Carissa Elizabeth Gaghan

Works (13)

Updated: October 16th, 2024 05:03

2024 journal article

Characterization of immune responses and immunopathology in turkeys experimentally infected with clostridial dermatitis-producing strains of Clostridium septicum

VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 269.

By: V. Criollo n, F. John, C. Gaghan n, O. Fletcher n, A. Thachil*, R. Crespo n , R. Kulkarni  n

author keywords: Clostridial dermatitis; Turkey; Clostridium septicum; Immune response; Immunopathology
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: April 8, 2024

2024 article

Evaluation of Adjuvant Effect of Cytosine-Guanosine-Oligodeoxynucleotide in Meat-Type Chickens Coadministered <i>In Ovo</i> with Herpesvirus of Turkey Vaccine

Boone, A. C., Kulkarni, R. R., Cortes, A. L., Gaghan, C., Mohammed, J., Villalobos, T., … Gimeno, I. M. (2024, February 1). VIRAL IMMUNOLOGY, Vol. 2.

By: A. Boone n, R. Kulkarni  n, A. Cortes n, C. Gaghan n, J. Mohammed*, T. Villalobos*, J. Esandi*, I. Gimeno n 

author keywords: herpesvirus of turkey; toll-like receptor 21; cellular immunity; immunocompetence; in ovo vaccination; chickens
TL;DR: Adding cytosine-guanosine oligodeoxynucleotides (CpG ODNs) to the HVT vaccine could enhance the adjuvant effect of HVT, and CpG ODN administration in ovo with or without HVT significantly increased frequencies of activated CD4+ and CD8+ T cells. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: February 2, 2024

2024 journal article

Immunization of turkeys with <i>Clostridium septicum</i> alpha toxin-based recombinant subunit proteins can confer protection against experimental Clostridial dermatitis

PLOS ONE, 19(4).

By: F. John, V. Criollo n, C. Gaghan n, A. Armwood n , J. Holmes n, A. Thachil*, R. Crespo n , R. Kulkarni  n

Ed(s): Y. Chang

UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 1, 2024

2024 journal article

Screening and selection of eubiotic compounds possessing immunomodulatory and anti-Clostridium perfringens properties

POULTRY SCIENCE, 103(8).

By: F. John, C. Gaghan n, J. Liu *, R. Wolfenden* & R. Kulkarni  n

author keywords: eubiotics; poultry; immunomodulation; Clostridium perfringens; antimicrobial property
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 22, 2024

2023 journal article

Effect of CpG-Oligonucleotide in Enhancing Recombinant Herpes Virus of Turkey-Laryngotracheitis Vaccine-Induced Immune Responses in One-Day-Old Broiler Chickens

VACCINES, 11(2).

By: C. Gaghan n, M. Browning n, A. Cortes n, I. Gimeno n  & R. Kulkarni  n

author keywords: infectious laryngotracheitis; CpG-ODN; adjuvant; immune response; chickens
TL;DR: Findings suggested that CpG-ODN can boost rHVT-LT-induced immune responses in day-old chicks, which may help in anti-ILT defense during their later stages of life. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 31, 2023

2023 journal article

Immune Response Evaluation in Commercial Turkeys Affected with Clostridial Dermatitis

AVIAN DISEASES, 67(1), 80–88.

By: V. Criollo n, C. Gaghan n, F. John, E. Orozco, A. Thachil*, R. Crespo n , R. Kulkarni  n

author keywords: clostridial dermatitis; gangrenous dermatitis; Clostridium septicum; immune response; macrophages
MeSH headings : Animals; Clostridium Infections / veterinary; Turkeys; Interleukin-13; Poultry Diseases / epidemiology; Clostridium; Dermatitis / veterinary; Immunity
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: May 22, 2023

2023 journal article

In Ovo Vaccination with Recombinant Herpes Virus of the Turkey-Laryngotracheitis Vaccine Adjuvanted with CpG-Oligonucleotide Provides Protection against a Viral Challenge in Broiler Chickens

VIRUSES-BASEL, 15(10).

