Bohua Zhang

Also known as: Bohua Zhang

Ultrasound, Transducers, Magnetic microbubbles, Thrombolysis

Works (41)

Updated: October 22nd, 2024 09:42

2024 journal article

Rotational Intravascular Multidirectional Ultrasound Catheter for Sonothrombolysis of Retracted Clots: An in Vitro and in Vivo Study

Engineering.

By: H. Wu  n, J. Kim *, B. Zhang n , G. Owens *, G. Stocker *, M. Chen  n, B. Kreager n, A. Cornett * ...

Source: ORCID
Added: September 15, 2024

2023 conference paper

A Miniaturized Transducer for Sonothrombolysis with Vortex Phase Modulation

IEEE International Ultrasonics Symposium, IUS.

By: J. Wang  n, H. Wu  n, B. Zhang n , M. Chen  n, S. Shovon n, H. Ware  n, X. Jiang  n

Contributors: J. Wang  n, H. Wu  n, B. Zhang n , M. Chen  n, S. Shovon n, H. Ware  n, X. Jiang  n

Source: ORCID
Added: September 15, 2024

2023 journal article

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

RESEARCH, 6, 1–13.

By: B. Zhang n , H. Wu n, H. Kim  n, P. Welch *, A. Cornett *, G. Stocker *, R. Nogueira *, J. Kim* ...

Contributors: B. Zhang n , H. Wu n, H. Kim  n, P. Welch *, A. Cornett *, G. Stocker *, R. Nogueira *, J. Kim* ...

UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 5, 2023

2023 journal article

Development of a Wearable Ultrasound Transducer for Sensing Muscle Activities in Assistive Robotics Applications

BIOSENSORS-BASEL, 13(1).

By: X. Xue n, B. Zhang n , S. Moon n, G. Xu *, C. Huang *, N. Sharma n , X. Jiang n

Contributors: X. Xue n, B. Zhang n , S. Moon n, G. Xu *, C. Huang *, N. Sharma n , X. Jiang n

author keywords: wearable ultrasound transducer; flexible ultrasound transducer; muscle movement; robotic prosthesis; powered exoskeleton; ultrasound imaging
MeSH headings : Animals; Swine; Robotics; Ultrasonography; Muscles; Transducers; Wearable Electronic Devices
UN Sustainable Development Goal Categories
Sources: ORCID, Web Of Science, NC State University Libraries
Added: January 16, 2023

2023 article

Intravascular sonothrombolysis with nanobubbles : <i>in</i>-<i>vitro</i> study

2023 IEEE 23RD INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY, NANO, pp. 376–379.

By: H. Wu n, B. Kreager n, M. Chen n, B. Zhang n , E. Abenojar *, A. Exner *, X. Jiang n

Contributors: H. Wu n, B. Kreager n, M. Chen n, B. Zhang n , E. Abenojar *, A. Exner *, X. Jiang n

author keywords: Micro/Nano-bubble mixture; Sonothrombolysis
TL;DR: An innovative method utilizing a stacked transducer for intravascular sonothrombolysis for higher lysis efficiency, employing a mixture of nanobubbles (NB) and microbubbles (MB) serves to enhance cavitation and improve the breakdown of clot structures. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 23, 2023

2023 review

Magnetic Nanoparticles Mediated Thrombolysis-A Review

[Review of ]. IEEE OPEN JOURNAL OF NANOTECHNOLOGY, 4, 109–132.

By: B. Zhang n  & X. Jiang n

Contributors: B. Zhang n  & X. Jiang n

author keywords: Magnetic fields; Magnetic nanoparticles; Drugs; Magnetic resonance imaging; Magnetic shielding; Magnetic noise; Coagulation; magnetic microbubbles; thrombolysis; thrombolytic agents; sonothrombolysis; magneto-sonothrombolysis
TL;DR: This study examines the current state of magnetic nanoparticles in the application of in vitro and in vivo thrombolysis under a static or dynamic magnetic field, as well as the combination of Magnetic nanoparticles with an acoustic field for dual-mode throm bolysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 5, 2023

2023 journal article

Miniaturized Stacked Transducer for Intravascular Sonothrombolysis With Internal-Illumination Photoacoustic Imaging Guidance and Clot Characterization

IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 70(8), 2279–2288.

