Chris Halweg
Also known as: Christopher Halweg; Christohper J Halweg; Chris J Halweg
Works (3)
Updated: April 3rd, 2024 19:42
2012 journal article
Differential effects of poly(ADP-ribose) polymerase inhibition on DNA break repair in human cells are revealed with Epstein-Barr virus
Proceedings of the National Academy of Sciences, 109(17), 6590–6595.
author keywords: base excision repair; BRCA
MeSH headings : Blotting, Western; Cell Cycle; DNA Damage; DNA Repair; Enzyme Inhibitors / pharmacology; Herpesvirus 4, Human / physiology; Humans; Infrared Rays; Plasmids / physiology; Poly(ADP-ribose) Polymerase Inhibitors; Polymerase Chain Reaction; Tumor Suppressor Protein p53 / physiology
TL;DR:
An in vivo repair assay based on large endogenous Epstein–Barr virus (EBV) circular episomes assessed quantitatively and simultaneously the induction and repair of SSBs and DSBs in human cells and demonstrated that the PARP1 protein was not essential for SSB repair.
(via Semantic Scholar)
www.pnas.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2010 journal article
Altered Gene Expression and DNA Damage in Peripheral Blood Cells from Friedreich's Ataxia Patients: Cellular Model of Pathology
PLoS Genetics, 6(1), e1000812.
Ed(s): C. Pearson
MeSH headings : Adolescent; Adult; Cells, Cultured; Child; Cohort Studies; DNA Damage; Female; Friedreich Ataxia / genetics; Friedreich Ataxia / pathology; Gene Expression; Humans; Iron-Binding Proteins / genetics; Male; Middle Aged; RNA / blood; RNA / genetics; Young Adult
TL;DR:
The data suggest that patients with prolonged frataxin deficiency undergo a systemic survival response to chronic genotoxic stress and consequent DNA damage detectable in blood, which may have predictive value in future clinical trials.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Sources: Crossref, NC State University Libraries
Added: September 28, 2019
2005 journal article
The rb7 matrix attachment region increases the likelihood and magnitude of transgene expression in tobacco cells: A flow cytometric study
PLANT CELL, 17(2), 418–429.
MeSH headings : Agrobacterium tumefaciens / genetics; DNA, Bacterial / genetics; Flow Cytometry / methods; Gene Expression Regulation, Plant; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Matrix Attachment Regions; Plants, Genetically Modified; Promoter Regions, Genetic / genetics; Recombinant Fusion Proteins / genetics; Recombinant Fusion Proteins / metabolism; Tobacco / cytology; Tobacco / genetics; Transformation, Genetic; Transgenes / genetics
TL;DR:
Flow cytometry is used to measure green fluorescent protein (GFP) expression in individual tobacco cells from lines transformed by Agrobacterium tumefaciens to conclude that MAR-mediated overall increases in transgene expression involve both likelihood and magnitude.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
Employment
Updated: September 11th, 2019 15:20
2013 - present
North Carolina State University Raleigh, NC, US
Teaching Assistant Professor
Biological Sciences
2008 - 2013
North Carolina State University Raleigh, NC, US
Lecturer
Genetics
2004 - 2008
National Institute of Environmental Health Sciences Durham, NC, US
Postdoc
Laboratory of Molecular Genetics
Education
Updated: September 11th, 2019 15:08
1998 - 2004
North Carolina State University Raleigh, NC, US
Ph.D.
Genetics
1996 - 1998
Iowa State University Ames, IA, US
B.S. Genetics
1994 - 1996
Ellsworth Community College Iowa Falls, Iowa, US
A.A. Liberal Arts and Sciences
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