Works (64)

Updated: July 21st, 2023 21:14

2023 journal article

Developmental cadmium exposure disrupts zebrafish vestibular calcium channels interfering with otolith formation and inner ear function

NEUROTOXICOLOGY, 96, 129–139.

By: A. Green n, A. Wall n, R. Weeks n, C. Mattingly n, K. Marsden n & A. Planchart n

author keywords: Cadmium; Developmental toxicology; Behavior; Vestibular system; P2X receptor; Zebrafish
MeSH headings : Animals; Zebrafish; Cadmium / toxicity; Otolithic Membrane; Vestibule, Labyrinth; Vestibular Diseases
Sources: Web Of Science, ORCID
Added: June 12, 2023

2022 article

Comparative Toxicogenomics Database (CTD): update 2023

Davis, A. P., Wiegers, T. C., Johnson, R. J., Sciaky, D., Wiegers, J., & Mattingly, C. J. (2022, September 28). NUCLEIC ACIDS RESEARCH, Vol. 9.

By: A. Davis n, T. Wiegers n, R. Johnson n, D. Sciaky n, J. Wiegers n & C. Mattingly n

MeSH headings : Humans; Toxicogenetics; Databases, Factual; Phenotype
Sources: Web Of Science, ORCID
Added: October 11, 2022

2021 journal article

CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies

CURRENT RESEARCH IN TOXICOLOGY, 2, 128–139.

By: A. Davis n, T. Wiegers n, J. Wiegers n, C. Grondin n, R. Johnson n, D. Sciaky n, C. Mattingly n

author keywords: Anatomy; Chemical; Phenotype; Disease; Environmental health; Database
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 journal article

Comparative Toxicogenomics Database (CTD): update 2021

NUCLEIC ACIDS RESEARCH, 49(D1), D1138–D1143.

By: A. Davis n, C. Grondin n, R. Johnson n, D. Sciaky n, J. Wiegers n, T. Wiegers n, C. Mattingly n

MeSH headings : Databases, Chemical; Databases, Factual; Databases, Genetic; Gene-Environment Interaction; Genome, Human / drug effects; Genomics / methods; Genotype; Humans; Internet; Knowledge Bases; Organ Specificity; Phenotype; Prescription Drugs / chemistry; Prescription Drugs / pharmacology; Software; Toxicogenetics / methods; Xenobiotics / chemistry; Xenobiotics / toxicity
Sources: Web Of Science, ORCID
Added: February 8, 2021

2021 journal article

Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database

CURRENT RESEARCH IN TOXICOLOGY, 2, 272–281.

By: C. Grondin n, A. Davis n, J. Wiegers n, T. Wiegers n, D. Sciaky n, R. Johnson n, C. Mattingly n

author keywords: E-cigarettes; Vaping; Juul; Respiratory disease; Database; Environmental exposure
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 journal article

Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases

CURRENT RESEARCH IN TOXICOLOGY, 2, 140–148.

By: D. Pinkhasova*, L. Jameson*, K. Conrow*, M. Simeone*, A. Davis n, T. Wiegers n, C. Mattingly n, M. Leung*

author keywords: Cannabis; Pesticide; Database; Regulation; Seizure; Contaminant
Sources: Web Of Science, ORCID
Added: January 3, 2022

2020 review

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

[Review of ]. NEUROPSYCHOPHARMACOLOGY, 45(7), 1086–1096.

By: J. Hollander*, D. Cory-Slechta*, F. Jacka*, S. Szabo*, T. Guilarte*, S. Bilbo*, C. Mattingly n, S. Moy* ...

MeSH headings : Environmental Exposure / adverse effects; Humans; Mental Disorders / etiology
Sources: Web Of Science, ORCID
Added: March 30, 2020

2020 journal article

Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease

TOXICOLOGICAL SCIENCES, 177(2), 392–404.

