Works (98)

Updated: August 12th, 2023 21:14

2022 journal article

2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(6).

By: J. Belardinelli*, W. Li*, K. Martin*, M. Zeiler*, E. Lian*, C. Avanzi*, C. Wiersma*, T. Nguyen n ...

co-author countries: United States of America 🇺🇸
author keywords: Mycobacterium abscessus; nontuberculous mycobacteria; biofilm; 2-aminoimidazoles; zinc
MeSH headings : Anti-Bacterial Agents / pharmacology; Biofilms; Humans; Imidazoles / pharmacology; Microbial Sensitivity Tests; Mycobacterium Infections, Nontuberculous; Mycobacterium abscessus; Zinc / pharmacology
Source: Web Of Science
Added: April 18, 2022

2021 journal article

Cheminformatics Analysis of Fluoroquinolones and Their Inhibition Potency Against Four Pathogens

MOLECULAR INFORMATICS, 40(5).

By: A. Borrel n, C. Melander* & D. Fourches n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Cheminformatics; Drug Discovery; Escherichia coli / drug effects; Fluoroquinolones / chemistry; Fluoroquinolones / pharmacology; Microbial Sensitivity Tests; Pseudomonas aeruginosa / drug effects; Quantitative Structure-Activity Relationship; Staphylococcus aureus / drug effects; Streptococcus pneumoniae / drug effects
Source: Web Of Science
Added: December 21, 2020

2019 journal article

2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain

SCIENTIFIC REPORTS, 9.

By: A. Jeon*, D. Ackart*, W. Li*, M. Jackson*, R. Melander n, C. Melander n, R. Abramovitch*, A. Chicco*, R. Basaraba*, A. Obregon-Henao*

co-author countries: United States of America 🇺🇸
MeSH headings : Adenosine Triphosphate / metabolism; Antitubercular Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Electron Transport / drug effects; Humans; Imidazoles / pharmacology; Microbial Sensitivity Tests; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / growth & development; Oxygen Consumption / drug effects; Proton-Motive Force / drug effects; Tuberculosis / drug therapy; Tuberculosis / microbiology
Source: Web Of Science
Added: February 25, 2019

2019 journal article

Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold

CHEMMEDCHEM, 14(9), 927–937.

By: T. Nguyen n, B. Minrovic*, R. Melander* & C. Melander

co-author countries: United States of America 🇺🇸
author keywords: 2-aminoimidazoles; biofilms; mycobacteria; synergy; tuberculosis
MeSH headings : Animals; Antitubercular Agents / chemistry; Antitubercular Agents / pharmacology; Biofilms / drug effects; Imidazoles / chemistry; Male; Mice; Microsomes / drug effects; Microsomes / metabolism; Mycobacterium tuberculosis / drug effects
Source: Web Of Science
Added: July 1, 2019

2019 journal article

Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii

ACS INFECTIOUS DISEASES, 5(7), 1223–1230.

By: S. Martin*, R. Melander*, C. Brackett n, A. Scott*, C. Chandler*, C. Nguyen n, B. Minrovic*, S. Harrill n ...

co-author countries: United States of America 🇺🇸
author keywords: antibiotic adjuvant; antibiotic resistance; Acinetobacter baumannii; macrolide antibiotics; glycopeptide antibiotics; lipopolysaccharide
MeSH headings : Acinetobacter Infections / drug therapy; Acinetobacter baumannii / drug effects; Animals; Anti-Bacterial Agents / administration & dosage; Anti-Bacterial Agents / pharmacology; Bacterial Outer Membrane / drug effects; Disease Models, Animal; Drug Resistance, Multiple, Bacterial / drug effects; Drug Synergism; Glycopeptides / administration & dosage; Glycopeptides / pharmacology; Macrolides / administration & dosage; Macrolides / pharmacology; Microbial Sensitivity Tests; Moths; Small Molecule Libraries / administration & dosage; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 5, 2019

2019 journal article

Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation

MEDCHEMCOMM, 10(3), 456–459.

By: T. Nguyen n, M. Peszko n, R. Melander* & C. Melander*

co-author countries: Philippines 🇵🇭 United States of America 🇺🇸
Source: Web Of Science
Added: April 22, 2019

2019 journal article

Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa

ACS INFECTIOUS DISEASES, 5(1), 141–151.

By: V. Hubble*, B. Hubbard n, B. Minrovic*, R. Melander* & C. Melander

co-author countries: United States of America 🇺🇸
author keywords: antibiotic resistance; antibiotic adjuvant; cystic fibrosis; Pseudomonas aeruginosa
MeSH headings : Adjuvants, Pharmaceutic / chemistry; Animals; Anti-Bacterial Agents / pharmacology; Azithromycin / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Cystic Fibrosis / drug therapy; Cystic Fibrosis / microbiology; Disease Models, Animal; Drug Repositioning; Larva / drug effects; Larva / microbiology; Microbial Sensitivity Tests; Moths / drug effects; Moths / microbiology; Pseudomonas aeruginosa / drug effects; Respiratory Tract Infections / drug therapy
Source: Web Of Science
Added: April 20, 2020

2018 review

Narrow-spectrum antibacterial agents

[Review of ]. MEDCHEMCOMM, 9(1), 12–21.

By: R. Melander n, D. Zurawski* & C. Melander n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2018 journal article

Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp.

FRONTIERS IN MOLECULAR BIOSCIENCES, 5.

