Works (7)

Updated: July 5th, 2023 15:40

2020 journal article

Simultaneous voltammetric detection of glucose and lactate fluctuations in rat striatum evoked by electrical stimulation of the midbrain


By: A. Forderhase n, H. Styers n, C. Lee n & L. Sombers n

author keywords: Fast-scan cyclic voltammetry; Biosensor; In vivo; Carbon-fiber microelectrode; Astrocyte-to-neuron lactate shuttle; Neuroenergetics
MeSH headings : Animals; Biosensing Techniques; Corpus Striatum / chemistry; Corpus Striatum / metabolism; Electric Stimulation; Electrochemical Techniques; Glucose / analysis; Glucose / metabolism; Lactic Acid / analysis; Lactic Acid / metabolism; Male; Mesencephalon / chemistry; Mesencephalon / metabolism; Microelectrodes; Rats; Rats, Sprague-Dawley
TL;DR: These real-time measurements provide an unprecedented direct comparison of glucose and lactate dynamics in response to metabolic demand elicited by neuronal activation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (Web of Science)
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 3, 2020

2018 journal article

Carbon-Fiber Microbiosensor for Monitoring Rapid Lactate Fluctuations in Brain Tissue Using Fast-Scan Cyclic Voltammetry

Analytical Chemistry, 90(21), 12994–12999.

By: S. Smith n, S. Gosrani n, C. Lee n, G. McCarty n & L. Sombers n

MeSH headings : Animals; Biosensing Techniques / methods; Carbon Fiber / chemistry; Electrochemical Techniques / instrumentation; Electrochemical Techniques / methods; Enzymes, Immobilized / chemistry; Lactic Acid / analysis; Limit of Detection; Male; Microelectrodes; Mixed Function Oxygenases / chemistry; Neostriatum / metabolism; Rats, Sprague-Dawley; Sensitivity and Specificity
TL;DR: There is evidence that striatal lactate availability increases biphasically in response to electrical stimulation of the dopaminergic midbrain in the anesthetized rat, and this new tool for real-time detection of lactate dynamics promises to improve understanding of how lactateavailability underscores neuronal function and dysfunction. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: November 26, 2018

2018 journal article

Characterization of a Multiple-Scan-Rate Voltammetric Waveform for Real-Time Detection of Met-Enkephalin

ACS Chemical Neuroscience, 10(4), 2022–2032.

By: S. Calhoun n, C. Meunier n, C. Lee n, G. McCarty n & L. Sombers n

author keywords: carbon fiber; opioid; chromaffin cell; dopamine; cyclic voltammetry; microelectrode; FSCV
MeSH headings : Adrenal Glands / chemistry; Adrenal Glands / metabolism; Animals; Electrochemical Techniques / methods; Enkephalin, Methionine / analysis; Enkephalin, Methionine / metabolism; Male; Microinjections / methods; Organ Culture Techniques; Rats; Rats, Sprague-Dawley; Substantia Nigra / chemistry; Substantia Nigra / metabolism
TL;DR: This work evaluated the waveform parameters to increase sensitivity to methionine-enkephalin (M-ENK), an endogenous opioid neuropeptide implicated in pain, stress, and reward circuits and demonstrates how voltammetric waveforms can be customized to enhance detection of specific target analytes, broadly speaking. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: May 6, 2019

2017 journal article

Simultaneous Voltammetric Measurements of Glucose and Dopamine Demonstrate the Coupling of Glucose Availability with Increased Metabolic Demand in the Rat Striatum

ACS Chemical Neuroscience, 8(2), 272–280.

By: S. Smith n, C. Lee n, M. Dausch n, B. Horman n, H. Patisaul n, G. McCarty n, L. Sombers n

author keywords: Biosensor; carbon fiber microelectrode; neuroenergetics; glucose oxidase; cocaine; fast-scan cyclic voltammetry
MeSH headings : Animals; Biophysics; Cocaine / pharmacology; Corpus Striatum / cytology; Corpus Striatum / diagnostic imaging; Corpus Striatum / drug effects; Corpus Striatum / metabolism; Dopamine / metabolism; Dopamine Antagonists / pharmacology; Dopamine Uptake Inhibitors / pharmacology; Drug Combinations; Electric Stimulation; Extracellular Fluid / metabolism; Glial Fibrillary Acidic Protein / metabolism; Glucose / metabolism; Hydrogen Peroxide / metabolism; Male; Microelectrodes; Raclopride / pharmacology; Rats; Rats, Sprague-Dawley; Tyrosine 3-Monooxygenase / metabolism
TL;DR: This work evaluates several waveforms to enable the first simultaneous detection of endogenous glucose and dopamine at single recording sites, and directly demonstrates the coupling of glucose availability with increased metabolic demand. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2016 journal article