By: H. Wu n, Y. Tang *, B. Zhang n , P. Klippel*, Y. Jing *, J. Yao *, X. Jiang n

Contributors: H. Wu n, Y. Tang *, B. Zhang n , P. Klippel*, Y. Jing *, J. Yao *, X. Jiang n

author keywords: Intravascular ultrasound transducer; sonothrombolysis; deep tissue imaging; functional imaging; photoacoustic imaging; internal illumination
TL;DR: The findings have demonstrated the feasibility of the proposed PAT-guided intravascular sonothrombolysis with real-time feedback during the treatment process and the treatment efficiency for clinical application may not be optimized. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: February 1, 2023

2023 article

Quantitative characterization of the ultrasound thermal strains in tissue mimicking phantoms with different oil concentrations

Sheng, Z., Wei, R., Chen, M., Zhang, B., Kim, H., Geng, X., … Kim, K. (2023, March). JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA, Vol. 153.

By: Z. Sheng *, R. Wei *, M. Chen n, B. Zhang n , H. Kim  n, X. Geng *, X. Jiang n, K. Kim *

TL;DR: An ultrasound transducer that combines an acoustic heating array and an imaging array to achieve US-TSI with heating performed in a region of approximately 10 mm by 5 mm by 2 mm within a very short time period of about 50 ms compared both cardiac and breathing motions is developed. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: September 5, 2023

2023 journal article

Vortex-ultrasound for microbubble-mediated thrombolysis of retracted clots

APPLIED PHYSICS LETTERS, 123(7).

By: H. Kim  n, B. Zhang n , H. Wu n, J. Yao *, C. Shi * & X. Jiang n

Contributors: H. Kim  n, B. Zhang n , H. Wu n, J. Yao *, C. Shi * & X. Jiang n

TL;DR: The use of endovascular vortex ultrasound holds promise as a potential clinical option for the thrombolysis of retracted clots due to its potential to induce shear stress and enhance the clot lysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 5, 2023

2022 article

A Dual-Frequency Intravascular Ultrasound Transducer for Amplified Nanodroplet Vaporization Effects in Cavitation-Enhanced Sonothrombolysis

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: S. Moon n, H. Wu n, B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n

author keywords: Intravascular transducer; dual-frequency thrombolysis; Nanodroplets
TL;DR: A dual-frequency intravascular transducer intended for nanodroplet-specific sonothrombolysis was developed to improve clot mass reduction rate while retaining lower acoustic pressures than the typical nanODroplet vaporization threshold at sub-megahertz excitation (> 5 MPa). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

A Laser-Coupled Dual Excitation Intravascular Ultrasound Transducer for Sonothrombolysis

2022 IEEE NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE, NMDC, pp. 37–40.

By: B. Zhang n , H. Wu n & X. Jiang n

Contributors: B. Zhang n , H. Wu n & X. Jiang n

author keywords: laser ultrasound; carbon nanoparticles; ultrasound transducer; sonothrombolysis; catheter ultrasound
TL;DR: In this paper, a miniaturized dual excitation laser-coupled intravascular ultrasound transducer with both a piezoelectric stack and a laser ultrasoundTransducer, which can generate a low-frequency and high-frequencyDual excitation waves for thrombolysis is introduced. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 30, 2023

2022 article

A Model of High-Speed Endovascular Sonothrombolysis with Vortex Ultrasound-Induced Shear Stress to Treat Cerebral Venous Sinus Thrombosis

BioRxiv.

By: B. Zhang n , H. Wu  n, H. Kim  n, P. Welch *, A. Cornett *, G. Stocker *, R. Nogueira *, J. Kim * ...

Contributors: B. Zhang n , H. Wu  n, H. Kim  n, P. Welch *, A. Cornett *, G. Stocker *, R. Nogueira *, J. Kim * ...