By: M. Milton*, B. Minrovic n, D. Harris*, B. Kang*, D. Jung*, C. Lewis n, R. Thompson*, R. Melander n ...

co-author countries: United States of America 🇺🇸
author keywords: biofilms; antibiotic resistance; two-component systems; response regulators; Acinetobacter baumannii; Francisella
Source: Web Of Science
Added: January 28, 2019

2017 journal article

2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability

PLoS One, 12(7).

By: A. Jeon, A. Obregon-Henao, D. Ackart, B. Podell, J. Belardinelli, M. Jackson, T. Nguyen, M. Blackledge ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose

Scientific Reports, 7.

By: J. Yuen, S. Walper, B. Melde, M. Daniele & D. Stenger

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections

Drug Design Development and Therapy, 11, 153–162.

By: G. Draughn, C. Allen, P. Routh, M. Stone, K. Kirker, A. Boegli, R. Schuchman, K. Linder ...

Source: NC State University Libraries
Added: August 6, 2018

2017 journal article

Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display

BIOCONJUGATE CHEMISTRY, 28(7), 1807–1810.

By: R. Byrne-Nash*, D. Lucero*, N. Osbaugh*, R. Melander n, C. Melander n & D. Feldheim*

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Cell Division / drug effects; Drug Discovery / methods; Drug Resistance, Bacterial; Escherichia coli / cytology; Escherichia coli / drug effects; Escherichia coli Proteins / antagonists & inhibitors; Gold; Ligands; Membrane Transport Proteins; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Small Molecule Libraries
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria

BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753.

By: W. Barker n, S. Martin n, C. Chandler*, T. Nguyen n, T. Harris n, C. Goodell*, R. Melander n, Y. Doi*, R. Ernst*, C. Melander

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Adjuvants, Pharmaceutic / chemistry; Adjuvants, Pharmaceutic / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / genetics; Escherichia coli / drug effects; Escherichia coli Proteins / genetics; Escherichia coli Proteins / metabolism; Gram-Negative Bacteria / drug effects; Klebsiella pneumoniae / drug effects; Microbial Sensitivity Tests; Polymyxins / pharmacology; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds

MOLECULAR MICROBIOLOGY, 106(2), 223–235.

By: M. Milton*, C. Allen n, E. Feldmann n, B. Bobay n, D. Jung*, M. Stephens n, R. Melander n, K. Theisen n ...

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacterial Proteins / chemistry; Bacterial Proteins / metabolism; Bacterial Proteins / ultrastructure; Biofilms / drug effects; Francisella tularensis / metabolism; Gene Expression Regulation, Bacterial / genetics; Imidazoles / metabolism; Imidazoles / pharmacology; Protein Binding; Virulence / drug effects; Virulence Factors / genetics; Virulence Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2017 journal article

Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome

JOURNAL OF DENTAL RESEARCH, 96(7), 807–814.

By: S. Garcia*, M. Blackledge n, S. Michalek*, L. Su*, T. Ptacek*, P. Eipers*, C. Morrow*, E. Lefkowitz*, C. Melander n, H. Wu*

co-author countries: United States of America 🇺🇸
author keywords: microbiota; rats; dental enamel; microscopy; bacteria; microbial ecology
MeSH headings : Animals; Biofilms / drug effects; Dental Caries / prevention & control; Dental Enamel / drug effects; Imidazoles / pharmacology; Microbiota / drug effects; Microscopy, Confocal; Polymerase Chain Reaction; Rats; Streptococcus gordonii / drug effects; Streptococcus mutans / drug effects; Streptococcus sanguis / drug effects
Source: Web Of Science
Added: August 6, 2018

2017 article

The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach?

Melander, R. J., & Melander, C. (2017, August). ACS INFECTIOUS DISEASES, Vol. 3, pp. 559–563.

By: R. Melander n & C. Melander

co-author countries: United States of America 🇺🇸
MeSH headings : Adjuvants, Pharmaceutic / pharmacology; Animals; Anti-Bacterial Agents / pharmacology; Drug Interactions; Drug Resistance, Bacterial / drug effects; Drug Resistance, Bacterial / physiology; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / growth & development; Gram-Negative Bacteria / metabolism; Gram-Positive Bacteria / drug effects; Gram-Positive Bacteria / growth & development; Gram-Positive Bacteria / metabolism; Humans
Source: Web Of Science
Added: August 6, 2018

2017 journal article

The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(14), 3940–3944.

By: T. Nguyen n, M. Blackledge*, E. Lindsey n, B. Minrovic n, D. Ackart*, A. Jeon*, A. Obregon-Henao*, R. Melander n, R. Basaraba*, C. Melander

co-author countries: United States of America 🇺🇸
author keywords: aminobenzimidazoles; antibiotic resistance; medicinal chemistry; tuberculosis
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Discovery; Lactams / chemical synthesis; Lactams / chemistry; Lactams / pharmacology; Molecular Structure; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / enzymology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / enzymology; beta-Lactamase Inhibitors / chemical synthesis; beta-Lactamase Inhibitors / chemistry; beta-Lactamase Inhibitors / pharmacology; beta-Lactamases / metabolism
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus

ORGANIC & BIOMOLECULAR CHEMISTRY, 14(28), 6853–6856.

