Anisur Rahman

Works (6)

Updated: March 11th, 2024 08:14

2021 article

Association of maternal prenatal selenium concentration and preterm birth: a multicountry meta-analysis

Monangi, N., Xu, H., Khanam, R., Khan, W., Deb, S., Pervin, J., … Muglia, L. (2021, September 1). BMJ Global Health, Vol. 6.

By: N. Monangi *, H. Xu *, R. Khanam *, W. Khan *, S. Deb *, J. Pervin *, J. Price *, S. Kennedy * ...

author keywords: child health; environmental health; epidemiology; maternal health; nutrition
MeSH headings : Female; Gestational Age; Humans; Infant, Newborn; Pregnancy; Premature Birth / epidemiology; Selenium
topics (OpenAlex): Pregnancy and preeclampsia studies; Pregnancy and Medication Impact; Birth, Development, and Health
TL;DR: This study observed statistically significant associations between maternal Se concentration and PTB at some sites, but this did not generalise across the entire cohort, and there was a substantial heterogeneity among study cohorts and the random-effect meta-analysis did not achieve statistical significance. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 27, 2021

2020 article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

Nosbisch, J. L., Rahman, A., Mohan, K., Elston, T. C., Bear, J. E., & Haugh, J. M. (2020, April 7). PLoS Computational Biology, Vol. 16.

By: J. Nosbisch n, A. Rahman n, K. Mohan n, T. Elston*, J. Bear * & J. Haugh n 

MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
topics (OpenAlex): Cellular Mechanics and Interactions; 3D Printing in Biomedical Research; Cancer Cells and Metastasis
TL;DR: In simulations of wound invasion, efficient collective migration is achieved with thresholds for chemotaxis matching those of polarization in the reaction-diffusion models, and increasing DAG kinase activity can enhance the robustness of DAG/active PKC polarization with respect to chemoattractant concentration while decreasing their whole-cell levels. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2017 article

Kinetic Modeling and Analysis of the Akt/Mechanistic Target of Rapamycin Complex 1 (mTORC1) Signaling Axis Reveals Cooperative, Feedforward Regulation

Rahman, A., & Haugh, J. M. (2017, January 10). Journal of Biological Chemistry, Vol. 1, p. jbc.M116.761205.

By: A. Rahman n & J. Haugh n 

MeSH headings : Animals; Kinetics; Mechanistic Target of Rapamycin Complex 1; Mice; Models, Biological; Multiprotein Complexes / metabolism; NIH 3T3 Cells; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction; TOR Serine-Threonine Kinases / metabolism
topics (OpenAlex): PI3K/AKT/mTOR signaling in cancer; Protein Kinase Regulation and GTPase Signaling; Fungal Plant Pathogen Control
TL;DR: A model based on a putative feedforward loop orchestrated by Akt consistently predicted how the pathway was altered by depletion of key regulatory proteins, and elucidates two dynamical motifs: neutralization of a negative regulator, which characterizes how Akt indirectly activates m TORC1, and seesaw enzyme regulation, which describes how activated and inhibited states of mTORC1 are controlled in concert to produce a nonlinear, ultrasensitive response. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Data‐driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

Ahmed, S., Grant, K. G., Edwards, L. E., Rahman, A., Cirit, M., Goshe, M. B., & Haugh, J. M. (2014, January 1). Molecular Systems Biology, Vol. 10, pp. 718–718.

By: S. Ahmed n, K. Grant n, L. Edwards  n, A. Rahman n, M. Cirit n, M. Goshe n, J. Haugh n 

author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
topics (OpenAlex): Cellular Mechanics and Interactions; Melanoma and MAPK Pathways; Cell Image Analysis Techniques
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Deactivation of a Negative Regulator: A Distinct Signal Transduction Mechanism, Pronounced in Akt Signaling

Rahman, A., & Haugh, J. M. (2014, November 1). Biophysical Journal, Vol. 107, pp. L29–L32.

By: A. Rahman n & J. Haugh n 

MeSH headings : Kinetics; Models, Biological; Phosphorylation; Proto-Oncogene Proteins c-akt / metabolism; Signal Transduction
topics (OpenAlex): PI3K/AKT/mTOR signaling in cancer; Protein Kinase Regulation and GTPase Signaling; Microtubule and mitosis dynamics
TL;DR: It is shown that the indirect mechanism, pervasive in Akt signaling, has properties that are distinct from direct activation, and can be integrated in network motifs to produce desired responses, as in the case of feedforward loops. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Mesenchymal Chemotaxis Requires Selective Inactivation of Myosin II at the Leading Edge via a Noncanonical PLCγ/PKCα Pathway

Asokan, S. B., Johnson, H. E., Rahman, A., King, S. J., Rotty, J. D., Lebedeva, I. P., … Bear, J. E. (2014, December 1). Developmental Cell, Vol. 31, pp. 747–760.

By: S. Asokan*, H. Johnson n, A. Rahman n, S. King *, J. Rotty *, I. Lebedeva*, J. Haugh n , J. Bear *

MeSH headings : Animals; Cell Line; Cell Movement; Chemotaxis / physiology; Diglycerides / chemistry; Green Fluorescent Proteins / metabolism; Humans; Ligands; Mesoderm / physiology; Mice; Mice, Transgenic; Myosin Type II / metabolism; Phorbol Esters; Phospholipase C gamma / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C-alpha / metabolism; Signal Transduction
topics (OpenAlex): Cell Adhesion Molecules Research; Cellular Mechanics and Interactions; Tissue Engineering and Regenerative Medicine
TL;DR: It is demonstrated that local inactivation of Myosin IIA, through a noncanonical Ser1/2 phosphorylation of the regulatory light chain, is essential for mesenchymal chemotaxis and subsequent inhibition of MyOSin II activity at the leading edge are required. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

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