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Works (20)
Updated: April 6th, 2024 05:03
2024 journal article
Identification of hippocampal area CA2 in hamster and vole brain
JOURNAL OF COMPARATIVE NEUROLOGY, 532(3).
author keywords: aggression; hippocampus; social behavior
doi.org (repository)
Sources: Web Of Science, NC State University Libraries
Added: April 1, 2024
2023 journal article
Gestational exposure to FireMaster® 550 (FM 550) disrupts the placenta-brain axis in a socially monogamous rodent species, the prairie vole (<i>Microtus ochrogaster</i>)
MOLECULAR AND CELLULAR ENDOCRINOLOGY, 576.
author keywords: Pregnancy; EDCs; Endocrine disruptors; Neurotoxicology; Developmental toxicology; Organophosphate
TL;DR:
Prairie voles are used, a monogamous and bi-parental rodent, leveraged for decades to decipher the underpinnings of social behaviors, to examine the impact of fetal FR exposure on gene targets in the mid-gestational placenta and fetal brain and provide insights on the mechanisms by which FRs impair neurodevelopment and later in life social behaviors.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: October 16, 2023
2023 journal article
Maternal organophosphate flame retardant exposure alters the developing mesencephalic dopamine system in fetal rat
TOXICOLOGICAL SCIENCES, 191(2), 357–373.
author keywords: neurodevelopment; monoamine; OPFR; OPE; flame retardants; neurotransmitters; neurotoxicity; neurotoxicology; prenatal; reproductive and developmental toxicology; mesocortical dopamine system; tissue clearing light sheet microscopy.
TL;DR:
Results indicate maternal exposure to OPFRs alters the development trajectory of the embryonic dopaminergic system and adds to growing evidence of OPFR developmental neurotoxicity.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 12, 2024
2023 journal article
Skeletal effects following developmental flame-retardant exposure are specific to sex and chemical class in the adult Wistar rat
FRONTIERS IN TOXICOLOGY, 5.
author keywords: endocrine disrupting chemicals; flame retardants; sex difference; osteotoxicology; computed tomography; bone
TL;DR:
Although sex specificity was expected due to the sexual dimorphic nature of skeletal physiology, the mechanisms accounting for the male- and female-specific phenotypes remain to be determined and future work aims to clarify these unresolved issues.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 28, 2023
2022 journal article
Effects of developmental exposure to FireMaster (R) 550 (FM 550) on microglia density, reactivity and morphology in a prosocial animal model
NEUROTOXICOLOGY, 91, 140–154.
author keywords: Prefrontal cortex; Sex difference; Neurodevelopment; Endocrine disrupting chemicals; Flame retardants; Vole
MeSH headings : Animals; Arvicolinae; Female; Humans; Male; Mice; Microglia; Models, Animal; Organophosphates; Polybrominated Biphenyls; Pregnancy; Rats
TL;DR:
Overall, FM 550 exposure resulted in reduced numbers of microglia in most regions examined, with the 1000µg FM 550 exposed males particularly affected.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 20, 2022
2022 article
Impacts of Gestational FireMaster 550 (FM 550) Exposure on the Neonatal Cortex are Sex Specific and Largely Attributable to the Organophosphate Esters
Witchey, S. K., Doyle, M. G., Fredenburg, J. D., St Armour, G., Horman, B., Odenkirk, M. T., … Patisaul, H. B. (2022, September 8). NEUROENDOCRINOLOGY, Vol. 9.
TL;DR:
This study reveals multiple mechanisms by which the components of a common FR mixture are developmentally neurotoxic and that the OPFRs may be the compounds of greatest concern.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 26, 2022
2022 journal article
Individual and Combined Effects of Paternal Deprivation and Developmental Exposure to Firemaster 550 on Socio-Emotional Behavior in Prairie Voles
TOXICS, 10(5).
author keywords: endocrine disruptors; flame retardants; sexual differentiation; pair bond
TL;DR:
Evidence is provided that chemical and social stressors can have unique behavioral effects that differ by sex but may not produce worse outcomes in combination.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: June 13, 2022
2021 journal article
FireMaster (R) 550 (FM 550) exposure during the perinatal period impacts partner preference behavior and nucleus accumbens core medium spiny neuron electrophysiology in adult male and female prairie voles, Microtus ochrogaster
HORMONES AND BEHAVIOR, 134.
author keywords: Vole; Electrophysiology; Nucleus accumbens; Flame retardants; Endocrine disruptors; Neurodevelopment; Endocrine disrupting chemical
MeSH headings : Animals; Arvicolinae; Electrophysiology; Female; Grassland; Male; Neurons; Nucleus Accumbens; Organophosphates; Pair Bond; Polybrominated Biphenyls; Pregnancy; Social Behavior; Zebrafish
TL;DR:
The hypothesis that developmental exposure to FM 550 impacts attachment behaviors is supported and a novel FM 550 effect on neural electrophysiology is demonstrated.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 7, 2021
2021 journal article
Sex-specific Disruption of the Prairie Vole Hypothalamus by Developmental Exposure to a Flame Retardant Mixture
ENDOCRINOLOGY, 162(8).
