Ashley Timberlake Tucker

Works (6)

Updated: July 5th, 2023 15:45

2014 journal article

A DNA Mimic: The Structure and Mechanism of Action for the Anti-Repressor Protein AbbA

JOURNAL OF MOLECULAR BIOLOGY, 426(9), 1911–1924.

By: A. Tucker n, B. Bobay n, A. Banse*, A. Olson n, E. Soderblom *, M. Moseley *, R. Thompson n, K. Varney *, R. Losick *, J. Cavanagh n

author keywords: transition state regulator; AbbA; DNA mimic; molecular docking; NMR
MeSH headings : Bacillus subtilis / chemistry; Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Docking Simulation; Protein Conformation; Protein Multimerization
TL;DR: Interestingly, it is shown that AbbA has structural and surface characteristics that closely mimic the DNA phosphate backbone, enabling it to readily carry out its physiological function. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2014 journal article

Structure and DNA-Binding Traits of the Transition State Regulator AbrB

STRUCTURE, 22(11), 1650–1656.

By: A. Olson n, A. Tucker n, B. Bobay n, E. Soderblom *, M. Moseley *, R. Thompson n, J. Cavanagh n

MeSH headings : Bacillus subtilis / metabolism; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Binding Sites; DNA, Bacterial / metabolism; DNA-Binding Proteins / chemistry; DNA-Binding Proteins / metabolism; Magnetic Resonance Spectroscopy; Mass Spectrometry; Molecular Docking Simulation; Protein Multimerization; Protein Structure, Secondary; Transcription Factors / chemistry; Transcription Factors / metabolism
TL;DR: It is noted that AbrB possesses a strip of positive electrostatic potential encompassing its DNA-binding region and that its C-terminal domain aids in DNA binding. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 journal article

Chemical crosslinking and LC/MS analysis to determine protein domain orientation: Application to AbrB

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 431(2), 253–257.

By: A. Olson n, F. Liu n, A. Tucker n, M. Goshe n & J. Cavanagh n

author keywords: NMR; Solution structure; Chemical crosslinking; Domain orientation; AbrB; Gas-phase cleavable
MeSH headings : Amino Acid Sequence; Bacterial Proteins / chemistry; Chromatography, Liquid; Cross-Linking Reagents / chemistry; DNA-Binding Proteins / chemistry; Molecular Sequence Data; Protein Structure, Tertiary; Tandem Mass Spectrometry; Transcription Factors / chemistry
TL;DR: This work solved the NMR structures of both domains independently and utilized gas-phase cleavable chemical crosslinking and LC/MS(n) analysis to correctly position the domains within the full tetrameric AbrB protein structure. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.

By: S. Stowe n, A. Tucker*, R. Thompson*, A. Piper*, J. Richards*, S. Rogers*, L. Mathies n, C. Melander*, J. Cavanagh*

author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
TL;DR: The most effective antibiofilm compound had significant effects when used in conjunction with several standard antibiotics against resistant bacteria and was found to maintain the same low level of toxicity as when acting alone, bolstering its candidacy for further testing as an adjuvant. (via Semantic Scholar)
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2012 journal article

Structural insights into the calcium-dependent interaction between calbindin-D28K and caspase-3

FEBS LETTERS, 586(20), 3582–3589.

By: B. Bobay n, A. Stewart n, A. Tucker n, R. Thompson n, K. Varney * & J. Cavanagh n

author keywords: Calbindin-D28K; Caspase-3; Isothermal titration calorimetry; Molecular docking
MeSH headings : Calbindins; Calcium / metabolism; Caspase 3 / chemistry; Caspase 3 / metabolism; Enzyme Activation; Hydrogen Bonding; Molecular Docking Simulation; Protein Binding; Protein Conformation; S100 Calcium Binding Protein G / chemistry; S100 Calcium Binding Protein G / metabolism
TL;DR: Calbindin‐D28K and Caspase‐3 bind by isothermal titration calorimetry and this results in new insights into the mechanism by which these molecules bind to each other. (via Semantic Scholar)
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Added: August 6, 2018

2011 review

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

By: S. Stowe, J. Richards, A. Tucker, R. Thompson, C. Melander & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

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