Christian Corey Melander

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

Belardinelli, J. M., Li, W., Martin, K. H., Zeiler, M. J., Lian, E., Avanzi, C., … Jackson, M. (2022, March 9). International Journal of Molecular Sciences.

Cheminformatics Analysis of Fluoroquinolones and their Inhibition Potency Against Four Pathogens

Borrel, A., Melander, C., & Fourches, D. (2020, November 30). Molecular Informatics.

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

Jeon, A. B., Ackart, D. F., Li, W., Jackson, M., Melander, R. J., Melander, C., … Obregón-Henao, A. (2019, February 6). Scientific Reports.

Identification of Anti‐Mycobacterial Biofilm Agents Based on the 2‐Aminoimidazole Scaffold

Nguyen, T. V., Minrovic, B. M., Melander, R. J., & Melander, C. (2019, March 4). ChemMedChem.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., … Melander, C. (2019, April 19). ACS Infectious Diseases.

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

Nguyen, T. V., Peszko, M. T., Melander, R. J., & Melander, C. (2019, January 1). MedChemComm.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

Milton, M. E., Minrovic, B. M., Harris, D. L., Kang, B., Jung, D., Lewis, C. P., … Cavanagh, J. (2018, February 13). Frontiers in Molecular Biosciences.

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., & Melander, C. (2018, November 16). ACS Infectious Diseases.

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose

Scientific Reports, 7.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

Narrow-spectrum antibacterial agents

Melander, R. J., Zurawski, D. V., & Melander, C. (2017, November 6). MedChemComm.

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display

Byrne-Nash, R., Lucero, D. M., Osbaugh, N. A., Melander, R. J., Melander, C., & Feldheim, D. L. (2017, June 21). Bioconjugate Chemistry.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

Barker, W. T., Martin, S. E., Chandler, C. E., Nguyen, T. V., Harris, T. L., Goodell, C., … Melander, C. (2017, September 9). Bioorganic & Medicinal Chemistry.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2‐aminoimidazole‐based compounds

Milton, M. E., Allen, C. L., Feldmann, E. A., Bobay, B. G., Jung, D. K., Stephens, M. D., … Cavanagh, J. (2017, July 29). Molecular Microbiology.

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

Garcia, S. S., Blackledge, M. S., Michalek, S., Su, L., Ptacek, T., Eipers, P., … Wu, H. (2017, March 10). Journal of Dental Research.

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Melander, R. J., & Melander, C. (2017, May 26). ACS Infectious Diseases.

The Discovery of 2‐Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to β‐Lactam Antibiotics in a Pattern Distinct from β‐Lactamase Inhibitors

Nguyen, T. V., Blackledge, M. S., Lindsey, E. A., Minrovic, B. M., Ackart, D. F., Jeon, A. B., … Melander, C. (2017, March 1). Angewandte Chemie International Edition.

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

Stephens, M. D., Yodsanit, N., & Melander, C. (2016, January 1). Organic & Biomolecular Chemistry.

Marine sponge alkaloids as a source of anti-bacterial adjuvants

Melander, R. J., Liu, H.-bing, Stephens, M. D., Bewley, C. A., & Melander, C. (2016, November 9). Bioorganic & Medicinal Chemistry Letters.

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

Stephens, M. D., Yodsanit, N., & Melander, C. (2016, January 1). MedChemComm.

A new small molecule inhibits Streptococcus mutans biofilms in vitro and in vivo

Pan, W., Fan, M., Wu, H., Melander, C., & Liu, C. (2015, August 21). Journal of Applied Microbiology.

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

From Worms to Targeting Virulence Factors

Melander, R. J., & Melander, C. (2015, April 1). Chemistry & Biology.

Gold Nanoparticles to Improve HIV Drug Delivery

Garrido, C., Simpson, C. A., Dahl, N. P., Bresee, J., Whitehead, D. C., Lindsey, E. A., … Margolis, D. M. (2015, July 1). Future Medicinal Chemistry.

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

Richardson, M. A., Furlani, R. E., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Basaraba, R. J. (2015, February 4). Tetrahedron Letters.

Innovative strategies for combating biofilm-based infections

Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

Stowe, S., Thompson, R., Peng, L., Su, Z., Blackledge, M., Draughn, G., … Cavanagh, J. (2015, April 23). Current Drug Delivery.

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

Stephens, M. D., Hubble, V. B., Ernst, R. K., Hoek, M. L., Melander, R. J., Cavanagh, J., & Melander, C. (2015, September 30). MedChemComm.

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

Furlani, R. E., Richardson, M. A., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Melander, C. (2015, July 2). Bioorganic & Medicinal Chemistry Letters.

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

Brackett, C. M., Furlani, R. E., Anderson, R. G., Krishnamurthy, A., Melander, R. J., Moskowitz, S. M., … Melander, C. (2015, September 8). Tetrahedron.

Controlling bacterial behavior with indole-containing natural products and derivatives

Melander, R. J., Minvielle, M. J., & Melander, C. (2014, June 4). Tetrahedron.

