@article{linn-peirano_hepworth-warren_kinsella_diaz-campos_brenseke_cianciolo_schroeder_schreeg_2023, title={Ingesta-associated choledocholithiasis in horses: 2 cases and literature review}, volume={5}, ISSN={["1943-4936"]}, DOI={10.1177/10406387231177251}, abstractNote={ Equine ingesta-associated choledocholithiasis is a rare cause of morbidity and mortality. We describe here the clinical, gross, histologic, and microbiologic features of this condition in 2 horses and compare the features to 2 previous cases. Case 1 was a 4-y-old Thoroughbred mare with colic. Case 2 was an 18-y-old American Paint Horse mare with colic, chronic weight loss, and inappropriate mentation. Both had elevated biochemical markers of hepatocellular injury and cholestasis and were euthanized given a poor prognosis. Case 1 had a well-formed 5-cm choledocholith surrounding a piece of hay, and had chronic neutrophilic cholangiohepatitis, bridging fibrosis, and extrahepatic obstruction. Case 2 had an ill-formed choledocholith with occasional hay fragments, wood stick, and twigs, and had regionally extensive hepatocellular necrosis with mild neutrophilic cholangiohepatitis and bridging fibrosis. Enterococcus casseliflavus and Escherichia coli were isolated in both cases; Clostridium spp. were also isolated from case 2. All 4 reported cases had increased activity of cholestatic enzymes, hyperbilirubinemia, portal inflammation, and bridging fibrosis. Colic, pyrexia, leukocytosis with neutrophilia, and elevated hepatocellular enzyme activity were documented in 3 cases. Foreign material in all 4 cases was plant origin (choledochophytolithiasis), including hay ( n = 2), sticks/twigs ( n = 2), and grass awns ( n = 1). Ingesta-associated choledocholithiasis may be considered as a cause of colic, pyrexia, and elevated cholestatic biomarkers in horses. }, journal={JOURNAL OF VETERINARY DIAGNOSTIC INVESTIGATION}, author={Linn-Peirano, Sarah C. C. and Hepworth-Warren, Kate and Kinsella, Hannah and Diaz-Campos, Dubraska and Brenseke, Bonnie M. M. and Cianciolo, Rachel E. E. and Schroeder, Eric and Schreeg, Megan E. E.}, year={2023}, month={May} }