By: A. Davis*, T. Wiegers*, C. Grondin*, R. Johnson*, D. Sciaky*, J. Wiegers*, C. Mattingly n

author keywords: environmental health; chemical-induced pathways; air pollution; cardiovascular disease; database
MeSH headings : Air Pollutants / toxicity; Air Pollution; Cardiovascular Diseases / chemically induced; Environmental Exposure; Environmental Health; Humans; Toxicogenetics
Sources: Web Of Science, ORCID
Added: December 14, 2020

2019 journal article

The Comparative Toxicogenomics Database: update 2019

NUCLEIC ACIDS RESEARCH, 47(D1), D948–D954.

By: A. Davis n, C. Grondin n, R. Johnson n, D. Sciaky n, R. McMorran*, J. Wiegers n, T. Wiegers n, C. Mattingly n

MeSH headings : Databases, Pharmaceutical; Disease / genetics; Environmental Exposure; Humans; Phenotype; Toxicogenetics; Vocabulary, Controlled
Sources: Web Of Science, ORCID
Added: April 9, 2019

2018 journal article

Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database

ENVIRONMENTAL HEALTH PERSPECTIVES, 126(1).

By: C. Grondin n, A. Davis n, T. Wiegers n, J. Wiegers n & C. Mattingly n

MeSH headings : Databases, Factual; Environmental Exposure / adverse effects; Gene Ontology; Humans; Phenotype; Toxicogenetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

International Journal of Obesity, 42(7), 1285–1295.

Contriutors: A. Green n, C. Hoyo n, C. Mattingly n, Y. Luo n, J. Tzeng n, S. Murphy*, D. Buchwalter n, A. Planchart n

MeSH headings : Adipogenesis / drug effects; Animals; Cadmium / adverse effects; Cadmium / analysis; Cadmium / blood; Disease Models, Animal; Environmental Exposure / adverse effects; Environmental Exposure / analysis; Female; Humans; Infant, Newborn; Male; Maternal Exposure / adverse effects; Metals, Heavy / adverse effects; Metals, Heavy / analysis; Pediatric Obesity / blood; Pediatric Obesity / chemically induced; Pediatric Obesity / epidemiology; Pregnancy; Pregnant Women; Prenatal Exposure Delayed Effects / blood; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / epidemiology; Prospective Studies; Socioeconomic Factors; United States / epidemiology; Zebrafish / metabolism
Sources: Crossref, ORCID
Added: August 7, 2019

2018 journal article

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways

TOXICOLOGICAL SCIENCES, 165(1), 145–156.

By: A. Davis*, T. Wiegers*, J. Wiegers*, R. Johnson*, D. Sciaky*, C. Grondin, C. Mattingly n

author keywords: phenotype; database; curation; chemical; disease; adverse outcome pathway
MeSH headings : Adverse Outcome Pathways; Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / genetics; Gene Ontology; Gene-Environment Interaction; Humans; Phenotype; Toxicogenetics / methods
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies

Current Environmental Health Reports, 5(1), 110–124.

By: A. Planchart n, A. Green n, C. Hoyo n & C. Mattingly n

author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
MeSH headings : Animals; Cadmium / adverse effects; Disease Models, Animal; Humans; Lead / adverse effects; Mercury / adverse effects; Metabolic Syndrome / chemically induced; Metals, Heavy / adverse effects
Sources: Crossref, ORCID
Added: August 7, 2019

2017 review

Applying evolutionary genetics to developmental toxicology and risk assessment

[Review of ]. REPRODUCTIVE TOXICOLOGY, 69, 174–186.

By: M. Leung*, A. Procter n, J. Goldstone*, J. Foox*, R. DeSalle*, C. Mattingly n, M. Siddall*, A. Timme-Laragy*

author keywords: Evolutionary genetics; Developmental toxicology; Systems toxicology; Birth defects; Signaling pathways; High-throughput screening; Evo-Devo
MeSH headings : Animals; Computational Biology; Evolution, Molecular; Humans; Phylogeny; Risk Assessment; Systems Biology; Teratology
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 article

Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health

ANNUAL REVIEW OF PUBLIC HEALTH, VOL 38, Vol. 38, pp. 279–294.

