Casey C Nestor

https://orcid.org/0000-0001-5939-2131

Works (25)

Updated: August 8th, 2023 21:15
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2023 journal article

KNDy neurons as the GnRH pulse generator: Recent studies in ruminants

PEPTIDES, 164.

By: C. Nestor n , C. Merkley*, M. Lehman *, S. Hileman * & R. Goodman *

author keywords: Kisspeptin; Kiss1r; Nutrition; Proopiomelanocortin; Agouti-related peptide; Kisspeptin analogs
MeSH headings : Animals; Gonadotropin-Releasing Hormone; Arcuate Nucleus of Hypothalamus / metabolism; Dynorphins / metabolism; Neurokinin B / metabolism; Neurons / metabolism; Ruminants / metabolism; Kisspeptins / metabolism
Sources: Web Of Science, ORCID
Added: May 9, 2023

2022 article

The impact of undernutrition on KNDy (kisspeptin/neurokinin B/dynorphin) neurons in female lambs

Harlow, K. L., Griesgraber, M. J., Seman, A. D., Shuping, S. L., Sommer, J. R., Griffith, E. H., … Nestor, C. C. (2022, May 17). JOURNAL OF NEUROENDOCRINOLOGY, Vol. 34.

By: K. Harlow n , M. Griesgraber *, A. Seman*, S. Shuping n, J. Sommer n, E. Griffith n, S. Hileman *, C. Nestor n 

author keywords: dynorphin; kisspeptin; LH; neurokinin B; undernutrition; xxxx; fx1
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Body Weight; Dynorphins / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / metabolism; Malnutrition / metabolism; Neurokinin B / metabolism; Neurons / metabolism; RNA, Messenger / metabolism; Sheep
Sources: ORCID, Web Of Science
Added: April 14, 2022

2021 journal article

Evidence That Agouti-Related Peptide May Directly Regulate Kisspeptin Neurons in Male Sheep

METABOLITES, 11(3).

By: C. Merkley, S. Shuping, J. Sommer & C. Nestor 

Sources: Web Of Science, ORCID
Added: April 5, 2021

2021 journal article

Evidence that pubertal status impacts kisspeptin/neurokinin B/dynorphin neurons in the gilt(dagger)

BIOLOGY OF REPRODUCTION, 105(6), 1533–1544.

By: K. Harlow n , A. Renwick  n, S. Shuping n, J. Sommer n, C. Lents*, M. Knauer n, C. Nestor n 

author keywords: kisspeptin; NKB; dynorphin; swine; puberty
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / metabolism; Dynorphins / metabolism; Female; Kisspeptins / metabolism; Neurokinin B / metabolism; Neurons / physiology; Sexual Maturation; Sus scrofa / physiology
Sources: Web Of Science, ORCID
Added: April 18, 2022

2021 journal article

Kisspeptin, Neurokinin B, and Dynorphin Expression during Pubertal Development in Female Sheep

BIOLOGY-BASEL, 10(10).

By: E. Aerts*, K. Harlow n , M. Griesgraber *, E. Bowdridge *, S. Hardy*, C. Nestor n , S. Hileman *

author keywords: kisspeptin; neurokinin B; dynorphin; puberty; sheep; LH
Sources: Web Of Science, ORCID
Added: October 2, 2021

2020 article

Effects of genetic selection for early puberty on the hypothalamic-pituitary-ovarian axis in gilts

Harlow, K. L., Renwick, A., Shuping, S., Sommer, J., Knauer, M., & Nestor, C. (2020, November). JOURNAL OF ANIMAL SCIENCE, Vol. 98, pp. 212–212.

By: K. Harlow n , A. Renwick  n, S. Shuping n, J. Sommer n, M. Knauer n & C. Nestor n 

author keywords: puberty; gilt; neuroendocrine
Sources: Web Of Science, ORCID
Added: February 8, 2021

2020 journal article

Neuronal networks that regulate gonadotropin-releasing hormone/luteinizing hormone secretion during undernutrition: evidence from sheep

Domestic Animal Endocrinology, 3, 106469.

By: C. Merkley n, S. Shuping n & C. Nestor n 

author keywords: Undernutrition; GnRH; LH; KNDy; Sheep
MeSH headings : Animal Nutritional Physiological Phenomena; Animals; Gonadotropin-Releasing Hormone / physiology; Luteinizing Hormone / physiology; Malnutrition / veterinary; Reproduction / physiology; Sheep / physiology
Source: ORCID
Added: March 10, 2020

2018 journal article

Estradiol Protects Proopiomelanocortin Neurons Against Insulin Resistance.