By: M. Stephens n, N. Yodsanit* & C. Melander n

co-author countries: Thailand 🇹🇭 United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Carbamates / chemistry; Carbamates / pharmacology; Humans; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / physiology; Microbial Sensitivity Tests; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Staphylococcal Infections / drug therapy
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Marine sponge alkaloids as a source of anti-bacterial adjuvants

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(24), 5863–5866.

By: R. Melander n, H. Liu*, M. Stephens n, C. Bewley* & C. Melander

co-author countries: United States of America 🇺🇸
author keywords: Marine sponge; Pyrrole-imidazole alkaloid; Biofilm; Antibiotic; Adjuvant
MeSH headings : Acinetobacter baumannii / drug effects; Alkaloids / chemistry; Alkaloids / metabolism; Alkaloids / pharmacology; Animals; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / metabolism; Anti-Bacterial Agents / pharmacology; Dose-Response Relationship, Drug; Imidazoles / chemistry; Imidazoles / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Structure; Porifera; Pyrroles / chemistry; Pyrroles / pharmacology; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants

MEDCHEMCOMM, 7(1), 128–131.

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida

MEDCHEMCOMM, 7(10), 1952–1956.

By: M. Stephens n, N. Yodsanit* & C. Melander n

co-author countries: Thailand 🇹🇭 United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2016 journal article

Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity

TETRAHEDRON, 72(25), 3549–3553.

By: C. Brackett n, R. Furlani n, R. Anderson n, A. Krishnamurthy n, R. Melander n, S. Moskowitz*, R. Ernst*, C. Melander

co-author countries: United States of America 🇺🇸
author keywords: Antibiotic adjuvant; 2-Aminoimidazole; Colistin; ESKAPE pathogens; Acinetobacter baumannii; Pseudomonas aeruginosa
Source: Web Of Science
Added: August 6, 2018

2015 journal article

A new small molecule inhibits Streptococcus mutans biofilms invitro and in vivo

Journal of Applied Microbiology, 119(5), 1403–1411.

By: W. Pan*, M. Fan*, H. Wu, C. Melander n & C. Liu*

co-author countries: China 🇨🇳 United States of America 🇺🇸
MeSH headings : Animals; Anti-Bacterial Agents / administration & dosage; Biofilms / drug effects; Dental Caries / microbiology; Female; Humans; Imidazoles / administration & dosage; Mice; Rats; Rats, Sprague-Dawley; Streptococcal Infections / drug therapy; Streptococcal Infections / microbiology; Streptococcus mutans / drug effects; Streptococcus mutans / physiology; Triazoles / administration & dosage
Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Augmenting anti-cancer natural products with a small molecule adjuvant

Marine Drugs, 13(1), 65–75.

By: P. Wahome, K. Beauchesne, A. Pedone, J. Cavanagh, C. Melander, P. Zimba, P. Moeller

Source: NC State University Libraries
Added: August 6, 2018

2015 article

From Worms to Targeting Virulence Factors

Melander, R. J., & Melander, C. (2015, April 23). CHEMISTRY & BIOLOGY, Vol. 22, pp. 436–437.

By: R. Melander n & C. Melander

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Bacterial Proteins / metabolism; Caenorhabditis elegans / microbiology; Metalloendopeptidases / metabolism; Pseudomonas aeruginosa / physiology; Virulence Factors / metabolism
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Gold nanoparticles to improve HIV drug delivery

FUTURE MEDICINAL CHEMISTRY, 7(9), 1097–1107.

By: C. Garrido*, C. Simpson*, N. Dahl*, J. Bresee*, D. Whitehead n, E. Lindsey n, T. Harris n, C. Smith* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-HIV Agents / administration & dosage; Anti-HIV Agents / chemical synthesis; Anti-HIV Agents / chemistry; Brain / metabolism; Drug Carriers / chemistry; Endothelial Cells / cytology; Endothelial Cells / drug effects; Endothelial Cells / metabolism; Female; Gold / chemistry; HIV Core Protein p24 / antagonists & inhibitors; HIV Core Protein p24 / metabolism; HIV Infections / drug therapy; HIV-1 / physiology; Humans; Leukocytes, Mononuclear / cytology; Leukocytes, Mononuclear / drug effects; Leukocytes, Mononuclear / metabolism; Macrophages / cytology; Macrophages / drug effects; Macrophages / metabolism; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Metal Nanoparticles / ultrastructure; Mice; Mice, Inbred BALB C; Raltegravir Potassium / administration & dosage; Raltegravir Potassium / chemical synthesis; Raltegravir Potassium / chemistry; Tissue Distribution; Virus Replication / drug effects
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives

TETRAHEDRON LETTERS, 56(23), 3406–3409.

By: M. Richardson*, R. Furlani n, B. Podell*, D. Ackart*, J. Haugen*, R. Melander n, C. Melander, R. Basaraba*

co-author countries: United States of America 🇺🇸
author keywords: Advanced glycation end-products (AGES); Bis-2-aminoimidazole; Aminoguanidine; Diabetes
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Innovative strategies for combating biofilm-based infections

Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

By: R. Melander & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2015 journal article

Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii

CURRENT DRUG DELIVERY, 12(2), 223–230.

