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Works (24)
Updated: April 5th, 2024 05:19
2013 book
The science class you wish you had: The seven greatest scientific discoveries in history and the people who made them
New York: Perigee/Penguin Group.
Source: NC State University Libraries
Added: August 6, 2018
2011 journal article
Chronic treatment in vivo with beta-adrenoceptor agonists induces dysfunction of airway beta(2)-adrenoceptors and exacerbates lung inflammation in mice
BRITISH JOURNAL OF PHARMACOLOGY, 165(7), 2365–2377.
author keywords: beta-adrenoceptor; beta-agonist; receptor desensitization; airway remodelling; airway inflammation; asthma; loss of bronchoprotection; mouse
MeSH headings : Administration, Inhalation; Adrenergic beta-2 Receptor Agonists / administration & dosage; Adrenergic beta-2 Receptor Agonists / adverse effects; Animals; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / adverse effects; Asthma / complications; Asthma / drug therapy; Bronchoconstriction / drug effects; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin / administration & dosage; Ovalbumin / immunology; Pneumonia / etiology; Pneumonia / pathology; Pneumonia / physiopathology; Receptors, Adrenergic, beta-2 / deficiency; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / genetics
TL;DR:
A mouse model was aimed to develop a mouse model that demonstrated functional β‐agonist‐induced β2‐adrenoceptor desensitization in the context of allergic inflammatory airway disease.
(via Semantic Scholar)
open access via bpspubs.onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 article
Asbestos and Lung Disease
Brody, A. R. (2010, February). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 42, pp. 131–132.
MeSH headings : Asbestos / toxicity; Asbestosis / etiology; Humans; Lung Diseases / etiology; Lung Diseases / metabolism; Lung Neoplasms / etiology; Mesothelioma / etiology; Oxidants / metabolism
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Characterization of side population cells in human malignant mesothelioma cell lines
LUNG CANCER, 70(2), 146–151.
author keywords: Mesothelioma; Side population; Cancer stem cell; Hoechst 33342; Tumorigenicity; Flow cytometry
MeSH headings : Animals; Cell Line, Tumor; Cell Proliferation; Cell Separation; Cisplatin / pharmacology; Feasibility Studies; Flow Cytometry; Gene Expression Regulation, Developmental; Humans; Mesothelioma / diagnosis; Mesothelioma / drug therapy; Mesothelioma / pathology; Mice; Mice, SCID; Neoplasm Transplantation; Neoplastic Stem Cells / drug effects; Neoplastic Stem Cells / metabolism; Neoplastic Stem Cells / pathology; Side-Population Cells / drug effects; Side-Population Cells / metabolism; Side-Population Cells / pathology
TL;DR:
The data indicated that SP assay may not be appropriate for enriching putative CSCs in HMM cell lines, and thus warrants the development of a novel tool for mesothelial CSC study.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Mesenchymal Stem Cells Require MARCKS Protein for Directed ChemotaxisIn Vitro
American Journal of Respiratory Cell and Molecular Biology, 43(3), 253–258.
author keywords: mesenchymal; MARCKS; chemotaxis; chemokines; phosphorylation
MeSH headings : Animals; Blotting, Western; Bone Marrow Cells / cytology; Cell Differentiation; Cell Movement; Cells, Cultured; Chemokine CCL2 / pharmacology; Chemokine CXCL12 / pharmacology; Chemotaxis / drug effects; Complement C5a / pharmacology; Dose-Response Relationship, Drug; Fetal Blood; Fibroblasts / cytology; Fibroblasts / metabolism; Humans; In Vitro Techniques; Intracellular Signaling Peptides and Proteins / antagonists & inhibitors; Intracellular Signaling Peptides and Proteins / physiology; Lung / cytology; Lung / metabolism; Macrophages / cytology; Macrophages / metabolism; Membrane Proteins / antagonists & inhibitors; Membrane Proteins / physiology; Mesenchymal Stem Cells / cytology; Mice; Myristoylated Alanine-Rich C Kinase Substrate; Peptide Fragments / pharmacology; Phosphorylation
TL;DR:
It is illustrated, for the first time, that myristoylated alanine-rich C kinase substrate (MARCKS) protein plays an integral role in BM-MSC-directed chemotaxis in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref
Added: August 6, 2018
2009 journal article
Inhaled carbon nanotubes reach the subpleural tissue in mice
NATURE NANOTECHNOLOGY, 4(11), 747–751.
