Chris Halweg

Also known as: Christopher Halweg; Christohper J Halweg; Chris J Halweg

Works (3)

Updated: April 3rd, 2024 19:42

2012 journal article

Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus

Proceedings of the National Academy of Sciences, 109(17), 6590–6595.

By: W. Ma  n, C. Halweg n , D. Menendez  n & M. Resnick  n

author keywords: base excision repair; BRCA
MeSH headings : Blotting, Western; Cell Cycle; DNA Damage; DNA Repair; Enzyme Inhibitors / pharmacology; Herpesvirus 4, Human / physiology; Humans; Infrared Rays; Plasmids / physiology; Poly(ADP-ribose) Polymerase Inhibitors; Polymerase Chain Reaction; Tumor Suppressor Protein p53 / physiology
topics (OpenAlex): PARP inhibition in cancer therapy; DNA Repair Mechanisms
TL;DR: An in vivo repair assay based on large endogenous Epstein–Barr virus (EBV) circular episomes assessed quantitatively and simultaneously the induction and repair of SSBs and DSBs in human cells and demonstrated that the PARP1 protein was not essential for SSB repair. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019

2010 journal article

Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology

PLoS Genetics, 6(1), e1000812.

By: A. Haugen *, N. Di Prospero *, J. Parker, R. Fannin*, J. Chou*, J. Meyer *, C. Halweg* , J. Collins* ...

Ed(s): C. Pearson

MeSH headings : Adolescent; Adult; Cells, Cultured; Child; Cohort Studies; DNA Damage; Female; Friedreich Ataxia / genetics; Friedreich Ataxia / pathology; Gene Expression; Humans; Iron-Binding Proteins / genetics; Male; Middle Aged; RNA / blood; RNA / genetics; Young Adult
topics (OpenAlex): Genetic Neurodegenerative Diseases; Mitochondrial Function and Pathology; DNA Repair Mechanisms
TL;DR: The data suggest that patients with prolonged frataxin deficiency undergo a systemic survival response to chronic genotoxic stress and consequent DNA damage detectable in blood, which may have predictive value in future clinical trials. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019

2005 journal article

The rb7 matrix attachment region increases the likelihood and magnitude of transgene expression in tobacco cells: A flow cytometric study

PLANT CELL, 17(2), 418–429.

By: C. Halweg n , W. Thompson n  & S. Spiker n

MeSH headings : Agrobacterium tumefaciens / genetics; DNA, Bacterial / genetics; Flow Cytometry / methods; Gene Expression Regulation, Plant; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Matrix Attachment Regions; Plants, Genetically Modified; Promoter Regions, Genetic / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tobacco / cytology; Tobacco / genetics; Transformation, Genetic; Transgenes / genetics
topics (OpenAlex): Plant tissue culture and regeneration; Transgenic Plants and Applications; Plant Virus Research Studies
TL;DR: Flow cytometry is used to measure green fluorescent protein (GFP) expression in individual tobacco cells from lines transformed by Agrobacterium tumefaciens to conclude that MAR-mediated overall increases in transgene expression involve both likelihood and magnitude. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

Employment

Updated: September 11th, 2019 15:20

2013 - present

North Carolina State University Raleigh, NC, US
Teaching Assistant Professor Biological Sciences

2008 - 2013

North Carolina State University Raleigh, NC, US
Lecturer Genetics

2004 - 2008

National Institute of Environmental Health Sciences Durham, NC, US
Postdoc Laboratory of Molecular Genetics

Education

Updated: September 11th, 2019 15:08

1998 - 2004

North Carolina State University Raleigh, NC, US
Ph.D. Genetics

1996 - 1998

Iowa State University Ames, IA, US
B.S. Genetics

1994 - 1996

Ellsworth Community College Iowa Falls, Iowa, US
A.A. Liberal Arts and Sciences

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