Breanna Sheahan
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Works (8)
Updated: July 5th, 2023 15:34
2023 journal article
A LGR5 reporter pig model closely resembles human intestine for improved study of stem cells in disease
FASEB JOURNAL, 37(6).
author keywords: APC mutation; colorectal cancer; intestine; Lgr5; porcine; stem cell; transgenic large animal
MeSH headings : Humans; Swine; Animals; Mice; In Situ Hybridization, Fluorescence; Intestines; Stem Cells; Ileum; Colon; Coleoptera; Green Fluorescent Proteins / genetics; Receptors, G-Protein-Coupled / genetics
doi.org (publisher)
Sources: Web Of Science, ORCID
Added: June 12, 2023
2022 journal article
Prolonged oral antimicrobial administration prevents doxorubicin-induced loss of active intestinal stem cells
GUT MICROBES, 14(1).
author keywords: Microbiota; intestinal stem cells; doxorubicin; antibiotics; antimicrobials; DNA damage; germ free; injury; small intestine
MeSH headings : Administration, Oral; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Antineoplastic Agents / administration & dosage; Antineoplastic Agents / adverse effects; Bacteria / classification; Bacteria / drug effects; Bacteria / genetics; Bacteria / isolation & purification; Cell Survival / drug effects; Doxorubicin / administration & dosage; Doxorubicin / adverse effects; Gastrointestinal Microbiome / drug effects; Germ-Free Life; Humans; Jejunum / cytology; Jejunum / drug effects; Jejunum / microbiology; Mice; Mice, Inbred C57BL; Mucositis / microbiology; Mucositis / prevention & control; Stem Cells / cytology; Stem Cells / drug effects; Time Factors
Source: Web Of Science
Added: January 18, 2022
2021 journal article
Epithelial Regeneration After Doxorubicin Arises Primarily From Early Progeny of Active Intestinal Stem Cells
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(1), 119–140.
author keywords: Gastrointestinal; irradiation; LGR5; DNA damage response
MeSH headings : Antibiotics, Antineoplastic / pharmacology; Apoptosis / drug effects; Doxorubicin / pharmacology; Epithelial Cells / drug effects; Epithelial Cells / metabolism; Epithelial Cells / pathology; Humans; Intestines / drug effects; Intestines / metabolism; Regeneration / drug effects; Stem Cells / drug effects; Stem Cells / metabolism; Stem Cells / pathology
Source: Web Of Science
Added: August 16, 2021
2021 journal article
Multiomic analysis defines the first microRNA atlas across all small intestinal epithelial lineages and reveals novel markers of almost all major cell types
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 321(6), G668–G681.
author keywords: intestinal epithelium; marker; microRNA; Paneth; tuft
MeSH headings : Animals; Biomarkers / metabolism; Cell Lineage; Cell Separation; Cells, Cultured; Computational Biology; Dogs; Epithelial Cells / metabolism; Female; Flow Cytometry; Gene Expression Profiling; Intestinal Mucosa / cytology; Intestinal Mucosa / metabolism; Intestine, Small / cytology; Intestine, Small / metabolism; Male; Mice, Inbred C57BL; Mice, Transgenic; MicroRNAs / genetics; MicroRNAs / metabolism; Organoids; RNA-Seq; Single-Cell Analysis; Transcriptome
Source: Web Of Science
Added: January 3, 2022
2021 review
Secretory Sorcery: Paneth Cell Control of Intestinal Repair and Homeostasis
[Review of ]. CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 12(4), 1239–1250.
author keywords: Paneth cells; damage; intestine; ER stress; reversion
MeSH headings : Animals; Cell Differentiation; Cellular Microenvironment; Crohn Disease / etiology; Crohn Disease / metabolism; Crohn Disease / pathology; Disease Susceptibility; Homeostasis; Host Microbial Interactions; Humans; Intestinal Mucosa / microbiology; Intestinal Mucosa / physiology; Microbiota; Paneth Cells / physiology; Regeneration; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Wound Healing
Source: Web Of Science
Added: November 8, 2021
2020 journal article
Doxorubicin increases permeability of murine small intestinal epithelium and cultured T84 monolayers
SCIENTIFIC REPORTS, 10(1).
MeSH headings : Animals; Cell Line; Cell Membrane Permeability / drug effects; Doxorubicin / metabolism; Doxorubicin / pharmacology; Duodenum / metabolism; Epithelium / metabolism; Intestinal Mucosa / drug effects; Intestinal Mucosa / metabolism; Intestine, Small / drug effects; Intestine, Small / metabolism; Jejunum / metabolism; Male; Mice; Mice, Inbred C57BL; Permeability / drug effects; Tight Junctions / metabolism
Source: Web Of Science
Added: January 11, 2021
2019 journal article
Mist1 Expression Is Required for Paneth Cell Maturation
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, 8(4), 549–560.
author keywords: MIST1; Paneth Cells; Intermediate Cells
MeSH headings : Animals; Basic Helix-Loop-Helix Transcription Factors / biosynthesis; Basic Helix-Loop-Helix Transcription Factors / genetics; Basic Helix-Loop-Helix Transcription Factors / metabolism; Cell Differentiation / physiology; Cell Division / physiology; Cell Lineage; Endoplasmic Reticulum Stress; Endoplasmic Reticulum, Rough / physiology; Epithelium / metabolism; Female; Intestinal Mucosa / metabolism; Intestine, Small / physiology; Intestines / physiology; Mice; Mice, Knockout; Paneth Cells / metabolism; Paneth Cells / physiology; Signal Transduction; Stem Cells / cytology; Stem Cells / metabolism; Transcriptome
Source: Web Of Science
Added: December 16, 2019
2018 article
Decrypting the Crypt: Novel Monoclonal Antibodies to Identify Intestinal Stem Cell Populations
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY, Vol. 6, pp. 121–122.
Source: Web Of Science
Added: August 6, 2018
