Works (96)

2019 journal article

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

SCIENTIFIC REPORTS, 9.

By: A. Jeon, D. Ackart, W. Li, M. Jackson, R. Melander, C. Melander, R. Abramovitch, A. Chicco, R. Basaraba, A. Obregon-Henao

Source: NC State University Libraries
Added: February 25, 2019

2019 journal article

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

By: T. Nguyen, B. Minrovic, R. Melander & C. Melander

Source: Web Of Science
Added: July 1, 2019

2019 journal article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

ACS INFECTIOUS DISEASES, 5(7), 1223–1230.

By: S. Martin, R. Melander, C. Brackett, A. Scott, C. Chandler, C. Nguyen, B. Minrovic, S. Harrill ...

Source: Web Of Science
Added: August 5, 2019

2019 journal article

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

MEDCHEMCOMM, 10(3), 456–459.

By: T. Nguyen, M. Peszko, R. Melander & C. Melander

Source: Web Of Science
Added: April 22, 2019

2019 journal article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

ACS INFECTIOUS DISEASES, 5(1), 141–151.

By: V. Hubble, B. Hubbard, B. Minrovic, R. Melander & C. Melander

Source: Web Of Science
Added: April 20, 2020

2018 review

Narrow-spectrum antibacterial agents

[Review of ]. MedChemComm, 9(1), 12–21.

By: R. Melander, D. Zurawski & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

By: M. Milton, B. Minrovic, D. Harris, B. Kang, D. Jung, C. Lewis, R. Thompson, R. Melander ...

Source: NC State University Libraries
Added: January 28, 2019

2017 journal article

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

By: A. Jeon, A. Obregon-Henao, D. Ackart, B. Podell, J. Belardinelli, M. Jackson, T. Nguyen, M. Blackledge ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose

Scientific Reports, 7.

By: J. Yuen, S. Walper, B. Melde, M. Daniele & D. Stenger

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Probing the mechanism of LAL-32, a gold nanoparticle-based antibiotic discovered through small molecule variable ligand display

Bioconjugate Chemistry, 28(7), 1807–1810.

By: R. Byrne-Nash, D. Lucero, N. Osbaugh, R. Melander, C. Melander & D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

Bioorganic & Medicinal Chemistry, 25(20), 5749–5753.

By: W. Barker, S. Martin, C. Chandler, T. Nguyen, T. Harris, C. Goodell, R. Melander, Y. Doi, R. Ernst, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

Molecular Microbiology, 106(2), 223–235.

By: M. Milton, C. Allen, E. Feldmann, B. Bobay, D. Jung, M. Stephens, R. Melander, K. Theisen ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Targeting of streptococcus mutans biofilms by a novel small molecule prevents dental caries and preserves the oral microbiome

Journal of Dental Research, 96(7), 807–814.

By: S. Garcia, M. Blackledge, S. Michalek, L. Su, T. Ptacek, P. Eipers, C. Morrow, E. Lefkowitz, C. Melander, H. Wu

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The challenge of overcoming antibiotic resistance: An adjuvant approach?

ACS Infectious Diseases, 3(8), 559–563.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

The discovery of 2-aminobenzimidazoles that sensitize mycobacterium smegmatis and m. tuberculosis to beta-lactam antibiotics in a pattern distinct from beta-lactamase inhibitors

Angewandte Chemie [International Edition in English], 56(14), 3940–3944.

By: T. Nguyen, M. Blackledge, E. Lindsey, B. Minrovic, D. Ackart, A. Jeon, A. Obregon-Henao, R. Melander, R. Basaraba, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

Organic & Biomolecular Chemistry, 14(28), 6853–6856.

By: M. Stephens, N. Yodsanit & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Marine sponge alkaloids as a source of anti-bacterial adjuvants

Bioorganic & Medicinal Chemistry Letters, 26(24), 5863–5866.

By: R. Melander, H. Liu, M. Stephens, C. Bewley & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MedChemComm, 7(1), 128–131.

By: M. Stephens, V. Hubble, R. Ernst, M. Hoek, R. Melander, J. Cavanagh, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

MedChemComm, 7(10), 1952–1956.

By: M. Stephens, N. Yodsanit & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

Tetrahedron, 72(25), 3549–3553.

