@article{poirier_marsili_fossi_godard-codding_hernandez-ramon_si_divi_divi_kerr_wise_et al._2021, title={Polycyclic Aromatic Hydrocarbon-DNA Adducts in Gulf of Mexico Sperm Whale Skin Biopsies Collected in 2012}, volume={181}, ISSN={["1096-0929"]}, DOI={10.1093/toxsci/kfab016}, abstractNote={Abstract}, number={1}, journal={TOXICOLOGICAL SCIENCES}, author={Poirier, Miriam C. and Marsili, Letizia and Fossi, Maria Cristina and Godard-Codding, Celine A. J. and Hernandez-Ramon, Elena E. and Si, Nancy and Divi, Kathyayini V and Divi, Rao L. and Kerr, Iain and Wise, John Pierce and et al.}, year={2021}, month={May}, pages={115–124} }
 @article{wise_wise_wise_wise_gianios_xie_walter_boswell_zhu_zheng_et al._2020, title={A three year study of metal levels in skin biopsies of whales in the Gulf of Mexico after the Deepwater Horizon oil crisis (vol 205, pg 15, 2018)}, volume={230}, ISSN={["1878-1659"]}, DOI={10.1016/j.cbpc.2020.108721}, journal={COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY}, author={Wise, John Pierce, Jr. and Wise, James T. F. and Wise, Catherine F. and Wise, Sandra S. and Gianios, Christy, Jr. and Xie, Hong and Walter, Ron and Boswell, Mikki and Zhu, Cairong and Zheng, Tongzhang and et al.}, year={2020}, month={Apr} }
 @article{wise_hammel_herkert_ma_motsinger-reif_stapleton_breen_2020, title={Comparative Exposure Assessment Using Silicone Passive Samplers Indicates That Domestic Dogs Are Sentinels To Support Human Health Research}, volume={54}, ISSN={["1520-5851"]}, DOI={10.1021/acs.est.9b06605}, abstractNote={Silicone wristbands are promising passive samplers to support epidemiology studies in characterizing exposure to organic contaminants; however, investigating associated health risks remains challenging due to the latency period for many chronic diseases that take years to manifest. Dogs provide valuable insights as sentinels for exposure-related human disease because they share similar exposures in the home, have shorter lifespans, share many clinical/biological features, and have closely related genomes. Here, we evaluated exposures among pet dogs and their owners using silicone dog tags and wristbands to determine if contaminant levels were correlated with validated biomarkers. Significant correlations between measures on dog tags and wristbands were observed (rs = 0.38-0.90; p <0.05). Correlations with urinary biomarkers were often stronger in dog tags compared to human wristbands (rs = 0.50-0.71; p <0.01) for several organophosphate esters. This supports the value of using silicone bands with dogs to investigate health impacts on humans from shared exposures.}, number={12}, journal={ENVIRONMENTAL SCIENCE & TECHNOLOGY}, author={Wise, Catherine F. and Hammel, Stephanie C. and Herkert, Nicholas and Ma, Jun and Motsinger-Reif, Alison and Stapleton, Heather M. and Breen, Matthew}, year={2020}, month={Jun}, pages={7409–7419} }
 @article{wise_wise_wise_wise_zhu_browning_zheng_perkins_gianios_xie_et al._2019, title={Metal Levels in Whales from the Gulf of Maine: A One Environmental Health approach}, volume={216}, ISSN={["1879-1298"]}, DOI={10.1016/j.chemosphere.2018.10.120}, abstractNote={One Environmental Health has emerged as an important area of research that considers the interconnectedness of human, animal and ecosystem health with a focus on toxicology. The great whales in the Gulf of Maine are important species for ecosystem health, for the economies of the Eastern seaboard of the United States, and as sentinels for human health. The Gulf of Maine is an area with heavy coastal development, industry, and marine traffic, all of which contribute chronic exposures to environmental chemicals that can bioaccumulate in tissues and may gradually diminish an individual whale's or a population's fitness. We biopsied whales for three seasons (2010–2012) and measured the levels of 25 metals and selenium in skin biopsies collected from three species: humpback whales (Megaptera novaeangliae), fin whales (Balaenoptera physalus), and a minke whale (Balaenoptera acutorostrata). We established baseline levels for humpback and fin whales. Comparisons with similar species from other regions indicate humpback whales have elevated levels of aluminum, chromium, iron, magnesium, nickel and zinc. Contextualizing the data with a One Environmental Health approach finds these levels to be of potential concern for whale health. While much remains to understand what threats these metal levels may pose to the fitness and survival of these whale populations, these data serve as a useful and pertinent start to understanding the threat of pollution.}, journal={CHEMOSPHERE}, author={Wise, John Pierce, Jr. and Wise, James T. F. and Wise, Catherine F. and Wise, Sandra S. and Zhu, Cairong and Browning, Cynthia L. and Zheng, Tongzhang and Perkins, Christopher and Gianios, Christy, Jr. and Xie, Hong and et al.}, year={2019}, month={Feb}, pages={653–660} }
