Christian Corey Melander

Belardinelli, J. M., Li, W., Martin, K. H., Zeiler, M. J., Lian, E., Avanzi, C., … Jackson, M. (2022). 2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 23(6). https://doi.org/10.3390/ijms23062950

Borrel, A., Melander, C., & Fourches, D. (2021). Cheminformatics Analysis of Fluoroquinolones and Their Inhibition Potency Against Four Pathogens. MOLECULAR INFORMATICS, 40(5). https://doi.org/10.1002/minf.202000215

Jeon, A. B., Ackart, D. F., Li, W., Jackson, M., Melander, R. J., Melander, C., … Obregon-Henao, A. (2019). 2-aminoimidazoles collapse mycobacterial proton motive force and block the electron transport chain. SCIENTIFIC REPORTS, 9. https://doi.org/10.1038/s41598-018-38064-7

Nguyen, T. V., Minrovic, B. M., Melander, R. J., & Melander, C. (2019). Identification of Anti-Mycobacterial Biofilm Agents Based on the 2-Aminoimidazole Scaffold. CHEMMEDCHEM, 14(9), 927–937. https://doi.org/10.1002/cmdc.201900033

Martin, S. E., Melander, R. J., Brackett, C. M., Scott, A. J., Chandler, C. E., Nguyen, C. M., … Melander, C. (2019). Small Molecule Potentiation of Gram-Positive Selective Antibiotics against Acinetobacter baumannii. ACS INFECTIOUS DISEASES, 5(7), 1223–1230. https://doi.org/10.1021/acsinfecdis.9b00067

Nguyen, T. V., Peszko, M. T., Melander, R. J., & Melander, C. (2019). Using 2-aminobenzimidazole derivatives to inhibit Mycobacterium smegmatis biofilm formation. MEDCHEMCOMM, 10(3), 456–459. https://doi.org/10.1039/c9md00025a

Hubble, V. B., Hubbard, B. A., Minrovic, B. M., Melander, R. J., & Melander, C. (2019). Using Small-Molecule Adjuvants to Repurpose Azithromycin for Use against Pseudomonas aeruginosa. ACS INFECTIOUS DISEASES, 5(1), 141–151. https://doi.org/10.1021/acsinfecdis.8b00288

Melander, R. J., Zurawski, D. V., & Melander, C. (2018). [Review of Narrow-spectrum antibacterial agents]. MEDCHEMCOMM, 9(1), 12–21. https://doi.org/10.1039/c7md00528h

Milton, M. E., Minrovic, B. M., Harris, D. L., Kang, B., Jung, D., Lewis, C. P., … Cavanagh, J. (2018). Re-sensitizing Multidrug Resistant Bacteria to Antibiotics by Targeting Bacterial Response Regulators: Characterization and Comparison of Interactions between 2-Aminoimidazoles and the Response Regulators BfmR from Acinetobacter baumannii and QseB from Francisella spp. FRONTIERS IN MOLECULAR BIOSCIENCES, 5. https://doi.org/10.3389/fmolb.2018.00015

Jeon, A. B., Obregon-Henao, A., Ackart, D. F., Podell, B. K., Belardinelli, J. M., Jackson, M., … Basaraba, R. J. (2017). 2-aminoimidazoles potentiate beta-lactam antimicrobial activity against Mycobacterium tuberculosis by reducing beta-lactamase secretion and increasing cell envelope permeability. PLoS One, 12(7).

Yuen, J. D., Walper, S. A., Melde, B. J., Daniele, M. A., & Stenger, D. A. (2017). Electrolyte-sensing transistor decals enabled by ultrathin microbial nanocellulose. Scientific Reports, 7.

Draughn, G. L., Allen, C. L., Routh, P. A., Stone, M. R., Kirker, K. R., Boegli, A., … Cavanagh, J. (2017). Evaluation of a 2-aminoimidazole variant as adjuvant treatment for dermal bacterial infections. Drug Design Development and Therapy, 11, 153–162.

