Boyce Griffith

Works (3)

Updated: April 5th, 2024 12:25

2023 journal article

Microphysiological model of PIK3CA-driven vascular malformations reveals a role of dysregulated Rac1 and mTORC1/2 in lesion formation


By: W. Aw n, C. Cho n, H. Wang n, A. Cooper n, E. Doherty n, D. Rocco*, S. Huang n, S. Kubik n ...

MeSH headings : Humans; TOR Serine-Threonine Kinases / metabolism; Mechanistic Target of Rapamycin Complex 1 / metabolism; Sirolimus / pharmacology; Human Umbilical Vein Endothelial Cells / metabolism; Mitogen-Activated Protein Kinase Kinases / metabolism; Class I Phosphatidylinositol 3-Kinases / genetics; Class I Phosphatidylinositol 3-Kinases / metabolism; Vascular Malformations / metabolism; rac1 GTP-Binding Protein / metabolism
TL;DR: These findings demonstrate an in vitro platform for VMs and establish a role of dysregulated Rac1/PAK and mTORC1/2 signaling in PIK3CA-driven VMs. (via Semantic Scholar)
Source: Web Of Science
Added: March 27, 2023

2022 article

Concurrent ARFI Plaque Imaging and Wall Shear Stress Measurement in Human Carotid Artery, with Validation by Fluid Structure Interaction Models


By: K. Anand n, E. Kolahdouz*, J. Homeister*, M. Smith*, B. Griffith* & C. Gallippi n

author keywords: plane wave; vector flow; ARFI; VoA; WSS; FSI; simulation
TL;DR: The results demonstrate the feasibility of concurrent imaging of carotid plaque composition by ARFI VoA, vector flow, and WSS to better assess stroke risk. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: February 6, 2023

2019 journal article

Analyzing the effects of instillation volume on intravesical delivery using biphasic solute transport in a deformable geometry


By: S. Smith n, B. Griffith* & D. Zaharoff n

author keywords: bladder cancer; cystitis; intravesical delivery; FEBio
MeSH headings : Administration, Intravesical; Humans; Models, Theoretical; Urinary Bladder Diseases / drug therapy
TL;DR: The volume of instillation was found to have a substantial impact on the exposure of solute to the deeper muscle layers of the bladder, which are typically more difficult to reach and indicate the role that instillation volume may play in targeting particular layers ofThe bladder during an intravesical delivery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
5. Gender Equality (Web of Science)
Source: Web Of Science
Added: November 18, 2019

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