Bruce W Keene

Works (109)

Updated: April 4th, 2024 23:29

2022 journal article

Association of diet with clinical outcomes in dogs with dilated cardiomyopathy and congestive heart failure*

JOURNAL OF VETERINARY CARDIOLOGY, 40, 99–109.

By: A. Walker*, T. DeFrancesco n, J. Bonagura n, B. Keene n, K. Meurs n, S. Tou n, K. Kurtz*, B. Aona* ...

author keywords: Canine; Survival; Grain-free; Echocardiography; Nutritional
MeSH headings : Animals; Dogs; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / veterinary; Diet / veterinary; Dog Diseases / diagnosis; Echocardiography / veterinary; Edible Grain; Heart Failure / complications; Heart Failure / therapy; Heart Failure / veterinary; Retrospective Studies
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: June 6, 2022

2021 journal article

A deleterious mutation in the ALMS1 gene in a naturally occurring model of hypertrophic cardiomyopathy in the Sphynx cat

ORPHANET JOURNAL OF RARE DISEASES, 16(1).

author keywords: Hypertrophic cardiomyopathy; ALMS1; Feline; Mitogenic; Sphynx
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cats / genetics; Cell Cycle Proteins / genetics; Exons; Mice; Mutation / genetics
TL;DR: This study demonstrates a novel form of cardiomyopathy associated with ALMS1 in the cat, and suggests that variants in genes involved with cardiac development and cell regulation, like the AL MS1 gene, may deserve further consideration for association with familial hypertrophic cardiopathy. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 12, 2021

2021 journal article

Absence of known feline MYH7 and MYBPC3 variants in a diverse cohort of cats with hypertrophic cardiomyopathy

ANIMAL GENETICS, 52(4), 542–544.

By: . K. O'Donnell n, D. Adin n, C. Atkins n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n

author keywords: cardiomyopathy; feline; genetic; HCM; mutation
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / genetics; Cardiomyopathy, Hypertrophic / veterinary; Carrier Proteins / genetics; Carrier Proteins / metabolism; Cat Diseases / genetics; Cat Diseases / metabolism; Cats; Female; Genetic Variation; Male; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism
TL;DR: The lack of these MYBPC3 and MYH7 variants in this feline HCM population indicates that the clinical utility of genetic testing for these variants may be isolated to the two cat breeds in which these variants have been identified. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 17, 2021

2021 personal communication

Letter to the editor regarding "Efficacy of adding ramipril (VAsotop) to the combination of furosemide (Lasix) and pimobendan (VEtmedin) in dogs with mitral valve degeneration: The VALVE trial"

Atkins, C., Keene, B., DeFrancesco, T. C., Tou, S., Chetboul, V., Cote, E., … Stepien, R. L. (2021, March).

By: C. Atkins n, B. Keene n, T. DeFrancesco n, S. Tou n, V. Chetboul*, E. Cote*, S. Ettinger, P. Fox* ...

MeSH headings : Animals; Dogs; Furosemide / therapeutic use; Mitral Valve; Pyridazines / therapeutic use; Ramipril / therapeutic use
TL;DR: The VALVE trial did not assess the efficacy of RAAS suppression using biomarkers, and the question of whether ramipril adequately or optimally suppressed RAAS, while failing to improve survival in the face of these diuretic dosages, remains unanswered. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 15, 2021

2021 journal article

Myxomatous mitral valve disease in Miniature Schnauzers and Yorkshire Terriers: 134 cases (2007-2016)

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 259(12), 1428–1432.

By: D. DeProspero n, . Kerry A. O'Donnell, T. DeFrancesco n, B. Keene n, S. Tou n, D. Adin n, C. Atkins n, K. Meurs n

MeSH headings : Animals; Dog Diseases / epidemiology; Dogs; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / veterinary; Prospective Studies
TL;DR: Features of the disease among Miniature Schnauzers and Yorkshire Terriers were similar, but there were also a few discernable differences between these 2 breeds and from historical findings for dogs with MMVD of other breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2021 article

Use of whole genome analysis to identify shared genomic variants across breeds in canine mitral valve disease

Williams, B., Friedenberg, S. G., Keene, B. W., Tou, S. P., DeFrancesco, T. C., & Meurs, K. M. (2021, June 27). HUMAN GENETICS, Vol. 6.

By: B. Williams n, S. Friedenberg*, B. Keene n, S. Tou n, T. DeFrancesco n & K. Meurs n

MeSH headings : Animals; Breeding; Dog Diseases / genetics; Dogs; Genetic Variation; Genome-Wide Association Study; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Mutation; Whole Genome Sequencing
TL;DR: The findings indicate that development of MMVD in the dog may be related to a combination of genetic and environmental factors that impact specific molecular pathways rather than a single shared genetic variant across or within breeds. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: July 6, 2021

2021 article

What Is Your Diagnosis?

Tucker, S., Archibald, K., Cohen, E. B., Sommer, S., Keene, B. W., Minter, L. J., & Delk, K. W. (2021, December). JOURNAL OF AVIAN MEDICINE AND SURGERY, Vol. 35, pp. 486–493.

TL;DR: A captive 38-year-old female Chilean flamingo presented with an approximately 4-day history of being listless and moving slowly behind the flock and severe dilation of the left ventricle and decreased cardiac systolic function, which prompted diagnostic imaging and medical management of the cardiac abnormalities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 21, 2022

2020 journal article

Atenolol in cats with subclinical hypertrophic cardiomyopathy: a double-blind, placebo-controlled, randomized clinical trial of effect on quality of life, activity, and cardiac biomarkers

JOURNAL OF VETERINARY CARDIOLOGY, 30, 77–91.

By: A. Coleman n, T. DeFrancesco n, E. Griffiths n, B. Lascelles n, D. Kleisch n, C. Atkins n, B. Keene n

author keywords: Feline; Beta-btocker; Accelerometry
MeSH headings : Administration, Oral; Animals; Anti-Arrhythmia Agents / administration & dosage; Anti-Arrhythmia Agents / therapeutic use; Atenolol / administration & dosage; Atenolol / therapeutic use; Biomarkers / blood; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / blood; Cat Diseases / drug therapy; Cats; Double-Blind Method; Female; Male; Quality of Life; Treatment Outcome
TL;DR: This study failed to identify an effect of subclinical HCM on owner-assessed QOL or activity or a treatment effect of atenolol on these variables at the dosage evaluated, and these findings do not support a treatment benefit of atanolol for the goal of symptom reduction in cats with sub clinical HCM. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: September 21, 2020

2020 journal article

Clinical presentation, cardiovascular findings, etiology, and outcome of myocarditis in dogs: 64 cases with presumptive antemortem diagnosis (26 confirmed postmortem) and 137 cases with postmortem diagnosis only (2004-2017)

JOURNAL OF VETERINARY CARDIOLOGY, 30, 44–56.

By: S. Lakhdhir*, A. Viall*, E. Alloway n, B. Keene n, K. Baumgartner* & J. Ward*

author keywords: Troponin; Endocarditis; Duke criteria; Trypanosoma; Leishmania
MeSH headings : Animals; Autopsy / veterinary; Dog Diseases / blood; Dog Diseases / diagnostic imaging; Dog Diseases / microbiology; Dog Diseases / mortality; Dogs; Electrocardiography / veterinary; Female; Iowa; Male; Myocarditis / diagnostic imaging; Myocarditis / veterinary; North Carolina; Records / veterinary; Retrospective Studies; Troponin I / blood
TL;DR: Bacterial infection was the most common confirmed etiology of myocarditis in this study, and presence of pericardial effusion or azotemia were significant predictors of nonsurvival. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 21, 2020

2020 journal article

Renin-angiotensin aldosterone profile before and after angiotensin-converting enzyme-inhibitor administration in dogs with angiotensin-converting enzyme gene polymorphism

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(2), 600–606.

By: D. Adin*, C. Atkins n, O. Domenig, T. DeFrancesco n, B. Keene n, S. Tou n, J. Stern*, K. Meurs n

author keywords: ACE-inhibitor; enalapril; genotype; pharmacogenetic; pharmacogenomic
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Genetic Predisposition to Disease; Genotype; Humans; Mitral Valve Prolapse / enzymology; Mitral Valve Prolapse / genetics; Peptidyl-Dipeptidase A / genetics; Peptidyl-Dipeptidase A / metabolism; Polymorphism, Genetic; Renin-Angiotensin System / physiology; Retrospective Studies
TL;DR: The results support the use of aldosterone receptor antagonists with ACE‐inhibitors when RAAS inhibition is indicated for dogs, especially those positive for the ACE gene polymorphism, which did not alter baseline RAAS activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: March 16, 2020

2020 journal article

Retrospective evaluation of the safety and tolerability of pimobendan in cats with obstructive vs nonobstructive cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(6), 2211–2222.

By: J. Ward*, E. Kussin*, M. Tropf*, S. Tou n, T. DeFrancesco n & B. Keene n

author keywords: cardiac; cardiomyopathy; feline; hypertrophic; positive inotrope
MeSH headings : Animals; Cardiomyopathies / drug therapy; Cardiomyopathies / veterinary; Cardiotonic Agents / adverse effects; Cat Diseases / drug therapy; Cats; Heart Failure / drug therapy; Heart Failure / veterinary; Pyridazines / adverse effects; Retrospective Studies
TL;DR: Pimobendan is well tolerated in cats with cardiomyopathy and CHF, regardless of the presence of OTO, and was discontinued due to adverse effects in 4/260 cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: October 26, 2020

2020 journal article

Species differences in cardiovascular physiology that affect pharmacology and toxicology

CURRENT OPINION IN TOXICOLOGY, 23-24, 106–113.

By: R. Hamlin* & B. Keene n

author keywords: Comparative cardiovascular physiology; Comparative pharmacologic toxicology
TL;DR: In reviewing some of the more striking species differences and similarities in cardiovascular physiology, this paper hopes to stimulate interest in and inform the choices of scientists involved in surrogate model selection as they work to improve both the positive and negative predictive value of preclinical drug studies. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: January 25, 2021

2020 journal article

Temporal changes in clinical and radiographic variables in dogs with preclinical myxomatous mitral valve disease: The EPIC study

JOURNAL OF VETERINARY INTERNAL MEDICINE, 34(3), 1108–1118.

By: A. Boswood*, S. Gordon*, J. Haggstrom*, M. Vanselow*, G. Wess, R. Stepien*, M. Oyama*, B. Keene n ...

author keywords: canine; cardiovascular; clinical epidemiology; clinical trials; heart failure; physical examination; radiology and diagnostic imaging
MeSH headings : Animals; Cardiomegaly / veterinary; Dog Diseases / diagnosis; Dog Diseases / diagnostic imaging; Dogs; Female; Heart / diagnostic imaging; Heart Failure / complications; Heart Failure / pathology; Heart Failure / veterinary; Heart Rate; Heart Valve Diseases / pathology; Heart Valve Diseases / veterinary; Male; Mitral Valve / pathology; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / pathology; Mitral Valve Insufficiency / veterinary; Radiography, Thoracic / veterinary; Respiratory Rate
TL;DR: Findings reinforce the value of RR and RRR as indicators of impending or incipient CHF. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: April 6, 2020

2019 journal article

A missense variant in the titin gene in Doberman pinscher dogs with familial dilated cardiomyopathy and sudden cardiac death

Human Genetics, 138(5), 515–524.

