Cathryn D. Appel

Works (1)

Updated: July 5th, 2023 15:55

2007 journal article

Structural features of the guide : target RNA duplex required for archaeal box C/D sRNA-guided nucleotide 2 '-O-methylation

RNA, 13(6), 899–911.

By: C. Appel n & E. Maxwell

author keywords: box C/D RNA; sRNA; snoRNA; RNA; guided nucleotide modification; nucleotide methylation
MeSH headings : Archaeal Proteins / chemistry; Archaeal Proteins / genetics; Archaeal Proteins / metabolism; Base Pairing; Base Sequence; DNA Primers / genetics; Macromolecular Substances / chemistry; Macromolecular Substances / metabolism; Magnesium / metabolism; Methanococcales / genetics; Methanococcales / metabolism; Methylation; Molecular Sequence Data; Mutation; Nucleic Acid Conformation; Nucleotides / chemistry; Nucleotides / metabolism; RNA, Archaeal / chemistry; RNA, Archaeal / genetics; RNA, Archaeal / metabolism; RNA, Guide, Kinetoplastida / chemistry; RNA, Guide, Kinetoplastida / genetics; RNA, Guide, Kinetoplastida / metabolism; Ribonucleoproteins / chemistry; Ribonucleoproteins / genetics; Ribonucleoproteins / metabolism
TL;DR: Interestingly, D and D' target RNAs exhibited different levels of methylation when deoxynucleotides were inserted into the target RNA or when target methylation was carried out in elevated Mg(2+) concentrations, which suggested that unique structural features of the box C/D and C'/D' RNPs differentially affect their respective methylation capabilities. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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