Benjamin James Dorshorst

Works (4)

Updated: July 5th, 2023 15:49

2011 journal article

A Complex Genomic Rearrangement Involving the Endothelin 3 Locus Causes Dermal Hyperpigmentation in the Chicken

PLOS GENETICS, 7(12).

By: B. Dorshorst*, A. Molin*, C. Rubin *, A. Johansson*, L. Stromstedt *, M. Pham*, C. Chen *, F. Hallbook *, C. Ashwell n , L. Andersson *

MeSH headings : Animals; Base Sequence; Breeding; Cell Proliferation; Chick Embryo; Chickens / genetics; Chickens / growth & development; Chromosome Mapping; Endothelin-3 / genetics; Feathers / growth & development; Gene Duplication; Gene Expression Regulation, Developmental; Gene Rearrangement; Genome; Melanocytes / cytology; Melanocytes / metabolism; Molecular Sequence Data; Mutation; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable; Skin Pigmentation / genetics
TL;DR: It is concluded that the same structural variant underlies this phenotype in all chicken breeds and this complex genomic rearrangement causing a specific monogenic trait in the chicken illustrates how novel mutations with major phenotypic effects have been reused during breed formation in domestic animals. (via Semantic Scholar)
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Added: August 6, 2018

2010 journal article

Genomic Regions Associated with Dermal Hyperpigmentation, Polydactyly and Other Morphological Traits in the Silkie Chicken

JOURNAL OF HEREDITY, 101(3), 339–350.

By: B. Dorshorst n, R. Okimoto n & C. Ashwell n 

author keywords: fibromelanosis; hyperpigmentation; inhibitor of dermal melanin; polydactyly; Silkie
MeSH headings : Animals; Chickens / abnormalities; Chickens / genetics; Chromosome Mapping; Crosses, Genetic; Female; Genome; Hedgehog Proteins / genetics; Male; Polydactyly / genetics; Polymorphism, Single Nucleotide; Regulatory Sequences, Nucleic Acid / genetics; Sequence Analysis, DNA; Skin Pigmentation / genetics
TL;DR: The primary focus of this study was to identify loci contributing to dermal pigmentation in the Silkie chicken, and loci associated with various other morphological traits segregating in these populations were also detected. (via Semantic Scholar)
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2010 journal article

Genomic regions associated with antibody response to sheep red blood cells in the chicken

ANIMAL GENETICS, 42(3), 300–308.

By: B. Dorshorst n, P. Siegel * & C. Ashwell n 

author keywords: association analysis; chicken; immune response; major histocompatibility complex; quantitative trait loci estimation; sheep red blood cells
MeSH headings : Animals; Antibodies / genetics; Antibodies / immunology; Antibody Formation; Body Weight; Chickens; Disease Susceptibility / immunology; Erythrocytes / immunology; Genetic Markers; Genetic Variation; Genome; Genome-Wide Association Study; Genotype; Haplotypes; Immunity, Innate; Immunization; Major Histocompatibility Complex / genetics; Major Histocompatibility Complex / immunology; Phenotype; Quantitative Trait Loci; Sheep
TL;DR: It is concluded that while these phenotypes are inversely correlated in the selected lines, they are controlled by distinct genetic loci and may be reflective of intense selection pressure on loci affecting the partitioning of nutrients between the immune system and growth pathways. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Genetic mapping of the sex-linked barring gene in the chicken

POULTRY SCIENCE, 88(9).

By: B. Dorshorst n & C. Ashwell n 

author keywords: Barred Plymouth Rock; sex-linked barring; feather pigmentation; melanocyte
MeSH headings : Animals; Chickens / genetics; Chromosome Mapping / veterinary; Dose-Response Relationship, Drug; Feathers / physiology; Female; Genetic Linkage; Genetic Markers; Lymphoid Tissue / anatomy & histology; Male; Melanins / genetics; Organ Size; Phenotype; Sex Characteristics; Sex Chromosomes
TL;DR: The results indicate that further work directed at fine-mapping this region is necessary to identify this novel mechanism of melanocyte regulation, and suggests that several of these genes or their homologs are known to be involved in processes that could potentially explain the barring phenotype. (via Semantic Scholar)
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