MeSH headings : Aerosols / adverse effects; Animals; Immunity / drug effects; Inhalation Exposure / analysis; Male; Mice; Mice, Inbred C57BL; Nanotubes, Carbon / adverse effects; Nanotubes, Carbon / ultrastructure; Pleura / drug effects; Pleura / immunology; Pleura / ultrastructure; Pulmonary Fibrosis / chemically induced
TL;DR:
It is shown that multi-walled carbon nanotubes reach the sub-pleura in mice after a single inhalation exposure of 30 mg/m3 for 6 hours and it is suggested that minimizing inhalation of nanot tubes during handling is prudent until further long term assessments are conducted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Mesenchymal stem cells produce Wnt isoforms and TGF-beta(1) that mediate proliferation and procollagen expression by lung fibroblasts
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 297(5), L1002–L1011.
author keywords: peptide growth factors; pulmonary fibrosis
MeSH headings : Animals; Antibodies / pharmacology; Bone Marrow Cells / cytology; Cell Proliferation / drug effects; Coculture Techniques; Collagen Type I / genetics; Collagen Type I / metabolism; Culture Media, Conditioned / pharmacology; Fetal Blood / cytology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / metabolism; Gene Expression Regulation / drug effects; Humans; Intracellular Signaling Peptides and Proteins; Lung / cytology; Mesenchymal Stem Cells / cytology; Mesenchymal Stem Cells / drug effects; Mesenchymal Stem Cells / metabolism; Mice; Platelet-Derived Growth Factor / metabolism; Polymerase Chain Reaction; Protein Isoforms / metabolism; Proteins / pharmacology; Solubility / drug effects; Transforming Growth Factor beta1 / antagonists & inhibitors; Transforming Growth Factor beta1 / metabolism; Wnt Proteins / metabolism; beta Catenin / metabolism
TL;DR:
It is demonstrated that MSC from mice and humans produce Wnt proteins and TGF-beta1 that respectively stimulate LF proliferation and matrix production, two hallmarks of fibroproliferative lung disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 personal communication
Research on mesothelioma from brake exposure: Corporate influence remains relevant concern
Source: NC State University Libraries
Added: August 6, 2018
2009 journal article
Small Interfering RNAs (siRNAs) Targeting TGF-beta(1) mRNA Suppress Asbestos-Induced Expression of TGF-beta(1) and CTGF in Fibroblasts
JOURNAL OF ENVIRONMENTAL PATHOLOGY TOXICOLOGY AND ONCOLOGY, 28(2), 109–119.
author keywords: interstitial lung disease; RNA interference; small interfering RNA; transforming growth factor-beta(1); connective tissue growth factor; asbestos
MeSH headings : 3T3 Cells; Animals; Asbestos, Serpentine / toxicity; Base Sequence; Connective Tissue Growth Factor / genetics; DNA Primers; Disease Models, Animal; Fibroblasts / metabolism; Gene Knockdown Techniques; Lung Diseases, Interstitial / chemically induced; Lung Diseases, Interstitial / genetics; Mice; Polymerase Chain Reaction; RNA Interference; RNA, Messenger / genetics; RNA, Small Interfering / genetics; Transforming Growth Factor beta1 / genetics
TL;DR:
It is suggested that siRNAs could be effective in preventing or possibly arresting the progression of pulmonary fibrosis, and studies are underway in vivo to test this postulate.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
TNF-alpha induces TGF-beta(1) expression in lung fibroblasts at the transcriptional level via AP-1 activation
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, 13(8B), 1866–1876.