By: A. Manrai*, Y. Cui*, P. Bushel*, M. Hall*, S. Karakitsios*, C. Mattingly n, M. Ritchie*, C. Schmitt* ...

author keywords: exposures; bioinformatics; genomics; environment-wide association studies; data standards
MeSH headings : Biomedical Research; Computational Biology; Ecosystem; Environmental Exposure / adverse effects; Humans; Public Health; Risk Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

The Comparative Toxicogenomics Database: update 2017

NUCLEIC ACIDS RESEARCH, 45(D1), D972–D978.

By: A. Davis n, C. Grondin n, R. Johnson n, D. Sciaky n, B. King*, R. McMorran*, J. Wiegers n, T. Wiegers n, C. Mattingly n

MeSH headings : Computational Biology / methods; Databases, Chemical; Databases, Genetic; Gene Ontology; Humans; Search Engine; Signal Transduction; Toxicogenetics / methods; User-Computer Interface; Web Browser
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

Environmental Health Perspectives, 124(10), 1592–1599.

By: C. Grondin n, A. Davis n, T. Wiegers n, B. King*, J. Wiegers n, D. Reif n, J. Hoppin n, C. Mattingly n

Contriutors: C. Grondin n, A. Davis n, T. Wiegers n, B. King*, J. Wiegers n, D. Reif n, J. Hoppin n, C. Mattingly n

Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Advancing toxicology research using in vivo high throughput toxicology with small fish models

Altex-Alternatives to Animal Experimentation, 33(4), 435–452.

By: A. Planchart, C. Mattingly, D. Allen, P. Ceger, W. Casey, D. Hinton, J. Kanungo, S. Kullman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

MeSH headings : Biomedical Research; Data Mining / methods; Databases, Factual; Disease; Humans; Statistics as Topic; Time Factors
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

BioCreative V CDR task corpus: a resource for chemical disease relation extraction

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: J. Li*, Y. Sun*, R. Johnson n, D. Sciaky n, C. Wei*, R. Leaman*, A. Davis n, C. Mattingly n ...

MeSH headings : Computational Biology / methods; Data Mining / methods; Databases, Factual; Disease; Humans; Toxicogenetics / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson*, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

Contriutors: A. Watson, A. Planchart n, C. Mattingly n, C. Winkler*, D. Reif n & S. Kullman n

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
MeSH headings : Animals; Calcification, Physiologic / drug effects; Down-Regulation / drug effects; Microscopy, Confocal; Musculoskeletal Diseases / metabolism; Oryzias / embryology; Osteogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Real-Time Polymerase Chain Reaction; Skeleton / drug effects; Skeleton / metabolism; Trans-Activators / drug effects
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database

PLOS ONE, 11(5).

By: A. Davis n, T. Wiegers n, B. King*, J. Wiegers n, C. Grondin n, D. Sciaky n, R. Johnson n, C. Mattingly n

MeSH headings : Computational Biology; Databases, Genetic; Disease / genetics; Drug Repositioning; Gene Ontology; Humans; Toxicogenetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 review

Laying a Community-Based Foundation for Data-Driven Semantic Standards in Environmental Health Sciences

[Review of ]. ENVIRONMENTAL HEALTH PERSPECTIVES, 124(8), 1136–1140.