By: S. Stowe*, R. Thompson*, L. Peng*, Z. Su*, M. Blackledge*, G. Draughn, W. Coe, E. Johannes* ...

co-author countries: United States of America 🇺🇸
author keywords: 2-aminoimidazole; Acinetobacter baumannii; biofilm; membrane permeabilization; reverse amide; SEM
MeSH headings : Acinetobacter baumannii / drug effects; Amides / chemistry; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Cell Membrane Permeability / drug effects; Cells, Cultured; Cross Infection; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
Source: Web Of Science
Added: August 6, 2018

2015 journal article

Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823.

By: R. Furlani n, M. Richardson*, B. Podell*, D. Ackart*, J. Haugen*, R. Melander n, R. Basaraba*, C. Melander

co-author countries: United States of America 🇺🇸
author keywords: Advanced glycation end-product (AGE); 2-Aminoimidazole; Akabori; Diabetes
MeSH headings : Glycation End Products, Advanced / antagonists & inhibitors; Glycation End Products, Advanced / metabolism; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Molecular Structure; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Controlling bacterial behavior with indole-containing natural products and derivatives

TETRAHEDRON, 70(37), 6363–6372.

By: R. Melander n, M. Minvielle n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: Indole; Bacterial communication; Anti-virulence; Biofilm; Antibiotic resistance
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis

PATHOGENS AND DISEASE, 70(3), 359–369.

By: D. Ackart*, L. Hascall-Dove*, S. Caceres*, N. Kirk*, B. Podell*, C. Melander n, I. Orme*, J. Leid*, J. Nick*, R. Basaraba*

co-author countries: United States of America 🇺🇸
author keywords: Mycobacterium tuberculosis; drug resistant; drug tolerant; biofilm; microbial communities
MeSH headings : Antitubercular Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Culture Media; Deoxyribonuclease I / metabolism; Drug Resistance, Bacterial / genetics; Gene Expression Regulation, Bacterial / drug effects; Humans; Isoniazid / pharmacology; Microbial Sensitivity Tests; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / physiology; Polysorbates / pharmacology; Rifampin / pharmacology
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(14), 5295–5300.

By: J. Bresee*, C. Bond n, R. Worthington n, C. Smith*, J. Gifford*, C. Simpson*, C. Carter*, G. Wang* ...

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biocompatible Materials / chemical synthesis; Biocompatible Materials / chemistry; Biocompatible Materials / pharmacology; Dose-Response Relationship, Drug; Drug Resistance, Multiple, Bacterial / drug effects; Escherichia coli / drug effects; Gold / chemistry; Gold / pharmacology; Klebsiella pneumoniae / drug effects; Metal Nanoparticles / chemistry; Microbial Sensitivity Tests; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules

PATHOGENS AND DISEASE, 70(3), 370–378.

By: D. Ackart*, E. Lindsey n, B. Podell*, R. Melander n, R. Basaraba* & C. Melander

co-author countries: United States of America 🇺🇸
author keywords: tuberculosis; drug tolerant; biofilm; 2-aminoimidazole; drug resistant; isoniazid
MeSH headings : Antitubercular Agents / chemistry; Antitubercular Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Drug Resistance, Bacterial; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests; Mycobacterium smegmatis / drug effects; Mycobacterium smegmatis / physiology; Mycobacterium tuberculosis / drug effects; Mycobacterium tuberculosis / physiology; Phenotype
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance

ACS CHEMICAL BIOLOGY, 9(1), 122–127.

By: T. Harris n, R. Worthington n, L. Hittle*, D. Zurawski*, R. Ernst* & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacterial Proteins / genetics; Colistin / chemistry; Colistin / pharmacology; Down-Regulation / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / genetics; Gram-Negative Bacteria / metabolism; Gram-Negative Bacterial Infections / drug therapy; Humans; Lipid A / metabolism; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Transcription Factors / genetics
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens

JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458.

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Cell Line; Cell Survival / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Gram-Negative Bacteria / classification; Gram-Negative Bacteria / drug effects; Hemolysis / drug effects; Humans; Keratinocytes / cytology; Keratinocytes / drug effects; Microbial Sensitivity Tests; Sheep; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis

CHEMICAL COMMUNICATIONS, 50(100), 15860–15863.

By: J. Gifford*, J. Bresee*, C. Carter*, G. Wang*, R. Melander n, C. Melander, D. Feldheim*

co-author countries: United States of America 🇺🇸
MeSH headings : Cell Line; Cell Survival / drug effects; Erythrocytes / cytology; Erythrocytes / drug effects; Gold / chemistry; Hemolysis / drug effects; Humans; Metal Nanoparticles / chemistry; Metal Nanoparticles / toxicity; Microbial Sensitivity Tests; Mycobacterium smegmatis / drug effects; Sulfhydryl Compounds / chemistry
Source: Web Of Science
Added: August 6, 2018

2013 journal article

A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of beta-lactams against multi-drug resistant bacteria

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62, 59–70.

By: R. Furlani n, A. Yeagley n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: Biofilms; MRSA; Suppression of antibiotic resistance; 2-Aminoimidazoles
MeSH headings : Biofilms / drug effects; Dose-Response Relationship, Drug; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Molecular Structure; Structure-Activity Relationship; beta-Lactams / chemistry; beta-Lactams / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Biologically inspired strategies for combating bacterial biofilms

CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706.

By: M. Blackledge n, R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / metabolism; Bacterial Physiological Phenomena / drug effects; Biofilms / drug effects; Humans; Quorum Sensing / drug effects; Signal Transduction / drug effects
Source: Web Of Science
Added: August 6, 2018

2013 review

Combination approaches to combat multidrug-resistant bacteria

[Review of ]. TRENDS IN BIOTECHNOLOGY, 31(3), 177–184.

