Genetic basis of variation in cocaine and methamphetamine consumption in outbred populations of Drosophila melanogaster
Baker, B. M., Carbone, M. A., Huang, W., Anholt, R. R. H., & Mackay, T. F. C. (2021, May 31). Proceedings of the National Academy of Sciences, Vol. 118.
author keywords: extreme QTL genome-wide association mapping; Drosophila Genetic Reference Panel; RNA interference; advanced intercross population
MeSH headings : Animals; Cocaine / pharmacology; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster; Epistasis, Genetic; Female; Genome-Wide Association Study; Humans; Male; Methamphetamine / pharmacology; Polymorphism, Single Nucleotide; Quantitative Trait Loci; Sex Characteristics
topics (OpenAlex): Neurobiology and Insect Physiology Research; Physiological and biochemical adaptations; Genetics, Aging, and Longevity in Model Organisms
TL;DR:
It is shown that the genetic architecture underlying variation in voluntary cocaine and methamphetamine consumption differs between sexes and is dominated by variants in genes associated with connectivity and function of the nervous system.
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