Works (9)
Updated: February 12th, 2025 16:00
2024 review
A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis
[Review of ]. VETERINARY SCIENCES, 11(10).
author keywords: equine; gastrointestinal; colitis; diarrhea; ion channels; infectious disease
open access via doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2024
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
TL;DR:
This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023
2022 journal article
Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells
GUT MICROBES, 14(1).
author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
TL;DR:
Pro-survival signaling from microbiota in AMBx-treated mice to the aISCs is suggested, and that this signaling maintains aISC retention in the face of chemotherapeutic injury.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022
2021 journal article
Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(1), 119–140.
author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
TL;DR:
It is shown that DXR effectively depleted aISCs in the small intestine and subsequent epithelial regeneration depended on nonquiescent early progeny cells of a ISCs, which may rely on a dampened DDR in contrast to aISCS’ robust DDR, which facilitates expeditious apoptosis.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 16, 2021
2021 journal article
Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(6), G668–G681.
author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
TL;DR:
Comprehensive microRNA profiling in all major cell types of the mouse SI epithelium revealed highly enriched microRNA markers for almost every major cell type, and observed that the two most-enriched microRNAs in secretory progenitors are miR-1224 andMiR-672, the latter of which is deleted in hominin species.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022
2021 review
Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis
[Review of ]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(4), 1239–1250.
author keywords: Paneth cells; damage; intestine; ER stress; reversion
MeSH headings : Animals; Cell Differentiation; Cellular Microenvironment; Crohn Disease / etiology; Crohn Disease / metabolism; Crohn Disease / pathology; Disease Susceptibility; Homeostasis; Host Microbial Interactions; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Microbiota; Paneth Cells / physiology; Regeneration; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Wound Healing
TL;DR:
The numerous ways Paneth cells can influence intestinal stem cells and their niche are discussed and the ways in which these cells can alter cells and other organ systems are highlighted.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021
2020 journal article
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
TL;DR:
DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021
2019 journal article
Mist1 Expression Is Required for Paneth Cell Maturation
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.
author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
TL;DR:
MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress, which occurs downstream ofPaneth cell lineage allocation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: December 16, 2019
2018 article
Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, Vol. 6, pp. 121–122.
TL;DR:
The investigators were successfully able to prove, via single-cell growth analyses, immunofluorescence, and gene expression, that the monoclonal antibody F5C12 marks a population with essentially identical properties to Lgr5 sorted cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
Employment
Updated: November 30th, 2021 15:13
2020 - 2022
Duke University Durham, North Carolina, US
Post-doctoral associate
Pharmacology and Cancer Biology
2016 - 2020
North Carolina State University Raleigh, North Carolina, US
PhD student/NIH T32 fellow
Molecular Biomedical Sciences
2013 - 2016
University of Illinois System Urbana, IL, US
Equine Internal Medicine Resident
Clinical Sciences
2012 - 2013
University of Missouri Columbia, MO, US
Equine Medicine, Surgery, and Ambulatory Intern
Clinical Sciences