Works (8)
Updated: July 20th, 2023 21:17
2020 journal article
Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface
FRONTIERS IN MICROBIOLOGY, 11.
author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
TL;DR:
Identification of similar proteins in alternative bacterial species may help pinpoint next-generation host-adapted probiotic candidates.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
15. Life on Land
(OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020
2017 journal article
Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus
Frontiers in Microbiology, 8.
TL;DR:
Results elucidate the impact of ltaS deletion on the transcriptome and extracellular proteins of L. acidophilus, suggesting roles of LTA in cell morphology and ion homeostasis as a structural component of the Gram positive cell wall.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018
2017 journal article
The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM
FRONTIERS IN MICROBIOLOGY, 8.
author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
TL;DR:
The absence of PrtX within the exoproteome of a ΔprtX strain caused morphological changes, resulting in a pleiotropic increase of the organisms’ immunomodulatory properties and interactions with some intestinal epithelial cell components.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2016 journal article
AcmB Is an S-Layer-Associated beta-N-Acetylglucosaminidase and Functional Autolysin in Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(18), 5687–5697.
MeSH headings : Acetylglucosaminidase / genetics; Acetylglucosaminidase / metabolism; Bacterial Adhesion; Bacteriolysis; Cell Division; Cell Wall / chemistry; Computational Biology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; N-Acetylmuramoyl-L-alanine Amidase / genetics; N-Acetylmuramoyl-L-alanine Amidase / metabolism; Peptidoglycan / analysis
TL;DR:
It is demonstrated that multiple autolysins, responsible for breaking down the cell wall during cell division, are associated with the S-layer, the most widely used probiotic microbes incorporated in many dairy foods and dietary supplements.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Functional Analysis of an S-Layer-Associated Fibronectin-Binding Protein in Lactobacillus acidophilus NCFM
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(9), 2676–2685.
Ed(s): E. Dudley
MeSH headings : Bacterial Adhesion / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Fibronectins / metabolism; Intestines / microbiology; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Glycoproteins / metabolism; Mutation; Phylogeny; Protein Binding
TL;DR:
To investigate the functional role of LBA0191 (designated FbpB) in L. acidophilus NCFM, an fbpB-deficient strain was constructed and a mutant with a deletion of fBPB lost the ability to adhere to mucin and fibronectin in vitro.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2015 journal article
Conserved S-Layer-Associated Proteins Revealed by Exoproteomic Survey of S-Layer-Forming Lactobacilli
APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 82(1), 134–145.
Ed(s): H. Nojiri
MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Lactobacillus / chemistry; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Phylogeny; Proteomics
TL;DR:
Proteomic complexity and differences in the cell surface properties between S-layer- and non-S- layer-forming lactobacilli reveal the potential for SLAPs to mediate intimate probiotic interactions and signaling with the host intestinal mucosa.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
2014 review
Impact of genomics on the field of probiotic research: historical perspectives to modern paradigms
[Review of ]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 106(1), 141–156.
author keywords: Probiotic; Lactic acid bacteria; Fermentation; Genomics; Lactobacilli; Bifidobacteria
MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Biomedical Research / history; Canthaxanthin / history; Genomics / history; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Probiotics / chemistry; Probiotics / history
TL;DR:
The history of the probiotic concept and the current standard of integrated genomic techniques to discern the complex, beneficial relationships between probiotic microbes and their hosts are explored.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM
MICROBIOLOGY-SGM, 159, 2269–2282.
MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
TL;DR:
P phenotypic characterization of the deletion mutant demonstrated that the SLAP LBA1029 contributes to a pro-inflammatory TNF-α response from murine DCs, and appears to impart important surface display features and immunological properties to microbes that are coated by S-layers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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