical and Biological Ozone Research; Body Contouring and Surgery; Dermatologic Treatments and Research
Source: ORCID
Added: February 13, 2026

2025 article

Abnormal MAMs proteins can disrupt finely tuned signaling between ER and mitochondria in RTT brain

Pecorelli, A., Guiotto, A., Vallese, A., Melija, S., Cordone, V., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Pecorelli n, A. Guiotto n, A. Vallese*, S. Melija*, V. Cordone* & G. Valacchi n

topics (OpenAlex): Mitochondrial Function and Pathology
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Application of Antioxidant Mixture Prevents Cutaneous “Oxinflammaging” in Subjects Exposed to Particulate Matter

Ivarsson, J., Yan, Guiotto, A., Pecorelli, A., Sarandy, M. M., Lynch, S., … Valacchi, G. (2025, July 1). Journal of Cosmetic Dermatology, Vol. 24.

By: J. Ivarsson n, Yan, A. Guiotto n, A. Pecorelli*, M. Sarandy n, S. Lynch*, S. Anderias*, H. Choudhary* ...

author keywords: air pollution; OxInflammation; skin aging; skin barrier; topical application
MeSH headings : Humans; Female; Antioxidants / administration & dosage; Adult; Particulate Matter / adverse effects; Particulate Matter / toxicity; Skin Aging / drug effects; Young Adult; Ascorbic Acid / administration & dosage; Skin / drug effects; Skin / pathology; Skin / metabolism; Coumaric Acids / administration & dosage; Tocopherols / administration & dosage; Oxidative Stress / drug effects; Air Pollutants / adverse effects; Administration, Cutaneous; Filaggrin Proteins; Drug Combinations
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Thermoregulation and physiological responses
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 15, 2025

2025 article

Cadmium exposure affects the progression of human metastatic melanoma by inducing a deregulation of antioxidant cell response

Casoni, A., Trinchera, G., Cervellati, F., Pecorelli, A., Benedusi, M., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Casoni*, G. Trinchera*, F. Cervellati*, A. Pecorelli n, M. Benedusi* & G. Valacchi n

topics (OpenAlex): Heavy Metal Exposure and Toxicity
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Comparing UV and Diesel Cutaneous Damage and Evaluating the Protective Role of a Topical Antioxidant Mixture Containing Vitamin C, E and Ferulic Acid

Ivarsson, J., Pecorelli, A., Guiotto, A., Souza, M. M., Choudhary, H., Brieva, P., … Valacchi, G. (2025, March 1). Experimental Dermatology, Vol. 34.

By: J. Ivarsson*, A. Pecorelli*, A. Guiotto*, M. Souza*, H. Choudhary*, P. Brieva*, F. Ferrara*, G. Valacchi*

author keywords: air pollution; collagen; elastin; oxinflammation; skin ageing; skin barrier
MeSH headings : Antioxidants / administration & dosage; Humans; Coumaric Acids / administration & dosage; Coumaric Acids / pharmacology; Ultraviolet Rays / adverse effects; Filaggrin Proteins; Skin / drug effects; Skin / radiation effects; Oxidative Stress / drug effects; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Vehicle Emissions / toxicity; Skin Aging / drug effects; Skin Aging / radiation effects; Particulate Matter
topics (OpenAlex): Skin Protection and Aging; Vitamin C and Antioxidants Research; Bee Products Chemical Analysis
Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2025 article

Deregulation of the Nrf2 redox-sensitive pathway in autism spectrum disorder

Vallese, A., Melija, S., Hayek, J., Pecorelli, A., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Vallese*, S. Melija*, J. Hayek*, A. Pecorelli n & G. Valacchi n

topics (OpenAlex): Genomics, phytochemicals, and oxidative stress
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

ER-Mitochondria Associated Membranes (MAMS) dysfunction in Rett syndrome: Investigating calcium signaling alterations and potential therapeutic strategies

Melija, S., Pecorelli, A., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 5.

By: S. Melija*, A. Pecorelli n & G. Valacchi n

topics (OpenAlex): Genetics and Neurodevelopmental Disorders
Sources: NC State University Libraries, NC State University Libraries
Added: January 22, 2026

2025 article

In situ forming gels as subcutaneous delivery systems of curcumin and piperine

Pula, W., Pepe, A., Ferrara, F., Bondi, A., Mariani, P., Ortore, M. G., … Esposito, E. (2025, January 24). Scientific Reports, Vol. 15.

author keywords: Glyceryl Monooleate; Skin; Hexagonal phase; Curcumin; Piperine
MeSH headings : Curcumin / chemistry; Curcumin / administration & dosage; Curcumin / pharmacology; Benzodioxoles / administration & dosage; Benzodioxoles / chemistry; Polyunsaturated Alkamides / chemistry; Polyunsaturated Alkamides / administration & dosage; Polyunsaturated Alkamides / pharmacology; Piperidines / chemistry; Piperidines / administration & dosage; Alkaloids / chemistry; Alkaloids / administration & dosage; Gels / chemistry; Humans; Drug Delivery Systems; Injections, Subcutaneous; Drug Liberation; Glycerides / chemistry; Skin / metabolism; Skin / drug effects
topics (OpenAlex): Curcumin's Biomedical Applications; Piperaceae Chemical and Biological Studies; Advancements in Transdermal Drug Delivery
Sources: Web Of Science, NC State University Libraries
Added: February 10, 2025

2025 article

Lipid peroxidation-induced cell death in Rett syndrome

Guiotto, A., Vallese, A., Cordone, V., Cervellati, F., Benedusi, M., Hayek, J., … Valacchi, G. (2025, September 22). Free Radical Biology and Medicine, Vol. 241, pp. 243–257.

author keywords: Ferroptosis; Antioxidant defense; Oxidative stress; Lipid peroxidation; Ferritinophagy; Mitochondria
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research; Child Nutrition and Feeding Issues
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 7, 2025

2025 article

Mitochondrial abnormalities and oxinflammatory mechanisms in Rett syndrome presymptomatic/ symptomatic switch

Moradi, A., Muccini, M., Thalhammer, A., Pecorelli, A., Vallese, A., Gemmo, L., … Baj, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Moradi, M. Muccini, A. Thalhammer, A. Pecorelli*, A. Vallese*, L. Gemmo, V. Cordone, G. Valacchi*, G. Baj

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research; Child Nutrition and Feeding Issues
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Redox regulation of cutaneous olfactory receptors OR2AT4 and OR6M1: When the skin smells UV damage

Ivarsson, J., Colella, S., Vallese, A., Ferrara, F., Pecorelli, A., & Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: J. Ivarsson n, S. Colella*, A. Vallese*, F. Ferrara*, A. Pecorelli* & G. Valacchi n

topics (OpenAlex): Olfactory and Sensory Function Studies; Advanced Chemical Sensor Technologies
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Role of Scavenger Receptor B1 (SR-B1) in Improving Food Benefits for Human Health

Valacchi, G., & Pecorelli, A. (2025, February 3). Annual Review of Food Science and Technology, Vol. 16, pp. 403–432.

By: G. Valacchi n & A. Pecorelli n

author keywords: nutrients; phytochemicals; exposome; disease; antioxidants; diet; health; benefits
MeSH headings : Humans; Scavenger Receptors, Class B / metabolism; Animals; Functional Food
topics (OpenAlex): Nutritional Studies and Diet; Antioxidant Activity and Oxidative Stress; Cancer, Lipids, and Metabolism
Sources: Web Of Science, NC State University Libraries
Added: May 19, 2025

2025 article

Role of mitochondrial alterations as upstream triggers of NLRP3 inflammasome response in RETT syndrome

Cordone, V., Bianchi, A., Melija, S., Guiotto, A., Emidio, G. D., Tatone, C., … Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233, pp. S12–S13.

By: V. Cordone*, A. Bianchi*, S. Melija*, A. Guiotto n, G. Emidio*, C. Tatone*, A. Pecorelli n, G. Valacchi n

topics (OpenAlex): Testicular diseases and treatments; Inflammasome and immune disorders; Congenital Diaphragmatic Hernia Studies
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2025 article

Skin barrier protein responses to oxysterol exposure: from diet to outdoor stressors

Pecorelli, A., Casoni, A., Guiotto, A., Ruzza, M., Beltrami, L., Canepa, B., … Valacchi, G. (2025, May 30). Free Radical Biology and Medicine, Vol. 233.

By: A. Pecorelli n, A. Casoni*, A. Guiotto*, M. Ruzza*, L. Beltrami*, B. Canepa*, F. Biasi*, G. Poli*, G. Valacchi*

topics (OpenAlex): Exercise and Physiological Responses
Sources: Web Of Science, NC State University Libraries
Added: July 17, 2025

2024 article

Aberrant NLRP3 inflammasome response in Rett syndrome: from ex vivo to in vivo models for investigating pathogenetic mechanisms and new potential therapeutic strategies

Cordone, V., Pecorelli, A., Frescura, F., Vallese, A., Guiotto, A., Ferrara, F., … Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 13–14.

By: V. Cordone*, A. Pecorelli n, F. Frescura*, A. Vallese*, A. Guiotto*, F. Ferrara*, J. Hayek*, S. Beggiato*, L. Ferraro*, G. Valacchi n

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Abnormal Mitochondrion-NLRP3 Inflammasome crosstalk in the pathophysiology of Autism Spectrum Disorder

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., … Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 50–50.

By: A. Vallese n, V. Cordone*, F. Ferrara*, A. Guiotto n, L. Gemmo*, F. Cervellati*, J. Hayek*, A. Pecorelli n, G. Valacchi n

topics (OpenAlex): Adenosine and Purinergic Signaling; COVID-19 Impact on Reproduction; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study

Ferrara, F., Yan, Pecorelli, A., Guiotto, A., Colella, S., Pasqui, A., … Valacchi, G. (2024, April 8). Journal of Cosmetic Dermatology, Vol. 4.

