Barb Sherry
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Works (46)
Updated: August 16th, 2024 13:38
2023 journal article
Efficacy of an isoxazole-3-carboxamide analog of pleconaril in mouse models of Enterovirus-D68 and Coxsackie B5
ANTIVIRAL RESEARCH, 216.
author keywords: Antiviral; Coxsackievirus B5; Cryo-electron microscopy; Enteroviruses; EV-D68
MeSH headings : Animals; Mice; Enterovirus D, Human; Isoxazoles / pharmacology; Isoxazoles / therapeutic use; Cryoelectron Microscopy; Enterovirus Infections / drug therapy; Enterovirus; Antiviral Agents / pharmacology; Antiviral Agents / therapeutic use; Hand, Foot and Mouth Disease / drug therapy; Enterovirus B, Human
TL;DR:
11526092 represents a potent in vitro inhibitor of EV with in vivo efficacy in EV-D68 and CVB5 animal models suggesting it is worthy of further evaluation as a potential broad-spectrum antiviral therapeutic against EV.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: July 24, 2023
2021 journal article
Autocrine and paracrine interferon signalling as 'ring vaccination' and 'contact tracing' strategies to suppress virus infection in a host
author keywords: interferon; innate immunity; ring vaccination; partial differential equations; cellular automata
MeSH headings : Antiviral Agents; Contact Tracing; Humans; Immunity, Innate; Interferons; Vaccination; Virus Diseases
TL;DR:
It is argued that the interferon response can be seen as a parallel to population-level epidemic prevention strategies such as ‘contact tracing’ or ‘ring vaccination’ and may have implications for the outbreak control at the population scale more broadly.
(via Semantic Scholar)
open access via royalsocietypublishing.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: April 5, 2021
2019 journal article
Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection
Cellular and Molecular Gastroenterology and Hepatology, 8(1), 1–20.
author keywords: Cryptosporidiosis; Cytokine; Enterocyte; Protozoa
MeSH headings : Animals; Cell Line; Cryptosporidiosis / genetics; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidium parvum / physiology; Cytokines / genetics; Cytokines / metabolism; Disease Models, Animal; Gene Expression Profiling; Intestinal Mucosa / immunology; Mice; Mice, Inbred C57BL; Oligonucleotide Array Sequence Analysis; Swine; Up-Regulation
TL;DR:
These studies identify IFN-λ2/3 as a key epithelial defense mechanism against C parvum infection and Priming of IECs with recombinant human IFn-λ3 promoted cellular defense against CParvum infections and abrogated C parVum–induced loss of barrier function by decreasing paracellular permeability to sodium.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: July 15, 2019
2017 journal article
A Cytoplasmic RNA Virus Alters the Function of the Cell Splicing Protein SRSF2
JOURNAL OF VIROLOGY, 91(7).
author keywords: RNA processing; SRSF; reovirus; splicing
MeSH headings : Active Transport, Cell Nucleus; Amino Acid Sequence; Animals; Cell Nucleus / virology; Cytoplasm / virology; HEK293 Cells; Humans; Mice; Microtubules / metabolism; Orthoreovirus, Mammalian / physiology; Protein Binding; Protein Multimerization; RNA Splicing; RNA, Messenger / genetics; RNA, Messenger / metabolism; Serine-Arginine Splicing Factors / physiology; Viral Proteins / metabolism; Virus Replication
TL;DR:
It is demonstrated here that some mammalian reoviruses, RNA viruses that replicate strictly in the cytoplasm, express a protein variant that localizes to nuclear speckles, where it targets a cell mRNA splicing factor.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Spontaneous activation of a MAVS-dependent antiviral signaling pathway determines high basal interferon-beta expression in cardiac myocytes
Journal of Molecular and Cellular Cardiology, 111, 102–113.
