Alex Sohn

College of Sciences

Works (10)

Updated: March 29th, 2025 05:03

2025 journal article

Part A: Implementing an Analyte Panel and Sampling Protocol for Quality Control in Mass Spectrometry Imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 39(8).

By: Q. Mills n, R. Kibbe n, A. Sohn n, A. Percy*, K. Backiel* & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; quality control; stable isotope labeled; system suitability testing
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
Sources: Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 journal article

Part B: SLICE-MSI-A Machine Learning Interface for System Suitability Testing of Mass Spectrometry Imaging Platforms

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 39(8).

By: R. Kibbe n, Q. Mills n, A. Sohn n & D. Muddiman n 

author keywords: graphical user interface; machine learning; mass spectrometry imaging; quality control; system suitability testing
topics (OpenAlex): Machine Learning in Materials Science; Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications
Sources: Web Of Science, NC State University Libraries
Added: March 3, 2025

2025 article

Three-dimensional mass spectrometry imaging (3D MSI): incorporating top-hat IR-MALDESI and automatic <i>z</i>-axis correction

Sohn, A. L., Witherspoon, J. G., Smart, R. C., & Muddiman, D. C. (2025, February 3). ANALYTICAL AND BIOANALYTICAL CHEMISTRY, Vol. 2.

By: A. Sohn n, J. Witherspoon n, R. Smart n  & D. Muddiman n 

author keywords: 3D; Mass spectrometry imaging; Lipids; Automatic <italic>z</italic>-axis correction; Top-hat
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 3, 2025

2025 article

Topographic imaging with automatic z-axis correction of <i>Brassica oleracea</i> var. <i>viridis</i> leaves by IR-MALDESI mass spectrometry imaging

Topographic imaging with automatic z-axis correction of Brassica oleracea var. viridis leaves by IR-MALDESI mass spectrometry imaging. Analytical and Bioanalytical Chemistry.

By: Q. Mills n, S. Ashbacher n , A. Sohn n & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Plant imaging; Plant metabolomics; Plant biology; <italic>Brassica oleracea</italic> var. <italic>viridis</italic>
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 19, 2025

2024 journal article

A statistical approach to system suitability testing for mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(9).

By: A. Sohn n, R. Kibbe n, O. Dioli n, E. Hector n , H. Bai n, K. Garrard n, D. Muddiman n 

topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Pesticide Residue Analysis and Safety
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Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2024 journal article

Incorporation of Three Different Optical Trains into the IR-MALDESI Mass Spectrometry Imaging Platform to Characterize <i>Artemisia annua

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 35(6), 1245–1252.

By: S. Ashbacher n , Q. Mills n, A. Sohn n, D. Xie n  & D. Muddiman n 

Contributors: S. Ashbacher n , Q. Mills n, A. Sohn n, D. Xie n  & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; laseroptics; Artemisia annua
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography; Metabolomics and Mass Spectrometry Studies
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Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: May 1, 2024

2024 article

Leveraging Supervised Machine Learning Algorithms for System Suitability Testing of Mass Spectrometry Imaging Platforms

Kibbe, R. R., Sohn, A. L., & Muddiman, D. C. (2024, September 3). JOURNAL OF PROTEOME RESEARCH, Vol. 9.

By: R. Kibbe n, A. Sohn n & D. Muddiman n 

author keywords: mass spectrometry imaging; machine learning; quality control; system suitability testing; IR-MALDESI
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Machine Learning in Materials Science
Sources: Web Of Science, NC State University Libraries
Added: September 23, 2024

2023 article

Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI

Wang, M. F., Sohn, A. L., Samal, J., Erning, K., Segura, T., & Muddiman, D. C. (2023, March 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 3.

By: M. Wang n, A. Sohn n, J. Samal *, K. Erning *, T. Segura * & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; sucrose; PFA
MeSH headings : Mice; Animals; Spectrometry, Mass, Electrospray Ionization / methods; Lipidomics; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ions / chemistry; Lipids / analysis; Brain
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
TL;DR: Evidence from these investigations supports sucrose-embedding without ice matrix as an alternative preparatory technique for IR-MALDESI-MSI, and demonstrates improved spatial distribution of ions resulting from the cryo-protective property of sucrose and paraformaldehyde fixation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023

2023 journal article

SMART: A data reporting standard for mass spectrometry imaging

JOURNAL OF MASS SPECTROMETRY, 58(2).

By: Y. Xi n, A. Sohn n, A. Joignant n, S. Cologna *, B. Prentice * & D. Muddiman n 

author keywords: data reporting standards; mass spectrometry imaging
MeSH headings : Research Design; Mass Spectrometry / methods; Ions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Advanced Proteomics Techniques and Applications
TL;DR: The goal of this tutorial is to discuss the necessity of establishing a uniform reporting system to communicate MSI data in publications and presentations in a simple format to readily interpret the parameters and baseline outcomes of the data. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2022 journal article

Interrogating the Metabolomic Profile of Amyotrophic Lateral Sclerosis in the Post-Mortem Human Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging (MSI)

METABOLITES, 12(11).

By: A. Sohn n, L. Ping *, J. Glass *, N. Seyfried *, E. Hector n  & D. Muddiman n 

author keywords: IR-MALDESI MSI; mass spectrometry imaging; Amyotrophic lateral sclerosis (ALS); neurodegenerative disease; multiomic
topics (OpenAlex): Amyotrophic Lateral Sclerosis Research; Genetic Neurodegenerative Diseases; Mitochondrial Function and Pathology
TL;DR: This work is the first of its kind, reporting on the investigation of ALS post-mortem human brain tissue analyzed by multiomic MSI, and nearly 300 metabolites were identified across the sixteen samples where 25 were identified as dysregulated between disease cohorts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023

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