Works (6)
Updated: July 10th, 2023 21:17
2015 journal article
Coordinated regulation of Nrf2 and histone H3 serine 10 phosphorylation in arsenite-activated transcription of the human heme oxygenase-1 gene
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 1849(10), 1277–1288.
author keywords: Nrf2; Histone; Epigenetic; Arsenic; HO-1; Antioxidant response element
MeSH headings : Animals; Antioxidant Response Elements / genetics; Arsenites / pharmacology; Gene Expression Regulation, Enzymologic; Heme Oxygenase-1 / biosynthesis; Heme Oxygenase-1 / genetics; Heme Oxygenase-1 / metabolism; Histones / genetics; Histones / metabolism; Humans; Keratinocytes / metabolism; Mice; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / genetics; Phosphorylation; Promoter Regions, Genetic; Protein Binding; Signal Transduction; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is proposed that Nrf2 may influence H3S10 phosphorylation at the HO-1 ARE and additional promoter regions, which highlights the complex interplay between NRF2 and H 3S10osphorylation in arsenite-activatedHO-1 transcription.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Distinct regulatory mechanisms of the human ferritin gene by hypoxia and hypoxia mimetic cobalt chloride at the transcriptional and post-transcriptional levels
CELLULAR SIGNALLING, 26(12), 2702–2709.
author keywords: Hypoxia; Cobalt chloride; Hypoxia inducible factor (HIF); Iron regulatory protein (IRP); Nrf2; Ferritin
MeSH headings : Apoferritins / genetics; Cell Line, Tumor; Cobalt / pharmacology; Ferritins / genetics; Gene Expression Regulation / genetics; Humans; Hypoxia / genetics; Hypoxia-Inducible Factor 1, alpha Subunit / genetics; Iron-Regulatory Proteins / genetics; Protein Processing, Post-Translational / drug effects; Protein Processing, Post-Translational / genetics; RNA, Messenger / genetics; Transcription, Genetic / drug effects; Transcription, Genetic / genetics; Transcriptional Activation / drug effects; Transcriptional Activation / genetics
TL;DR:
It is demonstrated that hypoxia and cobalt chloride regulate ferritin heavy chain (ferritin H) expression by two distinct mechanisms through the interplay between DNA and mRNA elements at the transcriptional and post-transcriptional levels.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Role of AMP-Activated Protein Kinase in Ferritin H Gene Expression by Resveratrol in Human T Cells
BIOCHEMISTRY, 52(30), 5075–5083.
MeSH headings : AMP-Activated Protein Kinases / antagonists & inhibitors; AMP-Activated Protein Kinases / chemistry; AMP-Activated Protein Kinases / genetics; AMP-Activated Protein Kinases / metabolism; Antioxidants / chemistry; Antioxidants / pharmacology; Apoferritins / genetics; Apoferritins / metabolism; Enzyme Activation / drug effects; Gene Expression Regulation / drug effects; Glycogen Synthase Kinase 3 / antagonists & inhibitors; Glycogen Synthase Kinase 3 / genetics; Glycogen Synthase Kinase 3 / metabolism; Glycogen Synthase Kinase 3 beta; Humans; Jurkat Cells; K562 Cells; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Phosphorylation / drug effects; Protein Processing, Post-Translational / drug effects; RNA Interference; Response Elements / drug effects; Resveratrol; Serine / metabolism; Stilbenes / antagonists & inhibitors; Stilbenes / pharmacology; T-Lymphocytes / drug effects; T-Lymphocytes / metabolism
TL;DR:
It is found that AMP-activated protein kinase (AMPK) plays a key role in the activation of nuclear factor E2-related factor (Nrf2) and subsequent ARE-dependent ferritin H gene transcription by resveratrol.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2013 journal article
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4
FASEB JOURNAL, 27(9), 3763–3774.
author keywords: arsenic; histone methylation; antioxidant; oxidative stress
MeSH headings : Antioxidants / metabolism; Arsenic / toxicity; Cell Line; Cells, Cultured; Ferritins / genetics; Fibroblasts / cytology; Fibroblasts / metabolism; Histones / metabolism; Humans; Keratinocytes / cytology; Keratinocytes / metabolism; Methylation; NF-E2-Related Factor 2 / genetics; NF-E2-Related Factor 2 / metabolism; Oxidative Stress / drug effects; Oxidative Stress / genetics; Protein-Arginine N-Methyltransferases / genetics; Protein-Arginine N-Methyltransferases / metabolism; Repressor Proteins / genetics; Repressor Proteins / metabolism; Transcription, Genetic / drug effects; Transcription, Genetic / genetics
TL;DR:
To test the hypothesis that histone H4R3 and H3R17 methylation regulates ferritin transcription, PRMT1 and PRMT4 regulate the ARE and cellular antioxidant response to arsenic, and focused microarray characterized several oxidative stress response genes are subject toPRMT1 orPRMT4 regulation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 review
Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling
[Review of ]. CELLULAR SIGNALLING, 24(5), 981–990.
author keywords: Reactive oxygen species; MAPK; Shc; Nrf2; ATM; Iron
MeSH headings : Amino Acid Sequence; Animals; Gene Expression Regulation; Homeostasis; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Intracellular Signaling Peptides and Proteins / physiology; Molecular Sequence Data; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species / metabolism; Signal Transduction
TL;DR:
This review focuses on the molecular mechanisms through which ROS directly interact with critical signaling molecules to initiate signaling in a broad variety of cellular processes, such as proliferation and survival, ROS homeostasis and antioxidant gene regulation, mitochondrial oxidative stress, apoptosis, and aging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Transcriptional regulation of ferritin and antioxidant genes by HIPK2 under genotoxic stress
JOURNAL OF CELL SCIENCE, 123(22), 3863–3871.
author keywords: HIPK2; ATF1; Phosphorylation; Ferritin; Genotoxic stress; Transcription
MeSH headings : Activating Transcription Factor 1 / genetics; Activating Transcription Factor 1 / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cell Growth Processes / genetics; Cell Survival / genetics; DNA Damage; Ferritins / genetics; Ferritins / metabolism; Gene Expression Regulation; Humans; Phosphorylation; Protein Serine-Threonine Kinases / genetics; Protein Serine-Threonine Kinases / metabolism; Transcription Factors / genetics; Transcription Factors / metabolism
TL;DR:
HIPK2 (homeodomain-interacting protein kinase 2), a DNA-damage-responsive nuclear kinase, is a new ATF1 kinase involved in the regulation of ferritin H and other antioxidant detoxification genes in genotoxic stress conditions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018