Breanna Sheahan

Works (13)

Updated: February 20th, 2026 05:16

2026 article

Downregulation of a choline transporter gene in equine colitis indicates a role for choline supplementation to support the colonic epithelial barrier

Sheahan, B., O’Neill, M. K., Jeter, M. A., McDermott, L. B., & Megeed, H. S. (2026, January 1). SSRN Electronic Journal.

By: B. Sheahan n , M. O’Neill*, M. Jeter*, L. McDermott* & H. Megeed*

topics (OpenAlex): Inflammatory Bowel Disease; Drug Transport and Resistance Mechanisms; Folate and B Vitamins Research
Sources: NC State University Libraries, NC State University Libraries
Added: January 15, 2026

2025 article

A novel kirkovirus may be associated with equine gastrointestinal disease

Haywood, L. M. B., Clark, A., Hause, B., Sheahan, B., Haywood, L. M. B., Clark, A., … Sheahan, B. (2025, November 14). Equine Veterinary Journal.

By: L. Haywood n, A. Clark  n, B. Hause*, B. Sheahan n , L. Haywood, A. Clark, B. Hause, B. Sheahan

topics (OpenAlex): Animal Virus Infections Studies; Viral gastroenteritis research and epidemiology; Respiratory viral infections research
Sources: NC State University Libraries, NC State University Libraries, ORCID
Added: November 16, 2025

2025 article

Canine urothelial cell model to study intracellular bacterial community development by uropathogenic Escherichia coli

Gilbertie, J. M., Sheahan, B. J., Vaden, S. L., & Jacob, M. E. (2025, January 9). PLoS ONE, Vol. 20.

By: J. Gilbertie n, B. Sheahan n , S. Vaden n  & M. Jacob n

MeSH headings : Dogs; Animals; Uropathogenic Escherichia coli / pathogenicity; Urothelium / microbiology; Urothelium / cytology; Urinary Tract Infections / microbiology; Urinary Tract Infections / drug therapy; Adhesins, Escherichia coli / metabolism; Adhesins, Escherichia coli / genetics; Escherichia coli Infections / microbiology; Escherichia coli Infections / veterinary; Escherichia coli Infections / drug therapy; Fimbriae Proteins / genetics; Fimbriae Proteins / metabolism; Dog Diseases / microbiology; Urinary Bladder / microbiology; Humans
topics (OpenAlex): Urinary Tract Infections Management; Bladder and Urothelial Cancer Treatments; Gut microbiota and health
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 12, 2025

2025 article

Equine neutrophils selectively release neutrophil extracellular traps in response to chemical and bacterial agonists

Sheahan, B. J., Schubert, A. G., Schubert, W., Sheats, M. K., Schnabel, L. V., & Gilbertie, J. M. (2025, February 24). Frontiers in Veterinary Science, Vol. 12.

By: B. Sheahan n , A. Schubert n, W. Schubert*, M. Sheats n , L. Schnabel n  & J. Gilbertie n

author keywords: equine; neutrophils; neutrophil extracellular traps; citrullinated histones; NADPH-oxidase pathway; autophagy
topics (OpenAlex): Neutrophil, Myeloperoxidase and Oxidative Mechanisms; Nitric Oxide and Endothelin Effects; Immune Response and Inflammation
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Sources: Web Of Science, NC State University Libraries
Added: March 17, 2025

2024 article

A Review of Epithelial Ion Transporters and Their Roles in Equine Infectious Colitis

Haywood, L. M. B., & Sheahan, B. J. (2024, October 7). Veterinary Sciences, Vol. 11.

By: L. Haywood n & B. Sheahan n 

author keywords: equine; gastrointestinal; colitis; diarrhea; ion channels; infectious disease
topics (OpenAlex): Clostridium difficile and Clostridium perfringens research; Gastrointestinal motility and disorders; Helicobacter pylori-related gastroenterology studies
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 12, 2024

2023 article

A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease

Schaaf, C. R., Polkoff, K. M., Carter, A., Stewart, A. S., Sheahan, B., Freund, J., … Gonzalez, L. M. (2023, May 9). The FASEB Journal, Vol. 37.

By: C. Schaaf n, K. Polkoff n, A. Carter n, A. Stewart n , B. Sheahan n , J. Freund n, J. Ginzel *, J. Snyder * ...

author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
topics (OpenAlex): Cancer Cells and Metastasis; Digestive system and related health; Congenital gastrointestinal and neural anomalies
TL;DR: This study validates ISC isolation in a new porcine Leucine Rich Repeat Containing G Protein‐Coupled Receptor 5 (LGR5) reporter line and demonstrates the use of these pigs as a novel colorectal cancer model. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 12, 2023

2022 article

Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells

Sheahan, B. J., Theriot, C. M., Cortes, J. E., & Dekaney, C. M. (2022, January 11). Gut Microbes, Vol. 14.

By: B. Sheahan n , C. Theriot n, J. Cortes n & C. Dekaney n

author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
topics (OpenAlex): Oral health in cancer treatment; Metastasis and carcinoma case studies; Cancer Cells and Metastasis; Head and Neck Cancer Studies
TL;DR: Pro-survival signaling from microbiota in AMBx-treated mice to the aISCs is suggested, and that this signaling maintains aISC retention in the face of chemotherapeutic injury. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 18, 2022

2021 article

Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells

Sheahan, B. J., Freeman, A. N., Keeley, T. M., Samuelson, L. C., Roper, J., Hasapis, S., … Dekaney, C. M. (2021, January 1). Cellular and Molecular Gastroenterology and Hepatology, Vol. 12, pp. 119–140.

