Brant Robert Johnson

Works (8)

Updated: July 20th, 2023 21:17

2020 article

Deletion of S-Layer Associated Ig-Like Domain Protein Disrupts the Lactobacillus acidophilus Cell Surface

Klotz, C., Goh, Y. J., Sarah, O. F., Johnson, B., & Barrangou, R. (2020, March 17). Frontiers in Microbiology, Vol. 11.

By: C. Klotz n, Y. Goh n, O. Sarah n, B. Johnson n & R. Barrangou n 

author keywords: Lactobacillus; probiotic; S-layer; cell surface; S-layer associated protein; Ig-like domain
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Gut microbiota and health
TL;DR: Identification of similar proteins in alternative bacterial species may help pinpoint next-generation host-adapted probiotic candidates. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: April 27, 2020

2017 article

Deletion of Lipoteichoic Acid Synthase Impacts Expression of Genes Encoding Cell Surface Proteins in Lactobacillus acidophilus

Selle, K., Goh, Y. J., Johnson, B. R., Sarah, O. F., Andersen, J. M., Barrangou, R., & Klaenhammer, T. R. (2017, April 11). Frontiers in Microbiology, Vol. 8.

By: K. Selle n, Y. Goh n, B. Johnson n, O. Sarah n, J. Andersen n, R. Barrangou n , T. Klaenhammer n

topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Bacterial Genetics and Biotechnology
TL;DR: Results elucidate the impact of ltaS deletion on the transcriptome and extracellular proteins of L. acidophilus, suggesting roles of LTA in cell morphology and ion homeostasis as a structural component of the Gram positive cell wall. (via Semantic Scholar)
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Sources: NC State University Libraries, ORCID, NC State University Libraries
Added: August 6, 2018

2017 article

The S-layer Associated Serine Protease Homolog PrtX Impacts Cell Surface-Mediated Microbe-Host Interactions of Lactobacillus acidophilus NCFM

Johnson, B. R., Sarah, O. F., Goh, Y. J., Carroll, I., Barrangou, R., & Klaenhammer, T. R. (2017, June 30). Frontiers in Microbiology, Vol. 8.

By: B. Johnson n, O. Sarah n, Y. Goh n, I. Carroll *, R. Barrangou n  & T. Klaenhammer n

author keywords: serine protease; S-layer; S-layer associated proteins; Lactobacillus; probiotic; intestinal barrier integrity; mucin; fibronectin
topics (OpenAlex): Probiotics and Fermented Foods; Antimicrobial Peptides and Activities; Infant Nutrition and Health
TL;DR: The absence of PrtX within the exoproteome of a ΔprtX strain caused morphological changes, resulting in a pleiotropic increase of the organisms’ immunomodulatory properties and interactions with some intestinal epithelial cell components. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2016 article

AcmB Is an S-Layer-Associated β- N -Acetylglucosaminidase and Functional Autolysin in Lactobacillus acidophilus NCFM

Johnson, B. R., & Klaenhammer, T. R. (2016, July 16). Applied and Environmental Microbiology.

By: B. Johnson n & T. Klaenhammer n

MeSH headings : Acetylglucosaminidase / genetics; Acetylglucosaminidase / metabolism; Bacterial Adhesion; Bacteriolysis; Cell Division; Cell Wall / chemistry; Computational Biology; Gene Deletion; Genetic Complementation Test; Lactobacillus acidophilus / enzymology; Lactobacillus acidophilus / genetics; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; N-Acetylmuramoyl-L-alanine Amidase / genetics; N-Acetylmuramoyl-L-alanine Amidase / metabolism; Peptidoglycan / analysis
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Protein Hydrolysis and Bioactive Peptides
TL;DR: It is demonstrated that multiple autolysins, responsible for breaking down the cell wall during cell division, are associated with the S-layer, the most widely used probiotic microbes incorporated in many dairy foods and dietary supplements. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2016 article

Functional Analysis of an S-Layer-Associated Fibronectin-Binding Protein in Lactobacillus acidophilus NCFM

Hymes, J. P., Johnson, B. R., Barrangou, R., & Klaenhammer, T. R. (2016, February 27). (E. G. Dudley, Ed.). Applied and Environmental Microbiology, Vol. 82, pp. 2676–2685.