By: C. Gaghan n, M. Browning n, A. Fares n , M. Abdul-Careem *, I. Gimeno n  & R. Kulkarni  n

author keywords: infectious laryngotracheitis; vaccine; protection; CpG oligonucleotide; adjuvant; chickens
TL;DR: It is suggested that CpG-ODN can be used as an effective adjuvant for rHVT-LT in ovo vaccination to induce protective immunity against ILT in broiler chickens. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: October 18, 2023

2023 journal article

Intracloacal Inoculation of Broiler Chickens with Clostridium perfringens Strains: Evaluation of Necrotic Enteritis Disease Development and Lymphoid Immune Responses

MICROORGANISMS, 11(3).

By: C. Gaghan n, K. Gorrell n, K. Taha-Abdelaziz*, S. Sharif * & R. Kulkarni  n

author keywords: necrotic enteritis; Clostridium perfringens; chickens; intracloacal infection; immune response; virulence
TL;DR: Intracloacal C. perfringens inoculation seems to induce a highly regulated inflammatory response in the CT and other mucosal lymphoid organs and an intracloACal infection model may be useful in evaluating immune responses in chickens with subclinical NE. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: March 18, 2023

2022 journal article

Avian Macrophage Responses to Virulent and Avirulent Clostridium perfringens

PATHOGENS, 11(1).

By: R. Kulkarni  n, C. Gaghan n & J. Mohammed n

author keywords: macrophages; Clostridium perfringens; virulence; chicken; necrotic enteritis; immune response
TL;DR: Macrophage interaction with C. perfringens can lead to cellular activation and, the ability of this pathogen to induce macrophage responses may depend on its level of virulence (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: January 17, 2022

2022 journal article

Characterization of vaccine-induced immune responses against coccidiosis in broiler chickens

VACCINE, 40(29), 3893–3902.

By: C. Gaghan n, D. Adams  n, J. Mohammed n, R. Crespo n , K. Livingston n & R. Kulkarni  n

author keywords: Coccidiosis; Eimeria; Vaccine; Immunity; Immune response
MeSH headings : Animals; Chickens; Coccidiosis / prevention & control; Coccidiosis / veterinary; Eimeria; Eimeria tenella; Immunity; Oocysts; Poultry Diseases; Protozoan Vaccines; Toll-Like Receptor 2
TL;DR: Findings suggest that TLR21 and TLR2 may be involved in the immune cell recognition of Eimeria parasites and that the vaccine can induce a robust macrophage activation leading to a T helper-1 dominated protective response at both local and systemic lymphoid tissues. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 27, 2022

2022 journal article

Enumeration and speciation of coccidia affecting turkeys using flow cytometry method

JOURNAL OF APPLIED POULTRY RESEARCH, 31(3).

By: T. Boyett n, R. Crespo n , V. Vinueza n, C. Gaghan n, J. Mohammed n & R. Kulkarni  n

author keywords: Eimeria; coccidiosis; turkey; flow cytometry; diagnosis
UN Sustainable Development Goal Categories
15. Life on Land (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: May 13, 2022

2022 article

Mucosal and systemic lymphoid immune responses against Clostridium perfringens strains with variable virulence in the production of necrotic enteritis in broiler chickens

Kulkarni, R. R., Gaghan, C., Gorrell, K., & Fletcher, O. J. (2023, January 26). AVIAN PATHOLOGY, Vol. 1.

By: R. Kulkarni  n, C. Gaghan n, K. Gorrell n & O. Fletcher n

author keywords: Necrotic enteritis; Clostridium perfringens; chickens; immune response; virulence; cytokines; pathogenesis
MeSH headings : Animals; Clostridium perfringens / genetics; Clostridium Infections / veterinary; Chickens; Virulence; Enteritis / veterinary; Poultry Diseases / pathology; Immunity; Anti-Inflammatory Agents / metabolism
TL;DR: It is suggested that lymphoid immune responses during NE in chickens are spatially regulated such that the inflammatory responses against C. perfringens depend on the virulence of the strain. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: March 13, 2023

2022 review

Probiotics as Alternatives to Antibiotics for the Prevention and Control of Necrotic Enteritis in Chickens

[Review of ]. PATHOGENS, 11(6).

By: R. Kulkarni  n, C. Gaghan n, K. Gorrell n, S. Sharif * & K. Taha-Abdelaziz*

author keywords: necrotic enteritis; Clostridium perfringens; probiotics; disease control; lactobacilli; alternatives to antibiotics
TL;DR: Probiotic species tested in chickens have shown to improve bird performance, reduce C. perfringens colonization and NE-associated pathology, and modulate immune responses by downregulating expression of inflammatory cytokines. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: June 18, 2022

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