By: C. Mattingly n, R. Boyles*, C. Lawler*, A. Haugen*, A. Dearry* & M. Haendel*

MeSH headings : Cooperative Behavior; Environmental Exposure / standards; Environmental Exposure / statistics & numerical data; Environmental Health / standards; Humans; Internet; National Institute of Environmental Health Sciences (U.S.); United States
Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: D. Pelletier*, T. Wiegers n, A. Enayetallah*, C. Kibbey*, M. Gosink*, P. Koza-Taylor*, C. Mattingly n, M. Lawton*

MeSH headings : Animals; Computational Biology / methods; Computer Simulation; Database Management Systems; Databases, Factual; Humans; Mice; Toxicogenetics / methods; User-Computer Interface
Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 conference paper

Integrating literature-based curated data to predict mechanisms of toxicity

Presented at the OpenTox USA 2015, Baltimore, MD.

By: C. Mattingly

Event: OpenTox USA 2015 at Baltimore, MD on February 10-12, 2015

Source: NC State University Libraries
Added: August 10, 2019

2015 journal article

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

NUCLEIC ACIDS RESEARCH, 43(D1), D914–D920.

By: A. Davis n, C. Grondin n, K. Lennon-Hopkins n, C. Saraceni-Richards n, D. Sciaky n, B. King*, T. Wiegers n, C. Mattingly n

MeSH headings : Databases, Chemical / history; Disease / etiology; Disease / genetics; Genomics / history; History, 21st Century; Internet; Phenotype; Toxicogenetics / history
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

BioC interoperability track overview

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: D. Comeau*, R. Batista-Navarro*, H. Dai*, R. Dogan*, A. Yepes*, R. Khare*, Z. Lu*, H. Marques* ...

MeSH headings : Biomedical Research; Computational Biology; Data Mining; Database Management Systems; Databases, Factual; Internet; Natural Language Processing; Software
Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Web services-based text-mining demonstrates broad impacts for interoperability and process simplification

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: T. Wiegers n, A. Davis n & C. Mattingly n

MeSH headings : Data Mining / methods; Databases, Chemical; Databases, Genetic; Disease / genetics; Genes; Internet; Time Factors; Toxicogenetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

A CTD-Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug-disease and drug-phenotype interactions

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: A. Davis n, T. Wiegers n, P. Roberts n, B. King n, J. Lay n, K. Lennon-Hopkins n, D. Sciaky n, R. Johnson n ...

MeSH headings : Cooperative Behavior; Data Mining; Databases, Factual; Disease; Drug Industry; Humans; Pharmaceutical Preparations / metabolism; Phenotype; Publications; Toxicogenetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Text Mining Effectively Scores and Ranks the Literature for Improving Chemical-Gene-Disease Curation at the Comparative Toxicogenomics Database

PLOS ONE, 8(4).

By: A. Davis n, T. Wiegers n, R. Johnson*, J. Lay*, K. Lennon-Hopkins*, C. Saraceni-Richards*, D. Sciaky*, C. Murphy n, C. Mattingly n

MeSH headings : Algorithms; Data Mining / methods; Databases, Factual; Disease / genetics; Documentation; Humans; Metals, Heavy / toxicity; Molecular Sequence Annotation; Publications; Reproducibility of Results; Toxicogenetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Aquatic models, genomics and chemical risk management

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 155(1), 169–173.

By: K. Cheng*, D. Hinton*, C. Mattingly* & A. Planchart*

Contriutors: K. Cheng*, D. Hinton*, C. Mattingly* & A. Planchart*

author keywords: Aquatic toxicology; Phenome project; Zebrafish; Genomics; Atlas
MeSH headings : Animals; Computational Biology / methods; Databases, Factual; Ecotoxicology; Environmental Exposure / analysis; Environmental Monitoring / methods; Fishes / anatomy & histology; Fishes / genetics; Fishes / physiology; Gene-Environment Interaction; Genomics / methods; Internet; Models, Animal; Risk Factors; User-Computer Interface
Sources: Crossref, ORCID
Added: August 7, 2019

2012 article

BioCreative-2012 Virtual Issue

Wu, C. H., Arighi, C. N., Cohen, K. B., Hirschman, L., Krallinger, M., Lu, Z. Y., … al. (2012, December 5). DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: C. Wu*, C. Arighi*, K. Cohen*, L. Hirschman*, M. Krallinger*, Z. Lu*, C. Mattingly*, A. Valencia* ...

