Brian Denton

Works (28)

Updated: January 27th, 2025 08:20

2017 journal article

Probabilistic sensitivity analysis on Markov models with uncertain transition probabilities: an application in evaluating treatment decisions for type 2 diabetes

Health Care Management Science, 22(1), 34–52.

By: Y. Zhang n, H. Wu *, B. Denton*, J. Wilson n & J. Lobo *

author keywords: Robustness and sensitivity analysis; Markov model; Transition probability matrices; Medical decision-making; Monte Carlo simulation
MeSH headings : Decision Making; Diabetes Mellitus, Type 1 / therapy; Humans; Markov Chains; Models, Statistical; Monte Carlo Method; Probability; Uncertainty
topics (OpenAlex): Bayesian Modeling and Causal Inference; Statistical Methods and Bayesian Inference; Statistical Methods in Clinical Trials
TL;DR: This article describes two simulation-based approaches for conducting probabilistic sensitivity analysis on a given discrete-time, finite-horizon, infinite-state Markov model using TPMs that are sampled over a specified uncertainty set according to a relevant probability distribution. (via Semantic Scholar)
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16. Peace, Justice and Strong Institutions (OpenAlex)
Sources: Web Of Science, Crossref
Added: February 25, 2019

2013 article

Optimizing the simultaneous management of blood pressure and cholesterol for type 2 diabetes patients

Mason, J. E., Denton, B. T., Shah, N. D., & Smith, S. A. (2013, September 25). European Journal of Operational Research.

By: J. Mason n, B. Denton n, N. Shah * & S. Smith*

author keywords: OR in medicine; Markov decision process; Type 2 diabetes; Blood pressure treatment; Cholesterol treatment
topics (OpenAlex): Health Systems, Economic Evaluations, Quality of Life; Blood Pressure and Hypertension Studies; Lipoproteins and Cardiovascular Health
TL;DR: A Markov decision process (MDP) model is presented to determine the optimal timing of blood pressure and cholesterol medications for patients with type 2 diabetes and the trade off between quality-adjusted life years and costs of treatment. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

A comparison of decision-maker perspectives for optimal cholesterol treatment

Mason, J. E., & Denton, B. T. (2012, August 7). IBM Journal of Research and Development.

By: J. Mason n & B. Denton n

topics (OpenAlex): Health Systems, Economic Evaluations, Quality of Life; Pharmaceutical Economics and Policy; Advanced Causal Inference Techniques
TL;DR: A Markov decision process (MDP) is used to show how decision-maker perspectives can influence medical treatment decisions related to cardiovascular risk management in patients with type 2 diabetes, and an inverse MDP model is formulated to estimate the implied monetary value of a year of life, from the societal perspective, according to current U.S. treatment guidelines. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

An examination of the dynamic changes in prostate‐specific antigen occurring in a population‐based cohort of men over time

Inman, B. A., Zhang, J., Shah, N. D., & Denton, B. T. (2012, February 7). British Journal of Urology.

By: B. Inman *, J. Zhang *, N. Shah* & B. Denton n

MeSH headings : Adult; Age Factors; Aged; Aged, 80 and over; Cohort Studies; Early Detection of Cancer; Humans; Male; Middle Aged; Prostate-Specific Antigen / metabolism; Prostatic Neoplasms / diagnosis; ROC Curve; Sensitivity and Specificity
topics (OpenAlex): Prostate Cancer Diagnosis and Treatment; Prostate Cancer Treatment and Research; Statistical Methods and Inference
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Source: NC State University Libraries
Added: August 6, 2018

2012 article

Optimization of Prostate Biopsy Referral Decisions

Zhang, J., Denton, B. T., Balasubramanian, H., Shah, N. D., & Inman, B. A. (2012, July 15). Manufacturing & Service Operations Management.

By: J. Zhang *, B. Denton n, H. Balasubramanian *, N. Shah* & B. Inman *

author keywords: partially observable Markov decision process; PSA screening; biopsy; control-limit policy; stopping time problem
topics (OpenAlex): Prostate Cancer Diagnosis and Treatment; Prostate Cancer Treatment and Research; Statistical Methods and Inference
TL;DR: A nonstationary partially observable Markov decision process (POMDP) for prostate biopsy referral decisions that demonstrates a nondecreasing belief threshold in age, and provides sufficient conditions under which PSA screening should be discontinued for older patients. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2012 article

Simulation optimization of PSA-threshold based prostate cancer screening policies

Underwood, D. J., Zhang, J., Denton, B. T., Shah, N. D., & Inman, B. A. (2012, February 3). Health Care Management Science.

