Andrea Vallese

Works (21)

Updated: January 17th, 2025 09:57

2024 article

ABERRANT NLRP3 INFLAMMASOME RESPONSE IN RETT SYNDROME: FROM EX VIVO TO IN VIVO MODELS FOR INVESTIGATING PATHOGENETIC MECHANISMS AND NEW POTENTIAL THERAPEUTIC STRATEGIES

Cordone, V., Pecorelli, A., Frescura, F., Vallese, A., Guiotto, A., Ferrara, F., … Valacchi, G. (2024, June). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 218, pp. 13–14.

By: V. Cordone *, A. Pecorelli n , F. Frescura*, A. Vallese* , A. Guiotto*, F. Ferrara*, J. Hayek *, S. Beggiato *, L. Ferraro *, G. Valacchi n 

topics (OpenAlex): Genetics and Neurodevelopmental Disorders; Family and Disability Support Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

ABNORMAL MITOCHONDRION-NLRP3 INFLAMMASOME CROSSTALK IN THE PATHOPHYSIOLOGY OF AUTISM SPECTRUM DISORDER

Vallese, A., Cordone, V., Ferrara, F., Guiotto, A., Gemmo, L., Cervellati, F., … Valacchi, G. (2024, June). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 218, pp. 50–50.

By: A. Vallese n , V. Cordone *, F. Ferrara*, A. Guiotto n, L. Gemmo*, F. Cervellati *, J. Hayek *, A. Pecorelli n , G. Valacchi n 

topics (OpenAlex): Adenosine and Purinergic Signaling; COVID-19 Impact on Reproduction; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

COMPARISON OF POLLUTANT EFFECTS ON CUTANEOUS INFLAMMASOMES ACTIVATION

Ferrara, F., Ivarsson, J., Vallese, A., Guiotto, A., Colella, S., Pecorelli, A., & Valacchi, G. (2024, June). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 218, pp. 27–27.

By: F. Ferrara*, J. Ivarsson* , A. Vallese* , A. Guiotto*, S. Colella*, A. Pecorelli* , G. Valacchi* 

topics (OpenAlex): Cancer Immunotherapy and Biomarkers; Inflammasome and immune disorders
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Effect of Cu- and Fe- Isolated from Environmental Particulate Matter on Mitochondrial Dynamics in Human Colon CaCo-2 Cells

Cervellati, F., Benedusi, M., Casoni, A., Trinchera, G., Vallese, A., Ferrara, F., … Valacchi, G. (2024, December 31). BIOLOGICAL TRACE ELEMENT RESEARCH, Vol. 12.

By: F. Cervellati *, M. Benedusi *, A. Casoni*, G. Trinchera*, A. Vallese* , F. Ferrara*, M. Pietrogrande *, G. Valacchi n 

author keywords: Pollution; Mitochondria dynamics; Gastrointestinal tract; Oxinflammation; Particulate matter
topics (OpenAlex): Air Quality and Health Impacts; Climate Change and Health Impacts; Heavy Metal Exposure and Toxicity
Sources: Web Of Science, NC State University Libraries
Added: January 13, 2025

2024 article

FIRST EVIDENCE OF REDOX DAMAGE BY INDOOR POLLUTION IN LUNG TISSUE BY THE USE OF 2D AND 3D MODELS

Garces, M., Ferrara, F., Vallese, A., Benedusi, M., Cervellati, F., Magnani, N., … Valacchi, G. (2024, June). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 218, pp. 27–27.

By: M. Garces *, F. Ferrara*, A. Vallese* , M. Benedusi *, F. Cervellati *, N. Magnani*, A. Pecorelli* , P. Evelson *, G. Valacchi* 

topics (OpenAlex): Air Quality and Health Impacts; Air Quality Monitoring and Forecasting
Sources: Web Of Science, NC State University Libraries
Added: August 26, 2024

2024 article

Gut-derived wild blueberry phenolic acid metabolites modulate extrinsic cutaneous damage (vol 15, pg 7849, 2024)

Ivarsson, J., Bennett, A., Ferrara, F., Strauch, R., Vallese, A., Iorizzo, M., … Valacchi, G. (2024, October 1). FOOD & FUNCTION, Vol. 10.

