@article{moody_haslauer_kirk_kannan_loboa_mccarty_2010, title={In Situ Monitoring of Adipogenesis with Human-Adipose-Derived Stem Cells Using Surface-Enhanced Raman Spectroscopy}, volume={64}, ISSN={["1943-3530"]}, DOI={10.1366/000370210793335106}, abstractNote={ Methods capable of nondestructively collecting high-quality, real-time chemical information from living human stem cells are of increasing importance given the escalating relevance of stem cells in therapeutic and regenerative medicines. Raman spectroscopy is one such technique that can nondestructively collect real-time chemical information. Living cells uptake gold nanoparticles and transport these particles through an endosomal pathway. Once inside the endosome, nanoparticles aggregate into clusters that give rise to large spectroscopic enhancements that can be used to elucidate local chemical environments through the use of surface-enhanced Raman spectroscopy. This report uses 40-nm colloidal gold nanoparticles to create volumes of surface-enhanced Raman scattering (SERS) within living human-adipose-derived adult stem cells enabling molecular information to be monitored. We exploit this method to spectroscopically observe chemical changes that occur during the adipogenic differentiation of human-adipose-derived stem cells over a period of 22 days. It is shown that intracellular SERS is able to detect the production of lipids as little as one day after the onset of adipogenesis and that a complex interplay between lipids, proteins, and chemical messengers can be observed shortly thereafter. After 22 days of differentiation, the cells show visible and spectroscopic indications of completed adipogenesis yet still share spectral features common to the progenitor stem cells. }, number={11}, journal={APPLIED SPECTROSCOPY}, author={Moody, Benjamin and Haslauer, Carla M. and Kirk, Elizabeth and Kannan, Arthi and Loboa, Elizabeth G. and McCarty, Gregory S.}, year={2010}, month={Nov}, pages={1227–1233} }
 @article{roberts_moody_mccarty_sombers_2010, title={Specific Oxygen-Containing Functional Groups on the Carbon Surface Underlie an Enhanced Sensitivity to Dopamine at Electrochemically Pretreated Carbon Fiber Microelectrodes}, volume={26}, ISSN={["0743-7463"]}, DOI={10.1021/la9048924}, abstractNote={The in vivo use of carbon-fiber microelectrodes for neurochemical investigation has proven to be selective and sensitive when coupled with background-subtracted fast-scan cyclic voltammetry (FSCV). Various electrochemical pretreatments have been established to enhance the sensitivity of these sensors; however, the fundamental chemical mechanisms underlying these enhancement strategies remain poorly understood. We have investigated an electrochemical pretreatment in which an extended triangular waveform from -0.5 to 1.8 V is applied to the electrode prior to the voltammetric detection of dopamine using a more standard waveform ranging from -0.4 to 1.3 V. This pretreatment enhances the electron-transfer kinetics and significantly improves sensitivity. To gain insight into the chemical mechanism, the electrodes were studied using common analytical techniques. Contact atomic force microscopy (AFM) was used to demonstrate that the surface roughness was not altered on the nanoscale by electrochemical pretreatment. Raman spectroscopy was utilized to investigate oxide functionalities on the carbon surface and confirmed that carbonyl and hydroxyl functional groups were increased by electrochemical conditioning. Spectra collected after the selective chemical modification of these groups implicate the hydroxyl functionality, rather than the carbonyl, as the major contributor to the enhanced electrochemical signal. Finally, we have demonstrated that this electrochemical pretreatment can be used to create carbon microdisc electrodes with sensitivities comparable to those associated with larger, conventionally treated cylindrical carbon fiber microelectrodes.}, number={11}, journal={LANGMUIR}, author={Roberts, James G. and Moody, Benjamin P. and McCarty, Gregory S. and Sombers, Leslie A.}, year={2010}, month={Jun}, pages={9116–9122} }
 @article{moody_leotaud_mccarty_2010, title={Using surface-enhanced Raman spectroscopy to probe for genetic markers on single-stranded DNA}, volume={15}, number={2}, journal={Journal of Biomedical Optics}, author={Moody, B. and Leotaud, J. and McCarty, G. S.}, year={2010} }
 @article{moody_mccarty_2009, title={Solid state nanogaps for differential measurements of molecular properties}, volume={94}, number={12}, journal={Applied Physics Letters}, author={Moody, B. and McCarty, G. S.}, year={2009} }