Works (1)

Updated: July 5th, 2023 15:39

2016 journal article

Development of a human physiologically based pharmacokinetic (PBPK) model for dermal permeability for lindane


By: M. Sawyer n, M. Evans*, C. Wilson n, L. Beesley n, L. Leon n, C. Eklund*, E. Croom*, R. Pegram*

author keywords: PBPK; Lindane; Dermal permeability
MeSH headings : Algorithms; Diffusion; Hexachlorocyclohexane / pharmacokinetics; Humans; Insecticides / pharmacokinetics; Lipid Metabolism; Models, Biological; Permeability; Protein Binding; Skin / metabolism; Skin Absorption
TL;DR: The estimation of permeability coefficients using chemical binding in combination with in vivo data demonstrates the advantages of combining physiochemical properties with a PBPK model to predict dermal absorption. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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