By: K. Meurs n, S. Friedenberg*, J. Kolb*, C. Saripalli*, P. Tonino*, K. Woodruff n, N. Olby n, B. Keene n ...

MeSH headings : Amino Acid Sequence; Animals; Base Sequence; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Connectin / genetics; Death, Sudden, Cardiac / etiology; Death, Sudden, Cardiac / veterinary; Disease Models, Animal; Dogs; Female; Genetic Predisposition to Disease / genetics; Male; Mutation, Missense / genetics; Protein Kinases / genetics; Whole Genome Sequencing
TL;DR: The dog provides a large animal model of familial dilated cardiomyopathy and is an excellent model to improve the understanding of the genotypic phenotypic relationships, penetrance, expression and the pathophysiology of variants in the titin gene. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, Crossref
Added: June 17, 2019

2019 journal article

ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(3), 1127–1140.

By: B. Keene n, C. Atkins n, J. Bonagura n, P. Fox*, J. Haggstrom*, V. Fuentes*, M. Oyama*, J. Rush* ...

Contributors: B. Keene n, C. Atkins n, J. Bonagura n, P. Fox*, J. Häggström*, V. Fuentes*, M. Oyama*, J. Rush*, R. Stepien*, M. Uechi

author keywords: canine; congestive heart failure; evidence-based treatment; mitral
MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / therapy; Dogs; Heart Failure / diagnosis; Heart Failure / therapy; Heart Failure / veterinary; Hypertension, Pulmonary / diagnosis; Hypertension, Pulmonary / therapy; Hypertension, Pulmonary / veterinary; Mitral Valve Insufficiency / diagnosis; Mitral Valve Insufficiency / therapy; Mitral Valve Insufficiency / veterinary
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 1, 2019

2019 article

Clinical ethics consultation in a tertiary care veterinary teaching hospital

Adin, C. A., Moga, J. L., Keene, B. W., Fogle, C. A., Hopkinson, H. R., Weyhrauch, C. A., … Rosoff, P. M. (2019, January 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 254, pp. 52–60.

By: C. Adin*, J. Moga*, B. Keene*, C. Fogle*, H. Hopkinson*, C. Weyhrauch*, S. Marks*, R. Ruderman, P. Rosoff*

MeSH headings : Animal Rights; Animals; Ethics Consultation; Hospitals, Teaching; Humans; Tertiary Healthcare; United States
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: January 14, 2019

2019 journal article

Dilated cardiomyopathy in 151 Irish Wolfhounds: Characteristic clinical findings, life expectancy and causes of death

VETERINARY JOURNAL, 245, 15–21.

By: C. Vollmar*, A. Vollmar, B. Keene n, P. Fox*, S. Reese* & B. Kohn*

author keywords: Atrial fibrillation; Dogs; Cardiac death; Congestive heart failure; Sudden cardiac death
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnosis; Cardiomyopathy, Dilated / mortality; Cardiomyopathy, Dilated / veterinary; Cause of Death; Dog Diseases / diagnosis; Dog Diseases / mortality; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Female; Life Expectancy; Male; Retrospective Studies
TL;DR: CHF-DCM-AF in IW was associated with reduced life expectancy and CD, while most IW with preclinical DCM died from non-cardiac causes, while CHF was predominantly characterized by chylous pleural and mild pericardial effusions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: April 2, 2019

2019 journal article

Echocardiographic phenotype of canine dilated cardiomyopathy differs based on diet type

JOURNAL OF VETERINARY CARDIOLOGY, 21, 1–9.

By: D. Adin n, T. DeFrancesco n, B. Keene n, S. Tou n, K. Meurs n, C. Atkins n, B. Aona n, K. Kurtz n ...

author keywords: Nutritional; Heart failure; Dog; Taurine
MeSH headings : Animals; Cardiomyopathy, Dilated / diagnostic imaging; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / veterinary; Diet / adverse effects; Diet / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Edible Grain / adverse effects; Female; Male; Phenotype
TL;DR: Dietary-associated DCM occurs with some GF diets and can improve with nutritional management, including diet change, and the role of taurine supplementation, even without deficiency, is uncertain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

Holter monitoring demonstrates that ventricular arrhythmias are common in cats with decompensated and compensated hypertrophic cardiomyopathy

VETERINARY JOURNAL, 243, 21–25.

By: U. Bartoszuk, B. Keene*, M. Toaldo, N. Pereira, N. Summerfield, J. Matos, T. Glans

author keywords: Arrhythmias; Cardiac troponin I; Holter
MeSH headings : Animals; Arrhythmias, Cardiac / epidemiology; Arrhythmias, Cardiac / physiopathology; Arrhythmias, Cardiac / veterinary; Cardiomyopathy, Hypertrophic / epidemiology; Cardiomyopathy, Hypertrophic / physiopathology; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / epidemiology; Cat Diseases / physiopathology; Cats; Electrocardiography, Ambulatory / veterinary; Female; Heart Rate; Heart Ventricles / physiopathology; Male
TL;DR: Compared to healthy cats, ventricular arrh rhythmias were common in cats with cHCM and dHCM, but neither presence nor complexity of arrhythmias could be linked to prognosis, and there was no correlation between cTnI concentration and the number of arrHythmias. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: February 11, 2019

2019 journal article

Irish wolfhounds with subclinical atrial fibrillation: progression of disease and causes of death

JOURNAL OF VETERINARY CARDIOLOGY, 24, 48–57.

By: C. Vollmar*, A. Vollmar, B. Keene n, P. Fox*, S. Reese* & B. Kohn*

author keywords: Sudden death; Congestive heart failure; Cardiac death; Survival; Lone atrial fibrillation
MeSH headings : Animals; Atrial Fibrillation / mortality; Atrial Fibrillation / veterinary; Cause of Death; Disease Progression; Dog Diseases / mortality; Dog Diseases / physiopathology; Dogs; Female; Germany; Male; Pedigree; Records / veterinary
TL;DR: IW with subclinical AF commonly develop dilated cardiomyopathy and die from cardiac death and that of a contemporaneous control group of apparently healthy IW with sinus rhythm is compared. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: September 16, 2019

2019 journal article

Long-term incidence and risk of noncardiovascular and all-cause mortality in apparently healthy cats and cats with preclinical hypertrophic cardiomyopathy

JOURNAL OF VETERINARY INTERNAL MEDICINE, 33(6), 2572–2586.

By: P. Fox*, B. Keene n, K. Lamb, K. Schober*, V. Chetboul*, V. Fuentes*, J. Payne, G. Wess ...

author keywords: cancer; chronic kidney disease; epidemiology; mortality; survival
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / mortality; Cats; Female; Incidence; Male; Retrospective Studies; Risk Factors
TL;DR: All‐cause mortality was significantly greater in pHCM cats due to disease burden contributed by increased cardiovascular death superimposed upon noncardiovascular death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: October 28, 2019

2019 journal article

Myxomatous mitral valve disease in the miniature poodle: A retrospective study

VETERINARY JOURNAL, 244, 94–97.

By: K. Meurs n, D. Adin n, . K. O'Donnell n, B. Keene n, C. Atkins n, T. DeFrancesco n, S. Tou n

author keywords: Canine; Genetic; Miniature poodle; Mitral valve; Myxomatous valve
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / epidemiology; Dog Diseases / genetics; Dogs; Female; Male; Mitral Valve Prolapse / diagnostic imaging; Mitral Valve Prolapse / epidemiology; Mitral Valve Prolapse / genetics; Mitral Valve Prolapse / veterinary; North Carolina / epidemiology; Pedigree; Records; Retrospective Studies; Severity of Illness Index
TL;DR: In the miniature poodles reported here, MMVD appears to be a fairly late onset disease and often is a mild phenotype. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: April 2, 2019

2019 journal article

The effect of a surgical safety checklist on complication rates associated with permanent transvenous pacemaker implantation in dogs

JOURNAL OF VETERINARY CARDIOLOGY, 22, 72–83.

By: J. Ward*, A. McLaughlin n, R. Burzette* & B. Keene n

author keywords: Canine; Atrioventricular block; Heart block; Bradycardia
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bradycardia / surgery; Bradycardia / therapy; Bradycardia / veterinary; Checklist / statistics & numerical data; Dog Diseases / surgery; Dog Diseases / therapy; Dogs; Hospitals, Animal / statistics & numerical data; North Carolina; Pacemaker, Artificial / veterinary; Postoperative Complications / mortality; Postoperative Complications / prevention & control; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: Use of an SSC was associated with a decrease in the major complication rate and an increase in compliance with antibiotic protocols during pacemaker implantation in dogs, and results of this study support the use of the SSC in veterinary cardiology procedures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
4. Quality Education (Web of Science)
Source: Web Of Science
Added: May 6, 2019

2018 journal article

Evaluation of genes associated with human myxomatous mitral valve disease in dogs with familial myxomatous mitral valve degeneration

VETERINARY JOURNAL, 232, 16–19.

By: K. Meurs n, S. Friedenberg*, B. Williams n, B. Keene n, C. Atkins n, D. Adin n, B. Aona n, T. DeFrancesco n ...

author keywords: Canine; Cavalier King Charles spaniel; Dachshund; Genetic; Mitral valve; Myxomatous valve
MeSH headings : Animals; DNA / blood; Dog Diseases / genetics; Dogs; Heart Valve Diseases / genetics; Heart Valve Diseases / veterinary; Humans; Mitral Valve; Mitral Valve Prolapse / genetics; Mutation; Species Specificity; Whole Genome Sequencing / veterinary
TL;DR: Although mitral valve disease in the CKCS and Dachshund is a familial disease, it was hypothesized that a genetic mutation associated with the development of the human form of MMVD was associated withthe development of canine MMVD and this work identified genetic cause in the genes responsible for the human disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 journal article

International collaborative study to assess cardiovascular risk and evaluate long-term health in cats with preclinical hypertrophic cardiomyopathy and apparently healthy cats: The REVEAL Study

Journal of Veterinary Internal Medicine, 32(3), 930–943.

By: P. Fox, B. Keene, K. Lamb, K. Schober, V. Chetboul, V. Fuentes, G. Wess, J. Payne ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Longitudinal analysis of quality of life, clinical, radiographic, echocardiographic, and laboratory variables in dogs with preclinical myxomatous mitral valve disease receiving pimobendan or placebo: The EPIC study

Journal of Veterinary Internal Medicine, 32(1), 72–85.

By: A. Boswood, S. Gordon, J. Haggstrom, G. Wess, R. Stepien, M. Oyama, B. Keene, J. Bonagura ...

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model

AMERICAN JOURNAL OF BIOETHICS, 18(2), 41–53.