Expression of antimicrobial drug tolerance by attached communities ofMycobacterium tuberculosis

Ackart, D. F., Hascall-Dove, L., Caceres, S. M., Kirk, N. M., Podell, B. K., Melander, C., … Basaraba, R. J. (2014, January 29). Pathogens and Disease.

Nanoscale Structure–Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics

Bresee, J., Bond, C. M., Worthington, R. J., Smith, C. A., Gifford, J. C., Simpson, C. A., … Feldheim, D. L. (2014, March 13). Journal of the American Chemical Society.

Reversal ofMycobacterium tuberculosisphenotypic drug resistance by 2-aminoimidazole-based small molecules

Ackart, D. F., Lindsey, E. A., Podell, B. K., Melander, R. J., Basaraba, R. J., & Melander, C. (2014, January 29). Pathogens and Disease.

Small-Molecule Suppression of β-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014, August 19). Journal of Medicinal Chemistry.

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Gifford, J. C., Bresee, J., Carter, C. J., Wang, G., Melander, R. J., Melander, C., & Feldheim, D. L. (2014, January 1). Chemical Communications.

Biologically inspired strategies for combating bacterial biofilms

Blackledge, M. S., Worthington, R. J., & Melander, C. (2013, July 18). Current Opinion in Pharmacology.

Combination approaches to combat multidrug-resistant bacteria

Worthington, R. J., & Melander, C. (2013, January 18). Trends in Biotechnology.

Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram‐Negative and Gram‐Positive Bacteria

Minvielle, M. J., Eguren, K., & Melander, C. (2013, November 14). Chemistry - A European Journal.

Indole–triazole conjugates are selective inhibitors and inducers of bacterial biofilms

Minvielle, M. J., Bunders, C. A., & Melander, C. (2013, January 1). MedChemComm.

Overcoming Resistance to β-Lactam Antibiotics

Worthington, R. J., & Melander, C. (2013, March 26). The Journal of Organic Chemistry.

Programmable DNA-binding small molecules

Blackledge, M. S., & Melander, C. (2013, April 18). Bioorganic & Medicinal Chemistry.

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

Harris, T. L., Worthington, R. J., Hittle, L. E., Zurawski, D. V., Ernst, R. K., & Melander, C. (2013, October 16). ACS Chemical Biology.

Small-Molecule Inhibition of Bacterial Two-Component Systems to Combat Antibiotic Resistance and Virulence

Worthington, R. J., Blackledge, M. S., & Melander, C. (2013, July 1). Future Medicinal Chemistry.

2-Aminopyrimidine as a novel scaffold for biofilm modulation

Organic & Biomolecular Chemistry, 10(13), 2552–2561.

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of β-lactams against multi-drug resistant bacteria

Furlani, R. E., Yeagley, A. A., & Melander, C. (2012, December 19). European Journal of Medicinal Chemistry.

Deconvoluting Interspecies Bacterial Communication

Worthington, R. J., & Melander, C. (2012, May 29). Angewandte Chemie International Edition.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Stowe, S. D., Tucker, A. T., Thompson, R., Piper, A., Richards, J. J., Rogers, S. A., … Cavanagh, J. (2012, January 31). Drug and Chemical Toxicology.

Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper

Worthington, R. J., Rogers, S. A., Huigens, R. W., Melander, C., & Ritchie, D. F. (2012, June 13). Plant Disease, Vol. 96, pp. 1638–1644.

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

Thompson, R. J., Bobay, B. G., Stowe, S. D., Olson, A. L., Peng, L., Su, Z., … Cavanagh, J. (2012, November 27). Biochemistry.

Medicinal chemistry: Forcing an enemy into the open

Nature Chemistry, 4(9), 692–693.

N-Substituted 2-aminoimidazoleinhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

Yeagley, A. A., Su, Z., McCullough, K. D., Worthington, R. J., & Melander, C. (2012, October 9). Organic & Biomolecular Chemistry.

Potent Small‐Molecule Suppression of Oxacillin Resistance in Methicillin‐Resistant Staphylococcus aureus

Harris, T. L., Worthington, R. J., & Melander, C. (2012, October 9). Angewandte Chemie International Edition.

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae

Worthington, R. J., Bunders, C. A., Reed, C. S., & Melander, C. (2012, February 4). ACS Medicinal Chemistry Letters.

Small molecule control of bacterial biofilms

Organic & Biomolecular Chemistry, 10(37), 7457–7474.

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities

Budhathoki-Uprety, J., Peng, L. L., Melander, C., & Novak, B. M. (2012, February 21). ACS Macro Letters, Vol. 1, pp. 370–374.

1H, 13C, and 15N resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Olson, A. L., Bobay, B. G., Melander, C., & Cavanagh, J. (2011, August 3). Biomolecular NMR Assignments.

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms

Liu, C., Worthington, R. J., Melander, C., & Wu, H. (2011, March 15). Antimicrobial Agents and Chemotherapy.