By: D. Underwood n, J. Zhang *, B. Denton n, N. Shah* & B. Inman *

author keywords: Prostate cancer screening; Simulation optimization; Genetic algorithm; Ranking and selection
MeSH headings : Age Factors; Algorithms; Computer Simulation; Early Detection of Cancer / methods; Early Detection of Cancer / statistics & numerical data; False Positive Reactions; Health Policy; Humans; Male; Practice Guidelines as Topic; Prostate-Specific Antigen / blood; Prostatic Neoplasms / diagnosis; Quality-Adjusted Life Years
topics (OpenAlex): Prostate Cancer Diagnosis and Treatment; Statistical Methods in Clinical Trials; Health Systems, Economic Evaluations, Quality of Life
TL;DR: A simulation optimization method is described that integrates a simulation model in a genetic algorithm which uses a probabilistic method for selection of the best policy to design PSA screening policies based on expected quality adjusted life years. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Bi‐Criteria Scheduling of Surgical Services for an Outpatient Procedure Center

Gul, S., Denton, B. T., Fowler, J. W., & Huschka, T. (2011, February 17). Production and Operations Management.

By: S. Gul*, B. Denton n, J. Fowler * & T. Huschka*

author keywords: operating room; outpatient procedure; scheduling; simulation; genetic algorithm
topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Hemodynamic Monitoring and Therapy; Hospital Admissions and Outcomes
TL;DR: This analysis provides insight into the best scheduling heuristics, and the trade‐off between patient and health care provider‐based criteria, and the trade‐off between patient and health care provider‐based criteria. (via Semantic Scholar)
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1. No Poverty (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Dynamic Appointment Scheduling of a Stochastic Server with Uncertain Demand

Erdogan, S. A., & Denton, B. (2011, December 9). INFORMS Journal on Computing.

By: S. Erdogan  n & B. Denton n

author keywords: appointment scheduling; stochastic programming; health care
topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Hemodynamic Monitoring and Therapy; Healthcare Policy and Management
TL;DR: Two new stochastic linear programming formulations of appointment scheduling problems that are motivated by the management of health services, where customers are scheduled dynamically, one at a time, as they request appointments, are formulated. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2011 article

Optimization of PSA Screening Policies

Zhang, J., Denton, B. T., Balasubramanian, H., Shah, N. D., & Inman, B. A. (2011, September 20). Medical Decision Making.

By: J. Zhang  n, B. Denton n, H. Balasubramanian  n, N. Shah n & B. Inman  n

author keywords: prostate cancer; PSA; partially observable Markov decision process; patient perspective; societal perspective
MeSH headings : Attitude to Health; Bayes Theorem; Biomarkers, Tumor / blood; Biopsy, Needle; Early Detection of Cancer; Early Diagnosis; Guideline Adherence; Humans; Individuality; Male; Markov Chains; Minnesota; Patient Acceptance of Health Care / statistics & numerical data; Probability; Prostate / pathology; Prostate-Specific Antigen / blood; Prostatic Neoplasms / diagnosis; Prostatic Neoplasms / psychology; Quality of Life; Quality-Adjusted Life Years
topics (OpenAlex): Prostate Cancer Diagnosis and Treatment; Colorectal Cancer Screening and Detection; Prostate Cancer Treatment and Research
TL;DR: PSA testing done with traditional guidelines underperforms and therefore underestimates the potential benefit of screening, and PSA screening based on traditional guidelines is found to be worse than no screening at all. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2011 article

Optimizing Statin Treatment Decisions for Diabetes Patients in the Presence of Uncertain Future Adherence

Mason, J. E., England, D. A., Denton, B. T., Smith, S. A., Kurt, M., & Shah, N. D. (2011, April 29). Medical Decision Making.

By: J. Mason n, D. England n, B. Denton, S. Smith n, M. Kurt  n & N. Shah n

author keywords: adherence; diabetes; statins; Markov decision process
MeSH headings : Adult; Decision Making; Diabetes Mellitus, Type 2 / drug therapy; Female; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Male; Markov Chains; Middle Aged; Patient Compliance; Quality-Adjusted Life Years
topics (OpenAlex): Medication Adherence and Compliance; Pharmaceutical Economics and Policy; Health Systems, Economic Evaluations, Quality of Life
TL;DR: A Markov decision process (MDP) model is used to optimize the treatment decision for patients with type 2 diabetes and determines the optimal time of statin initiation that minimizes expected costs and maximizes expected quality-adjusted life years (QALYs). (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Improving Clinical Access and Continuity through Physician Panel Redesign

Balasubramanian, H., Banerjee, R., Denton, B., Naessens, J., & Stahl, J. (2010, June 11). Journal of General Internal Medicine.