Unmasking the Effects of L-DOPA on Rapid Dopamine Signaling with an Improved Approach for Nafion Coating Carbon-Fiber Microelectrodes

ANALYTICAL CHEMISTRY, 88(16), 8129–8136.

By: L. Qi n, E. Thomas n, S. White n, S. Smith n, C. Lee n, L. Wilson n, L. Sombers n

MeSH headings : Animals; Brain / drug effects; Brain / metabolism; Carbon / chemistry; Carbon Fiber; Dopamine / analysis; Electrochemical Techniques; Electrodes, Implanted; Evoked Potentials / drug effects; Levodopa / pharmacology; Male; Microelectrodes; Parkinson Disease / metabolism; Parkinson Disease / pathology; Rats; Rats, Sprague-Dawley; Signal Transduction / drug effects
TL;DR: Overall, this work describes a reliable tool that allows a better measure of L-DOPA augmented dopamine release in vivo, measured using fast-scan cyclic voltammetry. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2015 journal article

Bupropion Increases Selection of High Effort Activity in Rats Tested on a Progressive Ratio/Chow Feeding Choice Procedure: Implications for Treatment of Effort-Related Motivational Symptoms


By: P. Randall n, C. Lee n, S. Podurgiel n, E. Hart n, S. Yohn n, M. Jones n, M. Rowland n, L. Lopez-Cruz, M. Correa n, J. Salamone n

author keywords: dopamine; nucleus accumbens; depression; fatigue; animal models
MeSH headings : Animals; Bupropion / pharmacology; Choice Behavior / drug effects; Choice Behavior / physiology; Chromatography, High Pressure Liquid; Dopamine / metabolism; Dopamine Uptake Inhibitors / pharmacology; Dopamine and cAMP-Regulated Phosphoprotein 32 / metabolism; Dose-Response Relationship, Drug; Food; Immunohistochemistry; Male; Microdialysis; Motivation / drug effects; Motivation / physiology; Nucleus Accumbens / drug effects; Nucleus Accumbens / physiology; Phosphorylation / drug effects; Psychotropic Drugs / pharmacology; Rats, Sprague-Dawley; Reinforcement Schedule
TL;DR: The ability of bupropion to increase exertion of effort in instrumental behavior may have implications for the pathophysiology and treatment of effort-related motivational symptoms in humans. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2015 journal article

The VMAT-2 inhibitor tetrabenazine alters effort-related decision making as measured by the T-maze barrier choice task: reversal with the adenosine A(2A) antagonist MSX-3 and the catecholamine uptake blocker bupropion

PSYCHOPHARMACOLOGY, 232(7), 1313–1323.

By: S. Yohn*, C. Thompson*, P. Randall*, C. Lee*, C. Muller*, Y. Baqi*, M. Correa*, J. Salamone*

author keywords: Dopamine; Accumbens; Behavioral activation; Motivation; Reward; Depression; Fatigue; Anergia
MeSH headings : Adenosine A2 Receptor Antagonists / pharmacology; Animals; Antidepressive Agents / pharmacology; Bupropion / pharmacology; Catecholamines / antagonists & inhibitors; Catecholamines / metabolism; Choice Behavior / drug effects; Choice Behavior / physiology; Decision Making / drug effects; Decision Making / physiology; Dopamine Antagonists / pharmacology; Dose-Response Relationship, Drug; Male; Maze Learning / drug effects; Maze Learning / physiology; Rats; Rats, Sprague-Dawley; Receptor, Adenosine A2A / physiology; Tetrabenazine / pharmacology; Vesicular Monoamine Transport Proteins / antagonists & inhibitors; Vesicular Monoamine Transport Proteins / physiology; Xanthines / pharmacology
TL;DR: The present studies characterized the effort-related effects of the vesicular monoamine transport (VMAT-2) inhibitor tetrabenazine, which produces depressive symptoms in humans and, at low doses, preferentially depletes dopamine. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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