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

Harris, T. L., Worthington, R. J., & Melander, C. (2011, June 25). Bioorganic & Medicinal Chemistry Letters.

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

Su, Z., Peng, L., & Melander, C. (2011, December 31). Tetrahedron Letters.

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Evaluation of 4,5‐Disubstituted‐2‐Aminoimidazole–Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

Su, Z., Peng, L., Worthington, R. J., & Melander, C. (2011, September 16). ChemMedChem.

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

Bunders, C., Cavanagh, J., & Melander, C. (2011, January 1). Organic & Biomolecular Chemistry.

Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles

Bresee, J., Maier, K. E., Boncella, A. E., Melander, C., & Feldheim, D. L. (2011, June 1). Small.

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chemical Communications (Cambridge, England), 47(17), 4896–4898.

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

Bunders, C. A., Minvielle, M. J., Worthington, R. J., Ortiz, M., Cavanagh, J., & Melander, C. (2011, November 17). Journal of the American Chemical Society.

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Organic & Biomolecular Chemistry, 8(12), 2814–2822.

Analysis of kinamycin D-mediated DNA cleavage

Heinecke, C. L., & Melander, C. (2010, January 21). Tetrahedron Letters.

Chemical Synthesis and Biological Screening of 2‐Aminoimidazole‐Based Bacterial and Fungal Antibiofilm Agents

Rogers, S. A., Bero, J. D., & Melander, C. (2010, January 4). ChemBioChem.

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Chemical Communications (Cambridge, England), 46(40), 7516–7518.

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

Bunders, C. A., Richards, J. J., & Melander, C. (2010, April 19). Bioorganic & Medicinal Chemistry Letters.

Modulating the development of E. coli biofilms with 2-aminoimidazoles

Reed, C. S., Huigens, R. W., Rogers, S. A., & Melander, C. (2010, August 21). Bioorganic & Medicinal Chemistry Letters.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

Rogers, S. A., Huigens, R. W., Cavanagh, J., & Melander, C. (2010, March 9). Antimicrobial Agents and Chemotherapy.

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Organic & Biomolecular Chemistry, 8(17), 3857–3859.

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

Rogers, S. A., Lindsey, E. A., Whitehead, D. C., Mullikin, T., & Melander, C. (2010, December 23). Bioorganic & Medicinal Chemistry Letters.

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

Rogers, S. A., Huigens, R. W., III, & Melander, C. (2009, July 2). Journal of the American Chemical Society.

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., … Melander, C. (2009, July 9). Journal of Medicinal Chemistry.

Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

Ballard, T. E., Richards, J. J., Aquino, A., Reed, C. S., & Melander, C. (2009, January 8). The Journal of Organic Chemistry.

Controlling Bacterial Biofilms

Richards, J. J., & Melander, C. (2009, August 13). ChemBioChem.

Evaluation of dihydrooroidin as an antifouling additive in marine paint

Melander, C., Moeller, P. D. R., Ballard, T. E., Richards, J. J., Huigens, R. W., & Cavanagh, J. (2009, February 10). International Biodeterioration & Biodegradation.

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

Huigens, R. W., III, Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, January 1). Organic & Biomolecular Chemistry.

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Huigens, R. W., Reyes, S., Reed, C. S., Bunders, C., Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009, December 7). Bioorganic & Medicinal Chemistry.

Construction and Screening of a 2‐Aminoimidazole Library Identifies a Small Molecule Capable of Inhibiting and Dispersing Bacterial Biofilms across Order, Class, and Phylum

Rogers, S. A., & Melander, C. (2008, June 4). Angewandte Chemie International Edition.

Control of bacterial biofilms with marine alkaloid derivatives

Huigens, R. W., III, Ma, L., Gambino, C., Moeller, P. D. R., Basso, A., Cavanagh, J., … Melander, C. (2008, February 21). Molecular BioSystems.

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

Richards, J. J., Reed, C. S., & Melander, C. (2008, June 29). Bioorganic & Medicinal Chemistry Letters.

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

Richards, J. J., Ballard, T. E., & Melander, C. (2008, January 1). Organic & Biomolecular Chemistry.

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications (Cambridge, England), (14), 1698–1700.

Inhibition of HIV Fusion with Multivalent Gold Nanoparticles

Bowman, M.-C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., & Melander, C. (2008, May 13). Journal of the American Chemical Society.

Kinamycin-mediated DNA cleavage under biomimetic conditions

Ballard, T. E., & Melander, C. (2008, March 10). Tetrahedron Letters.

Synthesis and Antibiofilm Activity of a Second‐Generation Reverse‐Amide Oroidin Library: A Structure–Activity Relationship Study

Ballard, T. E., Richards, J. J., Wolfe, A. L., & Melander, C. (2008, October 22). Chemistry - A European Journal.

Synthesis and Screening of an Oroidin Library against Pseudomonas aeruginosa Biofilms

Richards, J. J., Ballard, T. E., Huigens, R. W., & Melander, C. (2008, April 22). ChemBioChem.