MeSH headings : Adaptor Proteins, Signal Transducing / metabolism; Aging / metabolism; Animals; Antiviral Agents / metabolism; Female; Fibroblasts / metabolism; Fibroblasts / virology; Interferon-Induced Helicase, IFIH1 / metabolism; Interferon-beta / metabolism; Mammalian orthoreovirus 3 / physiology; Mice, Inbred C57BL; Mitochondria / metabolism; Mitochondrial Proteins / metabolism; Muscle Fibers, Skeletal / metabolism; Myocardium / metabolism; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Peroxisomes / metabolism; Protein Serine-Threonine Kinases / metabolism; Repressor Proteins / metabolism; Signal Transduction
TL;DR:
It is demonstrated here that the mitochondrial antiviral signaling (MAVS) pathway is spontaneously activated in unstimulated cardiac myocytes but not cardiac fibroblasts or skeletal muscle cells, and results provide the first mechanism for spontaneous high expression of the antiviral cytokine IFN-β in a poorly replenished and essential cell type.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
2016 journal article
NF-kappa B activation is cell type-specific in the heart
VIROLOGY, 502, 133–143.
author keywords: NF-kappa B; Myocarditis; Cardiac myocyte; Cardiac fibroblast; Cardiomyocyte; Golgi; Reovirus; Heart
MeSH headings : Animals; Cell Line; Cells, Cultured; Fibroblasts / metabolism; Fibroblasts / virology; Golgi Apparatus / metabolism; Golgi Apparatus / virology; Heart / virology; Humans; Mammalian orthoreovirus 3 / physiology; Mice; Mice, Inbred C57BL; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / genetics; NF-kappa B / metabolism; Organ Specificity; Reoviridae Infections / genetics; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Signal Transduction
TL;DR:
Results indicate that NF-κB-dependent signaling in the heart is cardiac cell type-specific, likely reflecting mechanisms that have evolved to balance responses that can be either protective or damaging to the heart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2016 journal article
Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy
AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.
MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
TL;DR:
Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2015 journal article
Generating primary cultures of murine cardiac myocytes and cardiac fibroblasts to study viral myocarditis
Cardiomyocytes: Methods and Protocols, 1299, 1–16.
Source: NC State University Libraries
Added: August 6, 2018
2014 journal article
Replication of Many Human Viruses Is Refractory to Inhibition by Endogenous Cellular MicroRNAs
JOURNAL OF VIROLOGY, 88(14), 8065–8076.
MeSH headings : Animals; Cell Line; Gene Silencing; Host-Pathogen Interactions; Humans; Immune Evasion; MicroRNAs / genetics; MicroRNAs / immunology; Virus Replication; Viruses / genetics; Viruses / growth & development; Viruses / immunology
TL;DR:
It is demonstrated that the replication of a wide range of pathogenic viruses is not enhanced in human cells engineered to be unable to produce mi RNAs, indicating that viruses have evolved to be resistant to inhibition by miRNAs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2013 journal article
An ITAM in a Nonenveloped Virus Regulates Activation of NF- B, Induction of Beta Interferon, and Viral Spread
Journal of Virology, 88(5), 2572–2583.
MeSH headings : Amino Acid Sequence; Animals; Cell Line; Enzyme Activation; Humans; Immunoreceptor Tyrosine-Based Activation Motif; Interferon-beta / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Mice; Molecular Sequence Data; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; NF-kappa B / metabolism; Phosphorylation; Protein Binding; Protein-Tyrosine Kinases / metabolism; Reoviridae / pathogenicity; Reoviridae / physiology; Sequence Alignment; Syk Kinase; Tyrosine / metabolism; Viral Proteins / chemistry; Viral Proteins / metabolism; Viral Tropism
TL;DR:
It is demonstrated for the first time that μ2 is phosphorylated, contains a functional ITAM, and activates NF-κB, and the results suggest that the cell type-specific effect of the μ2 ITAM on viral spread reflects the celltype-specific effects of NF-β and IFN-β.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2011 journal article
A Single-Amino-Acid Polymorphism in Reovirus Protein mu 2 Determines Repression of Interferon Signaling and Modulates Myocarditis
JOURNAL OF VIROLOGY, 86(4), 2302–2311.