author keywords: transforming growth factor-beta(1); tumour necrosis factor-alpha; activator-protein-1; lung fibrosis
MeSH headings : 3T3 Cells; Animals; Base Sequence; DNA Primers; Mice; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factor AP-1 / metabolism; Transforming Growth Factor beta1 / metabolism; Tumor Necrosis Factor-alpha / physiology
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2008 article
The latent form of TGF beta(1) is induced by TNF alpha through an ERK specific pathway and is activated by asbestos-derived reactive oxygen species in vitro and in vivo
JOURNAL OF IMMUNOTOXICOLOGY, Vol. 5, pp. 145–149.
author keywords: asbestos; transforming growth factor-beta 1; tumor necrosis factor-alpha; reactive oxygen species; lung fibrosis
MeSH headings : Animals; Asbestos / toxicity; Carcinogens / toxicity; Epithelial Cells / immunology; Epithelial Cells / metabolism; Extracellular Signal-Regulated MAP Kinases / genetics; Extracellular Signal-Regulated MAP Kinases / immunology; Extracellular Signal-Regulated MAP Kinases / metabolism; Latent TGF-beta Binding Proteins / genetics; Latent TGF-beta Binding Proteins / immunology; Latent TGF-beta Binding Proteins / metabolism; MAP Kinase Signaling System / drug effects; MAP Kinase Signaling System / genetics; MAP Kinase Signaling System / immunology; Macrophages, Alveolar / immunology; Macrophages, Alveolar / metabolism; Mice; Mice, Knockout; Pulmonary Alveoli / immunology; Pulmonary Alveoli / metabolism; Pulmonary Fibrosis / chemically induced; Pulmonary Fibrosis / genetics; Pulmonary Fibrosis / immunology; Pulmonary Fibrosis / metabolism; Reactive Oxygen Species / immunology; Reactive Oxygen Species / metabolism; Receptors, Tumor Necrosis Factor / genetics; Receptors, Tumor Necrosis Factor / immunology; Receptors, Tumor Necrosis Factor / metabolism; Smad Proteins / genetics; Smad Proteins / immunology; Smad Proteins / metabolism; Transforming Growth Factor beta1 / biosynthesis; Transforming Growth Factor beta1 / genetics; Transforming Growth Factor beta1 / immunology; Tumor Necrosis Factor-alpha / biosynthesis; Tumor Necrosis Factor-alpha / genetics; Tumor Necrosis Factor-alpha / immunology; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation / drug effects; Up-Regulation / genetics; Up-Regulation / immunology
TL;DR:
It is shown that over-expression of latent TGFβ1 prior to asbestos exposure of fibrogenic-resistant TNFα receptor knockout mice produces asbestos lesions with the same severity as seen in normal C57/Bl6 mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Engraftment of bone marrow progenitor cells in a rat model of asbestos-induced pulmonary fibrosis
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 176(4), 385–394.
author keywords: bone marrow; progenitor cell; asbestosis; fibrosis
MeSH headings : Animals; Asbestosis / pathology; Bone Marrow Cells / pathology; Bone Marrow Transplantation; Cell Movement; Cell Proliferation; Disease Models, Animal; Female; Fibroblasts / pathology; Green Fluorescent Proteins; Immunohistochemistry; In Situ Hybridization, Fluorescence; In Situ Nick-End Labeling; Luminescent Agents; Lung / pathology; Macrophages, Alveolar / pathology; Male; Myocytes, Smooth Muscle / pathology; Proliferating Cell Nuclear Antigen / analysis; Rats; Rats, Sprague-Dawley
TL;DR:
Bone marrow-derived cells migrated into developing fibrogenic lesions, differentiated into multiple cell types, and persisted for at least 2.5 weeks after the animals were exposed to aerosolized chrysotile asbestos fibers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Laser capture microdissection reveals dose-response of gene expression in situ consequent to asbestos exposure
INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY, 88(6), 415–425.