By: C. Brackett, R. Furlani, R. Anderson, A. Krishnamurthy, R. Melander, S. Moskowitz, R. Ernst, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

A new small molecule inhibits Streptococcus mutans biofilms invitro and in vivo

Journal of Applied Microbiology, 119(5), 1403–1411.

By: W. Pan, M. Fan, H. Wu, C. Melander & C. Liu

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

By: P. Wahome, K. Beauchesne, A. Pedone, J. Cavanagh, C. Melander, P. Zimba, P. Moeller

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

From worms to targeting virulence factors

Chemistry & Biology, 22(4), 436–437.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Gold nanoparticles to improve HIV drug delivery

Future Medicinal Chemistry, 7(9), 1097–1107.

By: C. Garrido, C. Simpson, N. Dahl, J. Bresee, D. Whitehead, E. Lindsey, T. Harris, C. Smith ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

Tetrahedron Letters, 56(23), 3406–3409.

By: M. Richardson, R. Furlani, B. Podell, D. Ackart, J. Haugen, R. Melander, C. Melander, R. Basaraba

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Innovative strategies for combating biofilm-based infections

Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Membrane-permeabilizing activity of reverse-amide 2-aminoimidazole antibiofilm agents against Acinetobacter baumannii

Current Drug Delivery, 12(2), 223–230.

By: S. Stowe, R. Thompson, L. Peng, Z. Su, M. Blackledge, G. Draughn, W. Coe, E. Johannes ...

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

Bioorganic & Medicinal Chemistry Letters, 25(21), 4820–4823.

By: R. Furlani, M. Richardson, B. Podell, D. Ackart, J. Haugen, R. Melander, R. Basaraba, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Controlling bacterial behavior with indole-containing natural products and derivatives

Tetrahedron, 70(37), 6363–6372.

By: R. Melander, M. Minvielle & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

Pathogens and Disease, 70(3), 359–369.

By: D. Ackart, L. Hascall-Dove, S. Caceres, N. Kirk, B. Podell, C. Melander, I. Orme, J. Leid, J. Nick, R. Basaraba

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Nanoscale structure-activity relationships, mode of action, and biocompatibility of gold nanoparticle antibiotics

Journal of the American Chemical Society, 136(14), 5295–5300.

By: J. Bresee, C. Bond, R. Worthington, C. Smith, J. Gifford, C. Simpson, C. Carter, G. Wang ...

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules

Pathogens and Disease, 70(3), 370–378.

By: D. Ackart, E. Lindsey, B. Podell, R. Melander, R. Basaraba & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Small molecule downregulation of PmrAB reverses lipid A modification and breaks colistin resistance

ACS Chemical Biology, 9(1), 122–127.

By: T. Harris, R. Worthington, L. Hittle, D. Zurawski, R. Ernst & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Small-molecule suppression of beta-lactam resistance in multidrug-resistant gram-negative pathogens

Journal of Medicinal Chemistry, 57(17), 7450–7458.

Source: NC State University Libraries
Added: August 6, 2018

2014 journal article

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

Chemical Communications, 50(100), 15860–15863.

By: J. Gifford, J. Bresee, C. Carter, G. Wang, R. Melander, C. Melander, D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of beta-lactams against multi-drug resistant bacteria

European Journal of Medicinal Chemistry, 62, 59–70.

By: R. Furlani, A. Yeagley & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Biologically inspired strategies for combating bacterial biofilms

Current Opinion in Pharmacology, 13(5), 699–706.

By: M. Blackledge, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 review

Combination approaches to combat multidrug-resistant bacteria

[Review of ]. Trends in Biotechnology, 31(3), 177–184.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Highly active modulators of indole signaling alter pathogenic behaviors in gram-negative and gram-positive bacteria

Chemistry (Weinheim An Der Bergstrasse, Germany), 19(51), 17595–17602.

By: M. Minvielle, K. Eguren & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms

MedChemComm, 4(6), 916–919.

By: M. Minvielle, C. Bunders & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

Organic & Biomolecular Chemistry, 11(1), 130–137.

By: A. Yeagley, Z. Su, K. McCullough, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Overcoming resistance to beta-lactam antibiotics

Journal of Organic Chemistry, 78(9), 4207–4213.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Programmable DNA-binding small molecules

Bioorganic & Medicinal Chemistry, 21(20), 6101–6114.

By: M. Blackledge & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2013 review

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

[Review of ]. Future medicinal chemistry, 5(11), 1265–1284.