MeSH headings : Animals; Cell Line; Cells, Cultured; Down-Regulation; Humans; Interferon-alpha / genetics; Interferon-alpha / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Mammalian orthoreovirus 3 / genetics; Mammalian orthoreovirus 3 / metabolism; Mice; Myocarditis / genetics; Myocarditis / metabolism; Myocarditis / virology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Orthoreovirus, Mammalian / genetics; Orthoreovirus, Mammalian / metabolism; Polymorphism, Single Nucleotide; Reoviridae Infections / genetics; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Signal Transduction; Viral Proteins / genetics
TL;DR:
It is demonstrated that a single amino acid difference between viruses can dictate virus strain-specific differences in suppression of the host IFN-β response and, consequently, damage to the heart.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance
JOURNAL OF VIROLOGY, 84(14), 6900–6908.
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Humans; Immunity; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Liver / pathology; Liver / virology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis / immunology; Myocarditis / pathology; Myocarditis / virology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / virology; Reoviridae / metabolism; Reoviridae / pathogenicity; Reoviridae Infections / immunology; Reoviridae Infections / pathology; Reoviridae Infections / virology; Spleen / pathology; Spleen / virology; Survival Rate; Tissue Distribution
TL;DR:
Cellular and humoral immune responses were equivalent in wild-type and IRF-3−/− animals, suggesting that IRf-3 functions independently of the adaptive immune response to enhance reovirus clearance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2010 journal article
Proteomic Analysis Reveals Virus-Specific Hsp25 Modulation in Cardiac Myocytes
JOURNAL OF PROTEOME RESEARCH, 9(5), 2460–2471.
author keywords: cardiac myocyte; myocarditis; reovirus; Hsp25; Hsp27; proteome; DIGE
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Nucleus / metabolism; Cells, Cultured; Cytoplasm / metabolism; Electrophoresis, Gel, Two-Dimensional; Fibroblasts / metabolism; Heat-Shock Proteins / metabolism; Interferons / metabolism; Mice; Molecular Chaperones; Myocarditis / metabolism; Myocarditis / virology; Myocardium / cytology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Neoplasm Proteins / metabolism; Orthoreovirus, Mammalian; Phosphorylation; Principal Component Analysis; Proteomics / methods; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR:
Results here provide the first evidence for a virus-induced decrease in Hsp25/27 and suggest that viruses may have evolved a mechanism to subvert this protective response, as they have for IFN.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2009 journal article
IFN-α expression and antiviral effects are subtype and cell type specific in the cardiac response to viral infection
Virology, 396(1), 59–68.
author keywords: Interferon; Cardiac myocyte; Cardiac fibroblast; Myocarditis; Reovirus
MeSH headings : Animals; Base Sequence; Cells, Cultured; Interferon-alpha / classification; Interferon-alpha / genetics; Interferon-alpha / physiology; Mice; Molecular Sequence Data; Myocarditis / prevention & control; Myocarditis / virology; Reverse Transcriptase Polymerase Chain Reaction; Transcription Factors / genetics; Virus Diseases / prevention & control
TL;DR:
It is demonstrated that IFN-alpha is induced in cardiac cells, that it is both subtype and cell type specific, and thatIt is likely important in the antiviral cardiac response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Crossref
Added: July 20, 2019
2009 review
Rotavirus and Reovirus Modulation of the Interferon Response
[Review of ]. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 29(9), 559–567.