Source: ORCID
Added: September 15, 2024

2022 article

A multi-directional transducer array for muscle shear wave anisotropy estimation

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: H. Wu n, B. Zhang n , G. Xu *, C. Huang * & X. Jiang n

author keywords: Multi-direction array; shear wave ultrasound imaging
TL;DR: A novel star-shape transducer array designed and fabricated in order to measure SWV for exploring the anisotropic properties of muscles showed a great potential in assessment of tissue anisotropy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery

Tang, Y., Wu, H., Klippel, P., Zhang, B., Huang, H.-Y. S., Jing, Y., … Yao, J. (2022, February 16). BIOMEDICAL ENGINEERING LETTERS, Vol. 12.

By: Y. Tang *, H. Wu n, P. Klippel*, B. Zhang n , H. Huang n , Y. Jing *, X. Jiang n, J. Yao *

Contributors: Y. Tang *, H. Wu n, P. Klippel*, B. Zhang n , H. Huang  n, Y. Jing *, X. Jiang n, J. Yao *

author keywords: Thrombosis; Photoacoustic tomography; Internal light illumination; Photoacoustic frequency; Retracted blood clot; Unretracted blood clot; Blood oxygenation
TL;DR: The results show that, with intravascular light delivery, clot oxygenation level can be accurately measured, and the clot age can thus be estimated, and it is found that retracted and unretracted clots had different acoustic frequency spectrum. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 7, 2022

2022 article

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery

ResearchSquare.

By: Y. Tang, H. Wu, P. Klippel, B. Zhang , H. Huang, Y. Jing, X. Jiang, J. Yao

Contributors: Y. Tang, H. Wu, P. Klippel, B. Zhang , H. Huang, Y. Jing, X. Jiang, J. Yao

Source: ORCID
Added: January 24, 2023

2022 article

Deep thrombosis characterization using photoacoustic imaging with intravascular light delivery

Research Square.

By: Y. Tang *, H. Wu  n, P. Klippel, B. Zhang n , H. Huang  n, Y. Jing, X. Jiang  n, J. Yao *

Contributors: Y. Tang *, H. Wu  n, P. Klippel, B. Zhang n , H. Huang  n, Y. Jing, X. Jiang  n, J. Yao *

Source: ORCID
Added: September 15, 2024

2022 article

Development of a wearable ultrasound transducer for sensing muscle activities in assistive robotics applications: In vivo study

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: X. Xue n, B. Zhang n , S. Moon n, G. Xu *, C. Huang *, N. Sharma n , X. Jiang n

author keywords: ultrasound transducers; wearable transducers; flexible transducers; muscle activities detection
TL;DR: This work aims to develop a novel wearable US device for detecting muscle activities, designed, fabricated, and characterized, and the feasibility of monitoring muscle activity in different regions was demonstrated by an in vivo human experiment. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Integration of Forward-viewing and Side-viewing Ultrasound Transducers in an Intravascular Sonothrombolysis Catheter

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: B. Zhang n , H. Wu n, J. Kim*, P. Dayton*, Z. Xu * & X. Jiang n

author keywords: ultrasound transducers; microbubbles; thrombus; thrombolysis; sonothrombolysis
TL;DR: The combination of forward and side-viewing (FSV) ultrasound waves is expected to extend the treatment region and improve thrombolysis efficiency compared to a forward or side-Viewing alone sonication. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Intracorporeal Sonoporation-Induced Drug/Gene Delivery Using a Catheter Ultrasound Transducer

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: M. Chen n, H. Kim  n, B. Zhang n , W. Yang n, T. Osada *, E. Crosby *, H. Lyerly *, X. Jiang n

Contributors: M. Chen n, H. Kim  n, B. Zhang n , W. Yang n, T. Osada *, E. Crosby *, H. Lyerly *, X. Jiang n

author keywords: cancer immunotherapy; drug delivery; gene delivery; intracorporeal sonoporation; catheter ultrasound transducer; intratumoral immunotherapy
TL;DR: The LUC assay demonstrated a significantly enhanced transfection, indicating the developed catheter transducer is promising for intracorporeal sonoporation-induced drug/gene delivery, such as intratumoral immunotherapy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: February 6, 2023

