Works (1)
Updated: July 5th, 2023 15:41
2014 journal article
Repurposing endogenous type I CRISPR-Cas systems for programmable gene repression
NUCLEIC ACIDS RESEARCH, 43(1), 674–681.
MeSH headings : CRISPR-Associated Proteins / genetics; CRISPR-Cas Systems; Cell Engineering; Escherichia coli / genetics; Gene Deletion; Transcription, Genetic
TL;DR:
It is found that deletion of the signature cas3 gene converted this immune system in Escherichia coli into a programmable gene regulator capable of reversible gene silencing of heterologous and endogenous genes.
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open access via academic.oup.com (publisher PDF)
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Added: August 6, 2018
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