By: B. Sheahan n , A. Freeman n, T. Keeley*, L. Samuelson *, J. Roper *, S. Hasapis*, C. Lee *, C. Dekaney n

author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
topics (OpenAlex): Cancer Cells and Metastasis; Metastasis and carcinoma case studies; Cancer Research and Treatments
TL;DR: It is shown that DXR effectively depleted aISCs in the small intestine and subsequent epithelial regeneration depended on nonquiescent early progeny cells of a ISCs, which may rely on a dampened DDR in contrast to aISCS’ robust DDR, which facilitates expeditious apoptosis. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 16, 2021

2021 article

Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types

Shanahan, M. T., Kanke, M., Oyesola, O. O., Hung, Y.-H., Koch-Laskowski, K., Singh, A. P., … Sethupathy, P. (2021, October 13). American Journal of Physiology-Gastrointestinal and Liver Physiology, Vol. 321, pp. G668–G681.

By: M. Shanahan *, M. Kanke *, O. Oyesola *, Y. Hung *, K. Koch-Laskowski *, A. Singh *, B. Peck *, M. Biraud n ...

author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
topics (OpenAlex): MicroRNA in disease regulation; Cancer-related molecular mechanisms research; RNA modifications and cancer
TL;DR: Comprehensive microRNA profiling in all major cell types of the mouse SI epithelium revealed highly enriched microRNA markers for almost every major cell type, and observed that the two most-enriched microRNAs in secretory progenitors are miR-1224 andMiR-672, the latter of which is deleted in hominin species. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 3, 2022

2021 article

Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis

Cray, P., Sheahan, B. J., & Dekaney, C. M. (2021, January 1). Cellular and Molecular Gastroenterology and Hepatology, Vol. 12, pp. 1239–1250.

By: P. Cray n, B. Sheahan n  & C. Dekaney n

author keywords: Paneth cells; damage; intestine; ER stress; reversion
MeSH headings : Animals; Cell Differentiation; Cellular Microenvironment; Crohn Disease / etiology; Crohn Disease / metabolism; Crohn Disease / pathology; Disease Susceptibility; Homeostasis; Host Microbial Interactions; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Microbiota; Paneth Cells / physiology; Regeneration; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Wound Healing
topics (OpenAlex): Gut microbiota and health; Epigenetics and DNA Methylation; Infant Nutrition and Health
TL;DR: The numerous ways Paneth cells can influence intestinal stem cells and their niche are discussed and the ways in which these cells can alter cells and other organ systems are highlighted. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: November 8, 2021

2020 article

Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers

Cray, P., Sheahan, B. J., Cortes, J. E., & Dekaney, C. M. (2020, December 8). Scientific Reports, Vol. 10.

By: P. Cray n, B. Sheahan n , J. Cortes n & C. Dekaney n

MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
topics (OpenAlex): Barrier Structure and Function Studies; Gut microbiota and health; Helicobacter pylori-related gastroenterology studies; Inhalation and Respiratory Drug Delivery
TL;DR: DXR increases paracellular transit of small macromolecules, including bacterial products, through the epithelium, by altering expression of tight junctional components and dynamic loosening of cellular tight junctions. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: January 11, 2021

2019 article

Mist1 Expression Is Required for Paneth Cell Maturation

Dekaney, C. M., King, S., Sheahan, B., & Cortes, J. E. (2019, January 1). Cellular and Molecular Gastroenterology and Hepatology, Vol. 8, pp. 549–560.

By: C. Dekaney n, S. King  n, B. Sheahan n  & J. Cortes n

author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
topics (OpenAlex): Epigenetics and DNA Methylation; Infant Nutrition and Health; Neonatal Respiratory Health Research; Immune Cell Function and Interaction; IL-33, ST2, and ILC Pathways; Cancer-related molecular mechanisms research
TL;DR: MIST1 plays an important role in organization of the Paneth cell secretory apparatus and managing endoplasmic reticulum stress, which occurs downstream ofPaneth cell lineage allocation. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019

2018 article

Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations

Sheahan, B., & Dekaney, C. M. (2018, January 1). Cellular and Molecular Gastroenterology and Hepatology, Vol. 6, pp. 121–122.

By: B. Sheahan n  & C. Dekaney n

topics (OpenAlex): Cancer Cells and Metastasis; Digestive system and related health
TL;DR: The investigators were successfully able to prove, via single-cell growth analyses, immunofluorescence, and gene expression, that the monoclonal antibody F5C12 marks a population with essentially identical properties to Lgr5 sorted cells. (via Semantic Scholar)
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2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Employment

Updated: November 30th, 2021 15:13

2020 - 2022

Duke University Durham, North Carolina, US
Post-doctoral associate Pharmacology and Cancer Biology

2016 - 2020

North Carolina State University Raleigh, North Carolina, US
PhD student/NIH T32 fellow Molecular Biomedical Sciences

2013 - 2016

University of Illinois System Urbana, IL, US
Equine Internal Medicine Resident Clinical Sciences

2012 - 2013

University of Missouri Columbia, MO, US
Equine Medicine, Surgery, and Ambulatory Intern Clinical Sciences

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