Byrne-Nash, R., Lucero, D. M., Osbaugh, N. A., Melander, R. J., Melander, C., & Feldheim, D. L. (2017). Probing the Mechanism of LAL-32, a Gold Nanoparticle-Based Antibiotic Discovered through Small Molecule Variable Ligand Display. BIOCONJUGATE CHEMISTRY, 28(7), 1807–1810. https://doi.org/10.1021/acs.bioconjchem.7b00199

Barker, W. T., Martin, S. E., Chandler, C. E., Nguyen, T. V., Harris, T. L., Goodell, C., … Melander, C. (2017). Small molecule adjuvants that suppress both chromosomal and mcr-1 encoded colistin-resistance and amplify colistin efficacy in polymyxin-susceptible bacteria. BIOORGANIC & MEDICINAL CHEMISTRY, 25(20), 5749–5753. https://doi.org/10.1016/j.bmc.2017.08.055

Milton, M. E., Allen, C. L., Feldmann, E. A., Bobay, B. G., Jung, D. K., Stephens, M. D., … Cavanagh, J. (2017). Structure of the Francisella response regulator QseB receiver domain, and characterization of QseB inhibition by antibiofilm 2-aminoimidazole-based compounds. MOLECULAR MICROBIOLOGY, 106(2), 223–235. https://doi.org/10.1111/mmi.13759

Garcia, S. S., Blackledge, M. S., Michalek, S., Su, L., Ptacek, T., Eipers, P., … Wu, H. (2017). Targeting of Streptococcus mutans Biofilms by a Novel Small Molecule Prevents Dental Caries and Preserves the Oral Microbiome. JOURNAL OF DENTAL RESEARCH, 96(7), 807–814. https://doi.org/10.1177/0022034517698096

Melander, R. J., & Melander, C. (2017, August). The Challenge of Overcoming Antibiotic Resistance: An Adjuvant Approach? ACS INFECTIOUS DISEASES, Vol. 3, pp. 559–563. https://doi.org/10.1021/acsinfecdis.7b00071

Nguyen, T. V., Blackledge, M. S., Lindsey, E. A., Minrovic, B. M., Ackart, D. F., Jeon, A. B., … Melander, C. (2017). The Discovery of 2-Aminobenzimidazoles That Sensitize Mycobacterium smegmatis and M. tuberculosis to beta-Lactam Antibiotics in a Pattern Distinct from beta-Lactamase Inhibitors. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 56(14), 3940–3944. https://doi.org/10.1002/anie.201612006

Stephens, M. D., Yodsanit, N., & Melander, C. (2016). Evaluation of ethyl N-(2-phenethyl) carbamate analogues as biofilm inhibitors of methicillin resistant Staphylococcus aureus. ORGANIC & BIOMOLECULAR CHEMISTRY, 14(28), 6853–6856. https://doi.org/10.1039/c6ob00706f

Melander, R. J., Liu, H.-bing, Stephens, M. D., Bewley, C. A., & Melander, C. (2016). Marine sponge alkaloids as a source of anti-bacterial adjuvants. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 26(24), 5863–5866. https://doi.org/10.1016/j.bmcl.2016.11.018

Stephens, M. D., Hubble, V. B., Ernst, R. K., Hoek, M. L., Melander, R. J., Cavanagh, J., & Melander, C. (2016). Potentiation of Francisella resistance to conventional antibiotics through small molecule adjuvants. MEDCHEMCOMM, 7(1), 128–131. https://doi.org/10.1039/c5md00353a

Stephens, M. D., Yodsanit, N., & Melander, C. (2016). Potentiation of the fosmidomycin analogue FR 900098 with substituted 2-oxazolines against Francisella novicida. MEDCHEMCOMM, 7(10), 1952–1956. https://doi.org/10.1039/c6md00365f

Brackett, C. M., Furlani, R. E., Anderson, R. G., Krishnamurthy, A., Melander, R. J., Moskowitz, S. M., … Melander, C. (2016). Second generation modifiers of colistin resistance show enhanced activity and lower inherent toxicity. TETRAHEDRON, 72(25), 3549–3553. https://doi.org/10.1016/j.tet.2015.09.019

Pan, W., Fan, M., Wu, H., Melander, C., & Liu, C. (2015). A new small molecule inhibits Streptococcus mutans biofilms invitro and in vivo. Journal of Applied Microbiology, 119(5), 1403–1411. https://doi.org/10.1111/jam.12940

Wahome, P. G., Beauchesne, K. R., Pedone, A. C., Cavanagh, J., Melander, C., Zimba, P., & Moeller, P. D. R. (2015). Augmenting anti-cancer natural products with a small molecule adjuvant. Marine Drugs, 13(1), 65–75.