By: F. Ferrara*, Yan, A. Pecorelli*, A. Guiotto*, S. Colella*, A. Pasqui*, J. Ivarrson*, S. Lynch* ...

author keywords: 4HNE; inflammasome; inflammation; pollution; skin barrier
MeSH headings : Humans; Female; Ultraviolet Rays / adverse effects; Adult; Antioxidants / administration & dosage; Single-Blind Method; Young Adult; Oxidative Stress / drug effects; Oxidative Stress / radiation effects; Particulate Matter / adverse effects; Particulate Matter / administration & dosage; Skin / radiation effects; Skin / drug effects; Skin / metabolism; Adolescent; Skin Aging / drug effects; Skin Aging / radiation effects; Ascorbic Acid / administration & dosage; Ascorbic Acid / pharmacology; Administration, Cutaneous; Lipid Peroxidation / drug effects; Lipid Peroxidation / radiation effects; Coumaric Acids
topics (OpenAlex): Skin Protection and Aging; melanin and skin pigmentation; Psoriasis: Treatment and Pathogenesis
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 15, 2024

2024 article

Comparison of pollutant effects on cutaneous inflammasomes activation.

Ferrara, F., Ivarsson, J., Vallese, A., Guiotto, A., Colella, S., Pecorelli, A., & Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 27–27.

By: F. Ferrara*, J. Ivarsson*, A. Vallese*, A. Guiotto*, S. Colella*, A. Pecorelli*, G. Valacchi*

topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Inflammasome and immune disorders
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 26, 2024

2024 article

Correction: Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage

Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallese, A., Iorizzo, M., … Valacchi, G. (2024, January 1). Food & Function, Vol. 10.

By: J. Ivarsson n, A. Bennett n, F. Ferrara*, R. Strauch n, A. Vallese*, M. Iorizzo*, A. Pecorelli n, M. Lila n, G. Valacchi*

topics (OpenAlex): Bee Products Chemical Analysis; Transgenic Plants and Applications; Fungal Biology and Applications
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024

2024 article

Evidence of altered redox homeostasis in trichothiodystrophy

Cordone, V., Guiotto, A., Bucay, V., Pecorelli, A., & Valacchi, G. (2024, January 1). Redox Experimental Medicine, Vol. 2024.

By: V. Cordone*, A. Guiotto n, V. Bucay, A. Pecorelli n & G. Valacchi n

author keywords: BACH; mitochondria; NRF2; trichothiodystrophy
topics (OpenAlex): Biochemical effects in animals; Redox biology and oxidative stress; Selenium in Biological Systems
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 23, 2024

2024 article

Feeding the Body Through the Skin: Ethosomes and Transethosomes as a New Topical Delivery System for Bioactive Compounds

Esposito, E., Pecorelli, A., Ferrara, F., Lila, M. A., & Valacchi, G. (2024, June 28). Annual Review of Food Science and Technology, Vol. 15, pp. 53–78.

By: E. Esposito*, A. Pecorelli*, F. Ferrara*, M. Lila n & G. Valacchi n

author keywords: skin; ethosome; transethosome; topical administration; transdermal delivery; inflammation
MeSH headings : Humans; Administration, Cutaneous; Animals; Skin / metabolism; Drug Delivery Systems; Skin Absorption
topics (OpenAlex): Advancements in Transdermal Drug Delivery; Proteins in Food Systems; Bee Products Chemical Analysis
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: September 3, 2024

2024 article

First evidence of redox damage by indoor pollution in lung tissue by the use of 2D and 3D models

Garcés, M., Ferrara, F., Vallese, A., Benedusi, M., Cervellati, F., Magnani, N., … Valacchi, G. (2024, June 1). Free Radical Biology and Medicine, Vol. 218, pp. 27–27.

topics (OpenAlex): Air Quality and Health Impacts; Air Quality Monitoring and Forecasting
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage

Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallase, A., Iorizzo, M., … Valacchi, G. (2024, January 1). Food & Function, Vol. 6.

By: J. Ivarsson n, A. Bennett n, F. Ferrara*, R. Strauch n, A. Vallase*, M. Iorizzo*, A. Pecorelli n, M. Lila n, G. Valacchi*

MeSH headings : Humans; Blueberry Plants / chemistry; Skin / metabolism; Skin / drug effects; Hydroxybenzoates / pharmacology; Ultraviolet Rays; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Coculture Techniques; Lipid Peroxidation / drug effects; Interleukin-8 / metabolism; Oxidative Stress / drug effects
topics (OpenAlex): Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities; Skin Protection and Aging
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 8, 2024

2024 article

NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., … Valacchi, G. (2024, October 19). Free Radical Biology and Medicine, Vol. 225, pp. 581–594.

By: A. Vallese*, V. Cordone*, F. Ferrara*, A. Guiotto*, L. Gemmo*, F. Cervellati*, J. Hayek*, A. Pecorelli*, G. Valacchi*

MeSH headings : Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Autism Spectrum Disorder / genetics; Humans; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; Mitochondria / metabolism; Mitochondria / pathology; Inflammasomes / metabolism; Inflammasomes / genetics; Reactive Oxygen Species / metabolism; Interleukin-1beta / metabolism; Interleukin-1beta / genetics; Male; Fibroblasts / metabolism; Fibroblasts / pathology; Lipopolysaccharides / pharmacology; Indenes; Child; Female; Caspase 1 / metabolism; Caspase 1 / genetics; Interleukin-18 / metabolism; Interleukin-18 / genetics; Furans / pharmacology; Cells, Cultured; Adenosine Triphosphate / metabolism; CARD Signaling Adaptor Proteins / metabolism; CARD Signaling Adaptor Proteins / genetics; Organophosphorus Compounds; Piperidines; Sulfonamides
topics (OpenAlex): Inflammasome and immune disorders; Kawasaki Disease and Coronary Complications; Neonatal Respiratory Health Research
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 12, 2024

2024 article

Nutlin-3 Loaded Ethosomes and Transethosomes to Prevent UV-Associated Skin Damage

Esposito, E., Ferrara, F., Drechsler, M., Bortolini, O., Ragno, D., Toldo, S., … Valacchi, G. (2024, January 21). Life, Vol. 14.

By: E. Esposito*, F. Ferrara*, M. Drechsler*, O. Bortolini*, D. Ragno*, S. Toldo*, A. Bondi*, A. Pecorelli* ...

author keywords: nutlin-3; ethosomes; transethosomes; skin damage; UV radiations
topics (OpenAlex): Skin Protection and Aging; Bee Products Chemical Analysis; Advancements in Transdermal Drug Delivery
TL;DR: Ex vivo data suggest a better efficacy of transethosomes to promote nutlin-3 delivery within the skin, with respect to ethosomes, as well as in ex vivo skin explants exposed to UV radiations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 12, 2024

2024 article

Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure

Ferrara, F., Pecorelli, A., Pambianchi, E., White, S., Choudhary, H., Casoni, A., & Valacchi, G. (2024, January 1). Experimental Dermatology, Vol. 33.

By: F. Ferrara*, A. Pecorelli*, E. Pambianchi*, S. White*, H. Choudhary*, A. Casoni*, G. Valacchi*

author keywords: 4HNE; COX2; inflammation; pollution; skin barrier
MeSH headings : Humans; Ascorbic Acid / pharmacology; Ultraviolet Rays / adverse effects; Environmental Pollutants; Vitamins; Antioxidants / pharmacology; Particulate Matter / toxicity; Air Pollutants
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Climate Change and Health Impacts
TL;DR: This study is among the first to investigate the combined effects of three of the most harmful outdoor stressors on human skin and confirms that daily topical of an antioxidant application may prevent pollution-induced skin damage. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 29, 2024

2023 article

A proteomic approach to investigate the role of the MECP2 gene mutation in Rett syndrome redox regulatory pathways

Pasqui, A., Cicaloni, V., Tinti, L., Guiotto, A., Tinti, C., Mori, A., … Valacchi, G. (2023, December 16). Archives of Biochemistry and Biophysics, Vol. 752.

By: A. Pasqui*, V. Cicaloni*, L. Tinti*, A. Guiotto n, C. Tinti*, A. Mori*, M. Bruttini*, J. Hayek* ...

author keywords: Rett syndrome; MECP2 mutations; Precision medicine; Proteomics; Oxidative stress
MeSH headings : Humans; Hydrogen Peroxide; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Oxidation-Reduction; Phenotype; Proteins; Proteomics; Rett Syndrome / genetics
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; RNA modifications and cancer; Ubiquitin and proteasome pathways
TL;DR: By employing a multidisciplinary approach encompassing proteomics and bioinformatics analyses, as well as molecular biology assays, the study uncovered phenotypic responses linked to specific MECP2 gene mutations, contributing to a better understanding of the complexity of RTT molecular pathways. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024

2023 article

Astaxanthin supplementation counters exercise-induced decreases in immune-related plasma proteins

Nieman, D. C., Woo, J., Sakaguchi, C. A., Omar, A. M., Tang, Y., Davis, K., … Zhang, Q. (2023, March 21). Frontiers in Nutrition, Vol. 10.

By: D. Nieman*, J. Woo*, C. Sakaguchi*, A. Omar*, Y. Tang*, K. Davis*, A. Pecorelli n, G. Valacchi n, Q. Zhang*

author keywords: astaxanthin; exercise; proteomics; oxylipins; inflammation; cytokines
topics (OpenAlex): Exercise and Physiological Responses; Muscle metabolism and nutrition; High Altitude and Hypoxia
TL;DR: It is supported that 4-week astaxanthin versus placebo supplementation did not counter exercise-induced increases in plasma cytokines and oxylipins but was linked to normalization of post-exercise plasma levels of numerous immune-related proteins including immunoglobulins within 24 h. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 17, 2023

2023 article

Blueberry Supplementation and Skin Health

Ivarsson, J., Pecorelli, A., Lila, M. A., & Valacchi, G. (2023, June 12). Antioxidants, Vol. 12.

