2018 journal article

The pharmacokinetics of cytarabine administered subcutaneously, combined with prednisone, in dogs with meningoencephalomyelitis of unknown etiology

Journal of Veterinary Pharmacology & Therapeutics, 41(5), 638–643.

By: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n, A. Maller*, K. Bray*, R. Waldron*, A. Castel* ...

Contributors: B. Pastina n, P. Early n, R. Bergman*, J. Nettifee n, A. Maller*, K. Bray*, R. Waldron*, A. Castel* ...

author keywords: canine; cytarabine; MUE; Pharmacokinetics; sparse sampling; subcutaneous; canine; cytarabine; MUE; pharmacokinetics; sparse sampling; subcutaneous
MeSH headings : Animals; Antimetabolites, Antineoplastic / administration & dosage; Antimetabolites, Antineoplastic / blood; Antimetabolites, Antineoplastic / pharmacokinetics; Antimetabolites, Antineoplastic / therapeutic use; Cytarabine / administration & dosage; Cytarabine / blood; Cytarabine / pharmacokinetics; Cytarabine / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Combinations; Encephalomyelitis / drug therapy; Encephalomyelitis / veterinary; Female; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / blood; Immunosuppressive Agents / pharmacokinetics; Immunosuppressive Agents / therapeutic use; Injections, Subcutaneous; Male; Meningoencephalitis / drug therapy; Meningoencephalitis / veterinary; Prednisone / administration & dosage; Prednisone / blood; Prednisone / pharmacokinetics; Prednisone / therapeutic use
TL;DR: The pharmacokinetics of CA in dogs with MUE after a single 50 mg/m2 SC injection in dogs was similar to what has been previously reported in healthy beagles; there was moderate variability in the population estimates in this clinical population of dogs. (via Semantic Scholar)
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3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 19, 2018

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