Alora S. Lavoy

Works (13)

Updated: August 3rd, 2023 21:15

2019 journal article

Effects of Regulatory T Cell Depletion on NK Cell Responses against Listeria monocytogenes in Feline Immunodeficiency Virus Infected Cats

VIRUSES-BASEL, 11(11).

By: R. Simoes n, A. LaVoy n & G. Dean n

author keywords: feline immunodeficiency virus; NK cells; regulatory T cells; innate immunity; Treg depletion
MeSH headings : Animals; Cats; Dendritic Cells / immunology; Feline Acquired Immunodeficiency Syndrome / complications; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Female; Immunodeficiency Virus, Feline / immunology; Immunodeficiency Virus, Feline / physiology; Killer Cells, Natural / immunology; Listeria monocytogenes / immunology; Listeria monocytogenes / physiology; Listeriosis / immunology; Listeriosis / microbiology; Listeriosis / veterinary; Lymph Nodes / immunology; Lymphocyte Depletion; Opportunistic Infections / immunology; Opportunistic Infections / microbiology; Opportunistic Infections / veterinary; T-Lymphocytes, Regulatory / immunology
TL;DR: Treg depletion failed to improve the innate immune response of FIV-infected cats against Lm and this may be due to dendritic cell dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: December 30, 2019

2011 journal article

Assessment of Lactobacillus gasseri as a Candidate Oral Vaccine Vector

CLINICAL AND VACCINE IMMUNOLOGY, 18(11), 1834–1844.

By: L. Stoeker n, S. Nordone n, S. Gunderson n, L. Zhang  n, A. Kajikawa n, A. LaVoy n, M. Miller n, T. Klaenhammer n, G. Dean n

MeSH headings : Adjuvants, Immunologic / genetics; Administration, Oral; Animals; B-Lymphocytes / immunology; Bacterial Vaccines / administration & dosage; Bacterial Vaccines / genetics; Bacterial Vaccines / immunology; Blood / immunology; Colon / immunology; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers / administration & dosage; Female; Flagellin / genetics; Genetic Vectors; Humans; Intestinal Mucosa / immunology; Lactobacillus / genetics; Lactobacillus / immunology; Mice; Mice, Inbred BALB C; Plasmids; Toll-Like Receptor 5 / immunology
TL;DR: In vivo studies established that treatment with L. gasseri led to a diversification of B-cell populations in the lamina propria of the murine colon and a significant decrease in the percentage of FoxP3+ colonic lymphocytes, and in vivo data clarify the interaction of L. Gasseri with the host immune system and support further investigation of the in vivo immunogenicity of the vector. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Dissimilar Properties of Two Recombinant Lactobacillus acidophilus Strains Displaying Salmonella FliC with Different Anchoring Motifs

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 77(18), 6587–6596.

By: A. Kajikawa n, S. Nordone, L. Zhang*, L. Stoeker*, A. LaVoy*, T. Klaenhammer n, G. Dean*

MeSH headings : Acids / metabolism; Antigens, Bacterial / genetics; Antigens, Bacterial / metabolism; Cells, Cultured; Cytokines / metabolism; Dendritic Cells / immunology; Dendritic Cells / microbiology; Drug Carriers; Drug Stability; Flagellin / genetics; Flagellin / metabolism; Genetic Vectors; Humans; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Peptide Hydrolases / metabolism; Recombinant Proteins / genetics; Recombinant Proteins / metabolism; Salmonella Vaccines / genetics; Salmonella Vaccines / immunology; Vaccines, Synthetic / genetics; Vaccines, Synthetic / immunology
TL;DR: Two recombinant L. acidophilus derivatives displaying Salmonella flagellin were constructed using different anchor motifs, and the surface-associated antigen was highly sensitive to simulated gastric and small intestinal juices. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 article

Immunogenicity of Lactobacillus gasseri-FliC as an oral mucosal vaccine adjuvant for HIV

RETROVIROLOGY, Vol. 6.

By: S. Gunderson n, S. Nordone n, A. LaVoy n, L. Zhang n, T. Klaenhammer n & G. Dean n

TL;DR: The immunogenicity of a novel Lactobacillus gasseri mucosal vaccine vector for use in oral delivery of HIV antigens is investigated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Toll-like receptor activation profiles of wild-type, recombinant, and mutant Lactobacillus: implications for vaccine design

RETROVIROLOGY, Vol. 6.