By: R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: antibiotic resistance; antibiotic adjuvant
MeSH headings : Adjuvants, Pharmaceutic / therapeutic use; Anti-Bacterial Agents / therapeutic use; Bacterial Infections / drug therapy; Bacterial Infections / microbiology; Drug Resistance, Multiple, Bacterial; Drug Therapy, Combination / methods; Humans
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria

CHEMISTRY-A EUROPEAN JOURNAL, 19(51), 17595–17602.

By: M. Minvielle n, K. Eguren n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: desformylflustrabromine; mechanistic probes; natural products; phenotype control; structure-activity relationships
MeSH headings : Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / metabolism; Biofilms / drug effects; Gram-Negative Bacteria / drug effects; Gram-Negative Bacteria / physiology; Gram-Positive Bacteria / drug effects; Gram-Positive Bacteria / physiology; Hydrocarbons, Brominated / chemical synthesis; Hydrocarbons, Brominated / chemistry; Hydrocarbons, Brominated / pharmacology; Indole Alkaloids / chemical synthesis; Indole Alkaloids / chemistry; Indole Alkaloids / pharmacology; Indoles / chemical synthesis; Indoles / chemistry; Indoles / pharmacology; Phenotype; Structure-Activity Relationship; Temperature; Trans-Activators / antagonists & inhibitors; Trans-Activators / metabolism; Tryptophanase / antagonists & inhibitors; Tryptophanase / metabolism
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms

MEDCHEMCOMM, 4(6), 916–919.

By: M. Minvielle n, C. Bunders n & C. Melander n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2013 journal article

N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization

ORGANIC & BIOMOLECULAR CHEMISTRY, 11(1), 130–137.

By: A. Yeagley n, Z. Su n, K. McCullough n, R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Cyclization; Guanidines / chemistry; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Molecular Structure; Structure-Activity Relationship; Triazoles / chemical synthesis; Triazoles / chemistry; Triazoles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Overcoming Resistance to beta-Lactam Antibiotics

JOURNAL OF ORGANIC CHEMISTRY, 78(9), 4207–4213.

By: R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Drug Discovery; Molecular Structure; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; beta-Lactam Resistance / drug effects; beta-Lactamase Inhibitors; beta-Lactams / chemical synthesis; beta-Lactams / chemistry; beta-Lactams / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 journal article

Programmable DNA-binding small molecules

BIOORGANIC & MEDICINAL CHEMISTRY, 21(20), 6101–6114.

By: M. Blackledge n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: Polyamide; Transcription; Minor groove; DNA binding
MeSH headings : Animals; DNA / chemistry; DNA / drug effects; DNA / genetics; Gene Expression / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Pyrroles / chemistry; Pyrroles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2013 review

Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence

[Review of ]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284.

By: R. Worthington n, M. Blackledge n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Bacteria / metabolism; Bacteria / pathogenicity; Bacterial Infections / drug therapy; Bacterial Proteins / antagonists & inhibitors; Bacterial Proteins / metabolism; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Histidine Kinase; Humans; Protein Kinases / chemistry; Protein Kinases / metabolism; Signal Transduction / drug effects; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology; Small Molecule Libraries / therapeutic use; Virulence / drug effects
Source: Web Of Science
Added: August 6, 2018

2012 journal article

2-Aminopyrimidine as a novel scaffold for biofilm modulation

Organic & Biomolecular Chemistry, 10(13), 2552–2561.

By: E. Lindsey, R. Worthington, C. Alcaraz & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles

TETRAHEDRON LETTERS, 53(10), 1204–1206.

By: Z. Su n, L. Peng n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: N-H insertion; 2-Aminoimidazole; Antibiotic; Polysubstitution; Heterocycle
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Deconvoluting Interspecies Bacterial Communication

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(26), 6314–6315.

By: R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: autoinducer-2; bacterial communication; 4; 5-dihydroxy-2; 3-pentanedione; NMR spectroscopy; quorum sensing
MeSH headings : Bacteria / chemistry; Pentanes / analysis; Quorum Sensing; Signal Transduction
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems

DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315.

co-author countries: United States of America 🇺🇸
author keywords: 2-aminoimidazole; adjuvant; biofilm; Caenorhabditis elegans; toxicity; Toxicity of 2-aminoimidazole; antibiofilm agents
MeSH headings : Adjuvants, Pharmaceutic / toxicity; Animals; Anti-Bacterial Agents / pharmacology; Anti-Bacterial Agents / toxicity; Biofilms / drug effects; Caenorhabditis elegans; Cell Line; Dose-Response Relationship, Drug; Environmental Exposure; Fertility / drug effects; Humans; Imidazoles / pharmacology; Imidazoles / toxicity; Keratinocytes / metabolism; Tetrazolium Salts; Thiazoles; Toxicity Tests
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper

PLANT DISEASE, 96(11), 1638–1644.

By: R. Worthington, S. Rogers*, R. Huigens*, C. Melander* & D. Ritchie n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2012 journal article

H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis

BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95–98.

