Alexander R. Bogdan

Works (4)

Updated: July 5th, 2023 15:39

2019 article

Iron-induced transferrin receptor-1 mRNA destabilization: A response to “Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation”

Miyazawa, M., Bogdan, A. R., Hashimoto, K., & Tsuji, Y. (2019, September 11). Iron-induced transferrin receptor-1 mRNA destabilization: A response to “Neither miR-7-5p nor miR-141-3p is a major mediator of iron-responsive transferrin receptor-1 mRNA degradation.” RNA, Vol. 25, pp. 1416–1420.

By: M. Miyazawa*, A. Bogdan*, K. Hashimoto* & Y. Tsuji n 

MeSH headings : Iron; MicroRNAs; RNA Stability; RNA, Messenger; Receptors, Transferrin
topics (OpenAlex): RNA Research and Splicing; RNA regulation and disease; RNA modifications and cancer
TL;DR: There are several critical issues contained in the article by Connell and colleagues that require further consideration and the opportunity to reply here. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 28, 2019

2018 article

Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2

Miyazawa, M., Bogdan, A. R., & Tsuji, Y. (2018, November 15). Cell Chemical Biology, Vol. 26, pp. 85-+.

By: M. Miyazawa n, A. Bogdan n & Y. Tsuji n 

MeSH headings : Adolescent; Adult; Aged; Animals; Antineoplastic Agents / metabolism; Antineoplastic Agents / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Cells, Cultured; Cisplatin / metabolism; Cisplatin / pharmacology; Drug Screening Assays, Antitumor; Female; Fetus; Humans; Iron / metabolism; Iron Deficiencies; Iron Regulatory Protein 2 / antagonists & inhibitors; Iron Regulatory Protein 2 / genetics; Iron Regulatory Protein 2 / metabolism; Male; Mice; Middle Aged; Molecular Structure; Neoplasms, Experimental / drug therapy; Neoplasms, Experimental / metabolism; Neoplasms, Experimental / pathology
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Plant Micronutrient Interactions and Effects
TL;DR: Cisplatin is an inhibitor of IRP2 that induces intracellular iron deficiency and combination of cisplatin and the iron chelator desferrioxamine enhanced cytotoxicity through augmented iron depletion in culture and xenograft mouse model. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2016 article

Siderophores in Iron Metabolism: From Mechanism to Therapy Potential

Wilson, B. R., Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y. (2016, November 4). Trends in Molecular Medicine, Vol. 22, pp. 1077–1090.

By: B. Wilson  n, A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / immunology; Bacteria / metabolism; Bacterial Infections / drug therapy; Bacterial Infections / immunology; Bacterial Infections / metabolism; Drug Discovery; Host-Pathogen Interactions / drug effects; Humans; Iron / immunology; Iron / metabolism; Lipocalin-2 / immunology; Lipocalin-2 / metabolism; Siderophores / immunology; Siderophores / metabolism
topics (OpenAlex): Iron Metabolism and Disorders; Hemoglobinopathies and Related Disorders; Antibiotic Resistance in Bacteria
TL;DR: This review discusses the recently described molecular mechanisms of siderophore iron trafficking between host and bacteria, highlighting the therapeutic potential of exploiting pathogen sidersophore machinery for the treatment of antibiotic-resistant bacterial infections. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 article

Regulators of Iron Homeostasis: New Players in Metabolism, Cell Death, and Disease

Bogdan, A. R., Miyazawa, M., Hashimoto, K., & Tsuji, Y. (2015, December 23). Trends in Biochemical Sciences, Vol. 41, pp. 274–286.

By: A. Bogdan n, M. Miyazawa n, K. Hashimoto n & Y. Tsuji n 

MeSH headings : Cell Death; Homeostasis; Humans; Iron / metabolism
topics (OpenAlex): Iron Metabolism and Disorders; Ferroptosis and cancer prognosis; Trace Elements in Health
TL;DR: New regulators of iron metabolism are highlighted, including iron-trafficking proteins [solute carrier family 39, SLC39, also known as ZRT/IRT-like protein, ZIP; and poly-(rC)-binding protein, PCBP] and a cargo receptor (NCOA4) that is crucial for release of ferritin-bound iron. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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