By: P. Rosoff*, J. Moga n, B. Keene n, C. Adin n, C. Fogle n, R. Ruderman*, H. Hopkinso n, C. Weyhrauch n

author keywords: end-of-life issues; ethics committees; professional-patient relationship
MeSH headings : Animal Welfare / ethics; Animals; Ethics Consultation; Euthanasia, Animal / ethics; Humans; Professional Competence; Tertiary Healthcare / ethics; Veterinarians / ethics; Veterinary Medicine / ethics
TL;DR: The staff of the North Carolina State University Veterinary Hospital, a specialty academic teaching institution, wanted to investigate whether similar success could be achieved in the tertiary care veterinary setting, and the background and rationale for this method were discussed. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2018 personal communication

Response to Open Peer Commentaries on "Resolving Ethical Dilemmas in a Tertiary Care Veterinary Specialty Hospital: Adaptation of the Human Clinical Consultation Committee Model"

By: P. Rosoff*, R. Ruderman*, J. Moga n, B. Keene n, C. Adin n, C. Fogle n, H. Hopkinson n, C. Weyhrauch n

MeSH headings : Ethics Committees, Clinical; Ethics Consultation; Humans; Morals; Tertiary Healthcare
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Accuracy of point-of-care lung ultrasonography for the diagnosis of cardiogenic pulmonary edema in dogs and cats with acute dyspnea

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 250(6), 666–675.

By: J. Ward*, G. Lisciandro, B. Keene*, S. Tou* & T. DeFrancesco*

MeSH headings : Animals; Cat Diseases / diagnosis; Cats; Dog Diseases / diagnosis; Dogs; Dyspnea / diagnosis; Dyspnea / veterinary; Observer Variation; Point-of-Care Systems; Prospective Studies; Pulmonary Edema / diagnosis; Pulmonary Edema / veterinary; Ultrasonography / instrumentation; Ultrasonography / veterinary
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Angiotensin-converting enzyme activity and inhibition in dogs with cardiac disease and an angiotensin-converting enzyme polymorphism

JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM, 18(4).

By: K. Meurs n, J. Stern n, C. Atkins n, D. Adin n, B. Aona n, J. Condit n, T. DeFrancesco n, Y. Reina-Doreste n ...

author keywords: Polymorphism; canine; angiotensin-converting enzyme; enalapril
MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Breeding; Dogs; Genotype; Heart Diseases / drug therapy; Heart Diseases / enzymology; Heart Diseases / genetics; Peptidyl-Dipeptidase A / genetics; Polymorphism, Genetic
TL;DR: It is possible that the genetic status and ACE activity of dogs may impact the response of dogs with this variant to an ACE inhibitor, and an ACE polymorphism is associated with lower levels of ACE activity. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2017 journal article

Effect of pimobendan in Dogs with preclinical myxomatous mitral valve disease and cardiomegaly: The EPIC study - A randomized clinical trial

Kleintier-Praxis, 62(2), 64–87.

By: A. Boswood, J. Haggstrom, S. Gordon, G. Wess, R. Stepiens, M. Oyama, B. Keene, J. Bonagura ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Pilot study to determine the feasibility of radiation therapy for dogs with right atrial masses and hemorrhagic pericardial effusion

Journal of Veterinary Cardiology, 19(2), 132–143.

By: M. Nolan n, M. Arkans n, D. LaVine n, T. DeFrancesco n, J. Myers*, E. Griffith n, L. Posner n, B. Keene n ...

author keywords: Heart-base tumor; Cardiac hemangiosarcoma; Canine
MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / radiotherapy; Dogs; Echocardiography; Female; Heart Atria; Heart Neoplasms / complications; Heart Neoplasms / radiotherapy; Heart Neoplasms / veterinary; Hemangiosarcoma / complications; Hemangiosarcoma / radiotherapy; Hemangiosarcoma / veterinary; Hemorrhage / complications; Hemorrhage / veterinary; Male; Pericardial Effusion / complications; Pericardial Effusion / veterinary; Pilot Projects; Postoperative Complications / veterinary; Treatment Outcome
TL;DR: RT alone, or in combination with chemotherapy, may provide clinical benefit to dogs with presumptive diagnoses of cardiac hemangiosarcoma, and appears to have reduced the frequency of periacardial tamponade that necessitated pericardiocentesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2017 journal article

The Effect of Heart Disease on Anesthetic Complications During Routine Dental Procedures in Dogs

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 53(4), 206–213.

By: J. Carter n, A. Motsinger-Reif n, W. Krug n & B. Keene n

MeSH headings : Anesthesia / adverse effects; Anesthesia / veterinary; Animals; Case-Control Studies; Dental Prophylaxis / veterinary; Dog Diseases / etiology; Dogs; Heart Diseases / complications; Heart Diseases / veterinary; Intraoperative Complications / etiology; Intraoperative Complications / veterinary; Retrospective Studies; Risk Factors
TL;DR: This study suggests dogs with heart disease, when anesthetized by trained personnel and carefully monitored during routine dental procedures, are not at significantly increased risk for anesthetic complications. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Development of a Veterinary Surgical Checklist

ERGONOMICS IN DESIGN, 24(4), 27–34.

By: A. McLaughlin*, J. Ward* & B. Keene*

author keywords: teams; teamwork; education and training; simulation; surgical procedure; health care; work systems; macroergonomics; product design; design methods; safety; human error; task analysis; Big 5 model; theory of mind
TL;DR: A new surgical checklist for veterinary cardiologists is described based on the literature and the application of human factors design and engendered communication, particularly by requiring the thoughts and expectations of team members to be stated explicitly. (via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education (Web of Science)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Effect of Pimobendan in dogs with preclinical myxomatous mitral valve disease and cardiomegaly: The EPIC study-a randomized clinical trial

Journal of Veterinary Internal Medicine, 30(6), 1765–1779.

By: A. Boswood, J. Haggstrom, S. Gordon, G. Wess, R. Stepien, M. Oyama, B. Keene, J. Bonagura ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Infective endocarditis in 13 cats

Journal of Veterinary Cardiology, 18(3), 213–225.

By: J. Palerme*, A. Jones*, J. Ward*, N. Balakrishnan n, K. Linder n, E. Breitschwerdt n, B. Keene n

author keywords: BAPGM; Bartonella; Duke criteria; Vegetative lesion
MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / physiopathology; Cats; Endocarditis, Bacterial / diagnosis; Endocarditis, Bacterial / drug therapy; Endocarditis, Bacterial / physiopathology; Endocarditis, Bacterial / veterinary; Female; Male; Prognosis; Retrospective Studies; Treatment Outcome
TL;DR: In contrast to dogs, cats with IE typically present with clinical signs consistent with cardiac decompensation and locomotor abnormalities suggestive of either thromboembolic disease or inflammatory arthritis, and prognosis is grave. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Outcome and survival in canine sick sinus syndrome and sinus node dysfunction: 93 cases (2002-2014)

JOURNAL OF VETERINARY CARDIOLOGY, 18(3), 199–212.

By: J. Ward n, T. DeFrancesco n, S. Tou n, C. Atkins n, E. Griffith n & B. Keene n

author keywords: Dog; Arrhythmia; Bradycardia; Sinus arrest; Pacemaker
MeSH headings : Animals; Dog Diseases / mortality; Dogs; Prognosis; Sick Sinus Syndrome / mortality; Sick Sinus Syndrome / veterinary; Sinoatrial Node / physiopathology; Survival Analysis; Treatment Outcome
TL;DR: Sinus node dysfunction and SSS represent a spectrum of sinoatrial node disease, which for some dogs may also involve a component of autonomic dysfunction, and medical management is often useful, particularly in atropine responsive dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Successful treatment of mitral valve endocarditis in a dog associated with 'Actinomyces canis-like' infection

JOURNAL OF VETERINARY CARDIOLOGY, 18(3), 271–277.

By: N. Balakrishnan n, K. Alexander n, B. Keene n, S. Kolluru n, M. Fauls n, I. Rawdon n, E. Breitschwerdt n

author keywords: Bacterial endocarditis; Blood culture; 16s rDNA PCR; Actinomycosis
MeSH headings : Actinomyces; Actinomycosis / veterinary; Animals; Dog Diseases / microbiology; Dogs; Echocardiography / veterinary; Endocarditis / microbiology; Endocarditis / veterinary; Heart Valve Diseases / microbiology; Heart Valve Diseases / veterinary; Male; Mitral Valve
TL;DR: A case of mitral valve endocarditis in a 9-year-old male-castrated Weimaraner caused by an Actinomyces canis-like bacterium, not previously reported in association with infection in dogs is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2016 journal article

Suspected acute myocardial infarction in a dystrophin-deficient dog

NEUROMUSCULAR DISORDERS, 26(6), 361–366.

By: S. Schneider*, A. Coleman n, L. Guo*, S. Tou n, B. Keene n & J. Kornegay*

author keywords: Muscular dystrophy; Duchenne muscular dystrophy; Golden retriever muscular dystrophy; Cardiomyopathy; Animal model; Myocardial infarction
MeSH headings : Animals; Biomarkers / blood; Dog Diseases / diagnosis; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Fatal Outcome; Female; Heart / diagnostic imaging; Heart / physiopathology; Muscular Dystrophy, Animal / complications; Muscular Dystrophy, Animal / diagnosis; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / physiopathology; Myocardial Infarction / complications; Myocardial Infarction / diagnostic imaging; Myocardial Infarction / physiopathology; Myocardial Infarction / veterinary; Myocardium / pathology
TL;DR: A 7-month-old GRMD dog with an apparent analogous episode of myocardial infarction is reported with acute signs of cardiac disease, including tachyarrhythmia, supraventricular premature complexes, and femoral pulse deficits. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Use of RNA-seq to identify cardiac genes and gene pathways differentially expressed between dogs with and without dilated cardiomyopathy

AMERICAN JOURNAL OF VETERINARY RESEARCH, 77(7), 693–699.

By: S. Friedenberg n, L. Chdid n, B. Keene n, B. Sherry n, A. Motsinger-Reif n & K. Meurs n

MeSH headings : Animals; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / metabolism; Cardiomyopathy, Dilated / veterinary; Dog Diseases / genetics; Dog Diseases / metabolism; Dogs; Down-Regulation; Female; Gene Expression; Heart Ventricles; Male; Myocardium / metabolism; RNA / genetics; Up-Regulation
TL;DR: Genes involved in cellular energy metabolism, especially metabolism of carbohydrates and fats, were significantly downregulated in dogs with DCM, and Expression of cardiac structural proteins was also altered in affected dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

A VALENTINE-SHAPED CARDIAC SILHOUETTE IN FELINE THORACIC RADIOGRAPHS IS PRIMARILY DUE TO LEFT ATRIAL ENLARGEMENT

VETERINARY RADIOLOGY & ULTRASOUND, 56(3), 245–250.

By: T. Oura n, A. Young*, B. Keene n, I. Robertson n, D. Jennings* & D. Thrall n

author keywords: atrium; cat; cardiomegaly; radiography; valentine shaped
MeSH headings : Animals; Cardiomegaly / diagnostic imaging; Cardiomegaly / etiology; Cardiomegaly / veterinary; Cat Diseases / diagnostic imaging; Cat Diseases / etiology; Cats; Cross-Sectional Studies; Echocardiography / veterinary; Female; Heart Atria / diagnostic imaging; Male; North Carolina; Radiography; Retrospective Studies
TL;DR: The hypothesis that a valentine-shaped cardiac silhouette in radiographs is due primarily to left atrial enlargement in cats is supported, with right atrial enlargeement only impacting the shape if concurrent with severe left atri enlargement. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Aldosterone breakthrough with benazepril in furosemide-activated renin-angiotensin-aldosterone system in normal dogs

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 38(1), 65–73.