Contributors: S. Gillera n, W. Marinello n , K. Cao n, n, H. Stapleton * & H. Patisaul n
author keywords: Social; anxiety; neurodevelopment; neural; endocrine disruptors; endocrine disrupting chemicals; oxytocin; vasopressin; dopamine
MeSH headings : Animals; Arginine Vasopressin / metabolism; Arvicolinae; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Male; Neurons / drug effects; Neurons / metabolism; Oxytocin / metabolism; Paraventricular Hypothalamic Nucleus / drug effects; Sex Factors; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
Results expand on previous work showing evidence of endocrine disruption of OT/AVP pathways, including to subpopulations of PVN AVP neurons that coordinate osmoregulatory functions in the periphery, by testing the hypothesis that FM 550 sex-specifically alters AVP and OT neuronal populations in critical nuclei.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: July 12, 2021
2020 journal article
Analysis of neurotransmitters in rat placenta exposed to flame retardants using IR-MALDESI mass spectrometry imaging
ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 412(15), 3745–3752.
author keywords: IR-MALDESI; Mass spectrometry imaging; Neurotransmitters; Exposomics
MeSH headings : Animals; Female; Flame Retardants / adverse effects; Infrared Rays; Neurotransmitter Agents / analysis; Optical Imaging / instrumentation; Optical Imaging / methods; Placenta / chemistry; Placenta / diagnostic imaging; Pregnancy; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
TL;DR:
Changes in the abundance and spatial distribution of neurotransmitters in rat placenta following chemical exposure could be determined using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020
2020 journal article
Developmental Exposure to the Flame Retardant Mixture Firemaster 550 Compromises Adult Bone Integrity in Male but not Female Rats
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 21(7).
author keywords: obesogen; endocrine disrupting chemicals; sex difference; adipose; trabecular; cortical bone; ppar gamma
MeSH headings : Animals; Bone and Bones / drug effects; Cellular Reprogramming / drug effects; Dust / analysis; Environmental Monitoring / methods; Female; Flame Retardants / adverse effects; Halogenation / drug effects; Lactation / drug effects; Male; Mesenchymal Stem Cells / drug effects; Organophosphates / adverse effects; Polybrominated Biphenyls / adverse effects; Rats; Rats, Wistar
TL;DR:
The fact that the phenotype was observed months after exposure suggests that FM 550 altered some fundamental aspect of mesenchymal stem cell reprogramming, and the severity of the phenotype and the human-relevance of the dose employed, affirm this is an adverse outcome meriting further exploration.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: June 15, 2020
2020 journal article
Effects of Prenatal Exposure to a Mixture of Organophosphhate Flame Ritardants on Placental Gene Expression and Serotonergic Innervaion in the Fetal Rat Brain
TOXICOLOGICAL SCIENCES, 176(1), 203–223.
author keywords: endocrine disruptors; endocrine toxicology; flame retardants; metabolome; neurotoxicity; developmental; neurotoxicology; neurotransmitter; developmental toxicity; prenatal; reproductive and developmental toxicology; developmental/teratology
MeSH headings : Animals; Brain / drug effects; Female; Fetal Development; Fetus; Flame Retardants / toxicity; Gene Expression; Humans; Male; Organophosphates; Organophosphorus Compounds; Placenta / metabolism; Plasticizers; Polybrominated Biphenyls; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Rats, Wistar; Serotonin / metabolism
TL;DR:
Findings suggest that OPFRs have the potential to impact the 5-HTergic system in the fetal forebrain by disrupting placental Trp metabolism.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: December 14, 2020
2020 journal article
Perinatal exposure to FireMaster (R) 550 (FM550), brominated or organophosphate flame retardants produces sex and compound specific effects on adult Wistar rat socioemotional behavior
HORMONES AND BEHAVIOR, 126.
author keywords: Behavior; Brain; Neurodevelopment; Endocrine disruptors; Endocrine disrupting chemicals; Flame retardants
MeSH headings : Animals; Animals, Newborn; Behavior, Animal / drug effects; Emotions / drug effects; Endocrine Disruptors / toxicity; Female; Flame Retardants / toxicity; Hydrocarbons, Brominated / toxicity; Male; Maternal Exposure / adverse effects; Organophosphates / toxicity; Polybrominated Biphenyls / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / physiopathology; Prenatal Exposure Delayed Effects / psychology; Rats; Rats, Wistar; Sex Characteristics; Social Behavior
TL;DR:
Examining adult Wistar rat offspring socioemotional behaviors following perinatal exposure to FM550 helps elucidate how different classes of flame retardants, independently and as a mixture, contribute to sex-specific behavioral effects of exposure.