Melander, R. J., & Melander, C. (2015, April 23). From Worms to Targeting Virulence Factors. CHEMISTRY & BIOLOGY, Vol. 22, pp. 436–437. https://doi.org/10.1016/j.chembiol.2015.04.005

Garrido, C., Simpson, C. A., Dahl, N. P., Bresee, J., Whitehead, D. C., Lindsey, E. A., … Margolis, D. M. (2015). Gold nanoparticles to improve HIV drug delivery. FUTURE MEDICINAL CHEMISTRY, 7(9), 1097–1107. https://doi.org/10.4155/fmc.15.57

Richardson, M. A., Furlani, R. E., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Basaraba, R. J. (2015). Inhibition and breaking of advanced glycation end-products (AGEs) with bis-2-aminoimidazole derivatives. TETRAHEDRON LETTERS, 56(23), 3406–3409. https://doi.org/10.1016/j.tetlet.2015.01.122

Melander, R. J., & Melander, C. (2015). Innovative strategies for combating biofilm-based infections. Biofilm-Based Healthcare-Associated Infections, Vol Ii, 831, 69–91.

Stowe, S. D., Thompson, R. J., Peng, L., Su, Z., Blackledge, M. S., Draughn, G. L., … Cavanagh, J. (2015). Membrane-Permeabilizing Activity of Reverse-Amide 2-Aminoimidazole Antibiofilm Agents Against Acinetobacter baumannii. CURRENT DRUG DELIVERY, 12(2), 223–230. https://doi.org/10.2174/1567201811666140924125740

Furlani, R. E., Richardson, M. A., Podell, B. K., Ackart, D. F., Haugen, J. D., Melander, R. J., … Melander, C. (2015). Second generation 2-aminoimidazole based advanced glycation end product inhibitors and breakers. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 25(21), 4820–4823. https://doi.org/10.1016/j.bmcl.2015.06.080

Melander, R. J., Minvielle, M. J., & Melander, C. (2014). Controlling bacterial behavior with indole-containing natural products and derivatives. TETRAHEDRON, 70(37), 6363–6372. https://doi.org/10.1016/j.tet.2014.05.089

Ackart, D. F., Hascall-Dove, L., Caceres, S. M., Kirk, N. M., Podell, B. K., Melander, C., … Basaraba, R. J. (2014). Expression of antimicrobial drug tolerance by attached communities of Mycobacterium tuberculosis. PATHOGENS AND DISEASE, 70(3), 359–369. https://doi.org/10.1111/2049-632x.12144

Bresee, J., Bond, C. M., Worthington, R. J., Smith, C. A., Gifford, J. C., Simpson, C. A., … Feldheim, D. L. (2014). Nanoscale Structure-Activity Relationships, Mode of Action, and Biocompatibility of Gold Nanoparticle Antibiotics. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 136(14), 5295–5300. https://doi.org/10.1021/ja408505n

Ackart, D. F., Lindsey, E. A., Podell, B. K., Melander, R. J., Basaraba, R. J., & Melander, C. (2014). Reversal of Mycobacterium tuberculosis phenotypic drug resistance by 2-aminoimidazole- based small molecules. PATHOGENS AND DISEASE, 70(3), 370–378. https://doi.org/10.1111/2049-632x.12143

Harris, T. L., Worthington, R. J., Hittle, L. E., Zurawski, D. V., Ernst, R. K., & Melander, C. (2014). Small Molecule Downregulation of PmrAB Reverses Lipid A Modification and Breaks Colistin Resistance. ACS CHEMICAL BIOLOGY, 9(1), 122–127. https://doi.org/10.1021/cb400490k

Brackett, C. M., Melander, R. J., An, I. H., Krishnamurthy, A., Thompson, R. J., Cavanagh, J., & Melander, C. (2014). Small-Molecule Suppression of beta-Lactam Resistance in Multidrug-Resistant Gram-Negative Pathogens. JOURNAL OF MEDICINAL CHEMISTRY, 57(17), 7450–7458. https://doi.org/10.1021/jm501050e

Gifford, J. C., Bresee, J., Carter, C. J., Wang, G., Melander, R. J., Melander, C., & Feldheim, D. L. (2014). Thiol-modified gold nanoparticles for the inhibition of Mycobacterium smegmatis. CHEMICAL COMMUNICATIONS, 50(100), 15860–15863. https://doi.org/10.1039/c4cc06236a