2022 article

Millisecond-Level Transient Temperature Monitoring Using an Ultra-Fast Response Thermocouple for Ultrasound-Induced Thermal Strain Imaging

2022 IEEE INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS).

By: M. Chen n, B. Zhang n , H. Kim  n, Z. Sheng, Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

author keywords: ultrasound-induced thermal strain imaging; ultra-fast response thermocouple; transient temperature monitoring
TL;DR: The proposed method is capable of monitoring transient temperature rise in biological tissue for US- TSI and obvious transient temperature rises within 50 ms can be observed for both laser tests and tissue tests. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: February 6, 2023

2022 article

Ultrasound and magnetic dual-mode stacked transducer for sonothrombolysis with a combination of nanodroplets and magnetic nanoparticles

2022 IEEE 22ND INTERNATIONAL CONFERENCE ON NANOTECHNOLOGY (NANO), pp. 71–74.

By: B. Zhang n , H. Wu n & X. Jiang n

Contributors: B. Zhang n , H. Wu n & X. Jiang n

TL;DR: A 4-element stacked transducer with a center frequency of 450 kHz, which can create ultrasonic waves in addition to a high frequency oscillating magnetic field to activate the superparamagnetic iron oxide nanoparticles (SPIONs) and nanodroplets is demonstrated. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries, ORCID
Added: December 12, 2022

2022 journal article

Ultrasound-Guided Intravascular Sonothrombolysis With a Dual Mode Ultrasound Catheter: In Vitro Study

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 69(6), 1917–1925.

By: H. Wu n, B. Zhang n , C. Huang *, C. Peng *, Q. Zhou * & X. Jiang n

Contributors: H. Wu n, B. Zhang n , C. Huang *, C. Peng *, Q. Zhou * & X. Jiang n

author keywords: Imaging-guided sonothombolysis; intravascular ultrasound transducer; ultrasound imaging
MeSH headings : Animals; Catheters; Cattle; Thromboembolism; Thrombosis / therapy; Transducers; Ultrasonography / methods; Ultrasonography, Interventional
TL;DR: The findings suggest that the proposed ultrasound-guided intravascular sonothrombolysis can be enhanced since the position of treatment transducer can be adjusted with the target at the clot due to the imaging guide. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 13, 2022

2021 journal article

A multi-pillar piezoelectric stack transducer for nanodroplet mediated intravascular sonothrombolysis

ULTRASONICS, 116.

By: H. Kim n , J. Kim n, H. Wu n, B. Zhang n , P. Dayton n & X. Jiang n

Contributors: H. Kim n , J. Kim n, H. Wu n, B. Zhang n , P. Dayton n & X. Jiang n

author keywords: Intravascular transducer; Sonothrombolysis; Nanodroplet; Piezoelectric stack; Small aperture
TL;DR: The ND-mediated intravascular sonothrombolysis using MPPS transducers was demonstrated with an unprecedented lysis rate, which may offer a new clinical option for DVT treatments. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 16, 2021

2021 article

Design and Simulation of Heating Transducer Arrays for Ultrasound-Induced Thermal Strain Imaging

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: M. Chen n, Z. Sheng *, H. Kim  n, B. Zhang n , Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

Contributors: M. Chen n, Z. Sheng *, H. Kim  n, B. Zhang n , Q. Chen *, K. Kim *, X. Geng *, X. Jiang n

author keywords: ultrasound-induced thermal strain imaging; atherosclerosis plaque; dual 1.5D heating arrays; dual-focus beamforming
TL;DR: The acoustic and thermal simulation results demonstrated that the designed dual heating arrays can induce a 2.1 °C temperature rise within 50 ms in a volume of 2 × 10 × 10 mm3(in terms of full width at half maximum, FWHM). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 15, 2022

2021 journal article

Dual-Frequency Intravascular Sonothrombolysis: An In Vitro Study

IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL, 68(12), 3599–3607.