MeSH headings : Active Transport, Cell Nucleus; Animals; Humans; Interferon Regulatory Factors / immunology; Interferon Regulatory Factors / metabolism; Interferon Type I / genetics; Interferon Type I / immunology; Interferon Type I / metabolism; Interferon-Stimulated Gene Factor 3 / immunology; Interferon-Stimulated Gene Factor 3 / metabolism; NF-kappa B / metabolism; RNA Helicases / immunology; RNA Helicases / metabolism; Rotavirus / immunology; Rotavirus / pathogenicity; Rotavirus Infections / genetics; Rotavirus Infections / immunology; Rotavirus Infections / virology; STAT Transcription Factors / metabolism; Signal Transduction; Viral Nonstructural Proteins / immunology; Viral Nonstructural Proteins / metabolism; Virulence
TL;DR:
Members of the family Reoviridae have evolved a variety of mechanisms to subvert the host's innate protective response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2008 journal article
237 Reovirus inhibits interferon signaling through a novel mechanism involving nuclear accumulation of IRF9
Cytokine, 43(3), 296.
Source: Crossref
Added: February 24, 2020
2008 journal article
Reovirus mu 2 Protein Inhibits Interferon Signaling through a Novel Mechanism Involving Nuclear Accumulation of Interferon Regulatory Factor 9
JOURNAL OF VIROLOGY, 83(5), 2178–2187.
MeSH headings : Animals; Cell Nucleus / metabolism; Cells, Cultured; Gene Expression Regulation; Humans; Interferon-Stimulated Gene Factor 3 / metabolism; Interferon-Stimulated Gene Factor 3, gamma Subunit / metabolism; Interferon-alpha / pharmacology; Interferon-beta / pharmacology; Mammalian orthoreovirus 3 / genetics; Mammalian orthoreovirus 3 / metabolism; Mammalian orthoreovirus 3 / pathogenicity; Mice; Myocarditis / virology; Orthoreovirus, Mammalian / genetics; Orthoreovirus, Mammalian / metabolism; Orthoreovirus, Mammalian / pathogenicity; Reassortant Viruses / genetics; Reassortant Viruses / metabolism; Reassortant Viruses / pathogenicity; STAT1 Transcription Factor / metabolism; STAT2 Transcription Factor / metabolism; Transcriptional Activation; Viral Proteins / genetics; Viral Proteins / metabolism
TL;DR:
The first report of an increase in IRF9 nuclear accumulation associated with viral subversion of the IFN response and couple virus strain-specific differences in IFN antagonism to the pathogenesis of viral myocarditis are reported.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses
JOURNAL OF VIROLOGY, 81(24), 13668–13680.
MeSH headings : Animals; Cells, Cultured; Fibroblasts / immunology; Fibroblasts / virology; Gene Expression Regulation; Humans; Interferon-alpha / genetics; Interferon-alpha / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Janus Kinases / genetics; Janus Kinases / metabolism; L Cells; Mammalian orthoreovirus 3 / pathogenicity; Mice; Mice, Knockout; Myocarditis / immunology; Myocarditis / virology; Myocytes, Cardiac / immunology; Myocytes, Cardiac / virology; Orthoreovirus, Mammalian / pathogenicity; Receptor, Interferon alpha-beta / genetics; Receptor, Interferon alpha-beta / metabolism; Reoviridae Infections / immunology; Reoviridae Infections / virology; STAT Transcription Factors / genetics; STAT Transcription Factors / metabolism
TL;DR:
It is found that greater basal expression of IFN-β in cardiac myocytes results in greater basal activated nuclear STAT1 and STAT2 and greater basal ISG mRNA expression and provides greater basal antiviral protection relative to cardiac fibroblasts, the first indication of an integrated network of cell-type-specific innate immune components for organ protection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2007 journal article
Retinoic acid-inducible gene-I and interferon-beta promoter stimulator-1 augment proapoptotic responses following mammalian reovirus infection via interferon regulatory factor-3
JOURNAL OF BIOLOGICAL CHEMISTRY, 282(30), 21953–21961.