By: L. Stoeker n, S. Nordone n, A. LaVoy n, R. Tallon n, T. Klaenhammer n & G. Dean n

TL;DR: This work is investigating the use of Lactobacillus spp. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Cloning of feline FOXP3 and detection of expression in CD4+CD25+ regulatory T cells

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 122(1-2), 159–166.

By: S. Lankford n, C. Petty n, A. La Voy n, S. Reckling n, W. Tompkins n & G. Dean n

author keywords: Foxp3; feline; Treg; regulatory T cells; toll-like receptors
MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cats; Cloning, Molecular; Forkhead Transcription Factors / chemistry; Forkhead Transcription Factors / genetics; Humans; Molecular Sequence Data; RNA, Messenger / analysis; T-Lymphocytes, Regulatory / metabolism; Toll-Like Receptors / physiology
TL;DR: The feline FOXP3 is 1293 nucleotides in length and codes for a protein that shares high homology to other species and provides useful tools to further investigate Foxp3 and Tregs in cats. (via Semantic Scholar)
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 article

Cytokine modulation of the innate immune response in feline immunodeficiency virus - Infected cats

Dean, G. A., Lavoy, A., Yearley, J., & Stanton, C. (2006, June 1). JOURNAL OF INFECTIOUS DISEASES, Vol. 193, pp. 1520–1527.

By: G. Dean n, A. Lavoy n, J. Yearley n & C. Stanton n

MeSH headings : Animals; Cats; Cytokines / biosynthesis; Cytokines / genetics; Cytokines / immunology; Disease Models, Animal; Female; Immunity, Innate; Immunodeficiency Virus, Feline / immunology; Immunologic Memory; Interferon-gamma / analysis; Lentivirus Infections / immunology; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Listeriosis / immunology; Listeriosis / microbiology; Lymph Nodes / immunology; Lymph Nodes / microbiology; Lymphocyte Subsets / immunology; Male; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: It is hypothesized that altered dendritic-cell function and increased regulatory T cell activity may underlie the innate immune defect in HIV infection. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Desmoglein-1 is a minor autoantigen in dogs with pemphigus foliaceus

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 110(3-4), 245–255.

By: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller* ...

Contributors: T. Olivry n , A. LaVoy n, S. Dunston n, R. Brown n, E. Lennon  n, S. Warren *, P. Prisayanh *, E. Müller*, M. Suter*, G. Dean n

author keywords: autoimmunity; blistering; canine; cadherin; desmosome; skin
MeSH headings : Animals; Autoantibodies / immunology; Autoantigens / immunology; Calcium / metabolism; Cell Line; Desmoglein 1 / immunology; Dog Diseases / immunology; Dogs; Glycosylation; Humans; Pemphigus / immunology; Pemphigus / veterinary
TL;DR: These studies establish canine dsg1 as a minor autoantigen for canine PF, and antigenic epitopes appear to be conformation- and glycosylation-dependent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2005 journal article

Cloning and expression of feline interleukin 15

CYTOKINE, 29(2), 77–83.

By: G. Dean n, A. Barger n & A. LaVoy n

author keywords: feline; feline immunodeficiency virus; interleukin 15
MeSH headings : Animals; Antibodies / immunology; Base Sequence; Blotting, Western; Cats; Cell Line; Cloning, Molecular; Cross Reactions; DNA Primers; DNA, Complementary; Humans; Immunohistochemistry; Interleukin-15 / genetics; Interleukin-15 / immunology; Plasmids; T-Lymphocytes / immunology
TL;DR: A cDNA encoding feline interleukin 15 (IL15) was cloned from the lymph node of a cat infected with feline infectious peritonitis virus and was shown to sustain primary feline lymphocytes, a feline T cell line, and mouse CTLL-2 cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pre-existing immunity to pathogenic Listeria monocytogenes does not prevent induction of immune responses to feline immunodeficiency virus by a novel recombinant Listeria monocytogenes vaccine

VACCINE, 23(12), 1479–1490.

