Works (1)
Updated: July 5th, 2023 14:48
2019 journal article
The regulatory TnaC nascent peptide preferentially inhibits release factor 2-mediated hydrolysis of peptidyl-tRNA
JOURNAL OF BIOLOGICAL CHEMISTRY, 294(50), 19224–19235.
author keywords: Regulatory nascent peptides; release factor; L-tryptophan; peptidyl transferase center; ribosomal arrest; gene regulation; translation termination; tnaC; GGQ tripeptide motif
MeSH headings : Escherichia coli K12; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Hydrolysis; Models, Molecular; Peptide Termination Factors / chemistry; Peptide Termination Factors / metabolism; RNA, Transfer, Amino Acyl / metabolism
TL;DR:
Results indicate that l-Trp preferentially blocks RF2 activity during translation termination of the tnaC gene, which depends on the identities of amino acid residues surrounding the RF2-GGQ functional motif.
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