By: A. Lantis n, M. Ames n, C. Atkins n, T. Defrancesco n, B. Keene n & S. Werre n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Angiotensin-Converting Enzyme Inhibitors / administration & dosage; Angiotensin-Converting Enzyme Inhibitors / pharmacology; Animals; Benzazepines / administration & dosage; Benzazepines / pharmacology; Diuretics / administration & dosage; Diuretics / pharmacology; Dogs / physiology; Dogs / urine; Drug Therapy, Combination; Furosemide / administration & dosage; Furosemide / pharmacology; Peptidyl-Dipeptidase A; Renin-Angiotensin System / drug effects; Renin-Angiotensin System / physiology
TL;DR: Benazepril decreased plasma ACE activity but did not prevent furosemide-induced RAAS activation, indicating aldosterone breakthrough (escape), particularly noteworthy in that breakthrough is observed at the time of initiation of RAAS suppression, as opposed to developing after months of therapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Cardiac regenerative potential of cardiosphere-derived cells from adult dog hearts

Journal of Cellular and Molecular Medicine, 19(8), 1805–1813.

By: M. Hensley n, J. Andrade n, B. Keene n, K. Meurs n, J. Tang n, Z. Wang*, T. Caranasos*, J. Piedrahita n ...

author keywords: cardiosphere-derived cells; dogs; dilated cardiomyopathy; stem cell therapy
MeSH headings : Aging; Animals; Apoptosis; Cell Differentiation; Cells, Cultured; Dogs; Female; Fibrosis; Heart / physiology; Heart Function Tests; Mice, SCID; Myocardium / pathology; Myocytes, Cardiac / cytology; Neovascularization, Physiologic; Paracrine Communication; Regeneration; Spheroids, Cellular / cytology
TL;DR: It is shown that canine CDCs can be produced from adult dog hearts and display similar phenotypes in comparison to previously studied CDCs derived from rodents and human beings. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018

2015 journal article

Complication Rates Associated with Transvenous Pacemaker Implantation in Dogs with High-Grade Atrioventricular Block Performed During versus After Normal Business Hours

JOURNAL OF VETERINARY INTERNAL MEDICINE, 29(1), 157–163.

By: J. Ward n, T. DeFrancesco n, S. Tou n, C. Atkins n, E. Griffith n & B. Keene n

author keywords: Canine; Heart block; Transvenous
MeSH headings : Animals; Atrioventricular Block / therapy; Atrioventricular Block / veterinary; Cardiovascular Surgical Procedures / adverse effects; Cardiovascular Surgical Procedures / veterinary; Dog Diseases / therapy; Dogs; Pacemaker, Artificial / veterinary; Postoperative Complications / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: AH transvenous pacemaker placement is associated with a higher rate of major complications (especially infections) compared to BH placement, and this difference may be because of a variety of human factor differences AH versus BH. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Cor triatriatum

Veterinary Image-Guided Interventions, 604–609.

By: B. Keene & S. Tou

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Impact of the canine double-deletion beta 1 adrenoreceptor polymorphisms on protein structure and heart rate response to atenolol, a beta 1-selective beta-blocker

PHARMACOGENETICS AND GENOMICS, 25(9), 427–431.

By: K. Meurs n, J. Stern n, Y. Reina-Doreste n, B. Maran n, L. Chdid n, S. Lahmers n, B. Keene n, K. Mealey n

author keywords: beta-adrenergic receptor; atenolol; beta-blocker; canine; polymorphism
MeSH headings : Adrenergic beta-1 Receptor Antagonists / administration & dosage; Adrenergic beta-1 Receptor Antagonists / pharmacology; Animals; Atenolol / administration & dosage; Atenolol / pharmacology; Dogs; Electrocardiography / veterinary; Heart Rate / drug effects; Models, Molecular; Protein Structure, Secondary; Receptors, Adrenergic, beta-1 / chemistry; Receptors, Adrenergic, beta-1 / genetics; Sequence Deletion
TL;DR: The heart rates of the dogs with deletions were lower than those of the control dogs (the average heart rates were significantly lower), and individual genome-based treatment recommendations could impact the management of dogs with heart disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Secondary prevention of cardiogenic arterial thromboembolism in the cat: the double-blind, randomized, positive-controlled feline arterial thromboembolism; clopidogrel vs. aspirin trial (FAT CAT)

JOURNAL OF VETERINARY CARDIOLOGY, 17, S306–S317.

By: D. Hogan*, P. Fox*, K. Jacob, B. Keene n, N. Laste*, S. Rosenthal, K. Sederquist*, H. Weng*

author keywords: Thromboprophylaxis; Thrombosis; Antithrombotics; Infarction; Cardioembolic
MeSH headings : Animals; Aspirin / adverse effects; Aspirin / therapeutic use; Cat Diseases / prevention & control; Cats; Clopidogrel; Double-Blind Method; Male; Platelet Aggregation Inhibitors / adverse effects; Platelet Aggregation Inhibitors / therapeutic use; Thromboembolism / prevention & control; Thromboembolism / veterinary; Ticlopidine / adverse effects; Ticlopidine / analogs & derivatives; Ticlopidine / therapeutic use
TL;DR: Clopidogrel administration significantly reduces the likelihood of recurrent CATE compared with aspirin in cats; both drugs were well tolerated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Case-control study of the effects of pimobendan on survival time in cats with hypertrophic cardiomyopathy and congestive heart failure

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 245(5), 534–539.

MeSH headings : Animals; Cardiomyopathy, Hypertrophic / drug therapy; Cardiomyopathy, Hypertrophic / mortality; Cardiomyopathy, Hypertrophic / veterinary; Cardiotonic Agents / therapeutic use; Case-Control Studies; Cat Diseases / drug therapy; Cat Diseases / mortality; Cats; Female; Heart Failure / drug therapy; Heart Failure / mortality; Heart Failure / veterinary; Male; Pyridazines / therapeutic use; Retrospective Studies
TL;DR: The addition of pimobendan to traditional treatment for CHF may provide a substantial clinical benefit in survival time for HCM-affected cats with CHF and possibly HOCM- affected cats withCHF. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 journal article

Outcome of positive-pressure ventilation in dogs and cats with congestive heart failure: 16 cases (1992-2012)

JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, 24(5), 586–593.

By: T. Edwards*, A. Coleman*, B. Brainard*, T. DeFrancesco n, B. Hansen n, B. Keene n, A. Koenig*

author keywords: cardiogenic; cardiovascular; heart failure; parenchymal disease; pulmonary edema; respiratory tract; small animal
MeSH headings : Animals; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Female; Heart Failure / therapy; Heart Failure / veterinary; Male; Positive-Pressure Respiration / veterinary; Retrospective Studies; Survival Rate; Time Factors; Treatment Outcome
TL;DR: Dogs and cats undergoing positive-pressure ventilation for CHF have a good overall prognosis for hospital discharge and require PPV for a relatively short duration and azotemia, oliguria or anuria, and the use of pentobarbital are negatively associated with outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Association of Dilated Cardiomyopathy with the Striatin Mutation Genotype in Boxer Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 27(6), 1437–1440.

By: K. Meurs n, J. Stern n, D. Sisson*, M. Kittleson*, S. Cunningham*, M. Ames n, C. Atkins n, T. DeFrancesco n ...

author keywords: Boxer; Dilated cardiomyopathy; Mutation; Striatin
MeSH headings : Animals; Arrhythmogenic Right Ventricular Dysplasia / genetics; Arrhythmogenic Right Ventricular Dysplasia / physiopathology; Arrhythmogenic Right Ventricular Dysplasia / veterinary; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / physiopathology; Cardiomyopathy, Dilated / veterinary; Case-Control Studies; Confidence Intervals; DNA / chemistry; DNA / genetics; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Female; Genotype; Male; Membrane Proteins / genetics; Polymerase Chain Reaction / veterinary; Sequence Deletion / genetics
TL;DR: This study demonstrates an association between DCM in the Boxer dog and the striatin mutation, particularly with the homozygous genotype, and suggests that there is at least 1 other cause of DCm in the boxer dog. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Cardiac structure and function in female carrier's of a canine model of Duchenne muscular dystrophy

RESEARCH IN VETERINARY SCIENCE, 94(3), 610–617.

By: A. Kane n, T. DeFrancesco n, M. Boyle*, D. Malarkey*, J. Ritchey*, C. Atkins n, J. Cullen n, J. Kornegay*, B. Keene n

author keywords: Cardiomyopathy; Carrier; GRMD; Duchenne muscular dystrophy
MeSH headings : Animals; Disease Models, Animal; Dog Diseases / genetics; Dog Diseases / pathology; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Electrocardiography / veterinary; Electrocardiography, Ambulatory / veterinary; Female; Heart / physiopathology; Heterozygote; Muscular Dystrophy, Animal / genetics; Muscular Dystrophy, Animal / pathology; Muscular Dystrophy, Animal / physiopathology; Myocardium / pathology
TL;DR: Despite cardiac mosaic dystrophin expression and degenerative cardiac lesions, GRMD carriers at up to 3 years of age could not be distinguished statistically from normal controls by echocardiography or 24-h Holter monitoring. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2013 journal article

Hybrid cutting balloon dilatation for treatment of cor triatriatum sinister in a cat

JOURNAL OF VETERINARY CARDIOLOGY, 15(3), 205–210.

By: J. Stern n, S. Tou n, P. Barker*, K. Hill*, A. Lodge*, K. Mathews n, B. Keene n

author keywords: Sinistrum; Pulmonary venous anomaly; Feline; Congenital heart disease; Dilatation
MeSH headings : Angioplasty, Balloon, Coronary / methods; Angioplasty, Balloon, Coronary / veterinary; Animals; Cat Diseases / diagnosis; Cat Diseases / therapy; Cats; Cor Triatriatum / diagnosis; Cor Triatriatum / therapy; Cor Triatriatum / veterinary; Echocardiography, Transesophageal / veterinary; Female
TL;DR: Based upon the outcome of this case, balloon dilatation appears to be a viable treatment option for cats affected with cor triatriatum sinister. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Outcomes and Complications Associated With Epicardial Pacemakers in 28 Dogs and 5 Cats

VETERINARY SURGERY, 42(5), 544–550.

MeSH headings : Animals; Arrhythmias, Cardiac / therapy; Arrhythmias, Cardiac / veterinary; Cat Diseases / therapy; Cats; Dog Diseases / therapy; Dogs; Female; Male; Pacemaker, Artificial / veterinary; Retrospective Studies; Treatment Outcome
TL;DR: Larger dogs (>10 kg) may be predisposed to more major complications with epicardial pacemaker (EP) implantation, and therefore implantation of EPs remains a suitable alternative. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2012 journal article

A splice site mutation in a gene encoding for PDK4, a mitochondrial protein, is associated with the development of dilated cardiomyopathy in the Doberman pinscher

HUMAN GENETICS, 131(8), 1319–1325.