By: J. Ivarsson n, A. Pecorelli*, M. Lila n & G. Valacchi n

author keywords: blueberries; skin; inflammation; polyphenol; antioxidant
topics (OpenAlex): Phytochemicals and Antioxidant Activities; Skin Protection and Aging; Bee Products Chemical Analysis
TL;DR: The argument for blueberries to possibly be an effective agent for skin health is built and the need for further research to elucidate the mechanisms behind the use of both topical application and dietary supplementation with blueberry to bolster cutaneous systems and defensive mechanisms is highlighted. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 14, 2023

2023 article

Cadmium exposure affects the progression of human metastatic melanoma by inducing a deregulation of antioxidant cell response

Casoni, A., Benedusi, M., Cervellati, F., Pecorelli, A., Ferrara, F., Vallese, A., & Valacchi, G. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 42–43.

By: A. Casoni*, M. Benedusi*, F. Cervellati*, A. Pecorelli*, F. Ferrara*, A. Vallese*, G. Valacchi n

topics (OpenAlex): Heavy Metal Exposure and Toxicity
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation

Ivarsson, J., Ferrara, F., Vallese, A., Guiotto, A., Colella, S., Pecorelli, A., & Valacchi, G. (2023, November 23). International Journal of Molecular Sciences, Vol. 24.

By: J. Ivarsson*, F. Ferrara*, A. Vallese*, A. Guiotto*, S. Colella*, A. Pecorelli*, G. Valacchi*

author keywords: oxinflammation; inflammasome; pollutants; skin
MeSH headings : Humans; Inflammasomes / metabolism; Environmental Pollutants / metabolism; Plastics / metabolism; Skin / metabolism; Air Pollutants / toxicity
topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2023 article

Constitutive activation of NLRP3 inflammasome machinery in ex-vivo models of Rett syndrome: from pathogenetic role to new potential therapeutic target

Cordone, V., Pecorelli, A., Ferrara, F., Guiotto, A., Hayek, J., Cervellati, C., … Valacchi, G. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 12–12.

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-κB p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients

Cordone, V., Vallese, A., Pecorelli, A., Guiotto, A., Ferrara, F., Benedusi, M., … Valacchi, G. (2023, March 1). Free Radical Biology and Medicine, Vol. 198, pp. S21–S22.

topics (OpenAlex): Immune Cell Function and Interaction; Nuclear Receptors and Signaling; IL-33, ST2, and ILC Pathways
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Development of Spray Dried Spirulina Protein-Berry Pomace Polyphenol Particles to Attenuate Pollution-Induced Skin Damage: A Convergent Food-Beauty Approach

Hoskin, R. T., Grace, M. H., Guiotto, A., Pecorelli, A., Valacchi, G., & Lila, M. A. (2023, July 15). Antioxidants, Vol. 12.

By: R. Hoskin n, M. Grace n, A. Guiotto n, A. Pecorelli n, G. Valacchi n & M. Lila n

author keywords: sustainability; value-added; repurposing; skin health; cosmeceuticals
topics (OpenAlex): Microencapsulation and Drying Processes; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: It is demonstrated that protein-polyphenol complexation is a synergistic strategy to stabilize and deliver residual fruit/algae phytoactives into cosmeceutical products for skin health applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 17, 2023

2023 article

Evaluation of Anti-Oxinflammatory and ACE-Inhibitory Properties of Protein Hydrolysates Obtained from Edible Non-Mulberry Silkworm Pupae (Antheraea assama and Philosomia ricinii)

Sarkar, P., Pecorelli, A., Woodby, B., Pambianchi, E., Ferrara, F., Duary, R. K., & Valacchi, G. (2023, February 19). Nutrients, Vol. 15.

author keywords: non-mulberry silkworm pupae; angiotensin converting enzyme-inhibitory peptides; antioxidative peptides; ultrafiltration; anti-inflammatory peptides
MeSH headings : Animals; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Antioxidants / pharmacology; Protein Hydrolysates / pharmacology; Bombyx; Pupa; Endothelial Cells; Lipopolysaccharides; Peptides / pharmacology; Hypertension; Hydrolysis
topics (OpenAlex): Insect Utilization and Effects; Protein Hydrolysis and Bioactive Peptides; Neurobiology and Insect Physiology Research
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 20, 2023

2023 article

Inflammasomes regulation by environmental pollutants in human skin

Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 38–39.

topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts
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UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 19, 2023

2023 article

Mitochondria and inflammasome involvement in Autism Spectrum Disorder

Pecorelli, A. (2023, March 1). Free Radical Biology and Medicine, Vol. 198, pp. S2–S2.

By: A. Pecorelli n

topics (OpenAlex): Adolescent and Pediatric Healthcare; Neonatal Respiratory Health Research; Adenosine and Purinergic Signaling
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 20–20.

topics (OpenAlex): COVID-19 Impact on Reproduction; Infant Development and Preterm Care
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Ox-inflammasome involvement in neuroinflammation

Vallese, A., Cordone, V., Pecorelli, A., & Valacchi, G. (2023, July 11). Free Radical Biology and Medicine, Vol. 207, pp. 161–177.

By: A. Vallese*, V. Cordone*, A. Pecorelli* & G. Valacchi n

MeSH headings : Humans; Inflammasomes; Neuroinflammatory Diseases; COVID-19; Inflammation; Neurodegenerative Diseases; NLR Family, Pyrin Domain-Containing 3 Protein
topics (OpenAlex): Inflammasome and immune disorders; Heme Oxygenase-1 and Carbon Monoxide; Neuroinflammation and Neurodegeneration Mechanisms
TL;DR: The current knowledge on the involvement of inflammasome in the main neuropathologies is provided, emphasizing the importance to further clarify the role of oxidative stress in its activation including therole of mitochondria in inflammaome-induced neuroinflammation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 5, 2023

2023 article

Protective role of Ibuprofen-Curcumin co-load nanomicelles against oxidative stress and inflammasome activation mediated by indoor pollution exposure in A549 cells

Garces, M., Pecorelli, A., Moretton, M., Magnani, N., Chiapetta, D., SilviaAlvarez, … Valacchi, G. (2023, November 1). Free Radical Biology and Medicine, Vol. 208, pp. S151–S152.

By: M. Garces*, A. Pecorelli*, M. Moretton*, N. Magnani*, D. Chiapetta*, SilviaAlvarez, P. Evelson*, G. Valacchi n

topics (OpenAlex): Curcumin's Biomedical Applications; Air Quality and Health Impacts; Biomarkers in Disease Mechanisms
Sources: Web Of Science, NC State University Libraries
Added: January 2, 2024

2023 article

Role of Coenzyme Q10 in mitochondrial dysfunction and oxidative damage in RETT syndrome

Silvestri, S., Marcheggiani, F., Orlando, P., Cirilli, I., Mengarelli, F., Vallese, A., … Tiano, L. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 16–16.

topics (OpenAlex): Coenzyme Q10 studies and effects
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

Scavenger receptor B1 involvement in chronic obstructive pulmonary disease pathogenesis

Cervellati, C., Casolari, P., Pecorelli, A., Sticozzi, C., Nucera, F., Papi, A., … Valacchi, G. (2023, January 1). Redox Experimental Medicine, Vol. 2023.

author keywords: oxidative stress; cigarette smoking; 4-hydroxy-2-nonenal
topics (OpenAlex): Chronic Obstructive Pulmonary Disease (COPD) Research; Antioxidant Activity and Oxidative Stress
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 4, 2024

2023 article

Tension as a key factor in skin responses to pollution

Pambianchi, E., Hagenberg, Z., Pecorelli, A., Pasqui, A., Therrien, J.-P., & Valacchi, G. (2023, September 25). Scientific Reports, Vol. 13.

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, A. Pasqui*, J. Therrien n & G. Valacchi n

MeSH headings : Animals; Humans; Skin; Epidermis; Integumentary System; Aggression; Antimicrobial Peptides
topics (OpenAlex): Skin Protection and Aging; Thermoregulation and physiological responses; Circadian rhythm and melatonin
TL;DR: The present work demonstrates that cutaneous exposure to ozone induces AMPs gene and protein levels and that the presence of tension can further modulate their expression, confirming the ability of pollution to induce the cutaneous expression of AMPs via redox signaling and corroborates the principle that skin explants are a good and reliable model to study skin responses. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 22, 2024

2023 article

The pathogenic axis between mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, November 1). Free Radical Biology and Medicine, Vol. 208, pp. S49–S49.

topics (OpenAlex): Infant Development and Preterm Care; Neonatal and fetal brain pathology; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 24, 2023

2023 article

The protective role of endothelial α1AMPK in aircraft noise-induced vascular dysfunction and oxidative stress is mediated by fasting, exercise and pharmacological treatment

Stamm, P., Kvandová, M., Kalinovic, S., Schmal, I., Mihaliková, D., Kuntic, M., … Münzel, T. (2023, May 1). Free Radical Biology and Medicine, Vol. 201, pp. 11–12.

By: P. Stamm*, M. Kvandová*, S. Kalinovic*, I. Schmal*, D. Mihaliková*, M. Kuntic*, M. Jimenez*, O. Hahad* ...

topics (OpenAlex): Noise Effects and Management
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2022 article

Aberrant Mitochondrial Bioenergetics Fuels Inflammasome Machinery in Autism Spectrum Disorder

Pecorelli, A., Francesca, F., Cordone, V., Guiotto, A., Cervellati, C., Hayek, J., & Valacchi, G. (2022, February 1). Free Radical Biology and Medicine, Vol. 2.

topics (OpenAlex): Tryptophan and brain disorders; COVID-19 Impact on Reproduction
Sources: Web Of Science, NC State University Libraries
Added: April 25, 2022

2022 article

Involvement Of Ferroptosis In Rett Syndrome

Guiotto, A., Cordone, V., Benedusi, M., CERVELLATI, F., Cervellati, C., Hayek, J., … Pecorelli, A. (2022, November 1). Free Radical Biology and Medicine, Vol. 192.