 @article{wiley_wise_breen_2019, title={Novel Noninvasive Diagnostics}, volume={49}, ISSN={["1878-1306"]}, DOI={10.1016/j.cvsm.2019.05.002}, abstractNote={Molecular diagnostics have revolutionized human oncology to allow early detection, targeted therapy, monitoring throughout treatment, and evidence of recurrence. By identifying genetic signatures associated with cancers, liquid biopsy techniques have been developed to diagnose and monitor cancer in noninvasive or minimally invasive ways. These techniques offer new opportunities for improving cancer screening, diagnosis, and monitoring the impact of therapy on the patients over time. Liquid biopsy also drives drug development programs. Similar diagnostics hold promise for comparable results in the veterinary field. Several noninvasive/minimally invasive techniques have been described in veterinary medicine that could be referred to as liquid biopsy.}, number={5}, journal={VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE}, author={Wiley, Claire and Wise, Catherine F. and Breen, Matthew}, year={2019}, month={Sep}, pages={781-+} }
 @article{wise_wise_wise_wise_gianios_xie_walter_boswell_zhu_zheng_et al._2018, title={A three year study of metal levels in skin biopsies of whales in the Gulf of Mexico after the Deepwater Horizon oil crisis}, volume={205}, ISSN={["1878-1659"]}, DOI={10.1016/j.cbpc.2017.12.003}, abstractNote={In response to the explosion of the Deepwater Horizon and the massive release of oil that followed, we conducted three annual research voyages to investigate how the oil spill would impact the marine offshore environment. Most investigations into the ecological and toxicological impacts of the Deepwater Horizon Oil crisis have mainly focused on the fate of the oil and dispersants, but few have considered the release of metals into the environment. From studies of previous oil spills, other marine oil industries, and analyses of oil compositions, it is evident that metals are frequently encountered. Several metals have been reported in the MC252 oil from the Deepwater Horizon oil spill, including the nonessential metals aluminum, arsenic, chromium, nickel, and lead; genotoxic metals, such as these are able to damage DNA and can bioaccumulate in organisms resulting in persistent exposure. In the Gulf of Mexico, whales are the apex species; hence we collected skin biopsies from sperm whales (Physeter macrocephalus), short-finned pilot whales (Globicephala macrorhynchus), and Bryde's whales (Balaenoptera edeni). The results from our three-year study of monitoring metal levels in whale skin show (1) genotoxic metals at concentrations higher than global averages previously reported and (2) patterns for MC252-relevant metal concentrations decreasing with time from the oil spill.}, journal={COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY}, author={Wise, John Pierce, Jr. and Wise, James T. F. and Wise, Catherine F. and Wise, Sandra S. and Gianios, Christy, Jr. and Xie, Hong and Walter, Ron and Boswell, Mikki and Zhu, Cairong and Zheng, Tongzhang and et al.}, year={2018}, month={Feb}, pages={15–25} }
 @article{wise_wise_wise_wise_2018, title={Chemically dispersed oil is cytotoxic and genotoxic to sperm whale skin cells}, volume={208}, ISSN={["1878-1659"]}, DOI={10.1016/j.cbpc.2017.10.009}, abstractNote={Two major oil crises in United States history, the 1989 Exxon-Valdez oil spill in Alaska and the 2010 Deepwater Horizon Oil Rig explosion in the Gulf of Mexico, drew attention to the need for toxicological experiments on oil and chemically dispersed oil. We are still learning the effects these spills had on wildlife. However, little data is known about the toxicity of these substances in marine mammals. The objective of this study is to determine the toxicity of Alaskan oil, as well as chemically dispersed oil. Oil experiments were performed using the water accommodated fraction of Alaskan oil (WAF) and the chemically enhanced water accommodated fraction of Alaskan oil (CEWAF). The Alaskan WAF is not cytotoxic to sperm whale skin cells though it did induce chromosome damage; S9-mediated metabolism did not affect the cytotoxicity of WAF but did increase the levels of chromosome damage. Alaskan CEWAF is more cytotoxic and genotoxic than the WAF; S9 mediated metabolism increased both cytotoxicity and genotoxicity of CEWAF. Analysis of the PAH content of Alaskan WAF and CEWAF revealed a forty-fold increase in the total levels of PAHs in CEWAF compared to WAF. These findings show that chemically dispersed oil leads to higher levels of PAH exposure which are more toxic and likely to lead to longer and more persistent health effects.}, journal={COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY}, author={Wise, Catherine F. and Wise, James T. F. and Wise, Sandra S. and Wise, John Pierce}, year={2018}, month={Jun}, pages={64–70} }
