Ashlyn T. Young

Works (12)

Updated: July 13th, 2023 21:14

2021 journal article

Synthesis of sonicated fibrin nanoparticles that modulate fibrin clot polymerization and enhance angiogenic responses

Colloids and Surfaces B: Biointerfaces, 204, 111805.

By: C. Roosa n, I. Muhamed n, A. Young n, K. Nellenbach n, M. Daniele n , F. Ligler n, A. Brown n 

author keywords: Fibrin; Nanoparticles; Wound healing; Regenerative medicine; Fibrin sealant
MeSH headings : Fibrin; Fibrin Tissue Adhesive; Nanoparticles; Polymerization; Wound Healing
TL;DR: It is shown that SFBNs may be a promising wound healing therapy that can be easily produced and delivered in a flowable formulation and support cell migration in an in vitro angiogenic sprouting assay, relevant for wound healing. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: July 19, 2021

2020 journal article

Chitosan Hydrogels for Synergistic Delivery of Chemotherapeutics to Triple Negative Breast Cancer Cells and Spheroids

PHARMACEUTICAL RESEARCH, 37(7).

By: J. Schneible n, A. Young n, M. Daniele n  & S. Menegatti n 

MeSH headings : Acetylation; Antineoplastic Combined Chemotherapy Protocols / administration & dosage; Antineoplastic Combined Chemotherapy Protocols / chemistry; Antineoplastic Combined Chemotherapy Protocols / pharmacology; Cell Line, Tumor; Cell Survival / drug effects; Chitosan / chemistry; Deoxycytidine / administration & dosage; Deoxycytidine / analogs & derivatives; Deoxycytidine / chemistry; Deoxycytidine / pharmacology; Doxorubicin / administration & dosage; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Carriers; Drug Compounding; Drug Liberation; Drug Synergism; Female; Humans; Hydrogels; Kinetics; Spheroids, Cellular; Triple Negative Breast Neoplasms / drug therapy; Triple Negative Breast Neoplasms / pathology; Gemcitabine
TL;DR: The ACS hydrogel delivery system accomplishes drug release kinetics and molar ratio that affords strong therapeutically synergism and provides a strong pre-clinical demonstration of the potential of the proposed system for complementing surgical resection of aggressive solid tumors. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 10, 2020

2020 journal article

Modified gaphene oxide (GO) particles in peptide hydrogels: a hybrid system enabling scheduled delivery of synergistic combinations of chemotherapeutics

JOURNAL OF MATERIALS CHEMISTRY B, 8(17), 3852–3868.

By: J. Schneible n, K. Shi n, A. Young n, S. Ramesh n, N. He*, C. Dowdey n, J. Dubnansky n, R. Libya ...

MeSH headings : Antibiotics, Antineoplastic / chemistry; Antibiotics, Antineoplastic / pharmacology; Cell Proliferation / drug effects; Cell Survival / drug effects; Doxorubicin / chemistry; Doxorubicin / pharmacology; Drug Delivery Systems; Drug Screening Assays, Antitumor; Graphite / chemistry; Humans; Hydrogels / chemistry; Molecular Dynamics Simulation; Particle Size; Peptides / chemistry; Surface Properties; Tumor Cells, Cultured
TL;DR: A homogeneous composite comprising modified graphene oxide (GO) nanoparticles embedded in a Max8 peptide hydrogel, which provides controlled kinetics and molar ratios of release of doxorubicin (DOX) and gemcitabine (GEM) and is tested against a triple negative breast cancer cell line. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2020 journal article

Photoinduced reconfiguration to control the protein-binding affinity of azobenzene-cyclized peptides

JOURNAL OF MATERIALS CHEMISTRY B, 8(33), 7413–7427.

By: K. Day n, J. Schneible n, A. Young n, V. Pozdin*, G. Driessche  n, L. Gaffney n, R. Prodromou n, D. Freytes n ...

MeSH headings : Amino Acid Sequence; Azo Compounds / chemistry; Hydrogen-Ion Concentration; Isomerism; Osmolar Concentration; Peptides, Cyclic / chemistry; Photochemical Processes
TL;DR: This study demonstrates a general method to develop azobenzene-cyclized peptide ligands with light-controlled affinity for target proteins by designing photo-switchable peptides targeting vascular cell adhesion marker 1 (VCAM1), a cell marker implicated in stem cell function. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 14, 2020

2020 journal article

Rheological Properties of Coordinated Physical Gelation and Chemical Crosslinking in Gelatin Methacryloyl (GelMA) Hydrogels

MACROMOLECULAR BIOSCIENCE, 20(12).

By: A. Young n, O. White n & M. Daniele n 

author keywords: animal source; gelatin; gelatin methacryloyl; gelation; GelMA; mechanical properties; photopolymerization
MeSH headings : Animals; Biocompatible Materials / chemistry; Bioprinting / methods; Cattle; Gelatin / chemistry; Hydrogels / chemistry; Methacrylates / chemistry; Printing, Three-Dimensional; Rheology; Swine; Tissue Engineering / trends
TL;DR: The effects of coordinated physical gelation and chemical crosslinking are demonstrated by precise photopatterning of cell-laden microstructures, inducing different cellular behavior depending on the selected mechanical properties of GelMA. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 14, 2020

2019 review

Monitoring of Microphysiological Systems: Integrating Sensors and Real-Time Data Analysis toward Autonomous Decision-Making

[Review of ]. ACS SENSORS, 4(6), 1454–1464.