Endocrinology.

MeSH headings : Animals; Calcium Channels, T-Type / genetics; Calcium Channels, T-Type / metabolism; Estradiol / pharmacology; Female; Guinea Pigs; Humans; Insulin / metabolism; Insulin Resistance; Male; Mice; Neurons / drug effects; Neurons / metabolism; Obesity / drug therapy; Obesity / genetics; Obesity / metabolism; Pro-Opiomelanocortin / metabolism; Signal Transduction / drug effects; Suppressor of Cytokine Signaling 3 Protein / genetics; Suppressor of Cytokine Signaling 3 Protein / metabolism; TRPC Cation Channels / genetics; TRPC Cation Channels / metabolism
Source: ORCID
Added: November 14, 2019

2018 review

Regulation of GnRH pulsatility in ewes

[Review of ]. REPRODUCTION, 156(3), R83–R99.

By: C. Nestor* , M. Bedenbaugh, S. Hileman, L. Coolen, M. Lehman & R. Goodman

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / physiology; Breeding; Dynorphins / physiology; Estradiol / pharmacology; Estrous Cycle; Feedback, Physiological; Female; Gonadotropin-Releasing Hormone / metabolism; Homeostasis / physiology; Kisspeptins / physiology; Luteinizing Hormone / metabolism; Neurokinin B / physiology; Neurons / physiology; Periodicity; Progesterone / pharmacology; Seasons; Sexual Maturation / physiology; Sheep / physiology
Sources: Web Of Science, ORCID
Added: October 19, 2018

2017 journal article

AgRP to Kiss1 neuron signaling links nutritional state and fertility

Proceedings of the National Academy of Sciences, 114(9), 2413–2418.

By: S. Padilla*, J. Qiu *, C. Nestor* , C. Zhang*, A. Smith*, B. Whiddon*, O. Rønnekleiv *, M. Kelly *, R. Palmiter *

MeSH headings : Agouti-Related Protein / deficiency; Agouti-Related Protein / genetics; Animals; Circadian Clocks / drug effects; Circadian Clocks / physiology; Clozapine / analogs & derivatives; Clozapine / pharmacology; Estrous Cycle / drug effects; Estrous Cycle / physiology; Female; Fertility / drug effects; Fertility / genetics; Gene Expression Regulation; Gonadotropin-Releasing Hormone / genetics; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Hypothalamus / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; Leptin / genetics; Leptin / metabolism; Luteinizing Hormone / genetics; Luteinizing Hormone / metabolism; Male; Mice; Mice, Transgenic; Neurons / cytology; Neurons / drug effects; Neurons / metabolism; Optogenetics; Reproduction / drug effects; Reproduction / genetics; Signal Transduction; Starvation / genetics; Stereotaxic Techniques
Sources: NC State University Libraries, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Agouti-related peptide neural circuits mediate adaptive behaviors in the starved state.

Nature Neuroscience.

MeSH headings : Aggression / physiology; Agouti-Related Protein / metabolism; Agouti-Related Protein / physiology; Amygdala / metabolism; Amygdala / physiology; Animals; Fear / physiology; Gene Knock-In Techniques; Hypothalamus / metabolism; Hypothalamus / physiology; Male; Mice; Neural Pathways / metabolism; Neural Pathways / physiology; Neurons / physiology; Peptide Fragments / metabolism; Peptide Fragments / physiology; Septal Nuclei / metabolism; Septal Nuclei / physiology; Starvation / physiopathology
Source: ORCID
Added: November 14, 2019

2016 journal article

High-frequency stimulation-induced peptide release synchronizes arcuate kisspeptin neurons and excites GnRH neurons

ELife, 5.

By: J. Qiu *, C. Nestor* , C. Zhang*, S. Padilla*, R. Palmiter *, M. Kelly *, O. Rønnekleiv *

MeSH headings : Action Potentials; Animals; Arcuate Nucleus of Hypothalamus / physiology; Electrophysiological Phenomena; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / metabolism; Mice; Neurokinin B / metabolism; Neurons / drug effects; Optogenetics; Real-Time Polymerase Chain Reaction
10 hypothes.is annotations
Sources: ORCID, Crossref
Added: November 14, 2019

2016 journal article

Optogenetic Stimulation of Arcuate Nucleus Kiss1 Neurons Reveals a Steroid-Dependent Glutamatergic Input to POMC and AgRP Neurons in Male Mice

Molecular Endocrinology, 30(6), 630–644.