By: H. Balasubramanian *, R. Banerjee *, B. Denton, J. Naessens * & J. Stahl *

author keywords: primary care access; continuity of care; systems engineering
MeSH headings : Adolescent; Adult; Aged; Aged, 80 and over; Appointments and Schedules; Continuity of Patient Care / standards; Continuity of Patient Care / trends; Female; Health Services Accessibility / standards; Health Services Accessibility / trends; Humans; Male; Middle Aged; Physicians, Primary Care / standards; Physicians, Primary Care / trends; Primary Health Care / standards; Primary Health Care / trends; Young Adult
topics (OpenAlex): Healthcare Policy and Management; Primary Care and Health Outcomes; Healthcare Operations and Scheduling Optimization
TL;DR: Redesigning primary care physician panels can improve access to and continuity of care for patients and provides shorter waiting time and higher continuity over a wide range of practice panel sizes. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2010 article

Operating Room Pooling and Parallel Surgery Processing Under Uncertainty

Batun, S., Denton, B. T., Huschka, T. R., & Schaefer, A. J. (2010, July 3). INFORMS Journal on Computing.

By: S. Batun *, B. Denton n, T. Huschka* & A. Schaefer *

topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Hospital Admissions and Outcomes; Hemodynamic Monitoring and Therapy
TL;DR: A novel two-stage stochastic mixed-integer programming model is presented to minimize total expected operating cost given that scheduling decisions are made before the resolution of uncertainty in surgery durations. (via Semantic Scholar)
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Source: NC State University Libraries
Added: August 6, 2018

2010 article

Optimal Allocation of Surgery Blocks to Operating Rooms Under Uncertainty

Denton, B. T., Miller, A. J., Balasubramanian, H. J., & Huschka, T. R. (2010, March 25). Operations Research.

By: B. Denton n, A. Miller *, H. Balasubramanian * & T. Huschka*

topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Risk and Portfolio Optimization; Hospital Admissions and Outcomes
TL;DR: A fast and easy-to-implement heuristic works fairly well, on average, across many instances, and the robust method performs approximately as well as the heuristic, is much faster than solving the stochastic recourse model, and has the benefit of limiting the worst-case outcome of the recourse problem. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 article

A Discrete Event Simulation Model to Evaluate Operational Performance of a Colonoscopy Suite

Berg, B., Denton, B., Nelson, H., Balasubramanian, H., Rahman, A., Bailey, A., & Lindor, K. (2009, September 22). Medical Decision Making.

By: B. Berg n, B. Denton n, H. Nelson *, H. Balasubramanian *, A. Rahman *, A. Bailey *, K. Lindor *

author keywords: colorectal cancer; colonoscopy; discrete event; simulation
MeSH headings : Appointments and Schedules; Colonoscopy / economics; Colonoscopy / statistics & numerical data; Colorectal Neoplasms / diagnosis; Computer Simulation; Efficiency, Organizational; Health Care Rationing; Humans; Models, Organizational; Personnel Staffing and Scheduling; Task Performance and Analysis; Workflow
topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Colorectal Cancer Screening and Detection; Healthcare Policy and Management
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Analysis of current approach and methodology for improvements

Interfaces, 39(3), 288–289.

By: B. Denton

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Comparison with historical data and impact

Interfaces, 39(3), 289–290.

By: B. Denton

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Improving the utilization of catheterization labs at Scottsdale Healthcare

Interfaces, 39(3), 288–288.

By: B. Denton

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Introduction: 2008 Franz Edelman Award for Achievement in Operations Research and the Management Sciences

Denton, B. T., & Sodhi, M. M. S. (2009, February 1). INFORMS Journal on Applied Analytics.

By: B. Denton & M. Sodhi *

author keywords: professional: comments on
topics (OpenAlex): Corporate Governance and Management
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Source: Web Of Science
Added: August 6, 2018

2009 article

Optimizing the Start Time of Statin Therapy for Patients with Diabetes

Denton, B. T., Kurt, M., Shah, N. D., Bryant, S. C., & Smith, S. A. (2009, May 1). Medical Decision Making.