By: A. Guiotto, V. Cordone, M. Benedusi, F. Cervellati, C. Cervellati, J. Hayek, G. Valacchi*, A. Pecorelli*

topics (OpenAlex): Cancer-related molecular mechanisms research; Ferroptosis and cancer prognosis; Circular RNAs in diseases
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 article

Loss of Scavenger Receptor B1 (SR-B1) in Brain of a Rett Syndrome Mouse Model

Pecorelli, A., Ferrara, F., Guiotto, A., Vallese, A., Cordone, V., Belmonte, G., … Valacchi, G. (2022, November 1). Free Radical Biology and Medicine, Vol. 192, pp. 90–91.

By: A. Pecorelli*, F. Ferrara*, A. Guiotto, A. Vallese*, V. Cordone, G. Belmonte, J. Hayek, C. Cervellati, G. Valacchi*

topics (OpenAlex): Genetics and Neurodevelopmental Disorders
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 article

Mutations Specific Redox Regulation Pathway In Rett Syndrome By The Use Of Transcriptomics And Proteomics Approaches

Pasqui, A., Cicaloni, V., Tinti, L., Mori, A., Bruttini, M., Pecorelli, A., … Valacchi, G. (2022, November 1). Free Radical Biology and Medicine, Vol. 192.

By: A. Pasqui*, V. Cicaloni*, L. Tinti*, A. Mori*, M. Bruttini*, A. Pecorelli n, C. Tinti*, F. Dotta*, S. Laura*, G. Valacchi n

topics (OpenAlex): Genetics and Neurodevelopmental Disorders
Sources: Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 article

Oxidative-Stress-Sensitive microRNAs in UV-Promoted Development of Melanoma

Pecorelli, A., & Valacchi, G. (2022, June 30). Cancers, Vol. 14, p. 3224.

By: A. Pecorelli n & G. Valacchi n

author keywords: skin cancer; sunlight; redox imbalance; miRNome; mutations; epigenome
topics (OpenAlex): melanin and skin pigmentation; Redox biology and oxidative stress; Skin Protection and Aging
TL;DR: Current evidence suggests a complex interaction between UV-promoted deregulation of redox-sensitive miRNAs and known signal-transduction pathways underlying malignant transformation of melanocytes to melanoma, which could have relevant implications for future therapeutic approaches aimed at counteracting UV-induced redox and miRNome imbalances. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 26, 2022

2022 article

The constitutive activation of TLR4-IRAK1- NFκB axis is involved in the early NLRP3 inflammasome response in peripheral blood mononuclear cells of Rett syndrome patients

Cordone, V., Ferrara, F., Pecorelli, A., Guiotto, A., Vitale, A., Amicarelli, F., … Valacchi, G. (2022, January 24). Free Radical Biology and Medicine, Vol. 3.

author keywords: MeCP2; p65; Oxinflammation; Interleukin-18; Interleukin-1 beta
MeSH headings : Humans; Inflammasomes / genetics; Inflammasomes / metabolism; Interleukin-1 Receptor-Associated Kinases / genetics; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; Leukocytes, Mononuclear / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Toll-Like Receptor 4 / genetics
topics (OpenAlex): Inflammasome and immune disorders; Genetics and Neurodevelopmental Disorders; Toxoplasma gondii Research Studies
TL;DR: The deregulation of inflammasome components was even found in THP-1 cells silenced for MECP2 and importantly, in plasma compartment of RTT subjects, from the earliest stages of the pathology or in correlation with the severity of MeCP2 mutations. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 14, 2022

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). Free Radical Biology and Medicine, Vol. 192, p. 28.

By: F. Ferrara*, V. Cordone*, A. Pecorelli n, M. Benedusi*, E. Pambianchi n, A. Guiotto*, A. Vallese*, F. Cervellati*, G. Valacchi n

topics (OpenAlex): Redox biology and oxidative stress; Heme Oxygenase-1 and Carbon Monoxide; S100 Proteins and Annexins
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, August 21). Redox Biology, p. [""].

author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Inflammasome and immune disorders; Medical and Biological Ozone Research
TL;DR: It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE). (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 12, 2022

2021 article

Alaskan Bog Blueberry (Vaccinium uliginosum) Extract as an Innovative Topical Approach to Prevent UV-Induced Skin Damage

Pambianchi, E., Hagenberg, Z., Pecorelli, A., Grace, M., Therrien, J.-P., Lila, M. A., & Valacchi, G. (2021, November 27). Cosmetics, Vol. 12.

By: E. Pambianchi n, Z. Hagenberg n, A. Pecorelli n, M. Grace n, J. Therrien n, M. Lila n, G. Valacchi n

author keywords: cosmeceuticals; environmental stressor; oxidation; inflammation; antioxidant; OxInflammation; phytochemicals
topics (OpenAlex): Skin Protection and Aging; Dermatology and Skin Diseases; Phytochemicals and Antioxidant Activities
TL;DR: It is observed that the topical application of BB extract on human ex vivo skin explants averted the UV-induced cutaneous OxInflammatory phenomenon by quenching the increase in the oxidative and inflammatory marker levels. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 2, 2021

2021 article

Alteration of cellular defensive response and a possible involvement of ferroptosis cell death in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, March 1). Free Radical Biology and Medicine, Vol. 165.

topics (OpenAlex): Genetics and Neurodevelopmental Disorders
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 article

Alterations in oxygen metabolism are associated to lung toxicity triggered by silver nanoparticles exposure

Garcés, M., Magnani, N. D., Pecorelli, A., Calabró, V., Marchini, T., Cáceres, L., … Evelson, P. (2021, February 16). Free Radical Biology and Medicine, Vol. 166, pp. 324–336.

By: M. Garcés*, N. Magnani*, A. Pecorelli*, V. Calabró*, T. Marchini*, L. Cáceres*, E. Pambianchi*, J. Galdoporpora* ...

author keywords: Nanoparticles; Lung epithelium; Nanotoxicology; Oxidative metabolism; NADPH oxidase; Mitochondria
MeSH headings : Animals; Hydrogen Peroxide; Lung; Metal Nanoparticles / toxicity; Mice; Oxygen; Silver
topics (OpenAlex): Nanoparticles: synthesis and applications; Acute Kidney Injury Research; Traumatic Brain Injury and Neurovascular Disturbances
TL;DR: Results show that AgNP exposure alters O2 metabolism leading to a redox imbalance, which may be responsible for the impaired lung function observed due to alveolar epithelial injury. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 19, 2021

2021 article

Altered Bone Status in Rett Syndrome

Pecorelli, A., Cordone, V., Schiavone, M. L., Caffarelli, C., Cervellati, C., Cerbone, G., … Valacchi, G. (2021, June 3). Life, Vol. 6.

author keywords: MeCP2; bone mineral density; bone metabolism; osteoblast; WNT pathway
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Autism Spectrum Disorder Research; Child Nutrition and Feeding Issues
TL;DR: Evidence from human and animal studies supports the idea that MECP2 mutation could be associated with altered epigenetic regulation of bone-related factors and signaling pathways, including SFRP4/WNT/β-catenin axis and RANKL/RANK/OPG system. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021

2021 article

Deferoxamine Treatment Improves Antioxidant Cosmeceutical Formulation Protection against Cutaneous Diesel Engine Exhaust Exposure

Pambianchi, E., Ferrara, F., Pecorelli, A., Benedusi, M., Choudhary, H., Therrien, J.-P., & Valacchi, G. (2021, November 30). Antioxidants, Vol. 12.

By: E. Pambianchi n, F. Ferrara*, A. Pecorelli n, M. Benedusi*, H. Choudhary*, J. Therrien*, G. Valacchi n

author keywords: cosmeceuticals; pollution; iron-chelator
topics (OpenAlex): Skin Protection and Aging; Air Quality and Health Impacts; Contact Dermatitis and Allergies
TL;DR: It is suggested that iron plays a key role in DEE-induced skin damage and its chelation could be an adjuvant strategy to reinforce antioxidant topical formulations. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 24, 2022

2021 article

Deregulated inflammasome response in Rett syndrome

Cordone, V., Pecorelli, A., Falone, S., Hayek, J., Amicarelli, F., & Valacchi, G. (2021, December 1). Free Radical Biology and Medicine, Vol. 12.

topics (OpenAlex): Peptidase Inhibition and Analysis; Adenosine and Purinergic Signaling; Genetics and Neurodevelopmental Disorders
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UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Impaired mitochondrial quality control in Rett Syndrome

Crivellari, I., Pecorelli, A., Cordone, V., Marchi, S., Pinton, P., Hayek, J., … Valacchi, G. (2021, February 4). Archives of Biochemistry and Biophysics, Vol. 700.

By: I. Crivellari*, A. Pecorelli n, V. Cordone*, S. Marchi*, P. Pinton*, J. Hayek*, C. Cervellati*, G. Valacchi n

author keywords: RTT Syndrome; Oxidative stress; Mitochondrial quality control; Mitophagy; Apoptosis
MeSH headings : Adolescent; Adult; Apoptosis; Caspase 3 / genetics; Caspase 3 / metabolism; Caspase 7 / genetics; Caspase 7 / metabolism; Child; Dynamins / genetics; Dynamins / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; GTP Phosphohydrolases / genetics; GTP Phosphohydrolases / metabolism; Humans; Membrane Proteins / genetics; Membrane Proteins / metabolism; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mitochondria / genetics; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Membrane Transport Proteins / genetics; Mitochondrial Membrane Transport Proteins / metabolism; Mitochondrial Proteins / genetics; Mitochondrial Proteins / metabolism; Mitophagy; Oxidation-Reduction; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Mitochondrial Function and Pathology; Endoplasmic Reticulum Stress and Disease
TL;DR: It is shown that RTT fibroblasts have networks of hyperfused mitochondria with morphological abnormalities and increased mitochondrial volume, shedding light on new aspects of mitochondrial dysfunction in RTT that are represented by defective mitochondrial QC pathways, providing new potential targets for a therapeutic intervention aimed at slowing down clinical course and manifestations in the affected patients. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 15, 2021

2021 article

Improper enzymatic defensive responses in Rett syndrome disorder

Guiotto, A., Cordone, V., Benedusi, M., Cervellati, F., Hayek, J., Cervellati, C., … Pecorelli, A. (2021, December 1). Free Radical Biology and Medicine, Vol. 12.

