Bernard M. Fischer

Works (7)

Updated: July 5th, 2023 16:04

2011 journal article

Chronic treatment in vivo with beta-adrenoceptor agonists induces dysfunction of airway beta(2)-adrenoceptors and exacerbates lung inflammation in mice

BRITISH JOURNAL OF PHARMACOLOGY, 165(7), 2365–2377.

By: R. Lin *, S. Degan *, B. Theriot*, B. Fischer*, R. Strachan *, J. Liang *, R. Pierce*, M. Sunday * ...

author keywords: beta-adrenoceptor; beta-agonist; receptor desensitization; airway remodelling; airway inflammation; asthma; loss of bronchoprotection; mouse
MeSH headings : Administration, Inhalation; Adrenergic beta-2 Receptor Agonists / administration & dosage; Adrenergic beta-2 Receptor Agonists / adverse effects; Animals; Anti-Asthmatic Agents / administration & dosage; Anti-Asthmatic Agents / adverse effects; Asthma / complications; Asthma / drug therapy; Bronchoconstriction / drug effects; Disease Models, Animal; Humans; Mice; Mice, Inbred BALB C; Mice, Knockout; Ovalbumin / administration & dosage; Ovalbumin / immunology; Pneumonia / etiology; Pneumonia / pathology; Pneumonia / physiopathology; Receptors, Adrenergic, beta-2 / deficiency; Receptors, Adrenergic, beta-2 / drug effects; Receptors, Adrenergic, beta-2 / genetics
TL;DR: A mouse model was aimed to develop a mouse model that demonstrated functional β‐agonist‐induced β2‐adrenoceptor desensitization in the context of allergic inflammatory airway disease. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 journal article

Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro - Signaling pathways controlling surface and gene expression

AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 22(6), 685–692.

By: T. Krunkosky n, B. Fischer n, L. Martin n, N. Jones  n, N. Akley n & K. Adler n

MeSH headings : Antibodies, Monoclonal; Bronchi / cytology; Cell Line; Epithelial Cells / enzymology; Epithelial Cells / immunology; Flow Cytometry; Gene Expression / immunology; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / immunology; L-Lactate Dehydrogenase / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Promoter Regions, Genetic / physiology; RNA Processing, Post-Transcriptional / physiology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Signal Transduction / immunology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) becaus... (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

Tumor necrosis factor-alpha stimulates mucin secretion and cyclic GMP production by guinea pig tracheal epithelial cells in vitro

Fischer, B. M., Rochelle, L. G., Voynow, J. A., Akley, N. J., & Adler, K. B. (1999, March). AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, Vol. 20, pp. 413–422.

By: B. Fischer n, L. Rochelle n, J. Voynow  n, N. Akley n & K. Adler n

MeSH headings : Animals; Cyclic GMP / biosynthesis; Cyclic GMP-Dependent Protein Kinases; Epithelial Cells / cytology; Epithelial Cells / drug effects; Epithelial Cells / immunology; Female; Guanylate Cyclase / metabolism; Guinea Pigs; Male; Models, Biological; Mucins / metabolism; Nitric Oxide / biosynthesis; Nitric Oxide Synthase / metabolism; Protein Kinase C / antagonists & inhibitors; Protein Kinases / metabolism; Signal Transduction; Trachea / cytology; Trachea / drug effects; Trachea / immunology; Tumor Necrosis Factor-alpha / pharmacology; Type C Phospholipases / antagonists & inhibitors
TL;DR: The results suggest that TNF-alpha stimulates secretion of mucin by GPTE cells via a mechanism(s) dependent on PC-PLC and PKC, and involving activation of NOS, generation of NO, production of cGMP, and activation of PKG. (via Semantic Scholar)
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Source: Web Of Science
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1998 journal article

Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro

FREE RADICAL BIOLOGY AND MEDICINE, 24(5), 863–868.

By: L. Rochelle*, B. Fischer n & K. Adler n

author keywords: oxygen radicals; nitric oxide; airway epithelium; free radical
MeSH headings : Animals; Cell Line; Enzyme Activation; Epithelial Cells / metabolism; Free Radicals; Guinea Pigs; Macrophages / metabolism; Mice; Nitric Oxide Synthase / metabolism; Nitric Oxide Synthase Type II; Nitric Oxide Synthase Type III; Nitrogen / metabolism; Oxidative Stress / physiology; Reactive Oxygen Species / metabolism; Trachea / cytology; Trachea / metabolism
TL;DR: Both ROS and RNS can be measured in the same lysates from airway epithelial cells, and that both ROS andRNS are produced in these cells in response to different stimuli. (via Semantic Scholar)
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Source: Web Of Science
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1997 review

Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators

[Review of ]. EUROPEAN RESPIRATORY JOURNAL, 10(9), 2139–2146.

By: L. Martin n, L. Rochelle n, B. Fischer n, T. Krunkosky n & K. Adler n

author keywords: airway; cytokines; eicosanoids; epithelium; inflammation; reactive oxygen/nitrogen species
MeSH headings : Animals; Cytokines / metabolism; Epithelium / metabolism; Humans; Inflammation / metabolism; Inflammation / physiopathology; Inflammation Mediators / metabolism; Lipid Metabolism; Reactive Oxygen Species / metabolism; Respiratory System / metabolism; Respiratory System / pathology
TL;DR: The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases, and molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleUKin-8 ( IL-8) are discussed. (via Semantic Scholar)
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Source: Web Of Science
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1997 article

The role of reactive oxygen and nitrogen species in the response of airway epithelium to particulates

Martin, L. D., Krunkosky, T. M., Dye, J. A., Fischer, B. M., Jiang, N. F., Rochelle, L. G., … Adler, K. B. (1997, September). ENVIRONMENTAL HEALTH PERSPECTIVES, Vol. 105, pp. 1301–1307.

By: L. Martin n, T. Krunkosky n, J. Dye  n, B. Fischer n, N. Jiang n, L. Rochelle n, N. Akley n, K. Dreher n, K. Adler n

author keywords: reactive oxygen/nitrogen species; signal transduction; airway inflammation; mucin hypersecretion; ICAM-1; TNF-alpha
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Source: Web Of Science
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1991 journal article

Efficacy and Toxicity of Doxorubicin/Cyclophosphamide Maintenance Therapy in Dogs with Multicentric Lymphosarcoma

Journal of Veterinary Internal Medicine, 5(5), 259–262.

By: G. Price, R. Page*, B. Fischer*, J. Levine*  & T. Gerig n

MeSH headings : Animals; Antineoplastic Combined Chemotherapy Protocols / adverse effects; Antineoplastic Combined Chemotherapy Protocols / therapeutic use; Cyclophosphamide / administration & dosage; Diarrhea / chemically induced; Diarrhea / veterinary; Dog Diseases / chemically induced; Dog Diseases / drug therapy; Dogs; Doxorubicin / administration & dosage; Female; Heart Diseases / chemically induced; Heart Diseases / veterinary; Lymphoma, Non-Hodgkin / drug therapy; Lymphoma, Non-Hodgkin / veterinary; Male; Neutropenia / chemically induced; Neutropenia / veterinary; Remission Induction; Vomiting / chemically induced; Vomiting / veterinary
TL;DR: The doxorubicin/cyclophosphamide protocol is safe and effective in treating canine multicentric lymphosarcoma and clinical stage, pretreatment steroid therapy, and hypoalbuminemia are prognostic factors for response to this protocol. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

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