By: H. Wu n, L. Goel n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n

Contributors: H. Wu n, L. Goel n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n

author keywords: Transducers; Acoustics; Ultrasonic imaging; Frequency measurement; Frequency control; Impedance; Broadband communication; Dual-frequency thrombolysis; intravascular ultrasound transducer; passive cavitation; sonothrombolysis
MeSH headings : Acoustics; Contrast Media; Microbubbles; Transducers; Ultrasonic Therapy
TL;DR: A new broadband intravascular transducer is developed and tests indicated that the MB-mediated, dual-frequency (750+500 kHz) sonothrombolysis yields an 85% higher lysis rate compared with the single-frequency treatment, and the lysis Rate increases with the difference between the two frequency components. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 24, 2021

2021 article

Intravascular Dual-frequency Ultrasound Transducer Using a Stack Composite

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: H. Wu n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n

Contributors: H. Wu n, H. Kim n , B. Zhang n , J. Kim*, P. Dayton*, Z. Xu *, X. Jiang n

author keywords: Intravascular transducer; dual-frequency thrombolysis; sonothrombolysis; ultrasound catheter
TL;DR: An intravascular ultrasound transducer with a composite structure is reported, which can operate with the dual-frequency condition for enhancing the cavitation effect of infused contrast agents and showed a 34% improvement in the lysis rate when theDual-frequency excitation was applied with the nanodroplets infusion. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 15, 2022

2021 article

Laser beam guided magnetic scanning catheter for sonothrombolysis with real-time clot detection

INTERNATIONAL ULTRASONICS SYMPOSIUM (IEEE IUS 2021).

By: B. Zhang n , H. Wu n & X. Jiang n

Contributors: B. Zhang n , H. Wu n & X. Jiang n

author keywords: ultrasound transducers; microbubbles; magnetic catheter; thrombolysis; sonothrombolysis
TL;DR: A novel magnetically driven scanning catheter device that integrates a stacked transducer, a tiny ring magnet, and fiber-optic laser sensors for clot spot tracking during the thrombolysis process is reported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 15, 2022

2021 journal article

Magneto-sonothrombolysis with combination of magnetic microbubbles and nanodroplets

ULTRASONICS, 116.

By: B. Zhang n , H. Wu n, L. Goel n, H. Kim n , C. Peng n, J. Kim n, P. Dayton n, Y. Gao *, X. Jiang n

Contributors: B. Zhang n , H. Wu n, L. Goel n, H. Kim n , C. Peng n, J. Kim n, P. Dayton n, Y. Gao *, X. Jiang n

author keywords: Magnetic microbubbles; Magnetic nanoparticles; Nanodroplets; Sonothrombolysis; Cavitation
TL;DR: It is demonstrated that tPA-mediated magneto-sonothrombolysis in combining NDs with MMBs could significantly enhance in vitro lysis of both unretracted clots and retracted clots in a flow model with 30 min treatment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 23, 2021

2021 article

Miniaturized Dual-Mode Intravascular Transducer for Sonothrombolysis

2021 IEEE 16TH NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE (NMDC 2021).

By: B. Zhang n , H. Wu n & X. Jiang n

Contributors: B. Zhang n , H. Wu n & X. Jiang n

author keywords: laser ultrasound; carbon nanoparticles; ultrasound transducer; sonothrombolysis; catheter ultrasound
TL;DR: A miniaturized dual-mode ultrasound transducer with piezoelectric stacks and a laser ultrasoundTransducer is presented, which combines a low-frequency tone burst sonication and a high-frequency laser ultrasound pulse excitation to achieve intravascular sonothrombolysis with enhanced thrombectomy efficiency and safety. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 2, 2022

2021 journal article

Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots

MICROSYSTEMS & NANOENGINEERING, 7(1).

By: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

Contributors: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

TL;DR: For the first time, it is demonstrated that a sub-megahertz, forward-viewing intravascular (FVI) transducer can be used for ND-mediated sonothrombolysis, in vitro and combined nanodroplet with tPA-mediatedSonothromBolysis was able to significantly enhance retracted clot lysis in retracted blood clots. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 15, 2021

2021 journal article

SAFETY EVALUATION OF A FORWARD-VIEWING INTRAVASCULAR TRANSDUCER FOR SONOTHROMBOLYSIS: AN IN VITRO AND EX VIVO STUDY

ULTRASOUND IN MEDICINE AND BIOLOGY, 47(11), 3231–3239.