By: R. Worthington, M. Blackledge & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

2-Aminopyrimidine as a novel scaffold for biofilm modulation

Organic & Biomolecular Chemistry, 10(13), 2552–2561.

By: E. Lindsey, R. Worthington, C. Alcaraz & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

Tetrahedron Letters, 53(10), 1204–1206.

By: Z. Su, L. Peng & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Deconvoluting interspecies bacterial communication

Angewandte Chemie [International Edition in English], 51(26), 6314–6315.

By: R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

Drug and Chemical Toxicology, 35(3), 310–315.

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Foliar-applied small molecule that suppresses biofilm formation and enhances control of copper-resistant Xanthomonas euvesicatoria on pepper

Plant Disease, 96(11), 1638–1644.

By: R. Worthington, S. Rogers, R. Huigens, C. Melander & D. Ritchie

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

Biomolecular NMR Assignments, 6(1), 95–98.

By: A. Olson, B. Bobay, C. Melander & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Identification of BfmR, a response regulator involved in biofilm development, as a target for a 2-aminoimidazole-based antibiofilm agent

Biochemistry, 51(49), 9776–9778.

By: R. Thompson, B. Bobay, S. Stowe, A. Olson, L. Peng, Z. Su, L. Actis, C. Melander, J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Medicinal chemistry: Forcing an enemy into the open

Nature Chemistry, 4(9), 692–693.

By: C. Melander & D. Margolis

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Potent small-molecule suppression of oxacillin resistance in methicillin-resistant Staphylococcus aureus

Angewandte Chemie [International Edition in English], 51(45), 11254–11257.

By: T. Harris, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Small molecule control of bacterial biofilms

Organic & Biomolecular Chemistry, 10(37), 7457–7474.

By: R. Worthington, J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Small molecule suppression of carbapenem resistance in NDM-1 producing Klebsiella pneumoniae

ACS Medicinal Chemistry Letters, 3(5), 357–361.

By: R. Worthington, C. Bunders, C. Reed & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Synthesis of guanidinium functionalized polycarbodiimides and their antibacterial activities

ACS Macro Letters, 1(3), 370–374.

By: J. Budhathoki-Uprety, L. Peng, C. Melander & B. Novak

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

Bioorganic & Medicinal Chemistry Letters, 21(15), 4516–4519.

By: T. Harris, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

A new small molecule specifically inhibits the cariogenic bacterium streptococcus mutans in multispecies biofilms

Antimicrobial Agents and Chemotherapy, 55(6), 2679–2687.

By: C. Liu, R. Worthington, C. Melander & H. Wu

Source: NC State University Libraries
Added: August 6, 2018

2011 review

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Evaluation of 4,5-disubstituted-2-aminoimidazole-triazole conjugates for antibiofilm/antibiotic resensitization activity against MRSA and Acinetobacter baumannii

Chemmedchem, 6(12), 2243–2251.

By: Z. Su, L. Peng, R. Worthington & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

Organic & Biomolecular Chemistry, 9(15), 5476–5481.

By: C. Bunders, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Growth inhibition of Staphylococcus aureus by mixed monolayer gold nanoparticles

Small (Weinheim An Der Bergstrasse, Germany), 7(14), 2027–2031.

By: J. Bresee, K. Maier, A. Boncella, C. Melander & D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chemical Communications (Cambridge, England), 47(17), 4896–4898.

By: L. Peng, J. DeSousa, Z. Su, B. Novak, A. Nevzorov, E. Garland, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Intercepting bacterial indole signaling with flustramine derivatives

Journal of the American Chemical Society, 133(50), 20160–20163.

By: C. Bunders, M. Minvielle, R. Worthington, M. Ortiz, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

Bioorganic & Medicinal Chemistry Letters, 21(4), 1257–1260.

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Organic & Biomolecular Chemistry, 8(12), 2814–2822.

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Analysis of kinamycin D-mediated DNA cleavage

Tetrahedron Letters, 51(11), 1455–1458.

By: C. Heinecke & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Chemical synthesis and biological screening of 2-aminoimidazole-based bacterial and fungal antibiofilm agents

Chembiochem, 11(3), 396–410.

By: S. Rogers, J. Bero & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Chemical Communications (Cambridge, England), 46(40), 7516–7518.

By: J. Bresee, K. Maier, C. Melander & D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

Bioorganic & Medicinal Chemistry Letters, 20(12), 3797–3800.