By: C. Nestor* , J. Qiu *, S. Padilla*, C. Zhang*, M. Bosch *, W. Fan*, R. Palmiter *, O. Rønnekleiv *, M. Kelly *, S. Aicher *

MeSH headings : Action Potentials / drug effects; Action Potentials / radiation effects; Agouti-Related Protein / metabolism; Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / radiation effects; Axons / metabolism; Axons / ultrastructure; Castration; Channelrhodopsins / metabolism; Glutamates / metabolism; Kisspeptins / metabolism; Light; Male; Mice, Inbred C57BL; Neurons / drug effects; Neurons / metabolism; Neurons / radiation effects; Optogenetics; Pro-Opiomelanocortin / metabolism; RNA, Messenger / genetics; RNA, Messenger / metabolism; Receptors, Metabotropic Glutamate / agonists; Receptors, Metabotropic Glutamate / metabolism; Steroids / pharmacology; Up-Regulation / drug effects; Up-Regulation / radiation effects; Vesicular Glutamate Transport Protein 2 / metabolism; gamma-Aminobutyric Acid / metabolism
Sources: ORCID, Crossref
Added: November 14, 2019

2014 journal article

Cross-talk between reproduction and energy homeostasis: central impact of estrogens, leptin and kisspeptin signaling

Hormone Molecular Biology and Clinical Investigation, 17(3).

By: C. Nestor* , M. Kelly & O. Rønnekleiv

author keywords: 17 beta-estradiol; kisspeptin; leptin; neuropeptide Y; pro-opiomelanocortin
MeSH headings : Animals; Energy Metabolism; Estradiol / metabolism; Estrogens / metabolism; Homeostasis; Humans; Kisspeptins / metabolism; Leptin / metabolism; Neurons / metabolism; Neuropeptide Y / metabolism; Phosphorylation; Pro-Opiomelanocortin / metabolism; Reproduction; STAT3 Transcription Factor / metabolism; Signal Transduction
Sources: Crossref, ORCID
Added: November 23, 2019

2014 journal article

Insulin Excites Anorexigenic Proopiomelanocortin Neurons via Activation of Canonical Transient Receptor Potential Channels

Cell Metabolism, 19(4), 682–693.

By: J. Qiu *, C. Zhang*, A. Borgquist*, C. Nestor* , A. Smith *, M. Bosch *, S. Ku*, E. Wagner *, O. Rønnekleiv *, M. Kelly *

MeSH headings : Agouti-Related Protein / metabolism; Animals; Eating / drug effects; Guinea Pigs; Insulin / pharmacology; KATP Channels / drug effects; Kisspeptins / metabolism; Mice; Models, Biological; Neurons / drug effects; Neurons / metabolism; Neuropeptide Y / metabolism; Patch-Clamp Techniques; Pro-Opiomelanocortin / metabolism; Proto-Oncogene Proteins c-fos / metabolism; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Signal Transduction / physiology; Transient Receptor Potential Channels / metabolism; Zinc / pharmacology
Sources: Crossref, ORCID
Added: November 24, 2019

2014 journal article

Neurokinin-3 Receptor Activation in the Retrochiasmatic Area is Essential for the Full Pre-Ovulatory Luteinising Hormone Surge in Ewes

Journal of Neuroendocrinology, 26(11), 776–784.

By: K. Porter*, S. Hileman *, S. Hardy*, C. Nestor* , M. Lehman * & R. Goodman *

author keywords: neurokinins; GnRH; oestrogen; NK3R; LH surge
MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Female; Hypothalamus / drug effects; Hypothalamus / metabolism; Luteinizing Hormone / blood; Neurons / drug effects; Neurons / metabolism; Ovulation / drug effects; Ovulation / metabolism; Peptide Fragments / pharmacology; Preoptic Area / drug effects; Preoptic Area / metabolism; Quinolines / pharmacology; Receptors, Neurokinin-3 / agonists; Receptors, Neurokinin-3 / antagonists & inhibitors; Receptors, Neurokinin-3 / metabolism; Sheep; Substance P / analogs & derivatives; Substance P / pharmacology
Sources: Crossref, ORCID
Added: November 23, 2019

2014 journal article

Research Resource: Gene Profiling of G Protein–Coupled Receptors in the Arcuate Nucleus of the Female

Molecular Endocrinology, 28(8), 1362–1380.