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Advanced biosensing and bioanalysis techniques; Advanced Battery Technologies Research
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UN Sustainable Development Goal Categories
14. Life Below Water (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Mitochondrial dynamics and quality control pathways impairment in Rett Syndrome and Autism Spectrum Disorder

Pecorelli, A., Guiotto, A., Cordone, V., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, December 1). Free Radical Biology and Medicine, Vol. 12.

topics (OpenAlex): Child Nutrition and Feeding Issues; Genetics and Neurodevelopmental Disorders; Attention Deficit Hyperactivity Disorder
Sources: Web Of Science, NC State University Libraries
Added: February 28, 2022

2021 article

Mitochondrial dysfunction fuels inflammasome machinery in Autism Spectrum Disorder

Pecorelli, A., Cordone, V., Guiotto, A., Cervellati, F., Benedusi, M., Cervellati, C., … Valacchi, G. (2021, March 1). Free Radical Biology and Medicine, Vol. 165.

topics (OpenAlex): COVID-19 Impact on Reproduction; Kawasaki Disease and Coronary Complications; Genetics and Neurodevelopmental Disorders
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 article

Novel Spray Dried Algae-Rosemary Particles Attenuate Pollution-Induced Skin Damage

Hoskin, R., Pambianchi, E., Pecorelli, A., Grace, M., Therrien, J.-P., Valacchi, G., & Lila, M. A. (2021, June 22). Molecules, Vol. 7, p. 3781.

By: R. Hoskin n, E. Pambianchi n, A. Pecorelli n, M. Grace n, J. Therrien*, G. Valacchi n, M. Lila n

author keywords: cosmeceuticals; pollution; phytochemicals; herbs
MeSH headings : Antioxidants / chemistry; Antioxidants / pharmacology; Cells, Cultured; Chlorella / chemistry; Cinnamates / chemistry; Depsides / chemistry; Environmental Exposure / adverse effects; Filaggrin Proteins; Humans; Rosmarinus / chemistry; Skin / injuries; Skin / metabolism; Skin / pathology; Skin Aging / drug effects
topics (OpenAlex): Skin Protection and Aging; Bee Products Chemical Analysis; Phytochemicals and Antioxidant Activities
TL;DR: The ex-vivo data clearly demonstrated the ability of RSP gel to prevent an oxinflammatory phenomenon in cutaneous tissue by decreasing the levels of 4-hydroxynonenal protein adducts and active matrix metalloproteinase-9 (MMP-9) by limiting the loss of filaggrin induced by DEE exposure. (via Semantic Scholar)
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6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 23, 2021

2021 article

Selective Fatty Acid Amide Hydrolase Inhibitors as Potential Novel Antiepileptic Agents

Grillo, A., Fezza, F., Chemi, G., Colangeli, R., Brogi, S., Fazio, D., … Giovanni, G. D. (2021, April 23). ACS Chemical Neuroscience, Vol. 5.

author keywords: Endocannabinoid system; fatty acid amide hydrolase; enzyme inhibitors; selective inhibitors; epilepsy; temporal lobe epilepsy; seizures
MeSH headings : Amidohydrolases; Anticonvulsants / pharmacology; Endocannabinoids; Enzyme Inhibitors / pharmacology; Humans; Seizures
topics (OpenAlex): Cannabis and Cannabinoid Research; Epilepsy research and treatment; Neuroscience and Neuropharmacology Research
TL;DR: The discovery of selective anandamide catabolic enzyme fatty acid amide hydrolase (FAAH) inhibitors with promising antiepileptic efficacy are reported, starting from a further investigation of the authors' prototypical inhibitor 2a. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 10, 2021

2021 article

The nitrate-nitrite-nitric oxide pathway improves neurovascular coupling under cerebral hypoperfusion conditions

Ferrara, F., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., Cervellati, F., & Valacchi, G. (2021, March 1). Free Radical Biology and Medicine, Vol. 165.

By: F. Ferrara, A. Pecorelli, M. Benedusi, E. Pambianchi, A. Guiotto, F. Cervellati, G. Valacchi

topics (OpenAlex): Traumatic Brain Injury and Neurovascular Disturbances; Neurological Disease Mechanisms and Treatments; Optical Imaging and Spectroscopy Techniques
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2020 article

A proteomics approach to further highlight the altered inflammatory condition in Rett syndrome

Cicaloni, V., Pecorelli, A., Cordone, V., Tinti, L., Rossi, M., Hayek, J., … Valacchi, G. (2020, November 5). Archives of Biochemistry and Biophysics, Vol. 696.

author keywords: Rare disease; Rett syndrome; Inflammatory status; NLRP3 inflammasome; Mass spectrometry-based proteomics
MeSH headings : Adult; Female; Fibroblasts / chemistry; Humans; Inflammation / complications; Inflammation / metabolism; Protein Interaction Maps; Proteome / analysis; Proteome / metabolism; Proteomics; Rett Syndrome / complications; Rett Syndrome / metabolism; Young Adult
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Endoplasmic Reticulum Stress and Disease; Autophagy in Disease and Therapy
TL;DR: Results provide a detailed insight into the molecular pathways involved in RTT immune dysfunction that, causing tissue and organ damage, can increase the vulnerability of affected patients to unknown endogenous factors or infections. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021

2020 article

Alterations of mitochondrial bioenergetics, dynamics, and morphology support the theory of oxidative damage involvement in autism spectrum disorder

Pecorelli, A., Ferrara, F., Messano, N., Cordone, V., Schiavone, M. L., Cervellati, F., … Valacchi, G. (2020, April 4). The FASEB Journal, Vol. 5.

author keywords: 4-hydroxynonenal; fission; fusion; mitophagy; nuclear factor erythroid 2-related factor 2
MeSH headings : Adolescent; Adult; Autism Spectrum Disorder / metabolism; Autism Spectrum Disorder / pathology; Case-Control Studies; Child; Energy Metabolism; Female; Fibroblasts / metabolism; Fibroblasts / pathology; Humans; Male; Mitochondria / metabolism; Mitochondria / pathology; Mitochondrial Dynamics; Mitochondrial Proteins / metabolism; Oxidative Stress; Young Adult
topics (OpenAlex): Autism Spectrum Disorder Research; Genetics and Neurodevelopmental Disorders; Genetics, Aging, and Longevity in Model Organisms
TL;DR: It is suggested that many of the changes observed in mitochondria could represent compensatory mechanisms by which ASD cells try to adapt to altered energy demand, possibly resulting from a chronic oxinflammatory status. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020

2020 article

Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations

Sbardella, D., Tundo, G. R., Cunsolo, V., Grasso, G., Cascella, R., Caputo, V., … Marini, S. (2020, April 8). Biochimica Et Biophysica Acta (BBA) - Molecular Basis of Disease, Vol. 1866.

By: D. Sbardella*, G. Tundo*, V. Cunsolo*, G. Grasso*, R. Cascella, V. Caputo, A. Santoro*, D. Milardi* ...

author keywords: Rett syndrome; Skin primary fibroblasts; Proteasome; alpha-Ring; PAC1; PAC2
MeSH headings : Codon, Nonsense / genetics; Dual Specificity Phosphatase 2 / genetics; Fibroblasts / metabolism; Gene Expression Regulation; Genetic Diseases, X-Linked / genetics; Genetic Diseases, X-Linked / pathology; Humans; Methyl-CpG-Binding Protein 2 / genetics; Neurodevelopmental Disorders / genetics; Neurodevelopmental Disorders / pathology; Primary Cell Culture; Proteasome Endopeptidase Complex / genetics; Proteolysis; Rett Syndrome / genetics; Rett Syndrome / pathology; Skin / metabolism; Skin / pathology; Ubiquitin / genetics
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Ubiquitin and proteasome pathways; Endoplasmic Reticulum Stress and Disease
TL;DR: Molecular, transcription and proteomic analyses indicate that MeCP2 mutations down-regulate the expression of one proteasome subunit, α7, and of two chaperones, PAC1 and PAC2, which bind each other in the earliest step of proteAsome biogenesis. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 15, 2020

2020 article

Inflammation in Neurological Disorders: The Thin Boundary Between Brain and Periphery

Cervellati, C., Trentini, A., Pecorelli, A., & Valacchi, G. (2020, March 7). Antioxidants and Redox Signaling, Vol. 7.

By: C. Cervellati*, A. Trentini*, A. Pecorelli* & G. Valacchi*

author keywords: Alzheimer's disease; inflammation; multiple sclerosis; vascular dementia
MeSH headings : Animals; Biomarkers; Blood-Brain Barrier / metabolism; Brain / metabolism; Brain / pathology; Disease Susceptibility; Dysbiosis; Humans; Inflammation / etiology; Inflammation / metabolism; Inflammation / pathology; Nervous System Diseases / etiology; Nervous System Diseases / metabolism; Nervous System Diseases / pathology; Oxidative Stress; Peripheral Nerves / metabolism; Peripheral Nerves / pathology
topics (OpenAlex): Neuroinflammation and Neurodegeneration Mechanisms; Alzheimer's disease research and treatments; S100 Proteins and Annexins
TL;DR: Reaching a definitive clinical/epidemiological appreciation of the etiopathogenic significance of the connection between peripheral and brain inflammation in neurologic disorders is pivotal since it could open novel therapeutic avenues for these diseases. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020

2020 article

Mechanisms involved in the unbalanced redox homeostasis in osteoblastic cellular model of Alkaptonuria

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Pambianchi, E., Santucci, A., & Valacchi, G. (2020, June 2). Archives of Biochemistry and Biophysics, Vol. 690.

author keywords: Alkaptonuria; Osteoblast; Oxidative stress; Nrf2; Mitochondria; NADPH oxidase
MeSH headings : Alkaptonuria / metabolism; Cell Line; DNA-Binding Proteins / metabolism; Homeostasis / physiology; Homogentisic Acid / metabolism; Humans; Hydrogen Peroxide / metabolism; Mitochondria / metabolism; Mitochondria / ultrastructure; NADPH Oxidases / metabolism; NF-E2-Related Factor 2 / metabolism; Osteoblasts / cytology; Oxidation-Reduction; Oxidative Stress / physiology; Signal Transduction; Superoxide Dismutase / metabolism; Thioredoxins / metabolism
topics (OpenAlex): Metabolism and Genetic Disorders; Biochemical Acid Research Studies; Alcoholism and Thiamine Deficiency
TL;DR: HGA is able to alter the cellular redox homeostasis by modulating the endogenous ROS production via NOX activation and mitochondrial dysfunctions and impair the cellular response mechanism, which can be useful for understanding the pathophysiology of AKU. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 19, 2021

2020 article

Postexercise Inflammasome Activation and IL-1β Production Mitigated by Flavonoid Supplementation in Cyclists

Nieman, D. C., Ferrara, F., Pecorelli, A., Woodby, B., Hoyle, A. T., Simonson, A., & Valacchi, G. (2020, September 15). International Journal of Sport Nutrition and Exercise Metabolism, Vol. 30, pp. 396–404.

