Works (6)
Updated: March 11th, 2024 08:14
2021 journal article
Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis
BMJ GLOBAL HEALTH, 6(9).
author keywords: child health; environmental health; epidemiology; maternal health; nutrition
MeSH headings : Female; Gestational Age; Humans; Infant, Newborn; Pregnancy; Premature Birth / epidemiology; Selenium
TL;DR:
This study observed statistically significant associations between maternal Se concentration and PTB at some sites, but this did not generalise across the entire cohort, and there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance.
(via Semantic Scholar)
gh.bmj.com (publisher PDF)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: September 27, 2021
2020 journal article
Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing
PLOS COMPUTATIONAL BIOLOGY, 16(4).
MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
TL;DR:
In simulations of wound invasion, efficient collective migration is achieved with thresholds for chemotaxis matching those of polarization in the reaction-diffusion models, and increasing DAG kinase activity can enhance the robustness of DAG/active PKC polarization with respect to chemoattractant concentration while decreasing their whole-cell levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020
2017 journal article
Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation
JOURNAL OF BIOLOGICAL CHEMISTRY, 292(7), 2866–2872.
MeSH headings : Animals; Kinetics; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes / metabolism; NIH 3T3 Cells; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
TL;DR:
A model based on a putative feedforward loop orchestrated by Akt consistently predicted how the pathway was altered by depletion of key regulatory proteins, and elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates m TORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states
MOLECULAR SYSTEMS BIOLOGY, 10(1).
author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling
BIOPHYSICAL JOURNAL, 107(10), L29–L32.
MeSH headings : Kinetics; Models, Biological; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction
TL;DR:
It is shown that the indirect mechanism, pervasive in Akt signaling, has properties that are distinct from direct activation, and can be integrated in network motifs to produce desired responses, as in the case of feedforward loops.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 journal article
Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLC gamma/PKC alpha Pathway
DEVELOPMENTAL CELL, 31(6), 747–760.
MeSH headings : Animals; Cell Line; Cell Movement; Chemotaxis / physiology; Diglycerides / chemistry; Green Fluorescent Proteins / metabolism; Humans; Ligands; Mesoderm / physiology; Mice; Mice, Transgenic; Myosin Type II / metabolism; Phorbol Esters; Phospholipase C gamma / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C-alpha / metabolism; Signal Transduction
TL;DR:
It is demonstrated that local inactivation of Myosin IIA, through a noncanonical Ser1/2 phosphorylation of the regulatory light chain, is essential for mesenchymal chemotaxis and subsequent inhibition of MyOSin II activity at the leading edge are required.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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