By: A. Young n, K. Rivera n, P. Erb n & M. Daniele n 

author keywords: microphysiological system (MPS); organ-on-chip; biosensor; real-time analysis; data; cyber-physical system
MeSH headings : Data Analysis; Humans; Lab-On-A-Chip Devices; Machine Learning; Microchip Analytical Procedures / methods; Monitoring, Physiologic / instrumentation; Monitoring, Physiologic / methods
TL;DR: In this Perspective, three stages of microphysiological system monitoring, including process, development, and function, are assessed and the unique features and remaining technical challenges for the required sensors are discussed. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 22, 2019

2019 journal article

Perylene-diimide-based n-type semiconductors with enhanced air and temperature stable photoconductor and transistor properties

DYES AND PIGMENTS, 174.

By: J. Yuen *, V. Pozdin n, A. Young n, B. Turner n, I. Giles *, J. Naciri*, S. Trammell *, P. Charles*, D. Stenger *, M. Daniele n 

author keywords: Perylene; n-type; Photoconductor; Field effect transistor; Air stable
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7. Affordable and Clean Energy (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 17, 2020

2018 journal article

Cardiac Stem Cell Patch Integrated with Microengineered Blood Vessels Promotes Cardiomyocyte Proliferation and Neovascularization after Acute Myocardial Infarction

ACS APPLIED MATERIALS & INTERFACES, 10(39), 33088–33096.

By: T. Su n, K. Huang n , M. Daniele n , M. Hensley  n, A. Young n, J. Tang n, T. Allen n, A. Vandergriff  n ...

author keywords: microvessels; hydrodynamic focusing; cardiac stem cells; cardiomyocyte proliferation; angiogenesis; myocardial infarction
MeSH headings : Animals; Cells, Cultured; Female; Human Umbilical Vein Endothelial Cells; Humans; Microfluidic Analytical Techniques; Myocardial Infarction / therapy; Myocardium / cytology; Myocytes, Cardiac / cytology; Myocytes, Cardiac / physiology; Neovascularization, Physiologic / physiology; Rats; Rats, Nude; Stem Cells / cytology; Stem Cells / physiology
TL;DR: It is shown that the endothelialized BMVs mimicked the natural architecture and function of capillaries and that the resultant vascularized cardiac patch (BMV-CSC patch) exhibited equivalent release of paracrine factors compared to those of coculture of genuine human CSCs and HUVECs after 7 days of in vitro culture. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 29, 2018

2018 journal article

Integrated phosphorescence-based photonic biosensor (iPOB) for monitoring oxygen levels in 3D cell culture systems

BIOSENSORS & BIOELECTRONICS, 123, 131–140.

By: K. Rivera n, V. Pozdin n, A. Young n, P. Erb n, N. Wisniewski*, S. Magness n, M. Daniele n 

author keywords: Oxygen; Microdevice; Organs-on-chips; Oxygen biosensor; Biosensors; Hypoxia
MeSH headings : Biosensing Techniques; Cell Culture Techniques; Cell Hypoxia; Cell Line, Tumor; Humans; Luminescent Measurements / methods; Oxygen / chemistry; Oxygen / metabolism; Photons
TL;DR: The design and engineering of a system to remotely monitor and control oxygen concentration inside a device for 3D cell culture is reported, integrating a photonic oxygen biosensor into the 3D tissue scaffold and regulate oxygen concentration via the control of purging gas flow. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 3, 2018

2018 journal article

Neuro-nano interfaces: Utilizing nano-coatings and nanoparticles to enable next-generation electrophysiological recording, neural stimulation, and biochemical modulation

Advanced Functional Materials, 28(12).

By: A. Young, N. Cornwell & M. Daniele 

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Platelet-Inspired Nanocells for Targeted Heart Repair After Ischemia/Reperfusion Injury

ADVANCED FUNCTIONAL MATERIALS, 29(4).

By: T. Su n, K. Huang n , H. Ma *, H. Liang n, P. Dinh n, J. Chen n, D. Shen n, T. Allen  n ...

author keywords: biomimetics; drug delivery; ischemic injury; platelets; stromal cell secretome
TL;DR: A platelet‐inspired nanocell (PINC) that incorporates both prostaglandin E2 (PGE2)‐modified platelet membrane and cardiac stromal cell‐secreted factors to target the heart after I/R injury is introduced, which represents a promising therapeutic delivery platform for treating myocardial ischemia/reperfusion injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 4, 2019

2016 journal article

Topically applied manganese-porphyrins BMX-001 and BMX-010 display a significant anti-inflammatory response in a mouse model of allergic dermatitis

ARCHIVES OF DERMATOLOGICAL RESEARCH, 308(10), 711–721.

By: K. Stover n, T. Fukuyama n, A. Young n, M. Daniele n , R. Oberley, J. Crapo, W. Baeumer

author keywords: Superoxide dismutase mimics; BMX-010; BMX-001; Allergic dermatitis; Mice
MeSH headings : Administration, Cutaneous; Administration, Oral; Animals; Cell Line; Dendritic Cells / drug effects; Dendritic Cells / metabolism; Dermatitis, Allergic Contact / drug therapy; Disease Models, Animal; Ear; Female; Humans; Infant, Newborn; Inflammation / drug therapy; Inflammation / metabolism; Interleukin-1beta / metabolism; Interleukin-4 / metabolism; Keratinocytes / drug effects; Keratinocytes / metabolism; Metalloporphyrins / administration & dosage; Metalloporphyrins / therapeutic use; Mice; Mice, Inbred BALB C; Pruritus / drug therapy; Skin / drug effects; Skin / metabolism; Skin Cream; Superoxide Dismutase / metabolism; Toluene 2,4-Diisocyanate / toxicity; p-Methoxy-N-methylphenethylamine / toxicity
TL;DR: Topical treatment with BMX cream resulted in a significant decrease in scratching behaviour in the compound 48/80 model, but not in the TDI model, and interestingly, the concentration of the cytokines IL-1β and IL-4 in inflamed skin was reduced by 80–90 % by all treatment options. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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