By: O. Rønnekleiv *, Y. Fang *, C. Zhang*, C. Nestor* , P. Mao* & M. Kelly *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / metabolism; Cells, Cultured; Female; Gene Expression Profiling; Mice, Inbred C57BL; Neurons / metabolism; Pro-Opiomelanocortin / metabolism; Receptors, G-Protein-Coupled / genetics; Receptors, G-Protein-Coupled / metabolism; Transcriptome
Sources: Crossref, ORCID
Added: November 23, 2019

2013 journal article

Evidence that Orphanin FQ Mediates Progesterone Negative Feedback in the Ewe

Endocrinology, 154(11), 4249–4258.

By: C. Nestor* , L. Coolen *, G. Nesselrod*, M. Valent*, J. Connors*, S. Hileman *, G. Cheng*, M. Lehman *, R. Goodman *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / metabolism; Estradiol / administration & dosage; Estradiol / pharmacology; Estrogen Receptor alpha / genetics; Estrogen Receptor alpha / metabolism; Estrus; Feedback, Physiological; Female; Hypothalamus / metabolism; Luteinizing Hormone / genetics; Luteinizing Hormone / metabolism; Neurons / metabolism; Opioid Peptides / administration & dosage; Opioid Peptides / genetics; Opioid Peptides / metabolism; Opioid Peptides / pharmacology; Ovariectomy; Progesterone / administration & dosage; Progesterone / metabolism; Progesterone / pharmacology; Protein Transport; Receptors, Progesterone / metabolism; Sheep / physiology
Sources: Crossref, ORCID
Added: November 24, 2019

2013 journal article

Kisspeptin, Neurokinin B, and Dynorphin Act in the Arcuate Nucleus to Control Activity of the GnRH Pulse Generator in Ewes

Endocrinology, 154(11), 4259–4269.

By: R. Goodman *, S. Hileman *, C. Nestor* , K. Porter*, J. Connors*, S. Hardy*, R. Millar*, M. Cernea* ...

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / physiology; Dynorphins / genetics; Dynorphins / metabolism; Female; Gonadotropin-Releasing Hormone / genetics; Gonadotropin-Releasing Hormone / metabolism; Kisspeptins / genetics; Kisspeptins / metabolism; N-Methylaspartate / genetics; N-Methylaspartate / metabolism; Neurokinin B / genetics; Neurokinin B / metabolism; Neurons / classification; Neurons / metabolism; Receptors, Neurokinin-3 / genetics; Receptors, Neurokinin-3 / metabolism; Receptors, Opioid, kappa / genetics; Receptors, Opioid, kappa / metabolism; Sheep / physiology
Sources: Crossref, ORCID
Added: November 24, 2019

2012 journal article

Evidence That Dopamine Acts via Kisspeptin to Hold GnRH Pulse Frequency in Check in Anestrous Ewes

Endocrinology, 153(12), 5918–5927.

By: R. Goodman, M. Maltby*, R. Millar*, S. Hileman, C. Nestor* , B. Whited, A. Tseng, L. Coolen *, M. Lehman *

MeSH headings : Anestrus / drug effects; Animals; Dopamine / metabolism; Female; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry / methods; Kisspeptins / metabolism; Luteinizing Hormone / metabolism; Models, Biological; Neurons / metabolism; Receptors, Dopamine D2 / metabolism; Seasons; Sheep
Sources: Crossref, ORCID
Added: November 24, 2019

2012 journal article

Evidence of a Role for Kisspeptin and Neurokinin B in Puberty of Female Sheep

Endocrinology, 153(6), 2756–2765.