By: A. Olson n, B. Bobay n, C. Melander n & J. Cavanagh n

co-author countries: United States of America 🇺🇸
author keywords: AbrB; NMR; Bacillus anthracis; Transition state regulator
MeSH headings : Bacillus anthracis; Bacterial Proteins / chemistry; DNA-Binding Proteins / chemistry; Nuclear Magnetic Resonance, Biomolecular; Protein Structure, Secondary; Transcription Factors / chemistry
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent

BIOCHEMISTRY, 51(49), 9776–9778.

By: R. Thompson n, B. Bobay n, S. Stowe n, A. Olson n, L. Peng n, Z. Su n, L. Actis*, C. Melander n, J. Cavanagh n

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Bacterial Proteins / chemistry; Bacterial Proteins / physiology; Biofilms / drug effects; Imidazoles / pharmacology; Microscopy, Confocal; Models, Molecular
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Medicinal chemistry: Forcing an enemy into the open

Nature Chemistry, 4(9), 692–693.

By: C. Melander & D. Margolis

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(45), 11254–11257.

By: T. Harris n, R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: 2-aminoimidazoles; adjuvants; antibiotics; antibiotic resistance; MRSA
MeSH headings : Anti-Bacterial Agents / pharmacology; Drug Resistance; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Oxacillin / pharmacology
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae

ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361.

By: R. Worthington n, C. Bunders n, C. Reed n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: NDM-1; Klebsiella pneumoniae; antibiotic adjuvant; resistance suppression; 2-aminoimidazole
Source: Web Of Science
Added: August 6, 2018

2012 journal article

Small molecule control of bacterial biofilms

Organic & Biomolecular Chemistry, 10(37), 7457–7474.

By: R. Worthington, J. Richards & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities

ACS MACRO LETTERS, 1(3), 370–374.

By: J. Budhathoki-Uprety n, L. Peng n, C. Melander n & B. Novak*

co-author countries: United States of America 🇺🇸
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(6), 2679–2687.

By: C. Liu*, R. Worthington n, C. Melander n & H. Wu*

co-author countries: United States of America 🇺🇸
MeSH headings : Adhesins, Bacterial / analysis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Gene Expression Profiling; Streptococcus mutans / drug effects; Streptococcus mutans / genetics; Streptococcus mutans / growth & development
Source: Web Of Science
Added: August 6, 2018

2011 journal article

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(15), 4516–4519.

By: T. Harris n, R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: 2-Aminoimidazole; Amino aldehyde; Biofilm; Antibiotic
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2011 review

Anti-biofilm compounds derived from marine sponges

[Review of ]. Marine Drugs, 9(10), 2010–2035.

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii

CHEMMEDCHEM, 6(12), 2243–2251.

By: Z. Su n, L. Peng n, R. Worthington n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: aminoimidazoles; antibiotic resensitization; biofilms; MRSA; synergism
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / physiology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Imidazoles / chemistry; Methicillin-Resistant Staphylococcus aureus / drug effects; Methicillin-Resistant Staphylococcus aureus / physiology; Oxacillin / chemistry; Oxacillin / pharmacology; Structure-Activity Relationship; Triazoles / chemistry
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms

ORGANIC & BIOMOLECULAR CHEMISTRY, 9(15), 5476–5481.

By: C. Bunders n, J. Cavanagh n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Amides / chemical synthesis; Amides / chemistry; Amides / pharmacology; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Indole Alkaloids / chemistry; Indoles / chemical synthesis; Indoles / chemistry; Indoles / pharmacology; Inhibitory Concentration 50; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Quantitative Structure-Activity Relationship; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles

SMALL, 7(14), 2027–2031.

By: J. Bresee*, K. Maier*, A. Boncella*, C. Melander n & D. Feldheim n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / pharmacology; Gold / pharmacology; Hydrogen Bonding / drug effects; Hydrophobic and Hydrophilic Interactions / drug effects; Ligands; Metal Nanoparticles / chemistry; Microbial Sensitivity Tests; Spectrophotometry, Infrared; Staphylococcus aureus / drug effects; Staphylococcus aureus / growth & development; Sulfhydryl Compounds / pharmacology
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit

Chemical Communications (Cambridge, England), 47(17), 4896–4898.

By: L. Peng, J. DeSousa, Z. Su, B. Novak, A. Nevzorov, E. Garland, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2011 journal article

Intercepting Bacterial Indole Signaling with Flustramine Derivatives

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163.

By: C. Bunders n, M. Minvielle n, R. Worthington n, M. Ortiz n, J. Cavanagh n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Escherichia coli / metabolism; Hydrocarbons, Brominated / metabolism; Indole Alkaloids / metabolism; Indoles / metabolism; Signal Transduction; Staphylococcus aureus / metabolism
Source: Web Of Science
Added: August 6, 2018

2011 journal article

Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(4), 1257–1260.

By: S. Rogers n, E. Lindsey n, D. Whitehead n, T. Mullikin n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: Biofilms; Anti-biofilm; Antibiotic; 2-Aminoimidazole; Menthyl carbamate
Source: Web Of Science
Added: August 6, 2018

2010 journal article

A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity

Organic & Biomolecular Chemistry, 8(12), 2814–2822.

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Analysis of kinamycin D-mediated DNA cleavage

TETRAHEDRON LETTERS, 51(11), 1455–1458.

By: C. Heinecke n & C. Melander n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents

CHEMBIOCHEM, 11(3), 396–410.