MeSH headings : Congresses as Topic; Cooperative Behavior; Data Mining; Databases, Genetic; Periodicals as Topic; Workflow
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Collaborative biocuration--text-mining development task for document prioritization for curation

Database, 2012(0), bas037–bas037.

By: T. Wiegers n, A. Davis n & C. Mattingly n

MeSH headings : Cooperative Behavior; Data Mining / methods; Databases, Genetic; Disease; Documentation / methods; Genes; Humans; Internet; Toxicogenetics; User-Computer Interface
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2012 journal article

Computation of Neutron Multiplicity Statistics Using Deterministic Transport

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 59(2), 314–322.

author keywords: Coincidence techniques; neutron detectors; inverse problems; simulation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Disease model curation improvements at Mouse Genome Informatics

Database, 2012(0), bar063–bar063.

By: S. Bello*, J. Richardson*, A. Davis*, T. Wiegers*, C. Mattingly*, M. Dolan*, C. Smith*, J. Blake*, J. Eppig*

MeSH headings : Animals; Database Management Systems; Databases, Factual; Disease Models, Animal; Genome; Humans; Mice / genetics; Molecular Sequence Annotation; User-Computer Interface
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database

Database, 2012(0), bar065–bar065.

By: A. Davis*, T. Wiegers*, M. Rosenstein* & C. Mattingly*

MeSH headings : Databases, Factual; Disease / classification; Humans; Subject Headings; Toxicogenetics
Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

Providing the Missing Link: the Exposure Science Ontology ExO

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 46(6), 3046–3053.

By: C. Mattingly n, T. McKone*, M. Callahan, J. Blake* & E. Hubal*

MeSH headings : Environmental Exposure / analysis; Environmental Health; Environmental Pollutants; Humans; Models, Theoretical
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Ranking Transitive Chemical-Disease Inferences Using Local Network Topology in the Comparative Toxicogenomics Database

PLOS ONE, 7(11).

By: B. King*, A. Davis n, M. Rosenstein*, T. Wiegers n & C. Mattingly n

MeSH headings : Cluster Analysis; Databases, Factual; Drug-Related Side Effects and Adverse Reactions / genetics; Gene Regulatory Networks; Humans; Protein Interaction Mapping; Toxicogenetics / methods
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database

Database-The Journal of Biological Databases and Curation.

By: A. Davis, R. Johnson, K. Lennon-Hopkins, D. Sciaky, M. Rosenstein, T. Wiegers, C. Mattingly

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The Comparative Toxicogenomics Database: update 2013

Nucleic Acids Research, 41(D1), D1104–D1114.

By: A. Davis*, C. Murphy, R. Johnson, J. Lay, K. Lennon-Hopkins, C. Saraceni-Richards, D. Sciaky, B. King ...

MeSH headings : Computer Graphics; Databases, Chemical; Disease / genetics; Internet; Software; Toxicogenetics
Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD

Bioinformation, 7(4), 154–156.

By: A. Davis, M. Rosenstein, T. Wiegers & C. Mattingly*

Sources: Crossref, ORCID
Added: August 7, 2019

2011 journal article

The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database

Database, 2011(0), bar034–bar034.

By: A. Davis*, T. Wiegers*, C. Murphy* & C. Mattingly*

MeSH headings : Database Management Systems; Databases, Factual; Disease; Humans; Internet; Pharmaceutical Preparations; Toxicogenetics; User-Computer Interface; Vocabulary, Controlled
Sources: Crossref, ORCID
Added: August 7, 2019

2010 journal article

2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium

Chemical Research in Toxicology, 23(3), 480–487.

