Anqi Tu

Works (6)

Updated: July 5th, 2023 15:31

2021 journal article

In situ detection of fatty acid C=C positional isomers by coupling on-tissue mCPBA epoxidation with infrared matrix-assisted laser desorption electrospray ionization mass spectrometry

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 35(13).

By: A. Tu n, K. Garrard n, N. Said * & D. Muddiman n 

TL;DR: The on-tissue mCPBA epoxidation was implemented into an ambient MS imaging workflow to offer a rapid and simple way for in situ identification and relative quantification of double bond positional isomers without the requirement for instrument modification. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 journal article

Spatially resolved metabolomic characterization of muscle invasive bladder cancer by mass spectrometry imaging

METABOLOMICS, 17(8).

By: A. Tu n, N. Said * & D. Muddiman n 

author keywords: Bladder cancer; IR-MALDESI mass spectrometry imaging; Metabolomics; Lipidomics; Intratumor heterogeneity
MeSH headings : Feasibility Studies; Humans; Metabolomics / methods; Muscle, Smooth / metabolism; Muscle, Smooth / pathology; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Urinary Bladder Neoplasms / diagnostic imaging; Urinary Bladder Neoplasms / metabolism; Urinary Bladder Neoplasms / pathology
TL;DR: Great promise is demonstrated of IR-MALDESI MSI to identify molecular changes derived from cancer and unveil tumor heterogeneity, which can potentially promote the discovery of clinically relevant biomarkers and allow for applications in precision medicine. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 2, 2021

2020 journal article

Lipidomic profiling of single mammalian cells by infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI)

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(29), 8211–8222.

By: Y. Xi  n, A. Tu n & D. Muddiman n 

author keywords: Single-cell analysis; Lipidome; Mass spectrometry; IR-MALDESI; Orbitrap
MeSH headings : Animals; HeLa Cells; Humans; Limit of Detection; Lipidomics; Rats; Reproducibility of Results; Single-Cell Analysis / methods; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: A rapid and sensitive method for investigating the lipid profiles of isolated single cells using infrared matrix-assisted laser desorption electrospray ionization mass spectrometry (IR-MALDESI-MS), which provides an important basis for future work on differentiation between normal and diseased cells at various developmental states. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: October 12, 2020

2019 journal article

Internal Energy Deposition in Infrared Matrix-Assisted Laser Desorption Electrospray Ionization With and Without the Use of Ice as a Matrix

JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY, 30(11), 2380–2391.

By: A. Tu n & D. Muddiman n 

author keywords: Internal energy deposition; IR-MALDESI; Mass spectrometry imaging; Survival yield method; Thermometer ions; Ambient ionization
TL;DR: Measurements with holo-myoglobin show that IR-MALDESI-MS retains the noncovalently bound heme-protein complexes under both native-like and denaturing conditions, while complete loss of the heme group occurred in denatured ESI-MS, showing that the softness of IR-MalDESI is equivalent or superior to ESI for biomolecules. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: November 25, 2019

2019 journal article

Systematic evaluation of repeatability of IR-MALDESI-MS and normalization strategies for correcting the analytical variation and improving image quality

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 411(22), 5729–5743.

By: A. Tu n & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Repeatability; Normalization
MeSH headings : Animals; Chickens; Female; Rats; Reproducibility of Results; Spectrometry, Mass, Electrospray Ionization / methods; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Results demonstrated that the majority of normalization approaches benefit data quality to some extent, and local normalization methods significantly outperform their global counterparts, resulting in a reduction of median %RSD up to 22. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: September 9, 2019

2018 journal article

Discriminating normal regions within cancerous hen ovarian tissue using multivariate hyperspectral image analysis

RAPID COMMUNICATIONS IN MASS SPECTROMETRY, 33(4), 381–391.

By: M. Lakeh *, A. Tu n, D. Muddiman n  & H. Abdollahi *

MeSH headings : Animals; Chickens / metabolism; Female; Least-Squares Analysis; Multivariate Analysis; Ovarian Neoplasms / chemistry; Ovarian Neoplasms / diagnosis; Ovarian Neoplasms / pathology; Ovarian Neoplasms / veterinary; Ovary / chemistry; Ovary / pathology; Poultry Diseases / diagnosis; Poultry Diseases / pathology; Principal Component Analysis; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR: Two unsupervised chemometric methods including PCA and MCR-ALS were applied for resolving and visualizing IR-MALDESI-MS data acquired from hen ovary tissues, improving the interpretation of mass spectrometry imaging results. (via Semantic Scholar)
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10. Reduced Inequalities (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 18, 2019

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