Brenna Zimmer

Biochemistry

Works (2)

Updated: April 5th, 2024 12:54

2022 review

Mechanisms of coordinating hyaluronan and glycosaminoglycan production by nucleotide sugars

[Review of ]. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 322(6), C1201–C1213.

By: B. Zimmer n, J. Barycki n & M. Simpson n 

Contributors: B. Zimmer n, J. Barycki n & M. Simpson n 

author keywords: hexosamine biosynthesis pathway; hyaluronan; nucleotide sugars; UDP-glucuronate; UDP-N-acetylglucosamine
MeSH headings : Glycosaminoglycans; Hyaluronan Synthases / genetics; Hyaluronic Acid / metabolism; Nucleotides; Sugars; Uridine Diphosphate N-Acetylglucosamine / metabolism
TL;DR: Recent structures of several key rate-limiting enzymes in the UDP-sugar synthesis pathways have offered new insights to the overall regulation of hyaluronan production by precursor fate decisions. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 27, 2022

2020 review

Integration of Sugar Metabolism and Proteoglycan Synthesis by UDP-glucose Dehydrogenase

[Review of ]. JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 69(1), 13–23.

By: B. Zimmer n, J. Barycki n & M. Simpson n 

Contributors: B. Zimmer n, J. Barycki n & M. Simpson n 

author keywords: developmental disorders; extracellular matrix; glucuronidation; glycosaminoglycan; hyaluronan; nucleotide sugars; post-translational modifications; proteoglycan; UDP-glucuronate
MeSH headings : Allosteric Regulation; Animals; Biosynthetic Pathways; Humans; Models, Molecular; Neoplasms / metabolism; Protein Processing, Post-Translational; Proteoglycans / metabolism; Sugars / metabolism; Uridine Diphosphate Glucose Dehydrogenase / chemistry; Uridine Diphosphate Glucose Dehydrogenase / metabolism
TL;DR: The cellular mechanisms that regulate UG DH expression are reviewed, the structural features of the enzyme are discussed, and the structures are used to provide a context for recent studies that link post-translational modifications and allosteric modulators of UGDH to its function in downstream pathways. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 24, 2020

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