By: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

Contributors: L. Goel n, H. Wu n, B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

author keywords: Intravascular sonothrombolysis; Safety; Retracted clots; Nanodroplets; Microbubbles; Ultrasound-assisted thrombolysis; Tissue plasminogen activator
MeSH headings : Animals; Microbubbles; Particle Size; Thrombolytic Therapy; Thrombosis / therapy; Tissue Plasminogen Activator; Transducers; Ultrasonic Therapy
TL;DR: In vitro and ex vivo tests using FVI transducers revealed a temperature rise of less than 1°C, no vessel damage as assessed by histology and no downstream clot particles >500 µm, which indicates that the F VI transducer poses minimal risk for sonothrombolysis applications and should be further evaluated in animal models. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 26, 2021

2021 article

Ultrasound Imaging-Guided Microbubble-Mediated Catheter-Directed Sonothrombolysis: An In-Vitro Study

2021 IEEE 16TH NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE (NMDC 2021).

By: C. Peng n, B. Zhang n , H. Wu n, P. Dayton n, Z. Xu * & X. Jiang n

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2021 article

Ultrasound and Magnetic Dual-Mode Stacked Transducer for High-Frequency Magneto- Sonothrombolysis

2021 IEEE 16TH NANOTECHNOLOGY MATERIALS AND DEVICES CONFERENCE (NMDC 2021).

By: B. Zhang n , H. Wu n & X. Jiang n

Contributors: B. Zhang n , H. Wu n & X. Jiang n

author keywords: microbubbles; magnetic nanoparticle; ultrasound transducer; sonothrombolysis
TL;DR: The results showed that the combined effects of localized hyperthermia from the high-frequency oscillation of SPIONs and mechanical shock waves from ultrasound could effectively enhance the tPA-mediated sonothrombolysis efficacy. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 2, 2022

2020 conference paper

Dual-frequency intravascular thrombolysis with miniaturized forward-looking transducers

IEEE International Ultrasonics Symposium, IUS, 2020-September.

By: H. Wu  n, L. Goel  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

Contributors: H. Wu  n, L. Goel  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

TL;DR: The results indicated that the dual-frequency treatment had a 18% higher thrombolysis rate with an increasing trend when the difference between two frequency components increased. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 24, 2023

2020 journal article

EXAMINING THE INFLUENCE OF LOW-DOSE TISSUE PLASMINOGEN ACTIVATOR ON MICROBUBBLE-MEDIATED FORWARD-VIEWING INTRAVASCULAR SONOTHROMBOLYSIS

ULTRASOUND IN MEDICINE AND BIOLOGY, 46(7), 1698–1706.

By: L. Goel n, H. Wu n, H. Kim n , B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

Contributors: L. Goel n, H. Wu n, H. Kim n , B. Zhang n , J. Kim n, P. Dayton n, Z. Xu *, X. Jiang n

author keywords: Sonothrombolysis; Intravascular sonothrombolysis; Microbubble-mediated sonothrombolysis; Clot lysis; Tissue plasminogen activator
MeSH headings : Animals; Cattle; Combined Modality Therapy; Mechanical Thrombolysis / methods; Microbubbles / therapeutic use; Thrombolytic Therapy / methods; Thrombosis / drug therapy; Thrombosis / therapy; Tissue Plasminogen Activator / administration & dosage; Tissue Plasminogen Activator / therapeutic use; Ultrasonic Therapy / methods
TL;DR: Changes in stable and inertial cavitation doses were observed, corresponding to changes in clot lysis in MB-mediated FVI sonothrombolysis with and without tPA. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: July 20, 2020

2020 conference paper

Laser Sensor Guided Intravascular Catheter with Ring Type Stack Transducer for Sonothrombolysis

IEEE International Ultrasonics Symposium, IUS, 2020-September.

