Works (2)

Updated: July 5th, 2023 15:21

2021 journal article

Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster


By: B. Baker*, M. Carbone n, W. Huang*, R. Anholt* & T. Mackay*

author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
TL;DR: It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 23, 2021

2019 journal article

Genetics of cocaine and methamphetamine consumption and preference in Drosophila melanogaster


By: C. Highfill n, B. Baker n, S. Stevens n, R. Anholt n & T. Mackay n

MeSH headings : Animals; Central Nervous System Stimulants / metabolism; Cocaine / metabolism; Disease Models, Animal; Dopamine Plasma Membrane Transport Proteins / antagonists & inhibitors; Dopamine Plasma Membrane Transport Proteins / genetics; Dopamine Plasma Membrane Transport Proteins / metabolism; Dopaminergic Neurons / metabolism; Drosophila Proteins / antagonists & inhibitors; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / drug effects; Drosophila melanogaster / genetics; Drosophila melanogaster / metabolism; Feeding Behavior; Female; Gene Expression Profiling; Gene Expression Regulation; Gene Regulatory Networks; Genome, Insect; Male; Methamphetamine / metabolism; Mushroom Bodies / metabolism; Mushroom Bodies / physiopathology; RNA, Small Interfering / genetics; RNA, Small Interfering / metabolism; Sex Characteristics; Substance-Related Disorders / genetics; Substance-Related Disorders / metabolism; Substance-Related Disorders / physiopathology
Source: Web Of Science
Added: June 24, 2019

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