By: S. Rogers n, J. Bero n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: aminoimidazoles; biofilms; MDRAB; MRSA; multidrug-resistant bacteria
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Antifungal Agents / chemical synthesis; Antifungal Agents / chemistry; Antifungal Agents / pharmacology; Biofilms / drug effects; Drug Resistance, Multiple, Bacterial / drug effects; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Identification of antibiotics using small molecule variable ligand display on gold nanoparticles

Chemical Communications (Cambridge, England), 46(40), 7516–7518.

By: J. Bresee, K. Maier, C. Melander & D. Feldheim

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12), 3797–3800.

By: C. Bunders n, J. Richards n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: 2-Aminoimidazoles; Bacterial biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemistry; Biofilms / drug effects; Escherichia coli / drug effects; Gram-Negative Bacteria / drug effects; Imidazoles / chemistry; Imidazoles / pharmacology; Plankton / drug effects; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Modulating the development of E. coli biofilms with 2-aminoimidazoles

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(21), 6310–6312.

By: C. Reed n, R. Huigens n, S. Rogers n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: 2-Aminoimidazoles; E. coli; Biofilms
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Drug Design; Escherichia coli / drug effects; Escherichia coli / growth & development; Hemolysis / drug effects; Humans; Imidazoles / chemical synthesis; Imidazoles / pharmacology; In Vitro Techniques; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112–2118.

By: S. Rogers n, R. Huigens n, J. Cavanagh n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Calcium Chloride / pharmacology; Chlorides / pharmacology; Colistin / pharmacology; Drug Resistance, Bacterial; Drug Resistance, Multiple; Drug Synergism; Enterococcus faecium / drug effects; Erythrocytes / drug effects; Escherichia coli / drug effects; Humans; Imidazoles / chemistry; Imidazoles / pharmacology; Magnesium / pharmacology; Manganese Compounds / pharmacology; Methicillin-Resistant Staphylococcus aureus / drug effects; Novobiocin / pharmacology; Staphylococcus epidermidis / drug effects; Tobramycin / pharmacology; Triazoles / pharmacology
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives

Organic & Biomolecular Chemistry, 8(17), 3857–3859.

By: S. Rogers, D. Whitehead, T. Mullikin & C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2010 journal article

The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674.

By: R. Huigens n, S. Reyes n, C. Reed n, C. Bunders n, S. Rogers n, A. Steinhauer n, C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: 2-Aminobenzimidazole; Chemical library synthesis; Antibiotic; Multidrug-resistant bacteria; Staphylococcus aureus; Acinetobacter baumannii
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Drug Resistance, Multiple, Bacterial; Methicillin-Resistant Staphylococcus aureus / drug effects; Microbial Sensitivity Tests; Molecular Conformation; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(29), 9868-+.

By: S. Rogers n, R. Huigens n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Benzimidazoles / chemical synthesis; Benzimidazoles / chemistry; Benzimidazoles / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Dose-Response Relationship, Drug; Gram-Positive Bacteria / drug effects; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship; Zinc / chemistry; Zinc / pharmacology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity

JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585.

By: J. Richards n, S. Reyes n, S. Stowe n, A. Tucker n, T. Ballard n, L. Mathies n, J. Cavanagh n, C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Amides / chemical synthesis; Amides / pharmacology; Amides / toxicity; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Caenorhabditis elegans / drug effects; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / physiology; Pyrroles / chemical synthesis; Pyrroles / pharmacology; Pyrroles / toxicity; Structure-Activity Relationship; Sulfonamides / chemical synthesis; Sulfonamides / pharmacology; Thiourea / chemical synthesis; Thiourea / pharmacology; Urea / chemical synthesis; Urea / pharmacology
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation

JOURNAL OF ORGANIC CHEMISTRY, 74(4), 1755–1758.

By: T. Ballard n, J. Richards n, A. Aquino n, C. Reed n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Acylation; Biofilms / drug effects; Oxidation-Reduction; Proteobacteria / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries / chemical synthesis; Small Molecule Libraries / chemistry; Small Molecule Libraries / pharmacology
Source: Web Of Science
Added: August 6, 2018

2009 review

Controlling Bacterial Biofilms

[Review of ]. CHEMBIOCHEM, 10(14), 2287–2294.

By: J. Richards n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: bacteriophages; biofilms; drug discovery; natural products; quorum sensing
MeSH headings : Anti-Bacterial Agents / pharmacology; Bacteria / growth & development; Bacterial Physiological Phenomena; Bacteriophages / growth & development; Biofilms / growth & development; Biological Products / pharmacology; Drug Design; Quorum Sensing / physiology; Small Molecule Libraries
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Evaluation of dihydrooroidin as an antifouling additive in marine paint

INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529–532.

By: C. Melander n, P. Moeller*, T. Ballard n, J. Richards n, R. Huigens n & J. Cavanagh n

co-author countries: United States of America 🇺🇸
author keywords: Antifouling; Biofilms; Natural products
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(4), 794–802.

By: R. Huigens n, S. Rogers n, A. Steinhauer n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Anti-Bacterial Agents / chemical synthesis; Biofilms / drug effects; Imidazoles / chemistry; Pseudomonas aeruginosa / drug effects; Small Molecule Libraries / chemical synthesis; Staphylococcus aureus / drug effects; Triazoles / chemical synthesis
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Tandem dispersion and killing of bacteria from a biofilm

ORGANIC & BIOMOLECULAR CHEMISTRY, 7(3), 603–606.