By: A. Planchart* & C. Mattingly*

Contriutors: A. Planchart* & C. Mattingly*

MeSH headings : Animals; Embryo, Nonmammalian / metabolism; Enhancer Elements, Genetic; Environmental Pollutants / pharmacology; Forkhead Transcription Factors / genetics; Gene Expression Regulation, Developmental / drug effects; Jaw / metabolism; Jaw / pathology; Jaw Abnormalities / chemically induced; Polychlorinated Dibenzodioxins / pharmacology; Receptors, Aryl Hydrocarbon / metabolism; Up-Regulation / drug effects; Zebrafish / genetics; Zebrafish / metabolism; Zebrafish Proteins / genetics; Zebrafish Proteins / metabolism
Sources: Crossref, ORCID
Added: August 10, 2019

2010 journal article

The Comparative Toxicogenomics Database: update 2011

Nucleic Acids Research, 39(Database), D1067–D1072.

By: A. Davis*, B. King*, S. Mockus*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers*, C. Mattingly*

MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Gene Regulatory Networks; Genes; Hazardous Substances / toxicity; Humans; Software; Toxicogenetics
Sources: Crossref, ORCID
Added: August 7, 2019

2010 chapter

Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)

In Nature Pathway Interaction Database.

By: C. Mattingly

Source: NC State University Libraries
Added: August 10, 2019

2009 journal article

Chemical databases for environmental health and clinical research

Toxicology Letters, 186(1), 62–65.

By: C. Mattingly*

author keywords: Chemical; Drug; Database; Toxicogenomics
MeSH headings : Animals; Databases, Factual; Drug-Related Side Effects and Adverse Reactions; Environmental Exposure; Environmental Health; Environmental Medicine; Environmental Pollutants / toxicity; Humans; Toxicogenetics
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks

Nucleic Acids Research, 37(Database), D786–D792.

By: A. Davis*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers* & C. Mattingly*

MeSH headings : Databases, Factual; Disease / etiology; Disease / genetics; Environmental Exposure; Genes; Genomics; Hazardous Substances / toxicity; Humans; Models, Biological; Proteins / drug effects; Proteins / genetics; Systems Integration; Toxicogenetics
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles

Bioinformation, 4(4), 173–174.

By: A. Davis, C. Murphy, C. Saraceni-Richards, M. Rosenstein, T. Wiegers, T. Hampton, C. Mattingly*

author keywords: gene; chemical; toxicogenomic; database; curation
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Genetic and environmental pathways to complex diseases

BMC Systems Biology, 3(1), 46.

By: J. Gohlke*, R. Thomas*, Y. Zhang*, M. Rosenstein*, A. Davis*, C. Murphy*, K. Becker*, C. Mattingly*, C. Portier*

MeSH headings : Databases, Genetic; Disease / genetics; Environment; Evolution, Molecular; Gene Expression Regulation; Genome-Wide Association Study; Genotype; Humans; Mental Disorders / etiology; Mental Disorders / genetics; Mental Disorders / metabolism; Mental Disorders / pathology; Metabolic Diseases / etiology; Metabolic Diseases / genetics; Metabolic Diseases / metabolism; Metabolic Diseases / pathology; Phenotype; Transcription, Genetic
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Perturbation of Defense Pathways by Low-Dose Arsenic Exposure in Zebrafish Embryos

Environmental Health Perspectives, 117(6), 981–987.

By: C. Mattingly*, T. Hampton, K. Brothers, N. Griffin & A. Planchart*

Contriutors: C. Mattingly*, T. Hampton, K. Brothers, N. Griffin & A. Planchart*

author keywords: arsenic; Comparative Toxicogenomics Database; embryonic development; gene regulatory networks; immunity; microarray; toxicogenomics; transcriptional profiling; zebrafish
MeSH headings : Animals; Arsenic / toxicity; Embryo, Nonmammalian; Gene Expression / drug effects; Oligonucleotide Array Sequence Analysis; Reverse Transcriptase Polymerase Chain Reaction; Water Pollutants, Chemical / toxicity; Zebrafish / metabolism
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)

BMC Bioinformatics, 10(1).