By: C. Nestor* , A. Briscoe*, S. Davis*, M. Valent*, R. Goodman * & S. Hileman *

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / cytology; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Female; Gonadotropin-Releasing Hormone / antagonists & inhibitors; Gonadotropin-Releasing Hormone / metabolism; Immunohistochemistry; Kisspeptins / metabolism; Kisspeptins / physiology; Luteinizing Hormone / metabolism; Male; Neurokinin B / metabolism; Neurokinin B / physiology; Neurons / drug effects; Neurons / metabolism; Oligopeptides / pharmacology; Orchiectomy; Ovariectomy; Peptide Fragments / pharmacology; Receptors, Neurokinin-3 / antagonists & inhibitors; Receptors, Neurokinin-3 / metabolism; Sexual Maturation / physiology; Sheep / metabolism; Sheep / physiology; Substance P / analogs & derivatives; Substance P / pharmacology; Time Factors
Sources: Crossref, ORCID
Added: November 24, 2019

2011 journal article

Evidence that the Arcuate Nucleus Is an Important Site of Progesterone Negative Feedback in the Ewe

Endocrinology, 152(9), 3451–3460.

By: R. Goodman, I. Holaskova, C. Nestor* , J. Connors, H. Billings, M. Valent, M. Lehman *, S. Hileman

MeSH headings : Animals; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / physiology; Feedback, Physiological / drug effects; Feedback, Physiological / physiology; Female; Hormone Antagonists / pharmacology; Luteinizing Hormone / blood; Mifepristone / pharmacology; Neurons / drug effects; Neurons / physiology; Ovariectomy; Progesterone / physiology; Receptors, Progesterone / physiology; Sheep
Sources: Crossref, ORCID
Added: November 24, 2019

2010 journal article

Inactivation of L-type calcium channel modulated by HCN2 channel

American Journal of Physiology-Cell Physiology, 298(5), C1029–C1037.

By: Y. Lin, J. Huang, Q. Zhang, J. Hollander *, J. Frisbee, K. Martin *, C. Nestor* , R. Goodman, H. Yu

author keywords: L-type calcium channel inactivation; hyperpolarization-activated cyclic nucleotide-gated channels; calmodulin; hippocampal neuron
MeSH headings : Animals; Calcium / metabolism; Calcium Channels, L-Type / genetics; Calcium Channels, L-Type / metabolism; Cell Line; Gene Expression Regulation / physiology; Hippocampus / metabolism; Humans; Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; Ion Channel Gating / physiology; Ion Channels / genetics; Ion Channels / metabolism; Potassium Channels; Protein Subunits; Rats; Signal Transduction
Sources: Crossref, ORCID
Added: November 24, 2019

2010 journal article

Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep

Endocrinology, 151(8), 3836–3846.

By: H. Billings*, J. Connors*, S. Altman*, S. Hileman *, I. Holaskova*, M. Lehman *, C. McManus*, C. Nestor*  ...

MeSH headings : Anestrus / blood; Anestrus / drug effects; Animals; Brain / drug effects; Brain / metabolism; Dopamine / metabolism; Female; Follicular Phase / drug effects; Follicular Phase / metabolism; Follicular Phase / physiology; Gonadotropin-Releasing Hormone / blood; Gonadotropin-Releasing Hormone / metabolism; Injections, Intraventricular; Luteal Phase / drug effects; Luteal Phase / metabolism; Luteal Phase / physiology; Luteinizing Hormone / blood; Luteinizing Hormone / metabolism; Models, Biological; Neurokinin B / pharmacology; Neurokinin B / physiology; Neurons / drug effects; Neurons / metabolism; Neurotransmitter Agents / pharmacology; Peptide Fragments / administration & dosage; Peptide Fragments / pharmacology; Receptors, Neurokinin-3 / agonists; Receptors, Neurokinin-3 / metabolism; Receptors, Neurokinin-3 / physiology; Sheep; Substance P / administration & dosage; Substance P / analogs & derivatives; Substance P / pharmacology
Sources: Crossref, ORCID
Added: November 24, 2019

2008 journal article

Evidence that γ-Aminobutyric Acid Is Part of the Neural Circuit Mediating Estradiol Negative Feedback in Anestrous Ewes

Endocrinology, 149(6), 2762–2772.

By: A. Bogusz*, S. Hardy*, M. Lehman *, J. Connors*, S. Hileman *, J. Sliwowska *, H. Billings*, C. McManus* ...

MeSH headings : Anestrus / drug effects; Anestrus / physiology; Animals; Baclofen / analogs & derivatives; Baclofen / pharmacology; Bicuculline / analogs & derivatives; Bicuculline / pharmacology; Dopamine / physiology; Estradiol / physiology; Feedback; Female; Muscimol / pharmacology; Neurons / drug effects; Neurons / physiology; Ovariectomy; Sheep; gamma-Aminobutyric Acid / physiology
Sources: Crossref, ORCID
Added: November 24, 2019