MeSH headings : Animals; Apoptosis / physiology; Cell Line; DEAD Box Protein 58; DEAD-box RNA Helicases / genetics; Fibroblasts / physiology; Genes, Reporter; HeLa Cells; Humans; Interferon Regulatory Factor-3 / physiology; Interferon-beta / genetics; Kidney; Mice; Promoter Regions, Genetic; Receptors, Immunologic; Reoviridae Infections / physiopathology; Transfection
TL;DR:
It is shown that reovirus activates IRF-3 with kinetics that parallel the activation of NF-κB, a known mediator of reov virus-induced apoptosis, suggesting a common mechanism of antiviral cytokine induction and activation of the cell death response.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Basal and reovirus-induced beta interferon (IFN-beta) and IFN-beta-stimulated gene expression are cell type specific in the cardiac protective response
JOURNAL OF VIROLOGY, 79(5), 2979–2987.
MeSH headings : Animals; Base Sequence; DNA / genetics; DNA-Binding Proteins / genetics; Fibroblasts / immunology; Fibroblasts / virology; Gene Expression Regulation; Humans; Interferon Regulatory Factor-7; Interferon-beta / genetics; Mammalian orthoreovirus 3 / immunology; Mammalian orthoreovirus 3 / pathogenicity; Mice; Mice, Knockout; Myocarditis / genetics; Myocarditis / immunology; Myocarditis / virology; Myocytes, Cardiac / immunology; Myocytes, Cardiac / virology; Orthoreovirus, Mammalian / immunology; Orthoreovirus, Mammalian / pathogenicity; Receptors, Interferon / deficiency; Receptors, Interferon / genetics; Reoviridae Infections / genetics; Reoviridae Infections / immunology; Reoviridae Infections / virology; Reverse Transcriptase Polymerase Chain Reaction
TL;DR:
It is suggested that the higher basal IFN-β and ISG expression in myocytes may play an important protective role in cardiac myocytes, and reovirus replicates to higher titers in cardiac fibroblasts than in cardiacMyocytes, suggesting that theIFN- β response controls reov virus replication equivalently in the two cell types.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2005 journal article
Organ-specific roles for transcription factor NF-kappa B in reovirus-induced apoptosis and disease
Journal of Clinical Investigation, 115(9), 2341–2350.
Source: NC State University Libraries
Added: August 6, 2018
2004 journal article
Caspase inhibition protects against reovirus-induced myocardial injury in vitro and in vivo
JOURNAL OF VIROLOGY, 78(20), 11040–11050.
MeSH headings : Animals; Apoptosis; Caspase 3; Caspase Inhibitors; Caspases / genetics; Caspases / metabolism; Heart / virology; Humans; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis / mortality; Myocarditis / pathology; Myocarditis / prevention & control; Myocarditis / virology; Myocardium / pathology; Reoviridae / pathogenicity; Viral Load
TL;DR:
This study indicates that apoptosis plays a critical role in mediating cardiac injury in the setting of viral myocarditis and is the first demonstration that caspase inhibition may serve as a novel therapeutic strategy for this devastating disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
PKR's protective role in viral myocarditis
VIROLOGY, 314(1), 92–100.
author keywords: myocarditis; reovirus; interferon; PKR
MeSH headings : Animals; Cells, Cultured; Disease Models, Animal; Enzyme Activation; Humans; Interferon-beta / biosynthesis; Mice; Mice, Inbred C57BL; Myocarditis / immunology; Myocarditis / virology; Myocardium / cytology; Orthoreovirus / pathogenicity; Reoviridae Infections / immunology; Reoviridae Infections / virology; Transfection; eIF-2 Kinase / metabolism
TL;DR:
KR is demonstrated to be critical for viral induction of IFN-beta in primary cardiac myocyte cultures and loss of PKR leads to an increase in virulence for both myocarditic and nonmyocarditic reoviruses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Interferon regulatory factor-1, interferon-beta, and reovirus-induced myocarditis
VIROLOGY, 298(1), 20–29.
