Works (2)

Updated: July 5th, 2023 15:55

2008 journal article

A Disease-causing Point Mutation in Human Mitochondrial tRNA(Met) Results in tRNA Misfolding Leading to Defects in Translational Initiation and Elongation


By: C. Jones*, C. Jones n, W. Graham n, P. Agris n & L. Spremulli*

MeSH headings : Animals; Base Sequence; Binding Sites; Cattle; Escherichia coli / enzymology; Humans; Mitochondria / enzymology; Mitochondria / metabolism; Mutation; Nucleic Acid Conformation; Nucleic Acid Denaturation; Optic Atrophy, Hereditary, Leber / genetics; Point Mutation; Protein Biosynthesis; RNA, Transfer, Met / chemistry; Thermodynamics
TL;DR: It is shown that the single 8U→C mutation leads to a failure of the tRNA to respond conformationally to Mg2+. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2006 journal article

A counterintuitive Mg2+-dependent and modification-assisted functional folding of mitochondrial tRNAs


By: C. Jones n, A. Spencer*, J. Hsu*, L. Spremulli*, S. Martinis*, M. DeRider n, P. Agris n

author keywords: mitochondrial RNA folding; aminoacylation; tRNA(Met); tRNA(Leu)
MeSH headings : Aminoacylation; Animals; Base Sequence; Cattle; Circular Dichroism; Electrophoretic Mobility Shift Assay; Escherichia coli / chemistry; Magnesium / metabolism; Magnesium / pharmacology; Molecular Sequence Data; Nucleic Acid Conformation / drug effects; Nucleic Acid Denaturation; RNA / chemistry; RNA / genetics; RNA Stability / drug effects; RNA, Mitochondrial; RNA, Transfer / chemistry; RNA, Transfer / genetics; Temperature; Yeasts / chemistry
TL;DR: Investigation of functional folding interactions of chemically synthesized and site-specifically modified mitochondrial and cytoplasmic tRNAs finds that Mg2+ is critical for folding of the truncated D-domain of bovine mtRNAMet with the tRNA's T-domain and indicates that conserved modifications assist and stabilize the formation of the functional mtRNA tertiary structure. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

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