Furlani, R. E., Yeagley, A. A., & Melander, C. (2013). A flexible approach to 1,4-di-substituted 2-aminoimidazoles that inhibit and disperse biofilms and potentiate the effects of beta-lactams against multi-drug resistant bacteria. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 62, 59–70. https://doi.org/10.1016/j.ejmech.2012.12.005

Blackledge, M. S., Worthington, R. J., & Melander, C. (2013). Biologically inspired strategies for combating bacterial biofilms. CURRENT OPINION IN PHARMACOLOGY, 13(5), 699–706. https://doi.org/10.1016/j.coph.2013.07.004

Worthington, R. J., & Melander, C. (2013). [Review of Combination approaches to combat multidrug-resistant bacteria]. TRENDS IN BIOTECHNOLOGY, 31(3), 177–184. https://doi.org/10.1016/j.tibtech.2012.12.006

Minvielle, M. J., Eguren, K., & Melander, C. (2013). Highly Active Modulators of Indole Signaling Alter Pathogenic Behaviors in Gram-Negative and Gram-Positive Bacteria. CHEMISTRY-A EUROPEAN JOURNAL, 19(51), 17595–17602. https://doi.org/10.1002/chem.201303510

Minvielle, M. J., Bunders, C. A., & Melander, C. (2013). Indole-triazole conjugates are selective inhibitors and inducers of bacterial biofilms. MEDCHEMCOMM, 4(6), 916–919. https://doi.org/10.1039/c3md00064h

Yeagley, A. A., Su, Z., McCullough, K. D., Worthington, R. J., & Melander, C. (2013). N-Substituted 2-aminoimidazole inhibitors of MRSA biofilm formation accessed through direct 1,3-bis(tert-butoxycarbonyl)guanidine cyclization. ORGANIC & BIOMOLECULAR CHEMISTRY, 11(1), 130–137. https://doi.org/10.1039/c2ob26469b

Worthington, R. J., & Melander, C. (2013). Overcoming Resistance to beta-Lactam Antibiotics. JOURNAL OF ORGANIC CHEMISTRY, 78(9), 4207–4213. https://doi.org/10.1021/jo400236f

Blackledge, M. S., & Melander, C. (2013). Programmable DNA-binding small molecules. BIOORGANIC & MEDICINAL CHEMISTRY, 21(20), 6101–6114. https://doi.org/10.1016/j.bmc.2013.04.023

Worthington, R. J., Blackledge, M. S., & Melander, C. (2013). [Review of Small-molecule inhibition of bacterial two-component systems to combat antibiotic resistance and virulence]. FUTURE MEDICINAL CHEMISTRY, 5(11), 1265–1284. https://doi.org/10.4155/fmc.13.58

Lindsey, E. A., Worthington, R. J., Alcaraz, C., & Melander, C. (2012). 2-Aminopyrimidine as a novel scaffold for biofilm modulation. Organic & Biomolecular Chemistry, 10(13), 2552–2561.

Su, Z., Peng, L., & Melander, C. (2012). A modular approach to the synthesis of 1,4,5-substituted-2-aminoimidazoles. TETRAHEDRON LETTERS, 53(10), 1204–1206. https://doi.org/10.1016/j.tetlet.2011.12.090

Worthington, R. J., & Melander, C. (2012). Deconvoluting Interspecies Bacterial Communication. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(26), 6314–6315. https://doi.org/10.1002/anie.201202440

Stowe, S. D., Tucker, A. T., Thompson, R., Piper, A., Richards, J. J., Rogers, S. A., … Cavanagh, J. (2012). Evaluation of the toxicity of 2-aminoimidazole antibiofilm agents using both cellular and model organism systems. DRUG AND CHEMICAL TOXICOLOGY, 35(3), 310–315. https://doi.org/10.3109/01480545.2011.614620

Worthington, R. J., Rogers, S. A., Huigens, R. W., III, Melander, C., & Ritchie, D. F. (2012). Foliar-Applied Small Molecule that Suppresses Biofilm Formation and Enhances Control of Copper-Resistant Xanthomonas euvesicatoria on Pepper. PLANT DISEASE, 96(11), 1638–1644. https://doi.org/10.1094/pdis-02-12-0190-re

Olson, A. L., Bobay, B. G., Melander, C., & Cavanagh, J. (2012). H-1, C-13, and N-15 resonance assignments and secondary structure prediction of the full-length transition state regulator AbrB from Bacillus anthracis. BIOMOLECULAR NMR ASSIGNMENTS, 6(1), 95–98. https://doi.org/10.1007/s12104-011-9333-2

Thompson, R. J., Bobay, B. G., Stowe, S. D., Olson, A. L., Peng, L., Su, Z., … Cavanagh, J. (2012). Identification of BfmR, a Response Regulator Involved in Biofilm Development, as a Target for a 2-Aminoimidazole-Based Antibiofilm Agent. BIOCHEMISTRY, 51(49), 9776–9778. https://doi.org/10.1021/bi3015289

Melander, C., & Margolis, D. M. (2012). Medicinal chemistry: Forcing an enemy into the open. Nature Chemistry, 4(9), 692–693.