(via Semantic Scholar)
Source: Web Of Science
Added: February 15, 2021
2019 journal article
PBDEs Concentrate in the Fetal Portion of the Placenta: Implications for Thyroid Hormone Dysregulation
ENDOCRINOLOGY, 160(11), 2748–2758.
MeSH headings : Animals; Female; Halogenated Diphenyl Ethers / pharmacokinetics; Humans; Male; Membrane Transport Proteins / metabolism; Placenta / metabolism; Pregnancy; Rats, Wistar; Thyroid Hormones / metabolism
TL;DR:
The placenta is a significant modifier of fetal exposures, and that polybrominated diphenyl ethers are impacting TH regulation in a sex-specific manner during this critical window of development.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: January 27, 2020
2019 journal article
Sex-specific behavioral effects following developmental exposure to tetrabromobisphenol A (TBBPA) in Wistar rats
NEUROTOXICOLOGY, 75, 136–147.
author keywords: brain; anxiety; endocrine disruptions; sex differences; hyperactivity; neural; sexually dimorphic; neurotoxic; flame retardants; elevated plus maze; neurodevelopment
MeSH headings : Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Flame Retardants / toxicity; Maze Learning / drug effects; Motor Activity / drug effects; Polybrominated Biphenyls / toxicity; Rats; Rats, Wistar / growth & development; Sex Factors
TL;DR:
It is demonstrated that exposure to environmental contaminants, like TBBPA, can have sex-specific effects on behavior highlighting the vulnerability of the developing brain.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 16, 2019
2018 journal article
EDC IMPACT: Molecular effects of developmental FM 550 exposure in Wistar rat placenta and fetal forebrain
ENDOCRINE CONNECTIONS, 7(2), 305–324.
author keywords: endocrine disruptors; flame retardants; behavior; serotonin; sexually dimorphic; EDC; brain
TL;DR:
It is demonstrated that environmental contaminants, like FM 550, have the potential to impact the developing brain by disrupting normal placental functions.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Sex Specific Placental Accumulation and Behavioral Effects of Developmental Firemaster 550 Exposure in Wistar Rats
SCIENTIFIC REPORTS, 7.
MeSH headings : Age Factors; Analysis of Variance; Animals; Behavior, Animal / drug effects; Dose-Response Relationship, Drug; Female; Flame Retardants / adverse effects; Flame Retardants / analysis; Male; Molecular Structure; Placenta / drug effects; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar; Sex Factors
TL;DR:
It is demonstrated that environmental chemicals may sex-dependently accumulate in the placenta, and that sex-biased exposure might translate to sex-specific adverse outcomes such as behavioral deficits.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2017 journal article
Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum
ACS Chemical Neuroscience, 8(2), 272–280.
author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
TL;DR:
This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites, and directly demonstrates the coupling of glucose availability with increased metabolic demand.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2016 journal article
Transplacental and Lactational Transfer of Firemaster (R) 550 Components in Dosed Wistar Rats
TOXICOLOGICAL SCIENCES, 153(2), 246–257.
author keywords: Firemaster 550; lactational transfer; gestational transfer; metabolites; rodent
MeSH headings : Animals; Dose-Response Relationship, Drug; Female; Flame Retardants / pharmacokinetics; Lactation; Male; Maternal-Fetal Exchange; Placenta / metabolism; Pregnancy; Rats; Rats, Wistar
TL;DR:
This study is the first to confirm ip-PPP as a urinary metabolite of ITPs and establish a pharmacokinetic profile of FM 550 in a mammalian model.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2014 journal article
Urinary Tetrabromobenzoic Acid (TBBA) as a Biomarker of Exposure to the Flame Retardant Mixture Firemaster ® 550
Environmental Health Perspectives, 122(9), 963–969.
MeSH headings : Adult; Aged; Animals; Biomarkers / metabolism; Bromobenzoates / urine; Dust / analysis; Environmental Exposure / analysis; Environmental Pollutants / urine; Female; Flame Retardants / metabolism; Hand; Humans; Male; Mass Spectrometry / methods; Middle Aged; Organophosphates / urine; Phthalic Acids / urine; Polybrominated Biphenyls / urine; Rats
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
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