Alex Sohn

College of Sciences

Works (6)

Updated: October 1st, 2024 05:04

2024 journal article

A statistical approach to system suitability testing for mass spectrometry imaging

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 38(9).

By: A. Sohn n, R. Kibbe n, O. Dioli n, E. Hector n , H. Bai n, K. Garrard n, D. Muddiman n 

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Sources: Web Of Science, NC State University Libraries
Added: March 18, 2024

2024 journal article

Incorporation of Three Different Optical Trains into the IR-MALDESI Mass Spectrometry Imaging Platform to Characterize <i>Artemisia annua</i>

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 35(6), 1245–1252.

By: S. Ashbacher n, Q. Mills n, A. Sohn n, D. Xie n  & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; laseroptics; Artemisia annua
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 1, 2024

2024 article

Leveraging Supervised Machine Learning Algorithms for System Suitability Testing of Mass Spectrometry Imaging Platforms

Kibbe, R. R., Sohn, A. L., & Muddiman, D. C. (2024, September 3). JOURNAL OF PROTEOME RESEARCH, Vol. 9.

By: R. Kibbe n, A. Sohn n & D. Muddiman n 

author keywords: mass spectrometry imaging; machine learning; quality control; system suitability testing; IR-MALDESI
Sources: Web Of Science, NC State University Libraries
Added: September 23, 2024

2023 article

Lipidomic Analysis of Mouse Brain to Evaluate the Efficacy and Preservation of Different Tissue Preparatory Techniques by IR-MALDESI-MSI

Wang, M. F., Sohn, A. L., Samal, J., Erning, K., Segura, T., & Muddiman, D. C. (2023, March 29). JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, Vol. 3.

By: M. Wang n, A. Sohn n, J. Samal *, K. Erning*, T. Segura * & D. Muddiman n 

author keywords: IR-MALDESI; mass spectrometry imaging; sucrose; PFA
MeSH headings : Mice; Animals; Spectrometry, Mass, Electrospray Ionization / methods; Lipidomics; Ice; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Ions / chemistry; Lipids / analysis; Brain
TL;DR: Evidence from these investigations supports sucrose-embedding without ice matrix as an alternative preparatory technique for IR-MALDESI-MSI, and demonstrates improved spatial distribution of ions resulting from the cryo-protective property of sucrose and paraformaldehyde fixation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 24, 2023

2023 journal article

SMART: A data reporting standard for mass spectrometry imaging

JOURNAL OF MASS SPECTROMETRY, 58(2).

By: Y. Xi n, A. Sohn n, A. Joignant n, S. Cologna *, B. Prentice * & D. Muddiman n 

author keywords: data reporting standards; mass spectrometry imaging
MeSH headings : Research Design; Mass Spectrometry / methods; Ions; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: The goal of this tutorial is to discuss the necessity of establishing a uniform reporting system to communicate MSI data in publications and presentations in a simple format to readily interpret the parameters and baseline outcomes of the data. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2022 journal article

Interrogating the Metabolomic Profile of Amyotrophic Lateral Sclerosis in the Post-Mortem Human Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization (IR-MALDESI) Mass Spectrometry Imaging (MSI)

METABOLITES, 12(11).

By: A. Sohn n, L. Ping *, J. Glass *, N. Seyfried *, E. Hector n  & D. Muddiman n 

author keywords: IR-MALDESI MSI; mass spectrometry imaging; Amyotrophic lateral sclerosis (ALS); neurodegenerative disease; multiomic
TL;DR: This work is the first of its kind, reporting on the investigation of ALS post-mortem human brain tissue analyzed by multiomic MSI, and nearly 300 metabolites were identified across the sixteen samples where 25 were identified as dysregulated between disease cohorts. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 3, 2023

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