By: K. Meurs n, S. Lahmers*, B. Keene n, S. White*, M. Oyama*, E. Mauceli*, K. Lindblad-Toh*

MeSH headings : Animals; Blotting, Western; Cardiomyopathy, Dilated / genetics; Cardiomyopathy, Dilated / veterinary; Chromosome Mapping / veterinary; Dog Diseases / genetics; Dogs; Genome-Wide Association Study; Microscopy, Electron; Mutation; Myocardium / ultrastructure; Protein Kinases / genetics; RNA Splicing; Real-Time Polymerase Chain Reaction
TL;DR: The identification of a splice site deletion in the PDK4 gene that is associated with the development of familial dilated cardiomyopathy in the Doberman pinscher dog is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2012 journal article

Canine models of Duchenne muscular dystrophy and their use in therapeutic strategies

Mammalian Genome, 23(1-2), 85–108.

By: J. Kornegay, J. Bogan, D. Bogan, M. Childers, J. Li, P. Nghiem, D. Detwiler, C. Larsen ...

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Complete atrioventricular block secondary to cardiac lymphoma in a dog

Journal of Veterinary Cardiology, 14(4), 537–539.

By: J. Stern n, J. Tobias n & B. Keene n

author keywords: Lymphoma; Cardiac lymphoma; Tumor; Septal tumor
MeSH headings : Animals; Atrioventricular Block / etiology; Atrioventricular Block / veterinary; Dog Diseases / diagnostic imaging; Dog Diseases / etiology; Dog Diseases / pathology; Dogs; Echocardiography / veterinary; Heart Neoplasms / complications; Heart Neoplasms / pathology; Heart Neoplasms / veterinary; Lymphoma, Non-Hodgkin / complications; Lymphoma, Non-Hodgkin / pathology; Lymphoma, Non-Hodgkin / veterinary; Male
TL;DR: Necropsy revealed multiple masses within the interventricular septum, ventricular free walls and atrial myocardium, and the final diagnosis was large cell (T-cell) lymphosarcoma. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Crossref
Added: August 14, 2021

2012 journal article

Cutting balloon catheterization for interventional treatment of cor triatriatum dexter: 2 Cases

Journal of Veterinary Cardiology, 14(4), 525–530.

By: N. LeBlanc*, T. DeFrancesco n, A. Adams*, C. Atkins n, S. Tou n, J. Fudge*, B. Keene n

author keywords: Conventional balloon angioplasty; Congenital heart disease; Cardiac anomalies
MeSH headings : Animals; Catheterization / instrumentation; Catheterization / veterinary; Cor Triatriatum / surgery; Cor Triatriatum / veterinary; Dog Diseases / surgery; Dogs; Female; Male; Treatment Outcome
TL;DR: Cutting balloon dilatation was performed successfully in two dogs with cor triatriatum dexter and clinical signs of ascites and, in both cases described, clinical signs resolved completely following cutting balloon Dilatation of the anomalous membrane. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2012 journal article

Surgical treatment of a pulmonary artery vascular hamartoma in a dog

Journal of the American Veterinary Medical Association, 240(7), 858–862.

By: G. Chanoit*, K. Mathews*, B. Keene*, M. Small & K. Linder*

MeSH headings : Animals; Dog Diseases / pathology; Dog Diseases / surgery; Dogs; Hamartoma / surgery; Hamartoma / veterinary; Male; Pulmonary Artery / pathology; Pulmonary Artery / surgery; Vascular Neoplasms / pathology; Vascular Neoplasms / surgery; Vascular Neoplasms / veterinary
TL;DR: Computed tomography was helpful in predicting the resectability of the intracardiac mass in this dog, and treatment with arteriotomy under inflow occlusion and mild hypothermia resulted in a favorable outcome. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2011 article

ECG of the Month

Tou, S. P., DeFrancesco, T. C., & Keene, B. W. (2011, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 239, pp. 55–57.

By: S. Tou n, T. DeFrancesco* & B. Keene*

MeSH headings : Animals; Bundle-Branch Block / diagnosis; Bundle-Branch Block / veterinary; Dog Diseases / diagnosis; Dogs; Electrocardiography / veterinary; Male; Tachycardia, Sinus / veterinary
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

Multicenter Evaluation of Plasma N-Terminal Probrain Natriuretic Peptide (NT-pro BNP) as a Biochemical Screening Test for Asymptomatic (occult) Cardiomyopathy in Cats

Journal of Veterinary Internal Medicine, 25(5), 1010–1016.

By: P. Fox, J. Rush, C. Reynolds, T. DeFrancesco, B. Keene, C. Atkins, S. Gordon, K. Schober ...

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Pulmonary atresia and ventricular septal defect with aortopulmonary collaterals in an adult dog

Journal of Veterinary Cardiology, 13(4), 271–275.

By: S. Tou n, B. Keene n & P. Barker*

MeSH headings : Abnormalities, Multiple / diagnosis; Abnormalities, Multiple / veterinary; Animals; Aorta, Thoracic / abnormalities; Aorta, Thoracic / physiopathology; Collateral Circulation; Dog Diseases / diagnosis; Dog Diseases / physiopathology; Dogs; Echocardiography / veterinary; Heart Septal Defects, Ventricular / diagnosis; Heart Septal Defects, Ventricular / veterinary; Male; Pulmonary Atresia / diagnosis; Pulmonary Atresia / veterinary
TL;DR: The antemortem diagnosis of the rare congenital defect PA-VSD in an adult dog with aortopulmonary collateral circulation arising from the descending thoracic aorta is described. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 14, 2021

2010 journal article

Successful treatment ofBartonella henselaeendocarditis in a cat

Journal of Feline Medicine and Surgery, 12(6), 483–486.

By: C. Perez n, J. Hummel n, B. Keene n, R. Maggi n, P. Diniz n & E. Breitschwerdt n

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bartonella Infections / diagnosis; Bartonella Infections / drug therapy; Bartonella Infections / veterinary; Bartonella henselae / isolation & purification; Cat Diseases / diagnosis; Cat Diseases / drug therapy; Cat Diseases / microbiology; Cats; Endocarditis, Bacterial / diagnosis; Endocarditis, Bacterial / drug therapy; Endocarditis, Bacterial / microbiology; Endocarditis, Bacterial / veterinary; Fluorescent Antibody Technique, Indirect / veterinary; Male; Treatment Outcome
TL;DR: In conjunction with previous case reports, infective endocarditis can be associated with natural B henselae infection in cats; however, early diagnosis and treatment may result in a better prognosis than previously reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2009 journal article

Acute Effect of Pimobendan and Furosemide on the Circulating Renin-Angiotensin-Aldosterone System in Healthy Dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, 23(5), 1003–1006.

By: M. Sayer n, C. Atkins n, Y. Fujii n, A. Adams n, T. DeFrancesco n & B. Keene n

author keywords: Furosemide; Heart failure; Inodilator; Pimobendan; Renin-angiotensin-aldosterone system
MeSH headings : Aldosterone / urine; Animals; Blood Urea Nitrogen; Chlorides / blood; Cross-Over Studies; Dogs / blood; Dogs / urine; Female; Furosemide / pharmacology; Male; Phosphorus / blood; Potassium / blood; Pyridazines / pharmacology; Renin-Angiotensin System / drug effects; Sodium / blood; Sodium Potassium Chloride Symporter Inhibitors / pharmacology; Vasodilator Agents / pharmacology
TL;DR: It is suggested that furosemide therapy, with or without pimobendan, should be accompanied by RAAS suppressive therapy, and short-term administration of high-dose pimobendedan, does not activate the RAAS in healthy dogs. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 review

Guidelines for the Diagnosis and Treatment of Canine Chronic Valvular Heart Disease

[Review of ]. JOURNAL OF VETERINARY INTERNAL MEDICINE, 23(6), 1142–1150.

Contributors: C. Atkins n, J. Bonagura*, S. Ettinger*, P. Fox*, S. Gordon*, J. Haggstrom*, R. Hamlin*, B. Keene n, V. Luis-Fuentes*, R. Stepien*

author keywords: Cardiology; Cardiovascular; Heart failure; Therapy
MeSH headings : Animals; Chronic Disease; Dog Diseases / diagnosis; Dogs; Heart Failure / therapy; Heart Failure / veterinary; Heart Valve Diseases / diagnosis; Heart Valve Diseases / therapy; Heart Valve Diseases / veterinary; Practice Guidelines as Topic
TL;DR: CVHD is the most common heart disease of dogs in many parts of the world, accounting for approximately 75% of canine cases of heart disease cases seen by veter-inary practices in North America. (via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: August 6, 2018

2009 journal article

Utility of plasma N-terminal pro-brain natriuretic peptide (NT-proBNP) to distinguish between congestive heart failure and non-cardiac causes of acute dyspnea in cats

Journal of Veterinary Cardiology, 11(Supplement 1), S51–S61.

By: P. Fox*, M. Oyama*, C. Reynolds*, J. Rush*, T. DeFrancesco n, B. Keene n, C. Atkins n, K. MacDonald* ...

Contributors: P. Fox*, M. Oyama*, C. Reynolds*, J. Rush*, T. DeFrancesco n, B. Keene n, C. Atkins n, K. MacDonald* ...

MeSH headings : Animals; Biomarkers / blood; Case-Control Studies; Cat Diseases / blood; Cat Diseases / diagnosis; Cats; Diagnosis, Differential; Dyspnea / blood; Dyspnea / diagnosis; Dyspnea / etiology; Dyspnea / veterinary; Female; Heart Failure / blood; Heart Failure / complications; Heart Failure / diagnosis; Heart Failure / veterinary; Male; Natriuretic Peptide, Brain / blood; Peptide Fragments / blood; Predictive Value of Tests; Prospective Studies; ROC Curve; Renal Insufficiency / blood; Renal Insufficiency / complications; Renal Insufficiency / diagnosis; Renal Insufficiency / veterinary; Respiration Disorders / blood; Respiration Disorders / complications; Respiration Disorders / diagnosis; Respiration Disorders / veterinary
TL;DR: NT-proBNP accurately discriminated CHF from respiratory disease causes of dyspnea and optimal cut-off values using receiver operating characteristic (ROC) curve analysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
10. Reduced Inequalities (OpenAlex)
Sources: Crossref, ORCID, NC State University Libraries
Added: October 24, 2019

2008 journal article

Comparison of the pharmacokinetic properties of bisoprolol and carvedilol in healthy dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 69(12), 1659–1663.

By: G. Beddies*, P. Fox, M. Papich*, V. Kanikanti, R. Krebber & B. Keene*

MeSH headings : Administration, Oral; Adrenergic beta-Antagonists / administration & dosage; Adrenergic beta-Antagonists / blood; Adrenergic beta-Antagonists / pharmacokinetics; Animals; Area Under Curve; Biological Availability; Bisoprolol / administration & dosage; Bisoprolol / blood; Bisoprolol / pharmacokinetics; Carbazoles / administration & dosage; Carbazoles / blood; Carbazoles / pharmacokinetics; Carvedilol; Cross-Over Studies; Dogs / metabolism; Half-Life; Injections, Intravenous; Male; Propanolamines / administration & dosage; Propanolamines / blood; Propanolamines / pharmacokinetics
TL;DR: Differences suggested that, in dogs, bisoprolol has less interindividual pharmacokinetic variability, compared with carvedilol, a third-generation beta1/beta2 and alpha1-adrenoceptor blocking agent. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Electrocardiographic, hematologic, histopathologic, and recovery characteristics from repeated morphine-chloralose anesthesia in dogs

International Journal of Applied Research in Veterinary Medicine, 6(3), 191–199.