By: C. Bunders, J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Modulating the development of E. coli biofilms with 2-aminoimidazoles

Bioorganic & Medicinal Chemistry Letters, 20(21), 6310–6312.

By: C. Reed, R. Huigens, S. Rogers & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Synergistic effects between conventional antibiotics and 2-aminoimidazole-derived antibiofilm agents

Antimicrobial Agents and Chemotherapy, 54(5), 2112–2118.

By: S. Rogers, R. Huigens, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Organic & Biomolecular Chemistry, 8(17), 3857–3859.

By: S. Rogers, D. Whitehead, T. Mullikin & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

Bioorganic & Medicinal Chemistry, 18(2), 663–674.

By: R. Huigens, S. Reyes, C. Reed, C. Bunders, S. Rogers, A. Steinhauer, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

A 2-aminobenzimidazole that inhibits and disperses gram-positive biofilms through a zinc-dependent mechanism

Journal of the American Chemical Society, 131(29), 9868-.

By: S. Rogers, R. Huigens & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Amide isosteres of oroidin: Assessment of antibiofilm activity and C. elegans Toxicity

Journal of Medicinal Chemistry, 52(15), 4582–4585.

By: J. Richards, S. Reyes, S. Stowe, A. Tucker, T. Ballard, L. Mathies, J. Cavanagh, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Antibiofilm activity of a diverse oroidin library generated through reductive acylation

Journal of Organic Chemistry, 74(4), 1755–1758.

By: T. Ballard, J. Richards, A. Aquino, C. Reed & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 review

Controlling bacterial biofilms

[Review of ]. Chembiochem, 10(14), 2287–2294.

By: J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Evaluation of dihydrooroidin as an antifouling additive in marine paint

International Biodeterioration & Biodegradation, 63(4), 529–532.

By: C. Melander, P. Moeller, T. Ballard, J. Richards, R. Huigens & J. Cavanagh

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

Organic & Biomolecular Chemistry, 7(4), 794–802.

By: R. Huigens, S. Rogers, A. Steinhauer & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2009 journal article

Tandem dispersion and killing of bacteria from a biofilm

Organic & Biomolecular Chemistry, 7(3), 603–606.

By: S. Rogers, M. Krayer, J. Lindsey & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum

Angewandte Chemie [International Edition in English], 47(28), 5229–5231.

By: S. Rogers & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Control of bacterial biofilms with marine alkaloid derivatives

Molecular BioSystems, 4(6), 614–621.

By: R. Huigens, L. Ma, C. Gambino, P. Moeller, A. Basso, J. Cavanagh, D. Wozniak, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

Bioorganic & Medicinal Chemistry Letters, 18(15), 4325–4327.

By: J. Richards, C. Reed & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

Organic & Biomolecular Chemistry, 6(8), 1356–1363.

By: J. Richards, T. Ballard & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications (Cambridge, England), (14), 1698–1700.

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhibition of HIV fusion with multivalent gold nanoparticles

Journal of the American Chemical Society, 130(22), 6896-.

By: M. Bowman, T. Ballard, C. Ackerson, D. Feldheim, D. Margolis & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Kinamycin-mediated DNA cleavage under biomimetic conditions

Tetrahedron Letters, 49(19), 3157–3161.

By: T. Ballard & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: A structure-activity relationship study

Chemistry (Weinheim An Der Bergstrasse, Germany), 14(34), 10745–10761.

By: T. Ballard, J. Richards, A. Wolfe & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms

Chembiochem, 9(8), 1267–1279.

By: J. Richards, T. Ballard, R. Huigens & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction

Journal of Organic Chemistry, 73(13), 5191–5193.

By: J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Targeting RNA with cysteine-constrained peptides

Bioorganic & Medicinal Chemistry Letters, 18(2), 565–567.

By: V. Burns, B. Bobay, A. Basso, J. Cavanagh & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2007 journal article

Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues

Journal of the American Chemical Society, 129(22), 6966-.

By: R. Huigens, J. Richards, G. Parise, T. Ballard, W. Zeng, R. Deora, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

Bioorganic & Medicinal Chemistry Letters, 16(19), 5148–5151.

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Tuning the oxidation properties of vanadium(V) through ligand stoichiometry

Tetrahedron Letters, 47(33), 5923–5926.

By: W. Zeng, T. Ballard & C. Melander

Source: NC State University Libraries
Added: August 6, 2018