 @article{speer_wise_young_aboueissa_bras_barandiaran_bermudez_marquez-d'acunti_wise_2018, title={The cytotoxicity and genotoxicity of particulate and soluble hexavalent chromium in leatherback sea turtle lung cells}, volume={198}, ISSN={["1879-1514"]}, DOI={10.1016/j.aquatox.2018.03.003}, abstractNote={Hexavalent chromium [Cr(VI)] is a marine pollution of concern as recent studies show it has a global distribution, with some regions showing high Cr concentrations in marine animal tissue, and it is extensively used. Leatherback sea turtles (Dermochelys coriacea) are an endangered marine species that may experience prolonged exposures to environmental contaminants including Cr(VI). Human activities have led to global Cr(VI) contamination of the marine environment. While Cr(VI) has been identified as a known human carcinogen, the health effects in marine species are poorly understood. In this study, we assessed the cytotoxic and genotoxic effects of particulate and soluble Cr(VI) in leatherback sea turtle lung cells. Both particulate and soluble Cr(VI) induced a concentration-dependent increase in cytotoxicity. Next, using a chromosome aberration assay, we assessed the genotoxic effects of Cr(VI) in leatherback sea turtle lung cells. Particulate and soluble Cr(VI) induced a concentration-dependent increase in clastogenicity in leatherback sea turtle lung cells. These data indicate that Cr(VI) may be a health concern for leatherback sea turtles and other long-lived marine species. Additionally, these data provide foundational support to use leatherback sea turtles as a valuable model species for monitoring the health effects of Cr(VI) in the environment and possibly as an indicator species to assess environmental human exposures and effects.}, journal={AQUATIC TOXICOLOGY}, author={Speer, Rachel M. and Wise, Catherine F. and Young, Jamie L. and Aboueissa, AbouEl-Makarim and Bras, Mark Martin and Barandiaran, Mike and Bermudez, Erick and Marquez-D'Acunti, Lirio and Wise, John Pierce, Sr.}, year={2018}, month={May}, pages={149–157} }
 @article{browning_wise_wise_2017, title={Prolonged particulate chromate exposure does not inhibit homologous recombination repair in North Atlantic right whale (Eubalaena glacialis) lung cells}, volume={331}, ISSN={["1096-0333"]}, DOI={10.1016/j.taap.2017.04.006}, abstractNote={Chromosome instability is a common feature of cancers that forms due to the misrepair of DNA double strand breaks. Homologous recombination (HR) repair is a high fidelity DNA repair pathway that utilizes a homologous DNA sequence to accurately repair such damage and protect the genome. Prolonged exposure (>72h) to the human lung carcinogen, particulate hexavalent chromium (Cr(VI)), inhibits HR repair, resulting in increased chromosome instability in human cells. Comparative studies have shown acute Cr(VI) exposure induces less chromosome damage in whale cells than human cells, suggesting investigating the effect of this carcinogen in other species may inform efforts to prevent Cr(VI)-induced chromosome instability. Thus, the goal of this study was to determine the effect of prolonged Cr(VI) exposure on HR repair and clastogenesis in North Atlantic right whale (Eubalaena glacialis) lung cells. We show particulate Cr(VI) induces HR repair activity after both acute (24h) and prolonged (120h) exposure in North Atlantic right whale cells. Although the RAD51 response was lower following prolonged Cr(VI) exposure compared to acute exposure, the response was sufficient for HR repair to occur. In accordance with active HR repair, no increase in Cr(VI)-induced clastogenesis was observed with increased exposure time. These results suggest prolonged Cr(VI) exposure affects HR repair and genomic stability differently in whale and human lung cells. Future investigation of the differences in how human and whale cells respond to chemical carcinogens may provide valuable insight into mechanisms of preventing chemical carcinogenesis.}, journal={TOXICOLOGY AND APPLIED PHARMACOLOGY}, author={Browning, Cynthia L. and Wise, Catherine F. and Wise, John Pierce, Sr.}, year={2017}, month={Sep}, pages={18–23} }
 @article{wise_wise_xie_guillette_zhu_wise_wise_2016, title={Hexavalent chromium is cytotoxic and genotoxic to American alligator cells}, volume={171}, ISSN={["1879-1514"]}, DOI={10.1016/j.aquatox.2015.12.004}, abstractNote={Metals are a common pollutant in the aquatic ecosystem. With global climate change, these levels are anticipated to rise as lower pH levels allow sediment bound metals to be released. The American alligator (Alligator mississippiensis) is an apex predator in the aquatic ecosystem and is considered a keystone species; as such it serves as a suitable monitor for localized pollution. One metal of increasing concern is hexavalent chromium (Cr(VI)). It is present in the aquatic environment and is a known human carcinogen and reproductive toxicant. We measured the cytotoxicity and genotoxicity of Cr(VI) in American alligator cells derived from scute tissue. We found that particulate and soluble Cr(VI) are both cytotoxic and genotoxic to alligator cells in a concentration-dependent manner. These data suggest that alligators may be used as a model for assessing the effects of environmental Cr(VI) contamination as well as for other metals of concern.}, journal={AQUATIC TOXICOLOGY}, author={Wise, Sandra S. and Wise, Catherine and Xie, Hong and Guillette, Louis J., Jr. and Zhu, Cairong and Wise, John Pierce, Jr. and Wise, John Pierce, Sr.}, year={2016}, month={Feb}, pages={30–36} }