By: D. Cunha, M. Buccellato, B. Keene, P. Rajala-Schultz, Y. Nishijima, Y. Ozkanlar, R. Hamlin

Source: NC State University Libraries
Added: August 6, 2018

2008 article

Supraventricular tachycardia in dogs: 65 cases (1990-2007)

Finster, S. T., DeFrancesco, T. C., Atkins, C. E., Hansen, B. D., & Keene, B. W. (2008, October). JOURNAL OF VETERINARY EMERGENCY AND CRITICAL CARE, Vol. 18, pp. 503–510.

By: S. Finster n, T. DeFrancesco n, C. Atkins n, B. Hansen n & B. Keene n

author keywords: atrial tachycardia; atrioventricular nodal reentry tachycardia; pre-excitation
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2008 journal article

Use of a nitinol gooseneck snare catheter for removal of adult Dirofilaria immitis in two cats

JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 233(9), 1441–1445.

By: M. Small, C. Atkins*, S. Gordon, A. Birkenheuer*, M. Booth-Sayer, B. Keene*, Y. Fujii*, M. Miller*

MeSH headings : Animals; Cardiac Catheterization / instrumentation; Cardiac Catheterization / methods; Cardiac Catheterization / veterinary; Cat Diseases / parasitology; Cat Diseases / surgery; Cats; Chylothorax / etiology; Chylothorax / parasitology; Chylothorax / surgery; Chylothorax / veterinary; Dirofilaria immitis / isolation & purification; Dirofilariasis / complications; Dirofilariasis / surgery; Female; Heart Failure / surgery; Heart Failure / veterinary; Male; Treatment Outcome
TL;DR: Findings suggested that use of a nitinol gooseneck snare catheter may be a safe and effective technique for removing adult D immitis from the right atrium and ventricle in cats and that successful removal of adult heartworms in infected cats may resolve clinical signs of right-sided congestive heart failure and chylothorax. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Cystoscopic-guided balloon dilation of a urethral stricture in a female dog

Canadian Veterinary Journal, 48(7), 731–733.

Source: NC State University Libraries
Added: August 6, 2018

2007 article

ECG of the month

Adams, A. K., & Keene, B. W. (2007, July 15). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 231, pp. 209–211.

By: A. Adams n & B. Keene*

MeSH headings : Animals; Dog Diseases / diagnosis; Dog Diseases / etiology; Dogs; Electrocardiography / methods; Electrocardiography / veterinary; Fatal Outcome; Heart Diseases / complications; Heart Diseases / congenital; Heart Diseases / veterinary; Male; Shock, Cardiogenic / diagnosis; Shock, Cardiogenic / etiology; Shock, Cardiogenic / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Estimation of 24-h aldosterone secretion in the dog using the urine aldosterone: Creatinine ratio

Journal of Veterinary Cardiology, 9(1), 1–7.

By: S. Gardner n, C. Atkins n, W. Rausch n, T. DeFrancesco n, D. Chandler & B. Keene n

MeSH headings : Aldosterone / metabolism; Aldosterone / urine; Animals; Creatinine / urine; Dog Diseases / diagnosis; Dog Diseases / urine; Dogs / metabolism; Dogs / urine; Female; Male; Radioimmunoassay / methods; Radioimmunoassay / veterinary; Renin-Angiotensin System / physiology
TL;DR: It is postulated that the urinary aldosterone:creatinine ratio, measured from spot urine samples, would correlate well with 24-h urinary a Aldosterone excretion, and would provide a simple index of ald testosterone excretion that would eliminate the need for 24-H urine collection. (via Semantic Scholar)
Sources: Crossref, NC State University Libraries
Added: November 16, 2019

2007 journal article

Evaluation of an accelerometer for at-home monitoring of spontaneous activity in dogs

AMERICAN JOURNAL OF VETERINARY RESEARCH, 68(5), 468–475.

By: B. Hansen*, D. Lascelles*, B. Keene*, A. Adams* & A. Thomson

MeSH headings : Animals; Dogs / physiology; Monitoring, Physiologic / instrumentation; Motor Activity / physiology; Time Factors; Videotape Recording
TL;DR: Use of an accelerometer was adequate for at-home activity monitoring, an important end point in clinical trials of treatment for chronic disease, and provided information about daily activity that is unattainable by other methods. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2007 journal article

Lack of GNB3 exon 9 polymorphism in primary hypertensive and normotensive dogs

VETERINARY RECORD, 160(19), 654–657.

By: O. Kuppinger, E. Fischer, S. Sum*, J. Hirschberger*, W. Rausch n, B. Keene n, F. Tippett*, R. Schulz

MeSH headings : Animals; Case-Control Studies; Dog Diseases / genetics; Dogs; Exons; Female; GTP-Binding Proteins / genetics; Gene Frequency; Genetic Predisposition to Disease; Genotype; Hypertension / genetics; Hypertension / veterinary; Male; Polymorphism, Single Nucleotide
TL;DR: It is concluded that canine primary hypertension is not associated with a polymorphism at either the respective human hypertension-associated nucleotide site or in the entire exon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Prospective clinical evaluation of an ELISA B-type natriuretic peptide assay in the diagnosis of congestive heart failure in dogs presenting with cough or dyspnea

JOURNAL OF VETERINARY INTERNAL MEDICINE, 21(2), 243–250.

author keywords: brain natriuretic peptide; cardiac biomarkers; heart disease
TL;DR: Measurement of BNP is useful in establishing or in excluding the diagnosis of CHF in dogs with cough or dyspnea, and B-type natriuretic peptide concentrations rose significantly as a function of severity ofCHF. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2007 journal article

Results of the veterinary enalapril trial to prove reduction in onset of heart failure in dogs chronically treated with enalapril alone for compensated, naturally occurring mitral valve insufficiency

Journal of the American Veterinary Medical Association, 231(7), 1061–1069.

By: C. Atkins n, B. Keene*, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, N. Edwards, P. Fox ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Antihypertensive Agents / therapeutic use; Death, Sudden, Cardiac / veterinary; Disease Progression; Disease-Free Survival; Dog Diseases / mortality; Dog Diseases / prevention & control; Dogs; Double-Blind Method; Enalapril / therapeutic use; Female; Heart Failure / mortality; Heart Failure / prevention & control; Heart Failure / veterinary; Kaplan-Meier Estimate; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / veterinary; Severity of Illness Index; Time Factors; Treatment Outcome
TL;DR: Chronic enalapril treatment of dogs with naturally occurring, moderate to severe MR significantly delayed onset of CHF, compared with placebo, on the basis of number ofCHF-free days, number of dogs free of CHFs at days 500 and study end, and increased time to a combined secondary endpoint of CHf-all-cause death. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2007 journal article

The effect of amlodipine and the combination of amlodipine and enalapril on the renin-angiotensin-aldosterone system in the dog

Journal of Veterinary Pharmacology and Therapeutics, 30(5), 394–400.

By: C. Atkins*, W. Rausch*, S. Gardner*, T. Defrancesco*, B. Keene* & J. Levine n

MeSH headings : Administration, Oral; Aldosterone / urine; Amlodipine / administration & dosage; Amlodipine / blood; Amlodipine / pharmacology; Animals; Antihypertensive Agents / administration & dosage; Antihypertensive Agents / blood; Antihypertensive Agents / pharmacology; Blood Pressure / drug effects; Blood Urea Nitrogen; Dogs / metabolism; Drug Therapy, Combination; Enalapril / administration & dosage; Enalapril / blood; Enalapril / pharmacology; Heart Rate / drug effects; Male; Renin-Angiotensin System / drug effects
TL;DR: Renin-angiotensin-aldosterone system activation was increased by approximately threefold (P < 0.05) with amlodipine administration, but this effect was blunted by enalapril, such that aldosterone excretion was no longer different from that observed under control conditions, although values for 24-h ald testosterone excretion did not return to pretreament levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

Assessment of drug-induced QT interval prolongation in conscious rabbits

Journal of Pharmacological and Toxicological Methods, 53(2), 168–173.

By: A. Kijtawornrat*, Y. Ozkanlar*, B. Keene n, B. Roche*, D. Hamlin* & R. Hamlin*

MeSH headings : Animals; Cisapride / adverse effects; Consciousness; Drug Evaluation, Preclinical / methods; Electrocardiography / instrumentation; Electrocardiography / methods; Enalaprilat / pharmacology; Female; Haloperidol / adverse effects; Injections, Intravenous; Long QT Syndrome / chemically induced; Long QT Syndrome / physiopathology; Male; Phenethylamines / adverse effects; Propranolol / pharmacology; Rabbits; Reproducibility of Results; Sulfonamides / adverse effects; Toxicity Tests
TL;DR: Results indicate that a bipolar transthoracic ECG recorded in conscious, sling-trained rabbits may provide an easy and economical methodology useful in predicting QTc lengthening of novel pharmacological entities. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 27, 2021

2006 journal article

Bartonella quintana Endocarditis in Dogs

Emerging Infectious Diseases, 12(12), 1869–1872.

By: P. Kelly*, J. Rolain, R. Maggi*, S. Sontakke*, B. Keene*, S. Hunter, H. Lepidi, K. Breitschwerdt ...

MeSH headings : Animals; Anti-Bacterial Agents / therapeutic use; Bartonella Infections / drug therapy; Bartonella Infections / microbiology; Bartonella Infections / veterinary; Bartonella quintana / growth & development; Dog Diseases / drug therapy; Dog Diseases / microbiology; Dogs; Endocarditis, Bacterial / drug therapy; Endocarditis, Bacterial / microbiology; Endocarditis, Bacterial / veterinary; Fatal Outcome; Male
TL;DR: PCR and sequencing provide the first evidence that B. quintana can be pathogenic in dogs, according to a large number of animal studies. (via Semantic Scholar)
Sources: NC State University Libraries, NC State University Libraries, Crossref
Added: August 6, 2018

2006 journal article

Coil occlusion of residual shunts after surgical closure of patent ductus arteriosus

VETERINARY SURGERY, 35(8), 781–785.

By: Y. Fujii n, B. Keene n, K. Mathews n, C. Atkins n, T. Defrancesco n, E. Hardie n, Y. Wakao n

MeSH headings : Animals; Dog Diseases / diagnostic imaging; Dog Diseases / surgery; Dog Diseases / therapy; Dogs; Ductus Arteriosus, Patent / diagnostic imaging; Ductus Arteriosus, Patent / surgery; Ductus Arteriosus, Patent / therapy; Ductus Arteriosus, Patent / veterinary; Echocardiography, Doppler, Color / veterinary; Embolization, Therapeutic / methods; Embolization, Therapeutic / veterinary; Female; Ligation / adverse effects; Ligation / veterinary; Male; Treatment Outcome
TL;DR: Transcatheter coil embolization appears to be a safe and minimally invasive procedure for complete occlusion of residual PDA flow after incomplete surgical ligation and should be considered for correction of hemodynamically significant residual shunts in dogs that have incomplete PDA Occlusion after open surgical ligate. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2006 journal article

Use of a failing rabbit heart as a model to predict torsadogenicity

TOXICOLOGICAL SCIENCES, 93(1), 205–212.