By: R. Stevens  n, A. LaVoy n, S. Nordone n, M. Burkhard* & G. Dean n

author keywords: Listeria monocytogenes; feline immunodeficiency virus; HIV
MeSH headings : Animals; Antibodies, Viral / analysis; Antigens, Viral / genetics; Antigens, Viral / immunology; Cats; Disease Models, Animal; Feces; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / prevention & control; Female; Gene Products, env / genetics; Gene Products, env / immunology; Gene Products, gag / genetics; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / genetics; Immunodeficiency Virus, Feline / immunology; Immunoglobulin A / analysis; Listeria monocytogenes / genetics; Listeria monocytogenes / immunology; Saliva / immunology; Vaccines, Synthetic / administration & dosage; Vaccines, Synthetic / immunology; Vagina / immunology; Viral Proteins / genetics; Viral Proteins / immunology; Viral Vaccines / administration & dosage; Viral Vaccines / immunology
TL;DR: Using a simplified approach to introduce individual and polyprotein FIV gag genes, it is shown that recombinant L. monocytogenes containing the entire gag expresses the full-length Gag polyprotein in a soluble secreted form. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Assessment of CD4+ and CD8+ IFN-gamma producing cells by ELISPOT in naive and FIV-infected cats

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 102(1-2), 77–84.

By: J. Sirriyah, G. Dean*, A. LaVoy* & M. Burkhard*

author keywords: feline immunodeficiency virus; ELISPOT; CD4+; CD8+; T-cell subsets
MeSH headings : Animals; CD4-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / immunology; Cats; Concanavalin A / immunology; Feline Acquired Immunodeficiency Syndrome / blood; Feline Acquired Immunodeficiency Syndrome / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / veterinary; Interferon-gamma / biosynthesis; Interferon-gamma / immunology; Lymphocyte Activation / immunology; Lymphocyte Count / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

Peptide mapping of feline immunodeficiency virus by IFN-gamma elispot

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 100(1-2), 49–59.

By: G. Dean n, A. LaVoy n & M. Burkhard n

author keywords: feline; peptide; ELISPOT; feline immunodeficiency virus; T-cell
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal / immunology; Antibody Specificity / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / virology; Gene Products, env / immunology; Gene Products, gag / immunology; Immunodeficiency Virus, Feline / immunology; Immunoenzyme Techniques / methods; Immunoenzyme Techniques / veterinary; Interferon-gamma / genetics; Interferon-gamma / immunology; Molecular Sequence Data; Peptide Fragments / immunology; Peptide Library; Peptide Mapping; RNA, Messenger / chemistry; RNA, Messenger / genetics; RNA-Directed DNA Polymerase / immunology; Reverse Transcriptase Polymerase Chain Reaction / veterinary
TL;DR: This work has developed a feline IFN-γ ELISPOT assay and used it to determine FIV-specific T-cell epitopes recognized by infected cats and its results will be useful in assessing cell-mediated responses to experimental FIV vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Investigation of recombinant human insulin-like growth factor type I in thymus regeneration in the acute stage of experimental FIV infection in juvenile cats

AIDS RESEARCH AND HUMAN RETROVIRUSES, 15(15), 1377–1388.

By: J. Woo *, G. Dean n, A. Lavoy n, R. Clark* & P. Moore *

MeSH headings : Animals; Cats; Disease Models, Animal; Feline Acquired Immunodeficiency Syndrome / drug therapy; Feline Acquired Immunodeficiency Syndrome / immunology; Feline Acquired Immunodeficiency Syndrome / pathology; Flow Cytometry; Humans; Immunodeficiency Virus, Feline; Insulin-Like Growth Factor I / therapeutic use; RNA, Viral / analysis; Recombinant Proteins / therapeutic use; Regeneration / drug effects; Reverse Transcriptase Polymerase Chain Reaction; Thymus Gland / immunology; Thymus Gland / pathology; Thymus Gland / physiology; Virus Replication
TL;DR: Thymus involvement and the development of thymic lesions in HIV-1 infection is hypothesized to suppress thymus function and limit T cell maturation and replenishment of the peripheral lymphoid pool, and thymotrophic agents, such as insulin-like growth factor type I (IGF-I), may represent adjunctive but important methods of treatment to protect or promote thymUS function. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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