By: S. Rogers n, M. Krayer n, J. Lindsey n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Bacteria / growth & development; Biofilms; Microbial Viability / drug effects; Photosensitizing Agents / chemistry; Photosensitizing Agents / pharmacology; Triazoles / chemistry; Triazoles / pharmacology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2008 journal article

Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(28), 5229–5231.

By: S. Rogers n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: biofilms; combinatorial chemistry; dispersion; inhibition; marine natural products
MeSH headings : Bacteria / drug effects; Biofilms / drug effects; Imidazoles / pharmacology; Imidazoles / therapeutic use; Small Molecule Libraries
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Control of bacterial biofilms with marine alkaloid derivatives

MOLECULAR BIOSYSTEMS, 4(6), 614–621.

By: R. Huigens n, L. Ma*, C. Gambino n, P. Moeller*, A. Basso n, J. Cavanagh n, D. Wozniak*, C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Acinetobacter baumannii / drug effects; Acylation; Alkaloids / chemical synthesis; Alkaloids / chemistry; Alkaloids / pharmacology; Animals; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Bordetella bronchiseptica / drug effects; Cell Line; Dose-Response Relationship, Drug; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Mice; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Rats; Staphylococcus aureus / drug effects
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(15), 4325–4327.

By: J. Richards n, C. Reed n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: biofilm; inhibition; dispersion; marine natural products; oroidin
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Humans; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues

ORGANIC & BIOMOLECULAR CHEMISTRY, 6(8), 1356–1363.

By: J. Richards n, T. Ballard n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Humans; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Inhibition and dispersion of proteobacterial biofilms

Chemical Communications (Cambridge, England), (14), 1698–1700.

Source: NC State University Libraries
Added: August 6, 2018

2008 journal article

Inhibition of HIV fusion with multivalent gold nanoparticles

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(22), 6896-+.

By: M. Bowman n, T. Ballard n, C. Ackerson n, D. Feldheim n, D. Margolis n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Amides / chemistry; Amides / pharmacology; Gold / chemistry; Gold / pharmacology; HIV Fusion Inhibitors / chemistry; HIV Fusion Inhibitors / pharmacology; HIV Infections / drug therapy; HIV-1 / physiology; Metal Nanoparticles / chemistry; Metal Nanoparticles / therapeutic use; Quaternary Ammonium Compounds / chemistry; Quaternary Ammonium Compounds / pharmacology
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Kinamycin-mediated DNA cleavage under biomimetic conditions

TETRAHEDRON LETTERS, 49(19), 3157–3161.

By: T. Ballard n & C. Melander n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study

CHEMISTRY-A EUROPEAN JOURNAL, 14(34), 10745–10761.

By: T. Ballard n, J. Richards n, A. Wolfe n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: amino acids; biological activity; drug design; medicinal chemistry; structure-activity relationships
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Drug Design; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms

CHEMBIOCHEM, 9(8), 1267–1279.

By: J. Richards n, T. Ballard n, R. Huigens n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: biological activity; drug design; medicinal chemistry; natural products; structure-activity relationships
MeSH headings : Biofilms; Cross-Linking Reagents / chemistry; Databases, Factual; Drug Design; Drug Evaluation, Preclinical; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction

JOURNAL OF ORGANIC CHEMISTRY, 73(13), 5191–5193.

By: J. Richards n & C. Melander n

co-author countries: United States of America 🇺🇸
MeSH headings : Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Bacteria / drug effects; Biofilms / drug effects; Combinatorial Chemistry Techniques; Imidazoles / chemical synthesis; Molecular Structure
Source: Web Of Science
Added: August 6, 2018

2008 journal article

Targeting RNA with cysteine-constrained peptides

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565–567.

By: V. Burns n, B. Bobay n, A. Basso n, J. Cavanagh n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: RNA; cyclic peptides; HADDOCK
MeSH headings : Base Sequence; Cysteine / chemistry; Humans; Models, Molecular; Peptides, Cyclic / chemistry; RNA / chemistry
Source: Web Of Science
Added: August 6, 2018

2007 journal article

Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues

Journal of the American Chemical Society, 129(22), 6966-.

By: R. Huigens, J. Richards, G. Parise, T. Ballard, W. Zeng, R. Deora, C. Melander

Source: NC State University Libraries
Added: August 6, 2018

2006 journal article

Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19), 5148–5151.

By: W. Zeng n, T. Ballard n, A. Tkachenko, V. Burns n, D. Feldheim n & C. Melander n

co-author countries: United States of America 🇺🇸
author keywords: kinamycins; lomaiviticins; DNA cleavage; diazofluorenes; antiproliferative activity
MeSH headings : Animals; Antineoplastic Agents / chemical synthesis; Antineoplastic Agents / pharmacology; Carbazoles / pharmacology; Cell Proliferation / drug effects; DNA Damage / drug effects; Fluorenes / chemical synthesis; Fluorenes / pharmacology; HeLa Cells; Humans; Molecular Mimicry; Structure-Activity Relationship
Source: Web Of Science
Added: August 6, 2018

2006 journal article

Tuning the oxidation properties of vanadium(V) through ligand stoichiometry

TETRAHEDRON LETTERS, 47(33), 5923–5926.

By: W. Zeng n, T. Ballard n & C. Melander n

co-author countries: United States of America 🇺🇸
Source: Web Of Science
Added: August 6, 2018

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