By: A. Kijtawornrat, Y. Nishijima, B. Roche, B. Keene* & R. Hamlin

author keywords: rabbits; torsade de pointes; myocardial failure; myocardial infarction; vulnerability; QT interval
MeSH headings : Amiodarone / pharmacology; Animals; Cardiac Output, Low / physiopathology; Cisapride / pharmacology; Dose-Response Relationship, Drug; Electrocardiography; Models, Animal; Phenethylamines / pharmacology; Quaternary Ammonium Compounds / pharmacology; Quinidine / pharmacology; Rabbits; Sulfonamides / pharmacology; Torsades de Pointes / chemically induced; Torsades de Pointes / physiopathology; Verapamil / pharmacology
TL;DR: Testing the hypothesis that rabbits with ischemic myocardial failure are at similarly increased risk of developing QTc prolongation and TdP following exposure to escalating doses of drugs found that two out of four test articles lengthenedQTc more in rabbits with myocardIAL failure than in normals. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Acute cardiovascular effects of tacrolimus in the isolated guinea pig heart

JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS, 28(3), 313–316.

By: Y. Ozkanlar*, A. Kijtawornrat*, R. Hamlin*, B. Keene n & B. Roche*

MeSH headings : Animals; Dose-Response Relationship, Drug; Guinea Pigs; Heart Conduction System / drug effects; Immunosuppressive Agents / administration & dosage; Immunosuppressive Agents / pharmacology; Male; Tacrolimus / administration & dosage; Tacrolimus / pharmacology
TL;DR: Tacrolimus is an immunosuppressive, macrolide antibiotic frequently used to minimize transplant rejections and has been shown to increase QTc (QT corrected for heart rate) dispersion in patients with kidney transplants, implying a risk for TdP. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2005 journal article

Pathology of end-stage remodeling in a family of cats with hypertrophic cardiomyopathy

VETERINARY PATHOLOGY, 42(4), 458–467.

By: M. Cesta*, C. Baty*, B. Keene n, I. Smoak n & D. Malarkey*

author keywords: burned-out phase; dilated phase; end stage; feline; hypertrophic cardiomyopathy; myocardial fibrosis
MeSH headings : Animals; Cardiomyopathy, Hypertrophic / pathology; Cardiomyopathy, Hypertrophic / veterinary; Cat Diseases / pathology; Cats; Fatal Outcome; Female; Histological Techniques / veterinary; In Situ Nick-End Labeling / veterinary; Male; Myocardium / pathology; Ventricular Remodeling / physiology
TL;DR: The objectives were to describe the pathologic alterations associated with ES-HCM and investigate the pathogenesis in three of the four cats, and to exclude apoptosis or coronary vessel spasm on the basis of the data presented. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2004 journal article

How many cardiac cycles must be measured to permit accurate RR, QT, and QTc estimates in conscious dogs?

Journal of Pharmacological and Toxicological Methods, 50(2), 103–108.

MeSH headings : Animals; Dogs; Electrocardiography / methods; Electrocardiography / statistics & numerical data; Electrocardiography / veterinary; Female; Heart Rate / physiology; Male; Observer Variation; Reproducibility of Results
TL;DR: It is concluded that measurements of RR and QT intervals made by a trained observer from 1 cardiac cycle accurately reflect those that are averaged from 3, 6, or 12 cycles whether the number of dogs per group is 12,6, or 4. (via Semantic Scholar)
Source: Crossref
Added: August 27, 2021

2004 journal article

Recovery of pelvic limb function in dogs following acute intervertebral disc herniations

JOURNAL OF NEUROTRAUMA, 21(1), 49–59.

By: N. Olby n, T. Harris n, J. Burr n, K. Munana n, N. Sharp n & B. Keene n

Contributors: N. Olby n, T. Harris n, J. Burr n, K. Muñana n, N. Sharp n & B. Keene n

author keywords: dog; disc herniation; functional recovery; spinal cord compression; spinal cord trauma
MeSH headings : Animals; Disease Models, Animal; Dogs; Hindlimb / physiopathology; Intervertebral Disc Displacement / complications; Intervertebral Disc Displacement / physiopathology; Lumbosacral Region / physiopathology; Pelvis / pathology; Recovery of Function; Spinal Cord Injuries / etiology; Spinal Cord Injuries / physiopathology; Thoracic Vertebrae / physiopathology
TL;DR: It is concluded that dogs with spontaneous disc herniations provide a useful model of acute spinal cord injury for clinical trials and are suitable for use in clinical trials on neuroprotective drugs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2004 journal article

Sensitivity and specificity of isolated perfused guinea pig heart to test for drug-induced lengthening of QTc

Journal of Pharmacological and Toxicological Methods, 49(1), 15–23.

By: R. Hamlin*, C. Cruze*, S. Mittelstadt*, A. Kijtawornrat*, B. Keene*, B. Roche*, T. Nakayama*, H. Nakayama*, D. Hamlin*, T. Arnold*

MeSH headings : Animals; Dose-Response Relationship, Drug; Drug-Related Side Effects and Adverse Reactions; Electrocardiography / drug effects; Guinea Pigs; Heart / drug effects; Heart / physiopathology; Heart Conduction System / drug effects; Heart Conduction System / physiopathology; In Vitro Techniques; Long QT Syndrome / chemically induced; Male; Models, Biological; Perfusion; Sensitivity and Specificity
TL;DR: The isolated perfused guinea pig heart is an in vitro preparation that could be utilized early in preclinical testing for identifying a liability to lengthen QTc in humans, but it is not believed that the concentration at which the liability is demonstrated in vitro necessarily predicts the concentrations at which a liability exists in man. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: Crossref
Added: August 27, 2021

2003 journal article

Accuracy of heart rate obtained by auscultation in atrial fibrillation

JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 39(3), 237–239.

By: T. Glaus n, M. Hassig n & B. Keene n

MeSH headings : Animals; Atrial Fibrillation / physiopathology; Atrial Fibrillation / veterinary; Chronic Disease; Dog Diseases / physiopathology; Dogs; Heart Auscultation / standards; Heart Auscultation / veterinary; Heart Rate; Male; Observer Variation; Predictive Value of Tests
TL;DR: Auscultatory estimates of heart rate in atrial fibrillation may be significantly inaccurate, and under some circumstances they may not provide a sound basis for making clinical decisions. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 article

Noninvasive transthoracic temporary cardiac pacing in dogs

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 17, pp. 663–667.

By: T. DeFrancesco n, B. Hansen n, C. Atkins n, J. Sidley n & B. Keene n

author keywords: advanced atrioventricular block; bradyarrhythmias; pacemaker; sinus node dysfunction
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2003 journal article

QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles

TOXICOLOGICAL SCIENCES, 76(2), 437–442.

By: R. Hamlin, A. Kijtawornrat, B. Keene & D. Hamlin

author keywords: guinea pig; QT; RR; QTc; anesthesia; electrophysiology
MeSH headings : Anesthesia; Animals; Anti-Arrhythmia Agents / pharmacology; Arrhythmias, Cardiac / physiopathology; Cisapride / pharmacology; Consciousness / physiology; Electrocardiography / methods; Female; Guinea Pigs; Heart / drug effects; Heart / physiology; Heart / physiopathology; Heart Rate / drug effects; Heart Rate / physiology; Ketoconazole / pharmacology; Long QT Syndrome / chemically induced; Long QT Syndrome / physiopathology; Male; Sotalol / pharmacology
TL;DR: QTc lengthened significantly in all conscious guinea pigs given, orally, cisapride, ketoconazole, and sotalol (positive test articles) and did not change with methylcellulose (the vehicle) or with propranolol, verapamil, or enalapril (negative controls). (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Spontaneous resolution of an isolated ventricular septal defect in a dog

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 223(2), 219–220.

By: W. Rausch* & B. Keene*

MeSH headings : Animals; Blood Flow Velocity / veterinary; Dogs / abnormalities; Echocardiography, Doppler, Color / methods; Echocardiography, Doppler, Color / veterinary; Female; Heart Defects, Congenital / diagnosis; Heart Defects, Congenital / veterinary; Heart Septal Defects, Ventricular / diagnosis; Heart Septal Defects, Ventricular / diagnostic imaging; Heart Septal Defects, Ventricular / veterinary
TL;DR: Findings in this dog suggest that interventricular septal defects may close spontaneously in some dogs, a common congenital heart disorder in some breeds of dogs. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Comparison of the effects of four antiarrhythmic treatments for familial ventricular arrhythmias in Boxers

Journal of the American Veterinary Medical Association, 221(4), 522–527.

By: K. Meurs*, A. Spier, N. Wright, C. Atkins*, T. DeFrancesco*, S. Gordon, R. Hamlin, B. Keene* ...

MeSH headings : Animals; Anti-Arrhythmia Agents / pharmacology; Anti-Arrhythmia Agents / therapeutic use; Arrhythmias, Cardiac / drug therapy; Arrhythmias, Cardiac / veterinary; Atenolol / therapeutic use; Dog Diseases / drug therapy; Dogs; Drug Therapy, Combination; Heart Rate; Mexiletine / therapeutic use; Procainamide / therapeutic use; Random Allocation; Sotalol / therapeutic use; Syncope / drug therapy; Syncope / veterinary; Treatment Outcome; Ventricular Premature Complexes / drug therapy; Ventricular Premature Complexes / veterinary
TL;DR: Significant reductions in number of VPC, severity of arrythmia, and maximum and mean HR were observed in dogs treated with mexiletine-atenolol or sotalol; occurrence of syncope was not significantly different between these 2 treatment groups. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Effects of long-term administration of enalapril on clinical indicators of renal function in dogs with compensated mitral regurgitation

Journal of the American Veterinary Medical Association, 221(5), 654–658.

By: C. Atkins n, W. Brown, J. Coats*, M. Crawford, T. DeFrancesco*, J. Edwards, P. Fox, B. Keene* ...

MeSH headings : Angiotensin-Converting Enzyme Inhibitors / adverse effects; Angiotensin-Converting Enzyme Inhibitors / therapeutic use; Animals; Blood Urea Nitrogen; Creatinine / blood; Dog Diseases / drug therapy; Dogs; Enalapril / adverse effects; Enalapril / therapeutic use; Female; Follow-Up Studies; Kidney / drug effects; Kidney Function Tests / veterinary; Male; Mitral Valve Insufficiency / complications; Mitral Valve Insufficiency / drug therapy; Mitral Valve Insufficiency / veterinary; Time Factors
TL;DR: Results suggest that administration of enalapril for up to 2 years did not have any demonstrable adverse effects on renal function in dogs with severe, compensated mitral regurgitation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Hypercalcemia and high parathyroid hormone-related protein concentration associated with malignant melanoma in a dog

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 221(2), 263-+.