By: D. Nieman*, F. Ferrara n, A. Pecorelli n, B. Woodby n, A. Hoyle*, A. Simonson*, G. Valacchi n

author keywords: cytokines; gasdermin D; IL-18; inflammation
topics (OpenAlex): Inflammasome and immune disorders; Exercise and Physiological Responses; Adipokines, Inflammation, and Metabolic Diseases
TL;DR: The data indicate that 2-week FLAV ingestion mitigated inflammasome activation, with a corresponding decrease in IL-1β release in cyclists after a 75-km cycling time trial, and support the strategy of ingesting high amounts of FLAV to mitigate postexercise inflammation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 9, 2020

2020 article

Protective effects of a comprehensive topical antioxidant against ozone-induced damage in a reconstructed human skin model

Pecorelli, A., McDaniel, D. H., Wortzman, M., & Nelson, D. B. (2020, May 8). Archives of Dermatological Research.

By: A. Pecorelli*, D. McDaniel, M. Wortzman & D. Nelson

author keywords: Antioxidants; Ozone; Oxidative damage; Cosmeceuticals; Free radicals; Reactive Oxygen Species (ROS)
MeSH headings : Administration, Cutaneous; Antioxidants / administration & dosage; Cell Culture Techniques; Cells, Cultured; Drug Evaluation, Preclinical; Epidermis / drug effects; Epidermis / pathology; Humans; Lipid Peroxidation / drug effects; Oxidative Stress / drug effects; Ozone / adverse effects; Reactive Oxygen Species / metabolism; Skin Aging / drug effects
topics (OpenAlex): Medical and Biological Ozone Research; Air Quality and Health Impacts; Climate Change and Health Impacts
TL;DR: A comprehensive topical antioxidant significantly diminished O 3 -induced oxidative damage in a human epidermal skin model and inhibited damage in tissues exposed to O 3 with no significant changes in epidermis structure. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2020 article

Proteomic profiling reveals mitochondrial alterations in Rett syndrome

Cicaloni, V., Pecorelli, A., Tinti, L., Rossi, M., Benedusi, M., Cervellati, C., … Valacchi, G. (2020, May 20). Free Radical Biology and Medicine, Vol. 155, pp. 37–48.

By: V. Cicaloni*, A. Pecorelli n, L. Tinti*, M. Rossi*, M. Benedusi*, C. Cervellati*, O. Spiga*, A. Santucci* ...

MeSH headings : Gene Expression Profiling; Humans; Methyl-CpG-Binding Protein 2 / genetics; Mutation; Proteome / genetics; Proteomics; Rett Syndrome / genetics
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Autophagy in Disease and Therapy; Endoplasmic Reticulum Stress and Disease
TL;DR: The proteomic analysis confirms the pathological relevance of mitochondrial dysfunction in RTT pathogenesis and progression and carries out the first comprehensive characterization of RTT cellular proteome, showing mainly changes in expression of proteins involved in the mitochondrial network. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 6, 2020

2020 article

Skin Health from the Inside Out

Woodby, B., Penta, K., Pecorelli, A., Lila, M. A., & Valacchi, G. (2020, January 6). Annual Review of Food Science and Technology, Vol. 11, pp. 235–254.

By: B. Woodby n, K. Penta n, A. Pecorelli n, M. Lila n & G. Valacchi n

author keywords: pollution; skin; diet; GI tract; inflammation; antioxidant; vitamins
MeSH headings : Antioxidants / metabolism; Humans; Reactive Oxygen Species / metabolism; Skin Physiological Phenomena
topics (OpenAlex): Skin Protection and Aging; Vitamin C and Antioxidants Research; Antioxidant Activity and Oxidative Stress
TL;DR: This review discusses how topical application of antioxidants, including vitamins C and E, carotenoids, resveratrol, and pycnogenol, can be combined with dietary supplementation of these antioxidant compounds in addition to probiotics and essential minerals to protect against outdoor stressor-induced skin damage, including the damage associated with aging. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 27, 2020

2019 article

13-HODE, 9-HODE and ALOX15 as potential players in Rett syndrome OxInflammation

Pecorelli, A., Cervellati, C., Cordone, V., Amicarelli, F., Hayek, J., & Valacchi, G. (2019, February 10). Free Radical Biology and Medicine, Vol. 134, pp. 598–603.

author keywords: Rett syndrome; Oxidative stress; Hydroxyoctadecadienoic acids; Inflammation; Omega-3 polyunsaturated fatty acids; Arachidonate 15-Lipoxygenase
MeSH headings : Adolescent; Adult; Arachidonate 15-Lipoxygenase / genetics; Arachidonate 15-Lipoxygenase / metabolism; Case-Control Studies; Child; Female; Humans; Inflammation / genetics; Inflammation / metabolism; Inflammation / pathology; Leukocytes, Mononuclear / metabolism; Linoleic Acids / metabolism; Linoleic Acids, Conjugated / metabolism; Male; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology; Young Adult
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; RNA modifications and cancer; Adenosine and Purinergic Signaling
TL;DR: Statistically significant correlation was demonstrated between the increased plasma HODEs levels and the lipoprotein-associated phospholipase A2 (Lp-PLA2) activity, and the possible ability of omega-3 polyunsaturated fatty acids supplementation in improving the oxinflammation status in RTT. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 1, 2019

2019 article

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation

Pecorelli, A., Cordone, V., Messano, N., Zhang, C., Falone, S., Amicarelli, F., … Valacchi, G. (2019, October 6). Redox Biology, Vol. 28.

author keywords: NLRP3; ASC; Inflammatory status; Cytokines; MeCP2
MeSH headings : Biomarkers; Cytokines / metabolism; Disease Susceptibility; Fibroblasts / metabolism; Fluorescent Antibody Technique; Humans; Inflammasomes / metabolism; Inflammation Mediators / metabolism; Interleukin-1beta / metabolism; NF-kappa B / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Protein Transport; Rett Syndrome / etiology; Rett Syndrome / metabolism
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Inflammasome and immune disorders; Adenosine and Purinergic Signaling
TL;DR: It is suggested that RTT patients exhibited a challenged inflammasome machinery at cellular and systemic level, which may contribute to the subclinical inflammatory state feedback observed in this pathology. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 30, 2019

2019 article

Antiglycative Activity and RAGE Expression in Rett Syndrome

Cordone, V., Pecorelli, A., Benedusi, M., Santini, S., Falone, S., Hayek, J., … Valacchi, G. (2019, February 15). Cells, Vol. 8.

author keywords: methylglyoxal; glyoxalases; advanced glycation end products; MeCP2; dicarbonyl stress; fibroblasts
MeSH headings : Adolescent; Adult; Antigens, Neoplasm / metabolism; Cell Survival / drug effects; Child; Female; Fibroblasts / drug effects; Fibroblasts / metabolism; Glycosylation; Humans; Lactoylglutathione Lyase / metabolism; Mitogen-Activated Protein Kinases / metabolism; Pyruvaldehyde / pharmacology; Rett Syndrome / metabolism; Rett Syndrome / pathology; Thiolester Hydrolases / metabolism; Young Adult
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Child Nutrition and Feeding Issues; Family and Disability Support Research
TL;DR: Besides OxInflammation, RTT is associated with reshaping of the major defense systems against dicarbonyl stress, along with an altered cellular stress response towards pro-glycating insults. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 25, 2019

2019 article

Blueberries Topical Application Prevents Ozone Induced Cutaneous Inflammasome Activation

Pambianchi, E., Francesca, F., Pecorelli, A., Woodby, B., Lila, M., & Valacchi, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S148–S148.