author keywords: reovirus; double-stranded RNA (dsRNA); viral myocarditis; cardiac myocytes; interferon (IFN); interferon regulatory factor (IRF)
MeSH headings : Animals; Animals, Newborn; Cells, Cultured; DNA-Binding Proteins / biosynthesis; DNA-Binding Proteins / deficiency; DNA-Binding Proteins / genetics; Female; Heart / virology; Interferon Regulatory Factor-1; Interferon-beta / biosynthesis; Interferon-beta / genetics; Male; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocardium / metabolism; Myocardium / pathology; Phosphoproteins / biosynthesis; Phosphoproteins / deficiency; Phosphoproteins / genetics; Reoviridae / pathogenicity; Viral Proteins / biosynthesis; Viral Proteins / genetics
TL;DR:
Surprisingly, it is found that reovirus failed to induce IRF-1 in the absence of the IFN-alpha/beta response, providing the first evidence that viruses may not induce IRf-1 directly.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Isolation of a reovirus from poult enteritis and mortality syndrome and its pathogenicity in turkey poults
AVIAN DISEASES, 46(1), 32–47.
author keywords: poult enteritis and mortality syndrome; reovirus; turkey; fecal filtrate
TL;DR:
It is demonstrated that ARV-CU98 does cause some of the clinical signs in PEMS, including intestinal alterations and significantly lower relative bursa and liver weights.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
The role of interferon regulatory factors in the cardiac response to viral infection
VIRAL IMMUNOLOGY, 15(1), 17–28.
MeSH headings : Animals; DNA-Binding Proteins / physiology; Interferon Regulatory Factor-1; Interferon Regulatory Factor-2; Interferon Regulatory Factor-3; Interferon-beta / genetics; Interferon-beta / physiology; Mice; Myocarditis / immunology; Phosphoproteins / physiology; Reoviridae Infections / immunology; Repressor Proteins; Transcription Factors / physiology; Transcription, Genetic
TL;DR:
The role of IRF-2 in regulation of IFN-beta expression is cell type-specific and differs between skeletal and cardiac muscle cells, suggesting that the heart may provide a unique environment for IRF function, critical for protection against virus-induced cardiac damage.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Calpain inhibition protects against virus-induced apoptotic myocardial injury
JOURNAL OF VIROLOGY, 75(1), 351–361.
MeSH headings : Animals; Apoptosis; Calpain / antagonists & inhibitors; Calpain / biosynthesis; Caspase Inhibitors; Creatine Kinase / blood; Cysteine Proteinase Inhibitors / therapeutic use; Dipeptides / therapeutic use; Mice; Myocarditis / prevention & control; Reoviridae Infections / complications; Reoviridae Infections / drug therapy; Reoviridae Infections / enzymology
TL;DR:
It is demonstrated that myocardial injury results from apoptosis, the first evidence for the importance of a calpain-associated pathway of apoptotic cell death in viral disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Interferon regulatory factor 3 is required for viral induction of beta interferon in primary cardiac myocyte cultures
Journal of Virology, 73(12), 10208–10213.
Source: NC State University Libraries
Added: August 6, 2018
1998 chapter
Pathogenesis of reovirus myocarditis
In K. L. Tyler & M. B. A. Oldstone (Eds.), Reoviruses. II, Cytopathogenicity and pathogenesis (Vol. 233, pp. 51–66).
Ed(s): . K. L. Tyler & M. Oldstone
MeSH headings : Animals; Cells, Cultured; Heart / virology; Humans; Interferon-alpha / physiology; Interferon-beta / biosynthesis; Interferon-beta / physiology; Myocarditis / immunology; Myocarditis / virology; Myocardium / cytology; Orthoreovirus / genetics; Orthoreovirus / physiology; RNA, Viral / biosynthesis; Reoviridae Infections / immunology; Reoviridae Infections / virology; Viral Core Proteins / physiology
TL;DR:
Enteroviruses (mainly coxsackieviruses) most likely account for 20%–50% or more of the cases and there is compelling evidence that enterovirus chronic myocarditis and acuteMyocarditis are immune-mediated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Reovirus induction of and sensitivity to beta interferon in cardiac myocyte cultures correlate with induction of myocarditis and are determined by viral core proteins
Journal of Virology, 72(2), 1314–1323.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
The reovirus protein mu2, encoded by the M1 gene, is an RNA-binding protein
Journal of Virology, 72(10), 8354–8357.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Construction and characterization of a reovirus double temperature-sensitive mutant
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 94(13), 6826–6830.