By: B. Pressler n, D. Rotstein*, J. Law*, T. Rosol, B. LeRoy, B. Keene*, M. Jackson*

MeSH headings : Animals; Dog Diseases / blood; Dog Diseases / etiology; Dogs; Fatal Outcome; Hypercalcemia / etiology; Hypercalcemia / veterinary; Male; Melanoma / complications; Melanoma / metabolism; Melanoma / veterinary; Mouth Neoplasms / complications; Mouth Neoplasms / metabolism; Mouth Neoplasms / veterinary; Parathyroid Hormone-Related Protein; Proteins / metabolism
TL;DR: A 12-year-old Cocker Spaniel with an oral malignant melanoma was evaluated for progressive lethargy and anorexia, andSerum parathyroid hormone-related protein concentration was markedly high, and the melanoma had moderate to marked immunostaining for this protein. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Percutaneous Balloon Pericardiotomy as a Treatment for Recurrent Pericardial Effusion in 6 Dogs

Journal of Veterinary Internal Medicine, 16(5), 541–546.

By: J. Sidley n, C. Atkins n, B. Keene n & T. DeFrancesco n

author keywords: cardiac tamponade; chemodectoma; heart base tumor; hemangiosarcoma; idiopathic pericardial effusion
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2002 journal article

Percutaneous retrieval of a jugular catheter fragment from the pulmonary artery of a foal

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 220(2), 212–214.

By: D. Little*, B. Keene*, C. Bruton, L. Smith, S. Powell & S. Jones*

MeSH headings : Animals; Catheterization / adverse effects; Catheterization / veterinary; Catheters, Indwelling; Diarrhea / therapy; Diarrhea / veterinary; Foreign-Body Migration / surgery; Horse Diseases / etiology; Horse Diseases / surgery; Horse Diseases / therapy; Horses; Jugular Veins; Male; Pulmonary Artery
TL;DR: This is the first report of successful retrieval of a catheter fragment from the pulmonary artery in a horse, and the owner inadvertently cut the catheter at the level of the hub during attempted removal. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2002 article

Prospective clinical evaluation of serum cardiac troponin T in dogs admitted to a veterinary teaching hospital

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 16, pp. 553–557.

By: T. DeFrancesco n, C. Atkins n, B. Keene n, . Coats n & M. Hauck n

author keywords: cardiomyopathy; congestive heart failure; doxorubicin-induced cardiotoxicity; neoplasia; skeletal muscle trauma
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Development of a functional scoring system in dogs with acute spinal cord injuries

AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(10), 1624–1628.

By: N. Olby n, L. De Risio, K. Munana*, M. Wosar, T. Skeen*, N. Sharp, B. Keene*

Contributors: N. Olby n, L. De Risio, K. Muñana*, M. Wosar, T. Skeen*, N. Sharp, B. Keene*

MeSH headings : Animals; Dog Diseases / physiopathology; Dogs; Gait / physiology; Hindlimb / physiopathology; Intervertebral Disc Displacement / physiopathology; Intervertebral Disc Displacement / veterinary; Observer Variation; Paraplegia / etiology; Paraplegia / veterinary; Reproducibility of Results; Severity of Illness Index; Spinal Cord Diseases / complications; Spinal Cord Diseases / physiopathology; Spinal Cord Diseases / veterinary; Statistics, Nonparametric; Videotape Recording
TL;DR: Pelvic limb gait of dogs recovering from thoracolumbar spinal cord injuries can be reliably quantified, using a numeric scale, and this scale will facilitate the performance of clinical trials aimed at improving the outcome of acute spinal Cord injuries. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018

2001 journal article

Metabolic and structural abnormalities in dogs with early left ventricular dysfunction induced by incessant tachycardia

AMERICAN JOURNAL OF VETERINARY RESEARCH, 62(6), 889–894.

By: K. Mc Entee n, T. Flandre n, C. Dessy n, D. Desmecht n, C. Clercx n, M. Balligand n, C. Michaux n, E. Jonville n ...

MeSH headings : Animals; Biopsy / veterinary; Carnitine / blood; Carnitine / metabolism; Dog Diseases / etiology; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Histocytochemistry / veterinary; Male; Microscopy, Electron / veterinary; Myocardium / metabolism; Myocardium / pathology; Myocardium / ultrastructure; Tachycardia / etiology; Tachycardia / pathology; Tachycardia / veterinary; Ventricular Dysfunction, Left / etiology; Ventricular Dysfunction, Left / metabolism; Ventricular Dysfunction, Left / pathology; Ventricular Dysfunction, Left / veterinary
TL;DR: Moderate to severe alterations in myocyte cytoarchitecture are present in dogs with ELVD induced by RRVP and that in Dogs with normal plasma carnitine concentrations, myocardial carnitines deficiency may be a biochemical marker of ELVD. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Natural history of hypertrophic cardiomyopathy and aortic thromboembolism in a family of domestic shorthair cats

JOURNAL OF VETERINARY INTERNAL MEDICINE, 15(6), 595–599.

By: C. Baty n, D. Malarkey n, C. Atkins n, T. DeFrancesco n, J. Sidley n & B. Keene n

author keywords: cardiac myocyte disarray; end stage; spontaneous echo contrast; systolic function; ventricular remodeling
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2001 journal article

Use of echocardiography for the diagnosis of heartworm disease in cats: 43 cases (1985-1997)

Journal of the American Veterinary Medical Association, 218(1), 66–69.

By: T. DeFrancesco n, C. Atkins*, M. Miller, K. Meurs* & B. Keene*

MeSH headings : Animals; Antibodies, Helminth / analysis; Antigens, Helminth / analysis; Cat Diseases / diagnostic imaging; Cat Diseases / parasitology; Cats; Dirofilaria immitis / immunology; Dirofilaria immitis / isolation & purification; Dirofilariasis / diagnostic imaging; Echocardiography / veterinary; Pulmonary Artery / diagnostic imaging; Pulmonary Artery / pathology; Radiography, Thoracic / veterinary; Retrospective Studies
TL;DR: Although echocardiography was less sensitive than antigen testing, it was a useful adjunctive test in cats that had negative antigen test results in which there was a suspicion of heartworm disease. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2000 journal article

Heartworm infection in cats: 50 cases (1985-1997)

JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 217(3), 355–358.

By: C. Atkins n, T. DeFrancesco n, . Coats n, J. Sidley n & B. Keene n

MeSH headings : Animals; Cat Diseases / diagnosis; Cat Diseases / epidemiology; Cats; Dirofilariasis / diagnosis; Dirofilariasis / epidemiology; Female; Male; Prognosis; Retrospective Studies; Risk Factors; Survival Analysis
TL;DR: Findings suggested that male cats were not predisposed to HWI, domestic shorthair cats were at increased risk, and indoor housing was only partially protective, while sex does not appear to be a risk factor for HWI in cats. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 article

Towards evidence-based veterinary medicine

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 14, pp. 118–119.

By: B. Keene n

MeSH headings : Animals; Controlled Clinical Trials as Topic; Evidence-Based Medicine / trends; Quality Control; Randomized Controlled Trials as Topic; Research Design; Veterinary Medicine / trends
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

A polymerase chain reaction screening strategy for the promoter of the canine dystrophin gene

American Journal of Veterinary Research, 60(9), 1040–1046.

By: S. Schatzberg, N. Olby, S. Steingold, B. Keene, C. Atkins, K. Meurs, G. Solomon, S. Goedegebuure, S. Wilton, N. Sharp

Source: NC State University Libraries
Added: August 6, 2018

1999 journal article

ECG changes after rabbit coronavirus infection

JOURNAL OF ELECTROCARDIOLOGY, 32(1), 21–32.

By: L. Alexander*, B. Keene*, B. Yount*, J. Geratz n, J. Small* & R. Baric*

author keywords: coronavirus; myocarditis; heart failure; ECG
MeSH headings : Animals; Atrioventricular Node / pathology; Atrioventricular Node / physiopathology; Cardiomyopathy, Dilated / etiology; Cardiomyopathy, Dilated / pathology; Cardiomyopathy, Dilated / physiopathology; Coronavirus Infections / complications; Coronavirus Infections / pathology; Coronavirus Infections / physiopathology; Death, Sudden, Cardiac; Disease Models, Animal; Electrocardiography; Follow-Up Studies; Male; Myocarditis / complications; Myocarditis / physiopathology; Myocarditis / virology; Rabbits
TL;DR: The ECG changes observed during RbCV infection are similar to the spectrum of interval/segment abnormalities, rhythm disturbances, conduction defects, and myocardial pathology seen in human myocarditis, heart failure, and dilated cardiomyopathy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Prevalence of heartworm infection in cats with signs of cardiorespiratory abnormalities

Journal of the American Veterinary Medical Association, 212(4), 517–520.

By: C. Atkins, T. DeFrancesco, M. Miller, K. Meurs & B. Keene

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Asystole associated with iohexol myelography in a dog

VETERINARY RADIOLOGY & ULTRASOUND, 38(4), 284–287.

By: G. Carroll, B. Keene n & L. Forrest*

author keywords: iohexol; myelogram; asystole
MeSH headings : Animals; Contrast Media / adverse effects; Dog Diseases / chemically induced; Dogs; Electrocardiography / veterinary; Female; Heart Arrest / chemically induced; Heart Arrest / diagnosis; Heart Arrest / veterinary; Iohexol / adverse effects; Myelography / adverse effects; Myelography / veterinary
TL;DR: This is a report of a 10-year-old female neutered Doberman Pinscher with a clinical diagnosis of myelopathy who was anesthetized using oxymorphone, thiopental, and halothane in oxygen for a cerebrospinal tap and a myelogram and recovered uneventfully from surgery. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1997 article

Results of the Multicenter Spaniel Trial (MUST): Taurine- and carnitine-responsive dilated cardiomyopathy in American cocker spaniels with decreased plasma taurine concentration

JOURNAL OF VETERINARY INTERNAL MEDICINE, Vol. 11, pp. 204–211.

By: M. Kittleson*, B. Keene n, P. Pion*, C. Loyer*, A. Beardow, D. Knight, J. Bonagura, D. Burgener ...

MeSH headings : Administration, Oral; Analysis of Variance; Animals; Breeding; Cardiomyopathy, Dilated / blood; Cardiomyopathy, Dilated / drug therapy; Cardiomyopathy, Dilated / veterinary; Carnitine / administration & dosage; Carnitine / blood; Carnitine / therapeutic use; Dog Diseases / blood; Dog Diseases / drug therapy; Dog Diseases / pathology; Dogs; Echocardiography / methods; Echocardiography / veterinary; Electrocardiography / methods; Electrocardiography / veterinary; Female; Male; Mitral Valve Insufficiency / mortality; Mitral Valve Insufficiency / physiopathology; Mitral Valve Insufficiency / veterinary; Myocardium / chemistry; Myocardium / pathology; Single-Blind Method; Taurine / administration & dosage; Taurine / blood; Taurine / therapeutic use
TL;DR: Whereas myocardial function did not return to normal in most dogs, it did improve enough to allow discontinuation of cardiovascular drug therapy and to maintain a normal quality of life for months to years. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

1996 journal article

Management of canine dilated cardiomyopathy

Canine Practice (Santa Barbara, Calif. : 1990), 21(1), 27.

By: B. Keene

Source: NC State University Libraries
Added: August 6, 2018

1991 journal article

ECG of the month

Journal of the American Veterinary Medical Association, 198(3), 408.

By: B. Keene & K. Flammer

Source: NC State University Libraries
Added: August 6, 2018

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