By: T. Wiegers*, A. Davis*, K. Cohen*, L. Hirschman* & C. Mattingly*

MeSH headings : Computational Biology / methods; Databases, Factual; Gene Regulatory Networks; Information Storage and Retrieval / methods; Toxicogenetics
Sources: Crossref, ORCID
Added: August 10, 2019

2008 journal article

An Evaluation of Information Content as a Metric for the Inference of Putative Conserved Noncoding Regions in DNA Sequences Using a Genetic Algorithms Approach

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 5(1), 1–14.

By: C. Bates Congdon*, J. Aman*, G. Nava*, H. Gaskins* & C. Mattingly*

author keywords: evolutionary computing; genetic algorithms; biology; genetics
MeSH headings : Algorithms; Animals; Base Sequence; Computational Biology / methods; Confidence Intervals; Conserved Sequence / genetics; Cystic Fibrosis Transmembrane Conductance Regulator / genetics; Enhancer Elements, Genetic / genetics; Glutathione Transferase / genetics; Humans; Models, Genetic; Regulatory Sequences, Nucleic Acid / genetics; Sequence Alignment; Sequence Analysis, DNA / methods; Sex-Determining Region Y Protein / genetics
Sources: Crossref, ORCID
Added: August 10, 2019

2008 journal article

The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

BMC Medical Genomics, 1(1).

By: A. Davis*, C. Murphy*, M. Rosenstein*, T. Wiegers* & C. Mattingly*

Sources: Crossref, ORCID
Added: August 10, 2019

2007 conference paper

Towards Interactive Visualization for Exploring Conserved Motifs in Noncoding DNA Sequence

2007 Frontiers in the Convergence of Bioscience and Information Technologies. Presented at the 2007 Frontiers in the Convergence of Bioscience and Information Technologies.

By: C. Congdon*, H. Gaskins*, G. Nava* & C. Mattingly*

Event: 2007 Frontiers in the Convergence of Bioscience and Information Technologies

Sources: Crossref, ORCID
Added: August 10, 2019

2006 journal article

The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies

Journal of Experimental Zoology Part A: Comparative Experimental Biology, 305A(9), 689–692.

By: C. Mattingly*, M. Rosenstein*, G. Colby*, J. Forrest Jr & J. Boyer*

MeSH headings : Animals; Databases, Factual; Humans; Toxicogenetics; Xenobiotics / toxicity
Sources: Crossref, ORCID
Added: August 10, 2019

2006 journal article

The Comparative Toxicogenomics Database: A Cross-Species Resource for Building Chemical-Gene Interaction Networks

Toxicological Sciences, 92(2), 587–595.

By: C. Mattingly*, M. Rosenstein, A. Davis, G. Colby, J. Forrest & J. Boyer

author keywords: CTD; chemicals; environment; GO; toxicology; pathways; interactions
MeSH headings : Animals; Databases, Factual; Environmental Health; Humans; Toxicogenetics
Sources: Crossref, ORCID
Added: August 10, 2019

2005 conference paper

Preliminary Results for GAMI: A Genetic Algorithms Approach to Motif Inference

2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. Presented at the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology.

By: C. Congdon*, C. Fizer*, N. Smith*, H. Gaskins*, J. Aman*, G. Nava*, C. Mattingly*

Event: 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Cell and Molecular Biology of Marine Elasmobranchs: Squalus acanthias and Raja erinacea

Zebrafish, 1(2), 111–120.

By: C. Mattingly*, A. Parton*, L. Dowell*, J. Rafferty* & D. Barnes*

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Marine Organism Cell Biology and Regulatory Sequence Discoveryin Comparative Functional Genomics

Cytotechnology, 46(2-3), 123–137.

