Angela Yao

College of Sciences

Works (4)

Updated: November 19th, 2025 16:16

2025 article

Mechanistic and Structural Analyses of Non-Heme Iron Enzyme TqaM for α-Tertiary Amino Acid Synthesis

Wang, H., Yao, A., Kanaida, M., Mori, T., Liu, S., Du, E. L., … Abe, I. (2025, October 28). Journal of the American Chemical Society, Vol. 11.

By: H. Wang *, A. Yao n, M. Kanaida*, T. Mori *, S. Liu  n, E. Du *, Y. Zheng n , T. Awakawa * ...

MeSH headings : Amino Acids / chemistry; Amino Acids / biosynthesis; Biocatalysis; Substrate Specificity; Oxygenases / chemistry; Oxygenases / metabolism; Oxygenases / genetics; Models, Molecular; Mutagenesis, Site-Directed; Nonheme Iron Proteins / chemistry; Nonheme Iron Proteins / metabolism
topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Metalloenzymes and iron-sulfur proteins; Enzyme Catalysis and Immobilization
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: November 16, 2025

2025 article

Multiple Catalytic Branch Points in the Mechanism of Pyrrolidine Formation During Kainoid Biosynthesis Leads to Diverse Reaction Outcomes

Chen, T.-Y., Ruszczycky, M. W., Yao, A., Li, X., Chien, T.-C., & Chang, W.-chen. (2025, August 5). Journal of the American Chemical Society, Vol. 8.

By: T. Chen n, M. Ruszczycky*, A. Yao n, X. Li n, T. Chien * & W. Chang n 

topics (OpenAlex): Metal-Catalyzed Oxygenation Mechanisms; Photosynthetic Processes and Mechanisms; Metalloenzymes and iron-sulfur proteins; Radical Photochemical Reactions
Sources: Web Of Science, NC State University Libraries
Added: August 18, 2025

2025 article

Studies of Isonitrile Synthases Help Elucidate the Mechanism of Isonitrile Installation

Chen, T.-Y., Kim, W., Guo, M., Yao, A., Zhang, Y. J., & Chang, W.-chen. (2025, June 30). ACS Catalysis, Vol. 6.

By: T. Chen n, W. Kim *, M. Guo *, A. Yao n, Y. Zhang * & W. Chang n 

author keywords: isonitrile; enzyme mechanism; substrate recognition; product inhibition; biosynthesis
topics (OpenAlex): Enzyme Catalysis and Immobilization; Biochemical and Molecular Research; Analytical Chemistry and Chromatography
Sources: Web Of Science, NC State University Libraries
Added: July 21, 2025

2023 article

Mechanistic Studies of Aziridine Formation Catalyzed by Mononuclear Non-Heme Iron Enzymes

Cha, L., Paris, J. C., Zanella, B., Spletzer, M., Yao, A., Guo, Y., & Chang, W.-chen. (2023, March 13). Journal of the American Chemical Society, Vol. 3.

By: L. Cha n , J. Paris *, B. Zanella n, M. Spletzer*, A. Yao n, Y. Guo *, W. Chang n 

MeSH headings : Iron / chemistry; Aziridines; Hydroxylation; Catalysis
topics (OpenAlex): Synthesis and Catalytic Reactions; Metal-Catalyzed Oxygenation Mechanisms; Neurological diseases and metabolism
TL;DR: The use of in silico methods to identify enzymes with potential aziridine-installing (aziridinase) functionality are reported and reconstitute enzymatic activity in vitro and demonstrate that an iron(IV)-oxo species initiates aziridine ring closure by the C-H bond cleavage. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 4, 2023

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