@article{huigens_reyes_reed_bunders_rogers_steinhauer_melander_2010, title={The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii}, volume={18}, ISSN={["1464-3391"]}, DOI={10.1016/j.bmc.2009.12.003}, abstractNote={Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains.}, number={2}, journal={BIOORGANIC & MEDICINAL CHEMISTRY}, author={Huigens, Robert W., III and Reyes, Samuel and Reed, Catherine S. and Bunders, Cynthia and Rogers, Steven A. and Steinhauer, Andrew T. and Melander, Christian}, year={2010}, month={Jan}, pages={663–674} } @article{huigens_rogers_steinhauer_melander_2009, title={Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates}, volume={7}, ISSN={["1477-0539"]}, DOI={10.1039/b817926c}, abstractNote={A chemically diverse library of TAGE-triazole conjugates was synthesized utilizing click chemistry on the TAGE scaffold. This library of small molecules was screened for anti-biofilm activity and found to possess the ability of inhibiting biofilm formation against Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa. One such compound in this library demonstrated the most potent inhibitory effect against Staphylococcus aureus biofilm formation that has been displayed by any 2-aminoimidazole derivative.}, number={4}, journal={ORGANIC & BIOMOLECULAR CHEMISTRY}, author={Huigens, Robert W., III and Rogers, Steven A. and Steinhauer, Andrew T. and Melander, Christian}, year={2009}, pages={794–802} }