Harris, T. L., Worthington, R. J., & Melander, C. (2012). Potent Small-Molecule Suppression of Oxacillin Resistance in Methicillin-Resistant Staphylococcus aureus. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 51(45), 11254–11257. https://doi.org/10.1002/anie.201206911

Worthington, R. J., Bunders, C. A., Reed, C. S., & Melander, C. (2012). Small Molecule Suppression of Carbapenem Resistance in NDM-1 Producing Klebsiella pneumoniae. ACS MEDICINAL CHEMISTRY LETTERS, 3(5), 357–361. https://doi.org/10.1021/ml200290p

Worthington, R. J., Richards, J. J., & Melander, C. (2012). Small molecule control of bacterial biofilms. Organic & Biomolecular Chemistry, 10(37), 7457–7474.

Budhathoki-Uprety, J., Peng, L. L., Melander, C., & Novak, B. M. (2012). Synthesis of Guanidinium Functionalized Polycarbodiimides and Their Antibacterial Activities. ACS MACRO LETTERS, 1(3), 370–374. https://doi.org/10.1021/mz200116k

Liu, C., Worthington, R. J., Melander, C., & Wu, H. (2011). A New Small Molecule Specifically Inhibits the Cariogenic Bacterium Streptococcus mutans in Multispecies Biofilms. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 55(6), 2679–2687. https://doi.org/10.1128/aac.01496-10

Harris, T. L., Worthington, R. J., & Melander, C. (2011). A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(15), 4516–4519. https://doi.org/10.1016/j.bmcl.2011.05.123

Stowe, S. D., Richards, J. J., Tucker, A. T., Thompson, R., Melander, C., & Cavanagh, J. (2011). [Review of Anti-biofilm compounds derived from marine sponges]. Marine Drugs, 9(10), 2010–2035.

Su, Z., Peng, L., Worthington, R. J., & Melander, C. (2011). Evaluation of 4,5-Disubstituted-2-Aminoimidazole-Triazole Conjugates for Antibiofilm/Antibiotic Resensitization Activity Against MRSA and Acinetobacter baumannii. CHEMMEDCHEM, 6(12), 2243–2251. https://doi.org/10.1002/cmdc.201100316

Bunders, C., Cavanagh, J., & Melander, C. (2011). Flustramine inspired synthesis and biological evaluation of pyrroloindoline triazole amides as novel inhibitors of bacterial biofilms. ORGANIC & BIOMOLECULAR CHEMISTRY, 9(15), 5476–5481. https://doi.org/10.1039/c1ob05605k

Bresee, J., Maier, K. E., Boncella, A. E., Melander, C., & Feldheim, D. L. (2011). Growth Inhibition of Staphylococcus aureus by Mixed Monolayer Gold Nanoparticles. SMALL, 7(14), 2027–2031. https://doi.org/10.1002/smll.201100420

Peng, L. L., DeSousa, J., Su, Z. M., Novak, B. M., Nevzorov, A. A., Garland, E. R., & Melander, C. (2011). Inhibition of Acinetobacter baumannii biofilm formation on a methacrylate polymer containing a 2-aminoimidazole subunit. Chemical Communications (Cambridge, England), 47(17), 4896–4898.

Bunders, C. A., Minvielle, M. J., Worthington, R. J., Ortiz, M., Cavanagh, J., & Melander, C. (2011). Intercepting Bacterial Indole Signaling with Flustramine Derivatives. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 133(50), 20160–20163. https://doi.org/10.1021/ja209836z

Rogers, S. A., Lindsey, E. A., Whitehead, D. C., Mullikin, T., & Melander, C. (2011). Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 21(4), 1257–1260. https://doi.org/10.1016/j.bmcl.2010.12.057

Su, Z. M., Rogers, S. A., McCall, W. S., Smith, A. C., Ravishankar, S., Mullikin, T., & Melander, C. (2010). A nitroenolate approach to the synthesis of 4,5-disubstituted-2-aminoimidazoles. Pilot library assembly and screening for antibiotic and antibiofilm activity. Organic & Biomolecular Chemistry, 8(12), 2814–2822.