By: E. Pambianchi, F. Francesca, A. Pecorelli, B. Woodby, M. Lila & G. Valacchi

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems

Grillo, A., Chemi, G., Brogi, S., Brindisi, M., Relitti, N., Fezza, F., … Gemma, S. (2019, September 4). European Journal of Medicinal Chemistry, Vol. 183.

author keywords: Endocannabinoid system; Fatty acid amide hydrolase; Enzyme inhibitors; Selective inhibitors; Dopamine ligands; Polypharmacology; Multitarget compounds; Dopamine receptor ligands
MeSH headings : Amidohydrolases / antagonists & inhibitors; Amidohydrolases / metabolism; Binding, Competitive; Cell Line; Cell Survival / drug effects; Dopamine / metabolism; Endocannabinoids / metabolism; Enzyme Inhibitors / chemistry; Enzyme Inhibitors / pharmacology; Humans; Ligands; Piperazines / chemistry; Piperazines / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
topics (OpenAlex): Cannabis and Cannabinoid Research; Pharmacological Receptor Mechanisms and Effects; Receptor Mechanisms and Signaling
TL;DR: The synthesis and biological characterization of compounds 5a-j inspired by the structure of the authors' potent and selective fatty acid amide hydrolase (FAAH) inhibitors and ligands of dopamine D2 or D3 receptor subtypes are described. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019

2019 article

Gallic acid loaded poloxamer gel as new adjuvant strategy for melanoma: A preliminary study

Sguizzato, M., Valacchi, G., Pecorelli, A., Boldrini, P., Simelière, F., Huang, N., … Esposito, E. (2019, November 2). Colloids and Surfaces B Biointerfaces, Vol. 185.

author keywords: Biocompatible polymers; Polymer gels; In vitro diffusion; Polymer membranes; Gallic acid; Franz cell
MeSH headings : Adjuvants, Immunologic / pharmacology; Adjuvants, Immunologic / therapeutic use; Cell Line; Cell Movement / drug effects; Diffusion; Elasticity; Gallic Acid / pharmacology; Gallic Acid / therapeutic use; Gels / chemistry; Humans; Kinetics; Melanoma / drug therapy; Phase Transition; Poloxamer / chemistry; Rheology; Temperature; Viscosity; Wound Healing / drug effects
topics (OpenAlex): Essential Oils and Antimicrobial Activity; Advancements in Transdermal Drug Delivery; Bee Products Chemical Analysis
TL;DR: Scratch wound healing and migration assays conducted on human keratinocytes and melanoma cells demonstrated the ability of gallic acid loaded gel to inhibit cellular migration, suggesting its potential as adjuvant strategy for melanoma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 13, 2020

2019 article

HGA Induces Oxidative Damage in an Osteoblastic Cellular Model of Alkaptonuria: Sources and Mechanisms

Schiavone, M. L., Pecorelli, A., Woodby, B., Ferrara, F., Santucci, A., & Valacchi, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S37–S38.

By: M. Schiavone, A. Pecorelli, B. Woodby, F. Ferrara, A. Santucci & G. Valacchi

topics (OpenAlex): Peroxisome Proliferator-Activated Receptors; Liver Disease Diagnosis and Treatment; Metabolism and Genetic Disorders
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Involvement of 4‐hydroxy‐2‐nonenal in pollution‐induced skin damage

Pecorelli, A., Woodby, B., Prieux, R., & Valacchi, G. (2019, May 14). BioFactors, Vol. 45, pp. 536–547.

By: A. Pecorelli n, B. Woodby n, R. Prieux* & G. Valacchi n

author keywords: ozone; particulate matter; cigarette smoke; peroxidation
MeSH headings : Air Pollutants / metabolism; Air Pollutants / toxicity; Aldehydes / metabolism; Aldehydes / toxicity; Dermatitis, Atopic / chemically induced; Dermatitis, Atopic / genetics; Dermatitis, Atopic / metabolism; Dermatitis, Atopic / pathology; Gene Expression Regulation / drug effects; Humans; Mitogen-Activated Protein Kinases / genetics; Mitogen-Activated Protein Kinases / metabolism; Oxidation-Reduction; Oxidative Stress; Ozone / metabolism; Ozone / toxicity; Particulate Matter / toxicity; Psoriasis / chemically induced; Psoriasis / genetics; Psoriasis / metabolism; Psoriasis / pathology; Reactive Oxygen Species / agonists; Reactive Oxygen Species / metabolism; Signal Transduction; Skin / drug effects; Skin / metabolism; Skin / pathology; Skin Aging / drug effects; Skin Aging / genetics; Skin Aging / pathology; Tobacco Smoke Pollution / adverse effects; Transcription Factors / genetics; Transcription Factors / metabolism
topics (OpenAlex): Skin Protection and Aging; Indoor Air Quality and Microbial Exposure; Air Quality and Health Impacts
TL;DR: Increased levels of HNE in the skin, in response to pollutants, likely accelerates skin aging and exacerbates existing skin inflammatory conditions; thus, targeting HNE formation could be an innovative cosmeceutical approach for topical applications. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: April 20, 2020

2019 article

Mixed Flavonoid Supplementation Attenuates Postexercise Plasma Levels of 4-Hydroxynonenal and Protein Carbonyls in Endurance Athletes

Nieman, D. C., Valacchi, G., Wentz, L. M., Ferrara, F., Pecorelli, A., Woodby, B., … Simonson, A. (2019, November 21). International Journal of Sport Nutrition and Exercise Metabolism, Vol. 30, pp. 112–119.

author keywords: inflammation exercise; oxidative stress; peripheral blood mononuclear cells
topics (OpenAlex): Exercise and Physiological Responses; Muscle metabolism and nutrition; Adipose Tissue and Metabolism
TL;DR: Flavonoid supplementation prior to intensive exercise decreased plasma peroxidation and oxidative damage, as determined by 4-hydroxynonenal. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 6, 2020

2019 article

Multiple mechanisms of Rottlerin toxicity in A375 melanoma cells

Ietta, F., Valacchi, G., Benincasa, L., Pecorelli, A., Cresti, L., & Maioli, E. (2019, August 13). BioFactors, Vol. 11.

By: F. Ietta*, G. Valacchi*, L. Benincasa*, A. Pecorelli*, L. Cresti* & E. Maioli*

author keywords: apoptosis; ER stress; melanoma; mitochondria; protein synthesis; rottlerin
MeSH headings : Acetophenones / pharmacology; Antineoplastic Agents / pharmacology; Apoptosis / drug effects; Benzopyrans / pharmacology; Cell Line, Tumor; Cell Proliferation / drug effects; Cyclin D1 / genetics; Endoplasmic Reticulum / drug effects; Endoplasmic Reticulum Stress / drug effects; Gene Expression Regulation, Neoplastic / drug effects; Humans; Melanoma / drug therapy; Melanoma / genetics; Melanoma / pathology; Mitochondria / drug effects; Mitochondria / genetics; Reactive Oxygen Species / metabolism; Signal Transduction / drug effects
topics (OpenAlex): Endoplasmic Reticulum Stress and Disease; Autophagy in Disease and Therapy; RNA Interference and Gene Delivery
TL;DR: In this cell line, rottlerin exhibits its main and newest cytotoxic properties, that is, growth arrest, apoptosis induction, and translation shutoff, and the drug markedly inhibited cell proliferation through cyclin D1 downregulation and induced apoptotic cell death as early as after 18 h treatment. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 26, 2019

2019 article

OxInflammation as a Aossible new Player in Rett Syndrome Pathophysiology

Pecorelli, A., Valacchi, G., Cordone, V., & Hayek, J. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S149–S149.

By: A. Pecorelli, G. Valacchi, V. Cordone & J. Hayek

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Child Nutrition and Water Access; Energy and Environment Impacts
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox Regulation of Antimicrobial Peptides

Woodby, B., Pambianchi, E., Francesca, F., Messano, N., Pecorelli, A., Therrien, J. P., & Valacchii, G. (2019, November 15). Free Radical Biology and Medicine, Vol. 145, pp. S54–S55.

By: B. Woodby, E. Pambianchi, F. Francesca, N. Messano, A. Pecorelli, J. Therrien, G. Valacchii

topics (OpenAlex): Simulation-Based Education in Healthcare; Innovations in Medical Education; Education and Critical Thinking Development
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4. Quality Education (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox Regulation of Cutaneous Inflammasome Pathway by Ozone Exposure

Ferrara, F., Pecorelli, A., Woodby, B., Pambianchi, E., Messano, N., Therrien, J. P., & Valacchi, G. (2019, December). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 145, pp. S22–S23.

By: F. Ferrara, A. Pecorelli, B. Woodby, E. Pambianchi, N. Messano, J. Therrien, G. Valacchi

topics (OpenAlex): Medical and Biological Ozone Research; Vitamin D Research Studies
Sources: Web Of Science, NC State University Libraries
Added: December 2, 2019

2019 article

Redox regulation of cutaneous inflammasome by ozone exposure

Ferrara, F., Pambianchi, E., Pecorelli, A., Woodby, B., Messano, N., Therrien, J.-P., … Valacchi, G. (2019, November 25). Free Radical Biology and Medicine, Vol. 152, pp. 561–570.

By: F. Ferrara*, E. Pambianchi*, A. Pecorelli*, B. Woodby*, N. Messano*, J. Therrien, M. Lila*, G. Valacchi*

MeSH headings : Caspase 1 / metabolism; Humans; Hydrogen Peroxide; Inflammasomes / metabolism; Interleukin-1beta / genetics; Interleukin-1beta / metabolism; NLR Family, Pyrin Domain-Containing 3 Protein / genetics; NLR Family, Pyrin Domain-Containing 3 Protein / metabolism; Oxidation-Reduction; Ozone / toxicity; Reactive Oxygen Species
topics (OpenAlex): Inflammasome and immune disorders; Heme Oxygenase-1 and Carbon Monoxide; Medical and Biological Ozone Research
TL;DR: It is demonstrated that O3 can activate cutaneous inflammasome in a redox dependent manner suggesting a possible role of this new pathway in pollution induced inflammatory skin conditions. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 13, 2020

2018 article

Inflammasome involvement in Rett syndrome subclinical inflammation

Pecorelli, A., Cordone, V., Falone, S., Romani, A., Benedusi, M., Hayek, J., … Valacchi, G. (2018, November 1). Free Radical Biology and Medicine, Vol. 128, pp. S108–109.

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Inflammasome and immune disorders
TL;DR: The results suggest a possible basal activation of inflammasome in RTT cells that, on the other hand, appear to be unable to respond properly at the inflammatory stimulus. (via Semantic Scholar)
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3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 19, 2018

2018 article

LB1553 AtmO3spheric skin damage: The oxInflammation phenomena

Valacchi, G., Pecorelli, A., Pambianchi, E., Ferrara, F., & Lila, M. (2018, August 22). Journal of Investigative Dermatology, Vol. 138, pp. B15–15.