MeSH headings : Animals; Genome, Viral; Humans; Mice; Mutation; RNA, Viral / genetics; Reoviridae / genetics; Temperature
TL;DR:
The infectious reovirus RNA system was used to construct a mutant with two temperature-sensitive lesions in genome segments M2 and S2, respectively, which elicits the formation of significant amounts of neutralizing antibodies in newborn mice.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Effect of a live attenuated intranasal vaccine on latency and shedding of feline herpesvirus 1 in domestic cats
ARCHIVES OF VIROLOGY, 142(12), 2389–2400.
MeSH headings : Administration, Intranasal; Alphaherpesvirinae / genetics; Alphaherpesvirinae / immunology; Alphaherpesvirinae / physiology; Animals; Cats; Female; Herpesviridae Infections / prevention & control; Herpesviridae Infections / virology; Prospective Studies; Vaccines, Attenuated / immunology; Viral Vaccines / immunology; Virus Latency; Virus Shedding
TL;DR:
The frequency and distribution of latent FHV1 detected in neurologic, ophthalmic, and other tissues by PCR were identical for vaccine-only and vaccine-challenge groups, thereby disproving previous hypotheses that tsFHV1 mutants administered by this route protect against latency.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
1997 journal article
High sensitivity polymerase chain reaction assay for active and latent feline herpesvirus-1 infections in domestic cats
VETERINARY RECORD, 140(13), 335–338.
MeSH headings : Animals; Biopsy / methods; Biopsy / veterinary; Blotting, Southern / methods; Blotting, Southern / veterinary; Cat Diseases / diagnosis; Cat Diseases / virology; Cats; Conjunctiva / chemistry; Conjunctiva / pathology; Conjunctiva / virology; DNA, Viral / analysis; DNA, Viral / genetics; Female; Herpesviridae / genetics; Herpesviridae / isolation & purification; Herpesviridae Infections / diagnosis; Herpesviridae Infections / veterinary; Herpesviridae Infections / virology; Neurons / chemistry; Neurons / pathology; Neurons / virology; Oropharynx / chemistry; Oropharynx / pathology; Oropharynx / virology; Polymerase Chain Reaction / methods; Polymerase Chain Reaction / veterinary; Sensitivity and Specificity; Specific Pathogen-Free Organisms
TL;DR:
The PCR reliably detected ≤240 copies of FHV-1 template DNA, significantly improving upon previously published PCR assays for the agent.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1996 journal article
Reovirus-induced acute myocarditis in mice correlates with viral RNA synthesis rather than generation of infectious virus in cardiac myocytes
Journal of Virology, 70(10), 6709–6715.
Source: NC State University Libraries
Added: August 1, 2019
1995 journal article
TRANSFERRIN SECRETION BY LENS EPITHELIAL-CELLS IN CULTURE
EXPERIMENTAL EYE RESEARCH, 60(6), 667–673.
author keywords: TRANSFERRIN; LENS; ANTIOXIDANTS; GROWTH FACTORS; AQUEOUS HUMOR
MeSH headings : Animals; Aqueous Humor / chemistry; Blotting, Northern; Cells, Cultured; Ciliary Body / metabolism; Dogs; Epithelium / metabolism; Lens, Crystalline / metabolism; Rabbits; Secretory Rate; Time Factors; Transferrin / metabolism; Vitreous Body / chemistry
TL;DR:
This is the first experimental demonstration that an intraocular tissue can make and secrete Tf, and transferrin secretion by the lens may contribute significantly to the IOF content of this important intraocular protein.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1994 journal article
Multiple viral core proteins are determinants of reovirus-induced acute myocarditis
Journal of Virology, 68(12), 8461–8465.