Heinecke, C. L., & Melander, C. (2010). Analysis of kinamycin D-mediated DNA cleavage. TETRAHEDRON LETTERS, 51(11), 1455–1458. https://doi.org/10.1016/j.tetlet.2009.12.142

Rogers, S. A., Bero, J. D., & Melander, C. (2010). Chemical Synthesis and Biological Screening of 2-Aminoimidazole-Based Bacterial and Fungal Antibiofilm Agents. CHEMBIOCHEM, 11(3), 396–410. https://doi.org/10.1002/cbic.200900617

Bresee, J., Maier, K. E., Melander, C., & Feldheim, D. L. (2010). Identification of antibiotics using small molecule variable ligand display on gold nanoparticles. Chemical Communications (Cambridge, England), 46(40), 7516–7518.

Bunders, C. A., Richards, J. J., & Melander, C. (2010). Identification of aryl 2-aminoimidazoles as biofilm inhibitors in Gram-negative bacteria. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(12), 3797–3800. https://doi.org/10.1016/j.bmcl.2010.04.042

Reed, C. S., Huigens, R. W., III, Rogers, S. A., & Melander, C. (2010). Modulating the development of E. coli biofilms with 2-aminoimidazoles. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 20(21), 6310–6312. https://doi.org/10.1016/j.bmcl.2010.08.075

Rogers, S. A., Huigens, R. W., III, Cavanagh, J., & Melander, C. (2010). Synergistic Effects between Conventional Antibiotics and 2-Aminoimidazole-Derived Antibiofilm Agents. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 54(5), 2112–2118. https://doi.org/10.1128/aac.01418-09

Rogers, S. A., Whitehead, D. C., Mullikin, T., & Melander, C. (2010). Synthesis and bacterial biofilm inhibition studies of ethyl N-(2-phenethyl) carbamate derivatives. Organic & Biomolecular Chemistry, 8(17), 3857–3859.

Huigens, R. W., III, Reyes, S., Reed, C. S., Bunders, C., Rogers, S. A., Steinhauer, A. T., & Melander, C. (2010). The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii. BIOORGANIC & MEDICINAL CHEMISTRY, 18(2), 663–674. https://doi.org/10.1016/j.bmc.2009.12.003

Rogers, S. A., Huigens, R. W., III, & Melander, C. (2009). A 2-Aminobenzimidazole That Inhibits and Disperses Gram-Positive Biofilms through a Zinc-Dependent Mechanism. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 131(29), 9868-+. https://doi.org/10.1021/ja9024676

Richards, J. J., Reyes, S., Stowe, S. D., Tucker, A. T., Ballard, T. E., Mathies, L. D., … Melander, C. (2009). Amide Isosteres of Oroidin: Assessment of Antibiofilm Activity and C. elegans Toxicity. JOURNAL OF MEDICINAL CHEMISTRY, 52(15), 4582–4585. https://doi.org/10.1021/jm900378s

Ballard, T. E., Richards, J. J., Aquino, A., Reed, C. S., & Melander, C. (2009). Antibiofilm Activity of a Diverse Oroidin Library Generated through Reductive Acylation. JOURNAL OF ORGANIC CHEMISTRY, 74(4), 1755–1758. https://doi.org/10.1021/jo802260t

Richards, J. J., & Melander, C. (2009). [Review of Controlling Bacterial Biofilms]. CHEMBIOCHEM, 10(14), 2287–2294. https://doi.org/10.1002/cbic.200900317

Melander, C., Moeller, P. D. R., Ballard, T. E., Richards, J. J., Huigens, R. W., III, & Cavanagh, J. (2009). Evaluation of dihydrooroidin as an antifouling additive in marine paint. INTERNATIONAL BIODETERIORATION & BIODEGRADATION, 63(4), 529–532. https://doi.org/10.1016/j.ibiod.2008.08.009

Huigens, R. W., III, Rogers, S. A., Steinhauer, A. T., & Melander, C. (2009). Inhibition of Acinetobacter baumannii, Staphylococcus aureus and Pseudomonas aeruginosa biofilm formation with a class of TAGE-triazole conjugates. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(4), 794–802. https://doi.org/10.1039/b817926c

