Barry Hedgespeth

Works (6)

Updated: April 5th, 2024 18:59

2023 journal article

The exon-skipping oligonucleotide, KitStop, depletes tissue-resident mast cells in vivo to ameliorate anaphylaxis

FRONTIERS IN IMMUNOLOGY, 14.

By: B. Hedgespeth n, D. Snider  n, K. Bitting n & G. Cruse n 

Contributors: B. Hedgespeth n, D. Snider  n, K. Bitting n & G. Cruse n 

author keywords: mast cell (MC); anaphylaxis; KIT; exon skipping; mast cell depletion
MeSH headings : Mice; Animals; Mast Cells; Anaphylaxis / genetics; Anaphylaxis / therapy; Mastocytosis; Allergens
TL;DR: The use of an exon-skipping oligonucleotide is reported to safely reduce the severity and duration of the anaphylactic response via mast cell depopulation in tissues, resulting in a significant reduction in systemic mast cell responses. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 6, 2023

2022 article

Identification of redundancy between human Fc epsilon RI beta and MS4A6A proteins points toward additional complex mechanisms for Fc epsilon RI trafficking and signaling

Bitting, K., Hedgespeth, B., Ehrhardt-Humbert, L. C., Arthur, G. K., Schubert, A. G., Bradding, P., … Cruse, G. (2022, December 7). ALLERGY, Vol. 12.

By: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

Contributors: K. Bitting n, B. Hedgespeth n, L. Ehrhardt-Humbert n, G. Arthur n, A. Schubert n, P. Bradding *, S. Tilley*, G. Cruse n 

author keywords: asthma; IgE; mast cells
MeSH headings : Animals; Humans; Mice; Basophils / metabolism; Cell Degranulation; Exons; Hypersensitivity / metabolism; Mast Cells / metabolism; Receptors, IgE / genetics; Receptors, IgE / metabolism; Signal Transduction
TL;DR: It is reported that targeting FcεRIβ with exon‐skipping oligonucleotides eliminates IgE‐mediated degranulation in mouse MCs, but equivalent targeting in human MCs was not effective at reducing degranulations. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 25, 2022

2021 journal article

A novel missense mutation of the NAT10 gene in a juvenile Schnauzer dog with chronic respiratory tract infections

JOURNAL OF VETERINARY INTERNAL MEDICINE, 35(3), 1542–1546.

By: B. Hedgespeth n, A. Birkenheuer n , S. Friedenberg*, N. Olby n  & K. Meurs n 

author keywords: ciliary dysplasia; congenital; genetics; microtubule; pneumonia; whole genome sequencing
MeSH headings : Animals; Dog Diseases / genetics; Dogs; Male; Mutation; Mutation, Missense; Respiratory Tract Infections / genetics; Respiratory Tract Infections / veterinary; Whole Genome Sequencing / veterinary
TL;DR: W Whole genome sequencing discovered a deleterious missense A/C mutation within the NAT10 gene, a gene essential for microtubule acetylation, appropriate ciliary development, and cytokinesis, suggesting a pathophysiological mechanism for this dog and highlighting an associated mutation or possible novel genetic cause of chronic respiratory infections in dogs. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 29, 2021

2021 journal article

Dysbiosis of fecal microbiota in cats with naturally occurring and experimentally induced Tritrichomonas foetus infection

PLOS ONE, 16(2).

By: M. Bierlein n, B. Hedgespeth n, M. Azcarate-Peril *, S. Stauffer n & J. Gookin n 

MeSH headings : Animals; Cats; Disease Models, Animal; Dysbiosis / complications; Feces / microbiology; Mice; Microbiota; Protozoan Infections / complications; Protozoan Infections / microbiology; Tritrichomonas foetus / physiology
TL;DR: It is hypothesized that T. foetus promotes dysbiosis by competition for fermentable substrates used by these bacteria and that metabolic byproducts may contribute to the pathogenesis of colonic inflammation and diarrhea. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: April 5, 2021

2021 journal article

Identification of an ATP/P2X7/mast cell pathway mediating ozone-induced bronchial hyperresponsiveness

JCI INSIGHT, 6(21).

By: X. Kong *, W. Bennett *, C. Jania*, K. Chason*, Z. German *, J. Adouli*, S. Budney*, B. Oby* ...

Contributors: X. Kong *, W. Bennett *, C. Jania*, K. Chason*, Z. German *, J. Adouli*, S. Budney*, B. Oby* ...

MeSH headings : Adenosine Triphosphate / metabolism; Animals; Bronchial Hyperreactivity / metabolism; Female; Humans; Mast Cells / metabolism; Mice; Ozone / adverse effects
TL;DR: The data demonstrated that ozone induced substantial ATP release from human airway epithelia in vitro and into the airways of mice in vivo and that ATP served as a potent inducer of mast cell degranulation and BHR, acting through P2X7 receptors on mast cells. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: January 31, 2022

2020 journal article

Association of fecal sample collection technique and treatment history with Tritrichomonas foetus polymerase chain reaction test results in 1717 cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 734–741.

By: B. Hedgespeth n, S. Stauffer n, J. Robertson n  & J. Gookin n 

author keywords: diarrhea; retrospective; risk factors; ronidazole
MeSH headings : Animals; Antiprotozoal Agents / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / parasitology; Cats; Feces / parasitology; Female; Male; Polymerase Chain Reaction / veterinary; Protozoan Infections, Animal / diagnosis; Protozoan Infections, Animal / drug therapy; Protozoan Infections, Animal / parasitology; Retrospective Studies; Ronidazole / therapeutic use; Specimen Handling / veterinary; Tritrichomonas foetus / isolation & purification; United States
TL;DR: Results of this study support that fecal samples collected by loop might be better for PCR diagnosis of T. foetus infection and Lack of association of ronidazole with PCR test results and a 21% all‐potential‐causes failure rate of rONidazoles in cats with preconfirmed infection are important limitations to use of this drug. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
5. Gender Equality (Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 27, 2020

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