By: D. Barnes*, C. Mattingly*, A. Parton*, L. Dowell*, C. Bayne* & J. Forrest*

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Promoting comparative molecular studies in environmental health research: an overview of the comparative toxicogenomics database (CTD)

The Pharmacogenomics Journal, 4(1), 5–8.

MeSH headings : Animals; Databases, Genetic / trends; Environmental Health / trends; Humans; Toxicogenetics / trends
Sources: Crossref, ORCID
Added: August 10, 2019

2003 journal article

The Comparative Toxicogenomics Database (CTD).

Environmental Health Perspectives, 111(6), 793–795.

By: C. Mattingly*, G. Colby*, J. Forrest* & J. Boyer*

author keywords: aquatic; comparative; database; environmental health; fishes; genomic; health; toxicogenomics; toxicology
MeSH headings : Animals; Databases, Factual; Environmental Health; Environmental Pollutants / adverse effects; Genetic Predisposition to Disease; Humans; Pharmacogenetics / statistics & numerical data; Pharmacogenetics / trends; Research / trends; Toxicology / trends
Sources: Crossref, ORCID
Added: August 10, 2019

2001 journal article

Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio).

Environmental Health Perspectives, 109(8), 845–849.

By: C. Mattingly*, J. McLachlan* & W. Toscano*

MeSH headings : Animals; Biomarkers / analysis; Cytochrome P-450 CYP1A1 / genetics; Eye Abnormalities / chemically induced; Green Fluorescent Proteins; Luminescent Proteins / biosynthesis; Models, Animal; Morphogenesis / drug effects; Polychlorinated Dibenzodioxins / toxicity; Receptors, Aryl Hydrocarbon / genetics; Spine / abnormalities; Transcription, Genetic; Transfection; Zebrafish / embryology
Sources: Crossref, ORCID
Added: August 10, 2019

2001 journal article

Posttranscriptional silencing of cytochrome P4501A1 (CYP1A1) during zebrafish (Danio rerio) development

Developmental Dynamics, 222(4), 645–654.

By: C. Mattingly* & W. Toscano*

author keywords: cytochrome P450; monooxygenase; zebrafish; Ah receptor; dioxin
MeSH headings : Aging / metabolism; Animals; Base Sequence / genetics; Cloning, Molecular; Cytochrome P-450 CYP1A1 / genetics; Cytochrome P-450 CYP1A1 / metabolism; Embryo, Nonmammalian / drug effects; Embryo, Nonmammalian / physiology; Environmental Pollutants / poisoning; Gene Expression Regulation; Gene Expression Regulation, Developmental; Gene Silencing; Molecular Sequence Data; Polychlorinated Dibenzodioxins / poisoning; RNA, Messenger / metabolism; Transcription, Genetic; Zebrafish / embryology; Zebrafish / genetics; Zebrafish / metabolism
Sources: Crossref, ORCID
Added: August 10, 2019

1999 journal article

Estrogen Receptor Reduces CYP1A1 Induction in Cultured Human Endometrial Cells

Journal of Biological Chemistry, 274(6), 3430–3438.

By: M. Ricci, D. Toscano*, C. Mattingly* & W. Toscano*

MeSH headings : Cell Line; Cytochrome P-450 CYP1A1 / biosynthesis; Cytochrome P-450 CYP1A1 / genetics; Endometrium / cytology; Endometrium / drug effects; Endometrium / enzymology; Enzyme Induction; Estradiol / pharmacology; Female; Humans; Polychlorinated Dibenzodioxins / pharmacology; RNA, Messenger / genetics; Receptors, Estrogen / physiology; Transcription, Genetic / drug effects
Sources: Crossref, ORCID
Added: August 10, 2019

Employment

Updated: September 9th, 2019 21:21

2019 - present

NC State University Raleigh, NC, US
Professor Biological Sciences

2018 - present

NC State University Raleigh, NC, US
Interim Head Biological Sciences

2012 - 2019

NC State University Raleigh, NC, US
Associate Professor Biological Sciences