Breanna Sheahan

Works (8)

Updated: April 5th, 2024 11:02

2023 journal article

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

FASEB JOURNAL, 37(6).

By: C. Schaaf n, K. Polkoff n, A. Carter n, A. Stewart n, B. Sheahan n, J. Freund n, J. Ginzel*, J. Snyder* ...

author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
Sources: Web Of Science, ORCID
Added: June 12, 2023

2022 journal article

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

GUT MICROBES, 14(1).

By: B. Sheahan n, C. Theriot n, J. Cortes n & C. Dekaney n

author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
Source: Web Of Science
Added: January 18, 2022

2021 journal article

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(1), 119–140.

By: B. Sheahan n, A. Freeman n, T. Keeley*, L. Samuelson*, J. Roper*, S. Hasapis*, C. Lee*, C. Dekaney n

author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
Source: Web Of Science
Added: August 16, 2021

2021 journal article

Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(6), G668–G681.

By: M. Shanahan*, M. Kanke*, O. Oyesola*, Y. Hung*, K. Koch-Laskowski*, A. Singh*, B. Peck*, M. Biraud n ...

author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
Source: Web Of Science
Added: January 3, 2022

2021 review

Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis

[Review of ]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(4), 1239–1250.

By: P. Cray*, B. Sheahan* & C. Dekaney n

author keywords: Paneth cells; damage; intestine; ER stress; reversion
MeSH headings : Animals; Cell Differentiation; Cellular Microenvironment; Crohn Disease / etiology; Crohn Disease / metabolism; Crohn Disease / pathology; Disease Susceptibility; Homeostasis; Host Microbial Interactions; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Microbiota; Paneth Cells / physiology; Regeneration; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Wound Healing
Source: Web Of Science
Added: November 8, 2021

2020 journal article

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

SCIENTIFIC REPORTS, 10(1).

By: P. Cray n, B. Sheahan n, J. Cortes n & C. Dekaney n

MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
Source: Web Of Science
Added: January 11, 2021

2019 journal article

Mist1 Expression Is Required for Paneth Cell Maturation

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.

By: C. Dekaney n, S. King n, B. Sheahan n & J. Cortes n

author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
Source: Web Of Science
Added: December 16, 2019

2018 article

Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, Vol. 6, pp. 121–122.

By: B. Sheahan n & C. Dekaney n

Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.