Rogers, S. A., Krayer, M., Lindsey, J. S., & Melander, C. (2009). Tandem dispersion and killing of bacteria from a biofilm. ORGANIC & BIOMOLECULAR CHEMISTRY, 7(3), 603–606. https://doi.org/10.1039/b817923a

Rogers, S. A., & Melander, C. (2008). Construction and screening of a 2-aminoimidazole library identifies a small molecule capable of inhibiting and dispersing bacterial biofilms across order, class, and phylum. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 47(28), 5229–5231. https://doi.org/10.1002/anie.200800862

Huigens, R. W., III, Ma, L., Gambino, C., Moeller, P. D. R., Basso, A., Cavanagh, J., … Melander, C. (2008). Control of bacterial biofilms with marine alkaloid derivatives. MOLECULAR BIOSYSTEMS, 4(6), 614–621. https://doi.org/10.1039/b719989a

Richards, J. J., Reed, C. S., & Melander, C. (2008). Effects of N-pyrrole substitution on the anti-biofilm activities of oroidin derivatives against Acinetobacter baumannii. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(15), 4325–4327. https://doi.org/10.1016/j.bmcl.2008.06.089

Richards, J. J., Ballard, T. E., & Melander, C. (2008). Inhibition and dispersion of Pseudomonas aeruginosa biofilms with reverse amide 2-aminoimidazole oroidin analogues. ORGANIC & BIOMOLECULAR CHEMISTRY, 6(8), 1356–1363. https://doi.org/10.1039/b719082d

Richards, J. J., Huigens, R. W., Ballard, T. E., Basso, A., Cavanagh, J., & Melander, C. (2008). Inhibition and dispersion of proteobacterial biofilms. Chemical Communications (Cambridge, England), (14), 1698–1700.

Bowman, M.-C., Ballard, T. E., Ackerson, C. J., Feldheim, D. L., Margolis, D. M., & Melander, C. (2008). Inhibition of HIV fusion with multivalent gold nanoparticles. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 130(22), 6896-+. https://doi.org/10.1021/ja710321g

Ballard, T. E., & Melander, C. (2008). Kinamycin-mediated DNA cleavage under biomimetic conditions. TETRAHEDRON LETTERS, 49(19), 3157–3161. https://doi.org/10.1016/j.tetlet.2008.03.019

Ballard, T. E., Richards, J. J., Wolfe, A. L., & Melander, C. (2008). Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study. CHEMISTRY-A EUROPEAN JOURNAL, 14(34), 10745–10761. https://doi.org/10.1002/chem.200801419

Richards, J. J., Ballard, T. E., Huigens, R. W., III, & Melander, C. (2008). Synthesis and screening of an oroidin library against Pseudomonas aeruginosa biofilms. CHEMBIOCHEM, 9(8), 1267–1279. https://doi.org/10.1002/cbic.200700774

Richards, J. J., & Melander, C. (2008). Synthesis of a 2-aminoimidazole library for antibiofilm screening utilizing the Sonogashira reaction. JOURNAL OF ORGANIC CHEMISTRY, 73(13), 5191–5193. https://doi.org/10.1021/jo800618q

Burns, V. A., Bobay, B. G., Basso, A., Cavanagh, J., & Melander, C. (2008). Targeting RNA with cysteine-constrained peptides. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 18(2), 565–567. https://doi.org/10.1016/j.bmcl.2007.11.096

Huigens, R. W., Richards, J. J., Parise, G., Ballard, T. E., Zeng, W., Deora, R., & Melander, C. (2007). Inhibition of Pseudomonas aeruginosa biofilm formation with bromoageliferin analogues. Journal of the American Chemical Society, 129(22), 6966-.

Zeng, W., Ballard, T. E., Tkachenko, A. G., Burns, V. A., Feldheim, D. L., & Melander, C. (2006). Mimicking the biological activity of diazobenzo[b]fluorene natural products with electronically tuned diazofluorene analogs. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16(19), 5148–5151. https://doi.org/10.1016/j.bmcl.2006.07.024

Zeng, W., Ballard, T. E., & Melander, C. (2006). Tuning the oxidation properties of vanadium(V) through ligand stoichiometry. TETRAHEDRON LETTERS, 47(33), 5923–5926. https://doi.org/10.1016/j.tetlet.2006.06.051