By: B. Denton, M. Kurt *, N. Shah*, S. Bryant* & S. Smith*

author keywords: diabetes; statins; Markov decision process
MeSH headings : Diabetes Mellitus, Type 2 / complications; Drug Administration Schedule; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors / administration & dosage; Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use; Hypercholesterolemia / complications; Hypercholesterolemia / drug therapy; Markov Chains; Models, Theoretical
topics (OpenAlex): Lipoproteins and Cardiovascular Health; Diabetes, Cardiovascular Risks, and Lipoproteins; Health Systems, Economic Evaluations, Quality of Life
TL;DR: A model to optimize the selection of patients for statin therapy of hypercholesterolemia, for patients with type 2 diabetes, using each of the risk models, finds that treatment decisions depend on the cardiovascular risk model used and the age, gender, and metabolic state of the patient. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Performance evaluation and parametric analysis of our recommendations

Interfaces, 39(3), 289–289.

By: B. Denton

Source: NC State University Libraries
Added: August 6, 2018

2009 article

Practice Abstracts

Denton, B. T. (2009, August 1). INFORMS Journal on Applied Analytics.

By: B. Denton

author keywords: industries: lumber and wood; Excel spreadsheet; mixed-integer programming (MIP) model
topics (OpenAlex): Quality and Supply Management; Operations Management Techniques
Source: Web Of Science
Added: August 6, 2018

2009 article

Practice Abstracts

Denton, B. T. (2009, November 10). INFORMS Journal on Applied Analytics.

By: B. Denton n

author keywords: health care; planning; economics; hospitals; efficiency; simulation
topics (OpenAlex): Advanced Manufacturing and Logistics Optimization; Scheduling and Optimization Algorithms; Operations Management Techniques
TL;DR: "Practice Abstracts" are intended to provide Interfaces readers with short descriptions of the most relevant aspects of operations research-based projects, in a form that is accessible to academics and practitioners in other organizations. (via Semantic Scholar)
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9. Industry, Innovation and Infrastructure (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2009 article

Practice Abstracts

Denton, B. T. (2009, November 10). INFORMS Journal on Applied Analytics.

By: B. Denton

author keywords: production scheduling; inventory planning; sequencing
topics (OpenAlex): Advanced Queuing Theory Analysis; Simulation Techniques and Applications; Petri Nets in System Modeling
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UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Appointment scheduling in health care: Challenges and opportunities

Gupta, D., & Denton, B. (2008, July 17). IIE Transactions.

By: D. Gupta * & B. Denton*

author keywords: appointment scheduling; health care operations management; access rules
topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Operations Management Techniques; Healthcare Technology and Patient Monitoring
TL;DR: A road map of the state of the art in the design of appointment management systems is provided and future opportunities for novel applications of IE/OR models are identified. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2008 article

Heuristics for balancing Operating Room and post-anesthesia resources under uncertainty

Iser, J. H., Denton, B. T., & King, R. E. (2008, December 1). 2008 Winter Simulation Conference, pp. 1601–1608.

By: J. Iser n, B. Denton n & R. King n 

topics (OpenAlex): Healthcare Operations and Scheduling Optimization; Scheduling and Optimization Algorithms; Advanced Queuing Theory Analysis
TL;DR: This work analyzes the structure of the problem, evaluates several heuristics based on competing performance measures for surgical suite efficiency, and presents results of numerical experiments and insights that can be derived from them. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 article

Introduction: 2007 Franz Edelman Award for Achievement in Operations Research and the Management Sciences

Denton, B., & Sodhi, M. M. S. (2008, February 1). INFORMS Journal on Applied Analytics.

By: B. Denton & M. Sodhi *

author keywords: professional : comments on
topics (OpenAlex): Complex Systems and Decision Making; Quality and Supply Management
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2008 article

Practice Abstracts

Denton, B. T. (2008, April 1). INFORMS Journal on Applied Analytics.

By: B. Denton

author keywords: simulation : applications; computers : computer science; system design : operation
topics (OpenAlex): Quality and Supply Management; Operations Management Techniques
Source: Web Of Science
Added: August 6, 2018

2007 article

Practice Abstracts

Denton, B. T. (2007, December 1). INFORMS Journal on Applied Analytics.

By: B. Denton

author keywords: concept design; multidisciplinary design optimization; combat systems
topics (OpenAlex): Quality and Supply Management; Operations Management Techniques
Source: Web Of Science
Added: August 6, 2018

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