By: J. Ivarsson n , A. Bennett n, F. Ferrara*, R. Strauch n, A. Vallese* , M. Iorizzo*, A. Pecorelli n , M. Lila n , G. Valacchi* 

topics (OpenAlex): Bee Products Chemical Analysis; Transgenic Plants and Applications; Fungal Biology and Applications
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: October 14, 2024

2024 journal article

NLRP3 inflammasome-mitochondrion loop in autism spectrum disorder

FREE RADICAL BIOLOGY AND MEDICINE, 225, 581–594.

By: A. Vallese n , V. Cordone *, F. Ferrara*, A. Guiotto n, L. Gemmo*, F. Cervellati *, J. Hayek *, A. Pecorelli* , G. Valacchi n 

topics (OpenAlex): Inflammasome and immune disorders; Kawasaki Disease and Coronary Complications; Neonatal Respiratory Health Research
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2024

2023 article

CADMIUM EXPOSURE AFFECTS THE PROGRESSION OF HUMAN METASTATIC MELANOMA BY INDUCING A DEREGULATION OF ANTIOXIDANT CELL RESPONSE

Casoni, A., Benedusi, M., Cervellati, F., Pecorelli, A., Ferrara, F., Vallese, A., & Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 42–43.

By: A. Casoni*, M. Benedusi *, F. Cervellati *, A. Pecorelli* , F. Ferrara*, A. Vallese* , G. Valacchi n 

topics (OpenAlex): Heavy Metal Exposure and Toxicity
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 24(23).

By: J. Ivarsson* , F. Ferrara*, A. Vallese* , A. Guiotto*, S. Colella*, A. Pecorelli* , G. Valacchi* 

author keywords: oxinflammation; inflammasome; pollutants; skin
topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts; Heme Oxygenase-1 and Carbon Monoxide
TL;DR: Among all environmental pollutants, O3, MP, and UV represented the main pollutants affecting cutaneous redox homeostasis; of note, the NLRP1 and NLRP6 inflammasomes were the main ones modulated by these outdoor stressors, suggesting their role as possible molecular targets in preventing skin disorders and the inflammaging events associated with environmental pollutants exposure. (via Semantic Scholar)
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Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 24, 2023

2023 article

Deregulated NLRP3 inflammasome response due to a constitutive activation of NF-kappa B p65 pro-inflammatory pathway in lymphomonocytes of Rett syndrome patients

Cordone, V., Vallese, A., Pecorelli, A., Guiotto, A., Ferrara, F., Benedusi, M., … Valacchi, G. (2023, March). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 198, pp. S21–S22.

By: V. Cordone *, A. Vallese* , A. Pecorelli n , A. Guiotto *, F. Ferrara*, M. Benedusi *, F. Cervellati *, J. Hayek *, G. Valacchi n 

topics (OpenAlex): Immune Cell Function and Interaction; Nuclear Receptors and Signaling; IL-33, ST2, and ILC Pathways
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

INFLAMMASOMES REGULATION BY ENVIRONMENTAL POLLUTANTS IN HUMAN SKIN

Ferrara, F., Pecorelli, A., Guiotto, A., Vallese, A., Cordone, V., Benedusi, M., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 38–39.

By: F. Ferrara*, A. Pecorelli* , A. Guiotto*, A. Vallese* , V. Cordone *, M. Benedusi *, F. Cervellati *, G. Valacchi* 

topics (OpenAlex): Inflammasome and immune disorders; Air Quality and Health Impacts
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

MITOCHONDRIAL DYSFUNCTION AND NLRP3 INFLAMMASOME ACTIVATION IN AUTISM SPECTRUM DISORDER

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 20–20.

