Works (5)

Updated: July 5th, 2023 15:43

2016 journal article

Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells


By: C. Fromen n, T. Rahhal*, G. Robbins*, M. Kai n, T. Shen*, J. Luft*, J. DeSimone n

author keywords: Nanoparticle; Lung; Dendritic cell; Pulmonary drug delivery; Vaccine
TL;DR: The interaction of nanoparticles with various types of lung antigen presenting cells is investigated in an attempt to understand the cellular mechanisms that explain the increased efficacy of cationic formulations as a pulmonary vaccine carrier. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Tumor Presence Induces Global Immune Changes and Enhances Nanoparticle Clearance

ACS NANO, 10(1), 861–870.

By: M. Kai n, H. Brighton, C. Fromen n, T. Shen, J. Luft, Y. Luft, A. Keeler, G. Robbins ...

author keywords: nanoparticle; orthotopie; pharmacokinetic; immunology; intravital
MeSH headings : Animals; Antineoplastic Agents / chemistry; Antineoplastic Agents / pharmacokinetics; Antineoplastic Agents / pharmacology; Cisplatin / chemistry; Cisplatin / pharmacokinetics; Cisplatin / pharmacology; Drug Compounding; Ear / anatomy & histology; Ear / blood supply; Humans; Hydrogels / chemistry; Immunity, Innate; Liver / drug effects; Liver / immunology; Liver / metabolism; Lung / drug effects; Lung / immunology; Lung / pathology; Lung Neoplasms / immunology; Lung Neoplasms / pathology; Lung Neoplasms / therapy; Macrophages / drug effects; Macrophages / metabolism; Mice; Mice, Inbred C57BL; Mice, Nude; Nanoparticles / chemistry; Nanoparticles / metabolism; Neoplasm Transplantation; Primary Cell Culture; Spleen / drug effects; Spleen / metabolism; Time-Lapse Imaging
TL;DR: It is found that tumor presence significantly increased clearance of PRINT hydrogel nanoparticles from the circulation, resulting in increased accumulation in the liver and spleen, due to an increase in M2-like macrophages. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Controlled analysis of nanoparticle charge on mucosal and systemic antibody responses following pulmonary immunization


By: C. Fromen n, G. Robbins*, T. Shen*, M. Kai n, J. Ting* & J. DeSimone n

author keywords: vaccine; cationic; nanoparticle; pulmonary; mucosal
MeSH headings : Animals; Antibody Formation; Antigens / administration & dosage; CD4-Positive T-Lymphocytes / immunology; Chemokines / biosynthesis; Cytokines / biosynthesis; Dendritic Cells / immunology; Hydrogels / administration & dosage; Hydrogels / chemistry; Immunity, Mucosal; Immunization / methods; Ligands; Lung / immunology; Mice; Mice, Inbred C57BL; Mice, Transgenic; Nanoparticles / administration & dosage; Nanoparticles / chemistry; Ovalbumin / administration & dosage; Ovalbumin / immunology; Static Electricity; Surface Properties; Toll-Like Receptors / metabolism; Vaccines, Subunit / administration & dosage
TL;DR: It is found that positively charged nanoparticles induce robust mucosal and systemic antibody responses following pulmonary administration, whereas negatively charge nanoparticles fail to do so, and these studies highlight the importance of NP surface charge when designing pulmonary vaccines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Distribution and Cellular Uptake of PEGylated Polymeric Particles in the Lung Towards Cell-Specific Targeted Delivery

Pharmaceutical Research, 32(10), 3248–3260.

By: T. Shen*, C. Fromen n, M. Kai n, J. Luft*, T. Rahhal*, G. Robbins*, J. DeSimone n

author keywords: Microparticle; Nanoparticle; PEGylation; Pulmonary drug delivery
MeSH headings : Animals; Cell Line; Chemokine CXCL2 / metabolism; Dendritic Cells / metabolism; Drug Delivery Systems / methods; Female; Granulocytes / metabolism; Hydrogel, Polyethylene Glycol Dimethacrylate / metabolism; Inflammation / metabolism; Interleukin-6 / metabolism; Lung / metabolism; Macrophages, Alveolar / metabolism; Mice; Mice, Inbred C57BL; Nanoparticles / metabolism; Particle Size; Polyethylene Glycols / metabolism; Polymers / metabolism
TL;DR: Surface modification with PEGylation was found to significantly increase lung residence times and homogeneous lung distribution, delaying macrophage clearance of all sizes, with the largest increase in residence time observed for 80 × 320 nm particles. (via Semantic Scholar)
Sources: Web Of Science, Crossref
Added: August 6, 2018

2013 journal article

Synthesis and characterization of monodisperse uniformly shaped respirable aerosols

AICHE JOURNAL, 59(9), 3184–3194.

By: C. Fromen n, T. Shen*, A. Larus*, P. Mack*, B. Maynor*, J. Luft*, J. DeSimone n

author keywords: aerosols; biomedical engineering; nanotechnology; particle technology; particle; count; measurements
TL;DR: Dynamic shape factors for this novel set of uniformly shaped particles were determined by correcting the drag of nonspherical particles in the ultra-Stokesian flow conditions of the aerodynamic particle sizer (APS). (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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