author keywords: asbestos-induced gene expression; laser capture microdissection; real time-polymerase; chain reaction
MeSH headings : Animals; Asbestos / toxicity; Asbestosis / genetics; Collagen Type I / genetics; Collagen Type I, alpha 1 Chain; Gene Expression Regulation; Genes, APC; Lung / metabolism; Male; Matrix Metalloproteinase 9 / genetics; Mice; Mice, Inbred C57BL; Microdissection; Microscopy, Electron, Scanning; Platelet-Derived Growth Factor / genetics; Proto-Oncogene Proteins c-sis / genetics; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta / genetics; Tumor Necrosis Factor-alpha / genetics
TL;DR:
To the knowledge, this is the first demonstration of a dose–response to a toxic particle in situ, and this response appears to be dependent on the number of fibres that deposits at the individual anatomic site.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1988 journal article
The lung matrix and inflammation: Part II. Biochemical and molecular mechanisms of fibrogenesis: implications for environmental lung disease
American Review of Respiratory Disease, 138, 1056–1057.
Source: NC State University Libraries
Added: August 6, 2018
1986 chapter
Intracellular translocation of inorganic particles.
In The cytoskeleton. (pp. 221–227).
TL;DR:
A variety of inorganic particles may be inhaled during environmental or occupational exposures and the presence of interstitial asbestos is known to induce the progression of fibrotic scarring by undefined mechanisms.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1983 journal article
Actin containing microfilaments of pulmonary epithelial cells provide a mechanism for translocating inhaled asbestos to the interstitium.
Chest, 83, 11S–13.
Source: NC State University Libraries
Added: August 6, 2018
1981 journal article
Studies on the mechanism of mucin secretion by cells of the porcine tracheal epithelium.
Proceedings of the Society for Experimental Biology and Medicine, 166, 96–106.
MeSH headings : Animals; Bucladesine / pharmacology; Colchicine / pharmacology; Culture Techniques; Cytochalasin B / pharmacology; Cytoskeleton / physiology; Epithelium / metabolism; Microtubules / physiology; Mucins / metabolism; Secretory Rate / drug effects; Swine; Trachea / metabolism; Vinblastine / pharmacology
TL;DR:
The results suggest a possible role for mi-crotubules and microfilaments in the intracellular movement and release of mucin.
(via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018
1980 journal article
Changes in the surface morphology of human alveolar macrophages induced by tobacco and marijuana smoking.
Chest, 1, 281–293.
Source: NC State University Libraries
Added: August 6, 2018
1980 article
The morphology of alveolar macrophage immunologic activation: a scanning electron microscopic study.
American Review of Respiratory Disease, Vol. 121, p. 269.
Source: NC State University Libraries
Added: August 6, 2018
1979 journal article
Functional and physiological correlates of human alveolar macrophage cell shape and surface morphology.
Chest, 75S, 280–282.
Source: NC State University Libraries
Added: August 6, 2018
1979 journal article
The human pulmonary alveolar macrophage: two distinct morphological populations.
Scanning Electron Microscopy, 3, 921–928.
Source: NC State University Libraries
Added: August 6, 2018
1978 conference paper
Association of microtubules and microfilaments with mucin granules in tracheal goblet cells their possible role in exocytosis.
Proceedings of the 9th International Congress on Electron Microscopy, 2, 500–501.
Source: NC State University Libraries
Added: August 6, 2018
1978 article
Localization of actin in surface ruffles of pulmonary alveolar macrophages: Effects of cytochalasin B, colchicine and cyclic AMP.
Journal of Cell Biology, Vol. 79, p. 276a.
Source: NC State University Libraries
Added: August 6, 2018
1978 article
Ultrastructural association of microtubules and microfilaments with mucin granules in porcine tracheobronchial tissue in organ culture.
404nOtfound, Vol. 37, p. 266.
Source: NC State University Libraries
Added: August 6, 2018
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