By: A. Vallese n , A. Pecorelli* , V. Cordone *, F. Ferrara*, M. Benedusi *, F. Cervellati *, J. Hayek *, G. Valacchi n 

topics (OpenAlex): COVID-19 Impact on Reproduction; Infant Development and Preterm Care
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 journal article

Ox-inflammasome involvement in neuroinflammation

FREE RADICAL BIOLOGY AND MEDICINE, 207, 161–177.

By: A. Vallese* , V. Cordone *, A. Pecorelli*  & G. Valacchi n 

topics (OpenAlex): Inflammasome and immune disorders; Heme Oxygenase-1 and Carbon Monoxide; Neuroinflammation and Neurodegeneration Mechanisms
TL;DR: The current knowledge on the involvement of inflammasome in the main neuropathologies is provided, emphasizing the importance to further clarify the role of oxidative stress in its activation including therole of mitochondria in inflammaome-induced neuroinflammation. (via Semantic Scholar)
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5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 article

ROLE OF COENZYME Q10 IN MITOCHONDRIAL DYSFUNCTION AND OXIDATIVE DAMAGE IN RETT SYNDROME

Silvestri, S., Marcheggiani, F., Orlando, P., Cirilli, I., Mengarelli, F., Vallese, A., … Tiano, L. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 16–16.

By: S. Silvestri *, F. Marcheggiani *, P. Orlando *, I. Cirilli *, F. Mengarelli*, A. Vallese* , A. Pecorelli* , G. Valacchi* , L. Tiano *

topics (OpenAlex): Coenzyme Q10 studies and effects
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

THE POSSIBLE MODULATION OF NRF2 AND NF-KB CROSSTALK BY SULFORAPHANE IN THE PROGRESSION OF HUMAN MELANOMA

Benedusi, M., Canella, R., Vallese, A., Casoni, A., Guerra, M., Rispoli, G., … Valacchi, G. (2023, May 20). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 201, pp. 57–57.

By: M. Benedusi *, R. Canella *, A. Vallese* , A. Casoni*, M. Guerra*, G. Rispoli *, F. Ferrara*, F. Cervellati *, G. Valacchi n 

topics (OpenAlex): Genomics, phytochemicals, and oxidative stress; Synthesis and Biological Evaluation; Synthesis and biological activity
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: June 19, 2023

2023 article

The pathogenic axis between mitochondrial dysfunction and NLRP3 inflammasome activation in Autism Spectrum Disorder

Vallese, A., Pecorelli, A., Cordone, V., Ferrara, F., Benedusi, M., Cervellati, F., … Valacchi, G. (2023, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 208, pp. S49–S49.

By: A. Vallese* , A. Pecorelli* , V. Cordone *, F. Ferrara*, M. Benedusi *, F. Cervellati *, J. Hayek *, G. Valacchi n 

topics (OpenAlex): Infant Development and Preterm Care; Neonatal and fetal brain pathology; Neonatal Respiratory Health Research
Sources: ORCID, Web Of Science, NC State University Libraries
Added: November 24, 2023

2023 journal article

The role of potassium current in the pulmonary response to environmental oxidative stress

Archives of Biochemistry and Biophysics, 2, 109534.

By: R. Canella *, M. Benedusi *, A. Vallese* , A. Pecorelli *, A. Guiotto *, F. Ferrara *, G. Rispoli *, F. Cervellati *, G. Valacchi *

Contributors: R. Canella *, M. Benedusi *, A. Vallese* , A. Pecorelli *, A. Guiotto *, F. Ferrara *, G. Rispoli *, F. Cervellati *, G. Valacchi *

topics (OpenAlex): Ion channel regulation and function; Nicotinic Acetylcholine Receptors Study; Ion Channels and Receptors
TL;DR: The data suggest that O3 is able to inhibit potassium current by targeting BK channel, and can contribute to identify the biomolecular pathway induced by O3 allowing a possible pharmacological intervention against oxidative stress damage in lung tissue. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Source: ORCID
Added: September 6, 2023