By: J. Hymes n, B. Johnson n, R. Barrangou n  & T. Klaenhammer n

Ed(s): E. Dudley

MeSH headings : Bacterial Adhesion / physiology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Fibronectins / metabolism; Intestines / microbiology; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Glycoproteins / metabolism; Mutation; Phylogeny; Protein Binding
topics (OpenAlex): Probiotics and Fermented Foods; Antimicrobial Peptides and Activities; Glycosylation and Glycoproteins Research
TL;DR: To investigate the functional role of LBA0191 (designated FbpB) in L. acidophilus NCFM, an fbpB-deficient strain was constructed and a mutant with a deletion of fBPB lost the ability to adhere to mucin and fibronectin in vitro. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2015 article

Conserved S-Layer-Associated Proteins Revealed by Exoproteomic Survey of S-Layer-Forming Lactobacilli

Johnson, B. R., Hymes, J., Sanozky-Dawes, R., Henriksen, E. D. C., Barrangou, R., & Klaenhammer, T. R. (2015, October 17). (H. Nojiri, Ed.). Applied and Environmental Microbiology, Vol. 82, pp. 134–145.

By: B. Johnson n, J. Hymes n, R. Sanozky-Dawes n, E. Henriksen n, R. Barrangou n  & T. Klaenhammer n

Ed(s): H. Nojiri

MeSH headings : Bacterial Proteins / chemistry; Bacterial Proteins / genetics; Bacterial Proteins / metabolism; Lactobacillus / chemistry; Lactobacillus / classification; Lactobacillus / genetics; Lactobacillus / metabolism; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / genetics; Lactobacillus acidophilus / metabolism; Membrane Glycoproteins / chemistry; Membrane Glycoproteins / genetics; Membrane Glycoproteins / metabolism; Molecular Sequence Data; Phylogeny; Proteomics
topics (OpenAlex): Probiotics and Fermented Foods; Microbial Metabolites in Food Biotechnology; Glycosylation and Glycoproteins Research
TL;DR: Proteomic complexity and differences in the cell surface properties between S-layer- and non-S- layer-forming lactobacilli reveal the potential for SLAPs to mediate intimate probiotic interactions and signaling with the host intestinal mucosa. (via Semantic Scholar)
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Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2014 article

Impact of genomics on the field of probiotic research: historical perspectives to modern paradigms

Johnson, B. R., & Klaenhammer, T. R. (2014, April 19). Antonie Van Leeuwenhoek.

By: B. Johnson n & T. Klaenhammer n

author keywords: Probiotic; Lactic acid bacteria; Fermentation; Genomics; Lactobacilli; Bifidobacteria
MeSH headings : Bacteria / classification; Bacteria / genetics; Bacteria / isolation & purification; Bacteria / metabolism; Biomedical Research / history; Canthaxanthin / history; Genomics / history; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Probiotics / chemistry; Probiotics / history
topics (OpenAlex): Probiotics and Fermented Foods; Gut microbiota and health; Microbial Metabolites in Food Biotechnology
TL;DR: The history of the probiotic concept and the current standard of integrated genomic techniques to discern the complex, beneficial relationships between probiotic microbes and their hosts are explored. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2013 article

Identification of extracellular surface-layer associated proteins in Lactobacillus acidophilus NCFM

Johnson, B., Selle, K., Sarah, O. F., Goh, Y. J., & Klaenhammer, T. (2013, September 4). Microbiology.

By: B. Johnson n, K. Selle n, O. Sarah n, Y. Goh n & T. Klaenhammer n

MeSH headings : Animals; Cells, Cultured; Chromatography, Liquid; Dendritic Cells / drug effects; Lactobacillus acidophilus / chemistry; Lactobacillus acidophilus / immunology; Mass Spectrometry; Membrane Glycoproteins / analysis; Membrane Glycoproteins / immunology; Mice; Tumor Necrosis Factor-alpha / metabolism
topics (OpenAlex): Probiotics and Fermented Foods; Bacterial Genetics and Biotechnology; Antimicrobial Peptides and Activities
TL;DR: P phenotypic characterization of the deletion mutant demonstrated that the SLAP LBA1029 contributes to a pro-inflammatory TNF-α response from murine DCs, and appears to impart important surface display features and immunological properties to microbes that are coated by S-layers. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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