Source: NC State University Libraries
Added: August 1, 2019
1993 journal article
Cytopathogenic effect in cardiac myocytes but not in cardiac fibroblasts is correlated with reovirus-induced acute myocarditis
Journal of Virology, 67(10), 6295–6298.
Source: NC State University Libraries
Added: August 1, 2019
1993 journal article
Lymphocytes protect against and are not required for reovirus-induced myocarditis
Journal of Virology, 67(10), 6119–6124.
Source: NC State University Libraries
Added: August 1, 2019
1991 journal article
Identification of the viral genes responsible for growth of strains of reovirus in cultured mouse heart cells.
Journal of Clinical Investigation, 87(5), 1628–1633.
author keywords: MYOCARDITIS; VIRAL PATHOGENESIS; THE M1 GENE
MeSH headings : Animals; Cells, Cultured; Genes, Viral; Heart / microbiology; L Cells / microbiology; Mice; Myocarditis / etiology; Reoviridae / genetics; Reoviridae / growth & development
TL;DR:
The M1 gene plays an important and specific role in determining the relative capacity of certain viral strains to grow in the heart, and a novel system for studies of viral myocarditis at a molecular genetic level is provided.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
1989 journal article
Derivation and characterization of an efficiently myocarditic reovirus variant
Journal of Virology, 63(11), 4840–4849.
Source: NC State University Libraries
Added: August 1, 2019
1989 journal article
The reovirus M1 gene, encoding a viral core protein, is associated with the myocarditic phenotype of a reovirus variant
Journal of Virology, 63(11), 4850–4856.
Source: NC State University Libraries
Added: August 1, 2019
1988 journal article
Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment.
Proceedings of the National Academy of Sciences, 85(20), 7743–7747.
MeSH headings : Antibodies, Monoclonal / immunology; Antibody Specificity; Binding, Competitive; Colorimetry; Culture Techniques; HeLa Cells; Humans; Hybridomas; Immunoblotting; Immunohistochemistry; Membrane Proteins / analysis; Membrane Proteins / immunology; Membrane Proteins / metabolism; Organ Specificity; Poliovirus / metabolism; Receptors, Virus / analysis; Receptors, Virus / immunology; Receptors, Virus / metabolism; Spinal Cord / microbiology
TL;DR:
Results strongly suggest that the 100-kDa band detected by antibody AF3 is, or is closely associated with, the poliovirus receptor site.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
1986 journal article
Use of monoclonal antibodies to identify four neutralization immunogens on a common cold picornavirus, human rhinovirus 14
Journal of Virology, 57(1), 246–257.
Source: NC State University Libraries
Added: August 1, 2019
1985 journal article
Evidence for at least two dominant neutralization antigens on human rhinovirus 14
Journal of Virology, 53(1), 137–143.
Source: NC State University Libraries
Added: August 1, 2019
1985 journal article
Structure of a human common cold virus and functional relationship to other picornaviruses
Nature, 317(6033), 145–153.
MeSH headings : Amino Acids / analysis; Antigens, Viral / analysis; Biological Evolution; Capsid / analysis; Chemical Phenomena; Chemistry; Crystallography; Models, Molecular; Picornaviridae / ultrastructure; Receptors, Virus / analysis; Rhinovirus / ultrastructure; Serotyping; Viral Proteins / analysis; Viral Structural Proteins
TL;DR:
The first atomic resolution structure of an animal virus, human rhinovirus 14, strikingly similar to known icosahedral plant RNA viruses, and four neutralizing immunogenic regions have been identified.
(via Semantic Scholar)
Source: Crossref
Added: July 20, 2019
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