2022 article

Loss of Scavenger Receptor B1 (SR-B1) in Brain of a Rett Syndrome Mouse Model

Pecorelli, A., Ferrara, F., Guiotto, A., Vallese, A., Cordone, V., Belmonte, G., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: A. Pecorelli* , F. Ferrara*, A. Guiotto, A. Vallese* , V. Cordone, G. Belmonte, J. Hayek, C. Cervellati, G. Valacchi* 

topics (OpenAlex): Genetics and Neurodevelopmental Disorders
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 journal article

Ubiquitination as a key regulatory mechanism for O-3-induced cutaneous redox inflammasome activation

REDOX BIOLOGY, 56.

By: F. Ferrara*, V. Cordone *, A. Pecorelli* , M. Benedusi *, E. Pambianchi*, A. Guiotto *, A. Vallese* , F. Cervellati *, G. Valacchi* 

Contributors: F. Ferrara*, V. Cordone *, A. Pecorelli* , M. Benedusi *, E. Pambianchi*, A. Guiotto *, A. Vallese* , F. Cervellati *, G. Valacchi* 

author keywords: Inflammasomes; OxInflammation; Proteasome; UBR2; N-end rule pathway
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Air Pollutants; Apoptosis Regulatory Proteins / genetics; Catalase / metabolism; Cytokines / metabolism; Environmental Pollutants; Humans; Hydrogen Peroxide / metabolism; Inflammasomes / metabolism; NLR Proteins / metabolism; Oxidation-Reduction; Ozone / metabolism; Particulate Matter; Reactive Oxygen Species / metabolism; Ubiquitin-Protein Ligases / metabolism; Ubiquitination
topics (OpenAlex): Heme Oxygenase-1 and Carbon Monoxide; Inflammasome and immune disorders; Medical and Biological Ozone Research
TL;DR: It is reported for the first time that O3, one of the most toxic pollutants, activates the NLRP1 inflammasome in human keratinocytes via oxidative stress mediators as hydrogen peroxide (H2O2) and 4-hydroxy-nonenal (4HNE). (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: September 12, 2022

2022 article

Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox Inflammasome activation

Ferrara, F., Cordone, V., Pecorelli, A., Benedusi, M., Pambianchi, E., Guiotto, A., … Valacchi, G. (2022, November 1). FREE RADICAL BIOLOGY AND MEDICINE, Vol. 192.

By: F. Ferrara*, V. Cordone *, A. Pecorelli n , M. Benedusi *, E. Pambianchi n, A. Guiotto *, A. Vallese* , F. Cervellati*, G. Valacchi n 

topics (OpenAlex): Redox biology and oxidative stress; Heme Oxygenase-1 and Carbon Monoxide; S100 Proteins and Annexins
Sources: ORCID, Web Of Science, NC State University Libraries
Added: March 6, 2023

2022 conference paper

[YIA] Evidence of ferroptosis involvement in Rett syndrome pathogenesis

Free Radical Biology and Medicine, 189, 15.

By: A. Guiotto *, V. Cordone *, A. Vallese* , M. Benedusi *, F. Cervellati *, J. Hayek *, C. Cervellati *, G. Valacchi *, A. Pecorelli  n

topics (OpenAlex): RNA modifications and cancer; Cancer-related molecular mechanisms research; Circular RNAs in diseases
Source: ORCID
Added: September 6, 2023

Employment

Updated: March 5th, 2025 06:11

2024 - present

University of Teramo Teramo, Abruzzo, IT
Research Fellow

2021 - 2024

University of Ferrara Ferrara, IT
PhD student

2023 - 2023

North Carolina State University Kannapolis, US
Visiting Researcher

Education

Updated: March 5th, 2025 06:15

2024 - present

University of L'Aquila L’Aquila, Abruzzo, IT
Psychological sciences and techniques

2019 - 2021

University of L'Aquila L’Aquila, IT
Biology of health and nutrition

2015 - 2018

University of L'Aquila L’Aquila, IT
Biological science

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