By: G. Valacchi n, A. Pecorelli*, E. Pambianchi*, F. Ferrara n & M. Lila*

topics (OpenAlex): Medical and Biological Ozone Research; Skin Protection and Aging
Sources: Web Of Science, NC State University Libraries
Added: October 19, 2018

2018 article

OxInflammation: From Subclinical Condition to Pathological Biomarker

Valacchi, G., Virgili, F., Cervellati, C., & Pecorelli, A. (2018, July 9). Frontiers in Physiology, Vol. 9.

By: G. Valacchi n, F. Virgili*, C. Cervellati* & A. Pecorelli n

author keywords: biomarkers; neurological disorders; oxidative stress; inflammation mediators; NF kappa B
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Immune Response and Inflammation; S100 Proteins and Annexins
TL;DR: The term “OxInflammation” is proposed as a novel operative term describing a permanent pro-oxidative feature that interact, in a positive feed-back manner, to a not yet clinically detectable inflammatory process, leading in a long run (chronically) to a systemic/local damage, as a consequence of the cross talk between inflammatory, and oxidative stress mediators. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
15. Life on Land (OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2018 article

Tropospheric ozone affects SRB1 levels via oxidative post-translational modifications in lung cells

Sticozzi, C., Pecorelli, A., Romani, A., Belmonte, G., Cervellati, F., Maioli, E., … Valacchi, G. (2018, July 27). Free Radical Biology and Medicine, Vol. 126, pp. 287–295.

By: C. Sticozzi*, A. Pecorelli*, A. Romani*, G. Belmonte*, F. Cervellati*, E. Maioli*, M. Lila*, C. Cervellati*, G. Valacchi*

MeSH headings : A549 Cells; Aldehydes / metabolism; Alveolar Epithelial Cells / drug effects; Alveolar Epithelial Cells / metabolism; Antioxidants / pharmacology; Biological Transport / drug effects; Catalase / genetics; Catalase / metabolism; Cell Survival / drug effects; Humans; Hydrogen Peroxide / metabolism; Lung / drug effects; Lung / metabolism; Lung / pathology; Oxidation-Reduction / drug effects; Oxidative Stress / drug effects; Ozone / pharmacology; Protein Processing, Post-Translational / drug effects; Scavenger Receptors, Class B / genetics; Scavenger Receptors, Class B / metabolism; Vitamin E / metabolism
topics (OpenAlex): Air Quality and Health Impacts; Antioxidant Activity and Oxidative Stress; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: To characterize the molecular mechanism involved in the redox modulation of SRB1, its cellular levels were assessed in human alveolar epithelial cells after O3 exposure and it was demonstrated that O3 induced the loss ofSRB1 protein levels, a mechanism that could account for SRB 1 protein loss. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 16, 2018

2017 article

4-hydroxynonenal protein adducts: Key mediator in Rett syndrome oxinflammation

Valacchi, G., Pecorelli, A., Cervellati, C., & Hayek, J. (2017, January 5). Free Radical Biology and Medicine, Vol. 111, pp. 270–280.

By: G. Valacchi n, A. Pecorelli n, C. Cervellati* & J. Hayek*

author keywords: Inflammation; Isoprostanes; Oxidative stress; Rare disease; Orphan disease; CDKL5; FOXG1; MecP2
MeSH headings : Aldehydes / metabolism; Brain / metabolism; Brain / pathology; Feedback, Physiological; Forkhead Transcription Factors / genetics; Forkhead Transcription Factors / metabolism; Humans; Inflammation; Isoprostanes / metabolism; Lipid Peroxidation / genetics; Methyl-CpG-Binding Protein 2 / genetics; Methyl-CpG-Binding Protein 2 / metabolism; Mutation; Nerve Tissue Proteins / genetics; Nerve Tissue Proteins / metabolism; Oxidative Stress; Proteasome Endopeptidase Complex / metabolism; Protein Processing, Post-Translational; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Rett Syndrome / genetics; Rett Syndrome / metabolism; Rett Syndrome / pathology
topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Adenosine and Purinergic Signaling; Endoplasmic Reticulum Stress and Disease
TL;DR: Aiming 4HNE as a therapeutic target could represent a coadjuvant treatment with some beneficial impact in these patients, in a pathology completely orphan of any therapy, with special emphasis on 4-hydroxynonenal (4HNE). (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

First dual AK/GSK-3β inhibitors endowed with antioxidant properties as multifunctional, potential neuroprotective agents

Brogi, S., Ramunno, A., Savi, L., Chemi, G., Alfano, G., Pecorelli, A., … Brindisi, M. (2017, June 10). European Journal of Medicinal Chemistry, Vol. 138, pp. 438–457.

By: S. Brogi*, A. Ramunno*, L. Savi*, G. Chemi*, G. Alfano*, A. Pecorelli n, E. Pambianchi n, P. Galatello* ...

author keywords: Antioxidant agents; Glycogen synthase kinase 3 beta (GSK-3 beta); Adenosine kinase (AK); Dual inhibitors; Molecular docking
MeSH headings : Adenosine Kinase / antagonists & inhibitors; Adenosine Kinase / metabolism; Antioxidants / chemical synthesis; Antioxidants / chemistry; Antioxidants / pharmacology; Cell Line, Tumor; Dose-Response Relationship, Drug; Glycogen Synthase Kinase 3 beta / antagonists & inhibitors; Glycogen Synthase Kinase 3 beta / metabolism; Humans; Hydrogen Peroxide / antagonists & inhibitors; Hydrogen Peroxide / pharmacology; Molecular Structure; Neuroblastoma / metabolism; Neuroblastoma / pathology; Neuroprotective Agents / chemical synthesis; Neuroprotective Agents / chemistry; Neuroprotective Agents / pharmacology; Oxidative Stress / drug effects; Protein Kinase Inhibitors / chemical synthesis; Protein Kinase Inhibitors / chemistry; Protein Kinase Inhibitors / pharmacology; Reactive Oxygen Species / metabolism; Structure-Activity Relationship
topics (OpenAlex): Bioactive Compounds and Antitumor Agents; Click Chemistry and Applications; Enzyme function and inhibition
TL;DR: The identification of compound 5l, as the first dual hAK/hGSK-3β inhibitor reported to date, holds promise for the development of new series of potential therapeutic agents for the treatment of neurodegenerative diseases characterized by an innovative pharmacological profile. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Keratinocytes oxidative damage mechanisms related to airbone particle matter exposure

Romani, A., Cervellati, C., Muresan, X. M., Belmonte, G., Pecorelli, A., Cervellati, F., … Valacchi, G. (2017, November 8). Mechanisms of Ageing and Development, Vol. 172, pp. 86–95.

author keywords: Air pollution; Particulate matter; Oxidative damage; Inflammation
MeSH headings : Cell Line, Transformed; Humans; Interleukin-1alpha / metabolism; Keratinocytes / metabolism; Keratinocytes / pathology; NF-E2-Related Factor 2 / metabolism; NF-kappa B / metabolism; Oxidation-Reduction / drug effects; Particulate Matter / toxicity
topics (OpenAlex): Air Quality and Health Impacts; Climate Change and Health Impacts; Indoor Air Quality and Microbial Exposure
TL;DR: Overall these data, suggest lipid and protein oxidative damage, as well as an increase of inflammatory response after being challenged with CAPs. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Novel Artificial Tears Containing Cross-Linked Hyaluronic Acid: An In Vitro Re-Epithelialization Study

Fallacara, A., Vertuani, S., Panozzo, G., Pecorelli, A., Valacchi, G., & Manfredini, S. (2017, November 30). Molecules, Vol. 22.

author keywords: anti-inflammatory; artificial tears; corneal epithelium; cyclin D1; dry eye syndrome; HA; HA-CL; IL-8; re-epithelialization
MeSH headings : Analysis of Variance; Biomarkers; Cell Line; Cell Survival; Cyclin D1 / metabolism; Drug Stability; Dry Eye Syndromes; Epithelium, Corneal / drug effects; Humans; Hyaluronic Acid / analysis; Hyaluronic Acid / chemistry; Hydrogen-Ion Concentration; Lubricant Eye Drops / analysis; Lubricant Eye Drops / chemical synthesis; Lubricant Eye Drops / chemistry; Lubricant Eye Drops / pharmacology; Re-Epithelialization / drug effects; Viscosity; Wound Healing / drug effects
topics (OpenAlex): Ocular Surface and Contact Lens; Corneal Surgery and Treatments; Glaucoma and retinal disorders
TL;DR: An in vitro evaluation of the re-epithelialization ability of two different preparations containing a recently synthetized HA cross-linked with urea showed no cellular toxicity, a slight decrease in IL-8 release, and restoration of epithelium integrity when the wounded 3D model was treated with S1 and S2. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2017 article

Potassium Ascorbate with Ribose: Promising Therapeutic Approach for Melanoma Treatment

Cavicchio, C., Benedusi, M., Pambianchi, E., Pecorelli, A., Cervellati, F., Savelli, V., … Valacchi, G. (2017, January 1). Oxidative Medicine and Cellular Longevity.

By: C. Cavicchio*, M. Benedusi*, E. Pambianchi n, A. Pecorelli n, F. Cervellati*, V. Savelli*, D. Calamandrei*, E. Maellaro* ...

MeSH headings : Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacology; Antineoplastic Agents / therapeutic use; Ascorbic Acid / chemistry; Cell Line, Tumor; Cell Proliferation / drug effects; Cell Survival / drug effects; Connexin 43 / genetics; Connexin 43 / metabolism; Humans; Melanoma / drug therapy; Melanoma / pathology; Microscopy, Electron, Scanning; Potassium / chemistry; Ribose / chemistry; Spheroids, Cellular / drug effects; Spheroids, Cellular / ultrastructure
topics (OpenAlex): Vitamin C and Antioxidants Research; Nanoparticles: synthesis and applications; bioluminescence and chemiluminescence research
TL;DR: The results suggest that PAR could be used as a safe adjuvant approach in support to conventional therapies for the treatment of melanoma. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

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