Christian Corey Melander

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(6).

Cheminformatics Analysis of Fluoroquinolones and Their Inhibition Potency Against Four Pathogens

MOLECULAR INFORMATICS, 40(5).

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

SCIENTIFIC REPORTS, 9.

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

ACS INFECTIOUS DISEASES, 5(7), 1223–1230.

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

MEDCHEMCOMM, 10(3), 456–459.

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

ACS INFECTIOUS DISEASES, 5(1), 141–151.

Narrow-spectrum antibacterial agents

[Review of ]. MEDCHEMCOMM, 9(1), 12–21.

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose

Scientific Reports, 7.

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display

BIOCONJUGATE CHEMISTRY, 28(7), 1807–1810.

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753.

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

MOLECULAR MICROBIOLOGY, 106(2), 223–235.

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

JOURNAL OF DENTAL RESEARCH, 96(7), 807–814.

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Melander, R. J., & Melander, C. (2017, August). ACS INFECTIOUS DISEASES, Vol. 3, pp. 559–563.

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(14), 3940–3944.

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

ORGANIC & BIOMOLECULAR CHEMISTRY, 14(28), 6853–6856.

Marine sponge alkaloids as a source of anti-bacterial adjuvants

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(24), 5863–5866.

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MEDCHEMCOMM, 7(1), 128–131.

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

MEDCHEMCOMM, 7(10), 1952–1956.

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

TETRAHEDRON, 72(25), 3549–3553.

A new small molecule inhibits Streptococcus mutans biofilms invitro and in vivo

Journal of Applied Microbiology, 119(5), 1403–1411.

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

From Worms to Targeting Virulence Factors

Melander, R. J., & Melander, C. (2015, April 23). CHEMISTRY & BIOLOGY, Vol. 22, pp. 436–437.

Gold nanoparticles to improve HIV drug delivery

FUTURE MEDICINAL CHEMISTRY, 7(9), 1097–1107.

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

TETRAHEDRON LETTERS, 56(23), 3406–3409.

Innovative strategies for combating biofilm-based infections

Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

CURRENT DRUG DELIVERY, 12(2), 223–230.

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823.

Controlling bacterial behavior with indole-containing natural products and derivatives

TETRAHEDRON, 70(37), 6363–6372.

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

PATHOGENS AND DISEASE, 70(3), 359–369.

Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(14), 5295–5300.

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules

PATHOGENS AND DISEASE, 70(3), 370–378.

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

ACS CHEMICAL BIOLOGY, 9(1), 122–127.

Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

CHEMICAL COMMUNICATIONS, 50(100), 15860–15863.

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of beta-lactams against multi-drug resistant bacteria

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62, 59–70.

Biologically inspired strategies for combating bacterial biofilms

CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706.

Combination approaches to combat multidrug-resistant bacteria

[Review of ]. TRENDS IN BIOTECHNOLOGY, 31(3), 177–184.

Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria

CHEMISTRY-A EUROPEAN JOURNAL, 19(51), 17595–17602.

Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms

MEDCHEMCOMM, 4(6), 916–919.

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

ORGANIC & BIOMOLECULAR CHEMISTRY, 11(1), 130–137.

Overcoming Resistance to beta-Lactam Antibiotics

JOURNAL OF ORGANIC CHEMISTRY, 78(9), 4207–4213.

Programmable DNA-binding small molecules

BIOORGANIC & MEDICINAL CHEMISTRY, 21(20), 6101–6114.

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

[Review of ]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284.

2-Aminopyrimidine as a novel scaffold for biofilm modulation

Organic & Biomolecular Chemistry, 10(13), 2552–2561.

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

TETRAHEDRON LETTERS, 53(10), 1204–1206.

Deconvoluting Interspecies Bacterial Communication

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(26), 6314–6315.

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.

Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper

PLANT DISEASE, 96(11), 1638–1644.

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95–98.

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

BIOCHEMISTRY, 51(49), 9776–9778.

Medicinal chemistry: Forcing an enemy into the open

Nature Chemistry, 4(9), 692–693.

Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(45), 11254–11257.

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae

ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361.

Small molecule control of bacterial biofilms

Organic & Biomolecular Chemistry, 10(37), 7457–7474.

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities

ACS MACRO LETTERS, 1(3), 370–374.

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(6), 2679–2687.

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(15), 4516–4519.

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

CHEMMEDCHEM, 6(12), 2243–2251.

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

ORGANIC & BIOMOLECULAR CHEMISTRY, 9(15), 5476–5481.

Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles

SMALL, 7(14), 2027–2031.

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chemical Communications (Cambridge, England), 47(17), 4896–4898.

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163.

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(4), 1257–1260.

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Organic & Biomolecular Chemistry, 8(12), 2814–2822.

Analysis of kinamycin D-mediated DNA cleavage

TETRAHEDRON LETTERS, 51(11), 1455–1458.

Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents

CHEMBIOCHEM, 11(3), 396–410.

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Chemical Communications (Cambridge, England), 46(40), 7516–7518.

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12), 3797–3800.

Modulating the development of E. coli biofilms with 2-aminoimidazoles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(21), 6310–6312.

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112–2118.

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Organic & Biomolecular Chemistry, 8(17), 3857–3859.

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674.

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(29), 9868-+.

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.

Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

JOURNAL OF ORGANIC CHEMISTRY, 74(4), 1755–1758.

Controlling Bacterial Biofilms

[Review of ]. CHEMBIOCHEM, 10(14), 2287–2294.

Evaluation of dihydrooroidin as an antifouling additive in marine paint

INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529–532.

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(4), 794–802.

Tandem dispersion and killing of bacteria from a biofilm

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(3), 603–606.

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(28), 5229–5231.

Control of bacterial biofilms with marine alkaloid derivatives

MOLECULAR BIOSYSTEMS, 4(6), 614–621.

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(15), 4325–4327.

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

ORGANIC & BIOMOLECULAR CHEMISTRY, 6(8), 1356–1363.

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications (Cambridge, England), (14), 1698–1700.

Inhibition of HIV fusion with multivalent gold nanoparticles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(22), 6896-+.

Kinamycin-mediated DNA cleavage under biomimetic conditions

TETRAHEDRON LETTERS, 49(19), 3157–3161.

Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study

CHEMISTRY-A EUROPEAN JOURNAL, 14(34), 10745–10761.

Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms

CHEMBIOCHEM, 9(8), 1267–1279.

Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction

JOURNAL OF ORGANIC CHEMISTRY, 73(13), 5191–5193.

Targeting RNA with cysteine-constrained peptides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565–567.

Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues

Journal of the American Chemical Society, 129(22), 6966-.

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19), 5148–5151.

Tuning the oxidation properties of vanadium(V) through ligand stoichiometry

TETRAHEDRON LETTERS, 47(33), 5923–5926.