By: B. Zhang n , H. Wu  n, L. Goel  n & X. Jiang  n

Contributors: B. Zhang n , H. Wu  n, L. Goel  n & X. Jiang  n

TL;DR: A novel sonothrombolysis catheter device that incorporates a ring-type stack transducer and optical fiber-based laser sensor for clot detection and treatment and showed about two-fold significantly improved lysis rate for both unretracted and retracted clot compare to the control group. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Source: ORCID
Added: January 24, 2023

2020 conference paper

Nanodroplet mediated intravascular sonothrombolysis of retracted clots

IEEE International Ultrasonics Symposium, IUS, 2020-September.

By: L. Goel  n, H. Wu  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

Contributors: L. Goel  n, H. Wu  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

TL;DR: The forward-viewing intravascular transducer was demonstrated, for the first time, for sonothrombolysis in a retracted clot model by combining NDs and tPA. (via Semantic Scholar)
Source: ORCID
Added: January 24, 2023

2020 conference paper

Nanodroplet-mediated intravascular sonothrombolysis: Cavitation study

Proceedings of the IEEE Conference on Nanotechnology, 2020-July, 185–188.

By: L. Goel  n, H. Wu  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

Contributors: L. Goel  n, H. Wu  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

TL;DR: The purpose of this study was to demonstrate the feasibility of using nanodroplets with the small aperture intravascular transducers, which would allow access to a wide range of locations, and to demonstrate that it was feasible to deliver nanodrplets mediated sonothrombolysis using the smallperture intrav vascular transducers. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: ORCID
Added: January 24, 2023

2019 conference paper

Intravascular Sonothrombolysis, in vitro, Using a Small Aperture, Forward-Viewing, Sub-Megahertz Transducer to Enhance tPA Treatment

IEEE International Ultrasonics Symposium, IUS, 2019-October, 2034–2036.

By: L. Goel  n, H. Wu  n, H. Kim  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

Contributors: L. Goel  n, H. Wu  n, H. Kim  n, B. Zhang n , J. Kim  n, P. Dayton  n, Z. Xu *, X. Jiang  n

TL;DR: It is demonstrated that a forward-viewing intravascular transducer can be used to enhance tPA mediated sonothrombolysis and is comparable to microbubble mediated sonothermolysis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: ORCID
Added: January 24, 2023

2019 journal article

Sonothrombolysis with magnetic microbubbles under a rotational magnetic field

ULTRASONICS, 98, 62–71.

By: B. Zhang n , H. Kim n , H. Wu n, Y. Gao * & X. Jiang n

Contributors: B. Zhang n , H. Kim n , H. Wu n, Y. Gao * & X. Jiang n

author keywords: Magnetic microbubbles; Magnetic nanoparticle; Thrombolysis; Sonothrombolysis; Cavitation
TL;DR: A new method using the rotational magnetic field to trap and vibrate magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically significantly enhances in vitro lysis of blood clot. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: September 9, 2019

2018 conference paper

Ultrasound thrombolysis with magnetic microbubbles under a rotational magnetic field

2018 IEEE 13th Nanotechnology Materials and Devices Conference, NMDC 2018.

By: B. Zhang n , X. Jiang  n & H. Wu  n

Contributors: B. Zhang n , X. Jiang  n & H. Wu  n

TL;DR: A new method using the rotational magnetic field to trap and vibrate the magnetic microbubbles at target clot region and then using an intravascular forward-looking ultrasound transducer to activate them acoustically to improve the sonothrombolysis treatment efficiency is reported. (via Semantic Scholar)
Source: ORCID
Added: January 24, 2023

Employment

Updated: May 24th, 2023 10:30

2023 - present

SHENQI MEDICAL (USA) SIRIUS TECHNOLOGY LTD. Sudbury, Massachusetts, US
Research Scientist

Education

Updated: May 24th, 2023 10:28

2014 - 2023

NC State University Raleigh, NC, US
Ph.D Candidate Mechanical and Aerospace Engineering

2012 - 2014

George Washington University Washington, DC, US
Master of Science Mechanical and Aerospace Engineering

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