Christopher I. Jones

Works (2)

Updated: July 5th, 2023 15:55

2008 article

A Disease-causing Point Mutation in Human Mitochondrial tRNAMet Results in tRNA Misfolding Leading to Defects in Translational Initiation and Elongation

Jones, C. N., Jones, C. I., Graham, W. D., Agris, P. F., & Spremulli, L. L. (2008, October 4). Journal of Biological Chemistry.

By: C. Jones *, C. Jones n, W. Graham n, P. Agris n & L. Spremulli*

MeSH headings : Animals; Base Sequence; Binding Sites; Cattle; Escherichia coli / enzymology; Humans; Mitochondria / enzymology; Mitochondria / metabolism; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optic Atrophy, Hereditary, Leber / genetics; Point Mutation; Protein Biosynthesis; RNA, Transfer, Met / chemistry; Thermodynamics
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Mitochondrial Function and Pathology
TL;DR: It is shown that the single 8U→C mutation leads to a failure of the tRNA to respond conformationally to Mg2+. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2006 article

A Counterintuitive Mg2+-dependent and Modification-assisted Functional Folding of Mitochondrial tRNAs

Jones, C. I., Spencer, A. C., Hsu, J. L., Spremulli, L. L., Martinis, S. A., DeRider, M., & Agris, P. F. (2006, August 1). Journal of Molecular Biology.

By: C. Jones n, A. Spencer*, J. Hsu *, L. Spremulli*, S. Martinis *, M. DeRider n, P. Agris n

author keywords: mitochondrial RNA folding; aminoacylation; tRNA(Met); tRNA(Leu)
MeSH headings : Aminoacylation; Animals; Base Sequence; Cattle; Circular Dichroism; Electrophoretic Mobility Shift Assay; Escherichia coli / chemistry; Magnesium / metabolism; Magnesium / pharmacology; Molecular Sequence Data; Nucleic Acid Conformation / drug effects; Nucleic Acid Denaturation; RNA / chemistry; RNA / genetics; RNA Stability / drug effects; RNA, Mitochondrial; RNA, Transfer / chemistry; RNA, Transfer / genetics; Temperature; Yeasts / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Genomics and Phylogenetic Studies
TL;DR: Investigation of functional folding interactions of chemically synthesized and site-specifically modified mitochondrial and cytoplasmic tRNAs finds that Mg2+ is critical for folding of the truncated D-domain of bovine mtRNAMet with the tRNA's T-domain and indicates that conserved modifications assist and stabilize the formation of the functional mtRNA tertiary structure. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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