Works (63)

Updated: April 11th, 2023 10:13

2022 article

Comparative Toxicogenomics Database (CTD): update 2023

Davis, A. P., Wiegers, T. C., Johnson, R. J., Sciaky, D., Wiegers, J., & Mattingly, C. J. (2022, September 28). NUCLEIC ACIDS RESEARCH, Vol. 9.

By: A. Davis, T. Wiegers, R. Johnson, D. Sciaky, J. Wiegers & C. Mattingly

Sources: Web Of Science, ORCID
Added: October 11, 2022

2021 journal article

CTD anatomy: Analyzing chemical-induced phenotypes and exposures from an anatomical perspective, with implications for environmental health studies

CURRENT RESEARCH IN TOXICOLOGY, 2, 128–139.

author keywords: Anatomy; Chemical; Phenotype; Disease; Environmental health; Database
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 journal article

Comparative Toxicogenomics Database (CTD): update 2021

NUCLEIC ACIDS RESEARCH, 49(D1), D1138–D1143.

Sources: Web Of Science, ORCID
Added: February 8, 2021

2021 journal article

Predicting molecular mechanisms, pathways, and health outcomes induced by Juul e-cigarette aerosol chemicals using the Comparative Toxicogenomics Database

CURRENT RESEARCH IN TOXICOLOGY, 2, 272–281.

author keywords: E-cigarettes; Vaping; Juul; Respiratory disease; Database; Environmental exposure
Sources: Web Of Science, ORCID
Added: January 3, 2022

2021 journal article

Regulatory status of pesticide residues in cannabis: Implications to medical use in neurological diseases

CURRENT RESEARCH IN TOXICOLOGY, 2, 140–148.

By: D. Pinkhasova*, L. Jameson*, K. Conrow*, M. Simeone*, A. Davis, T. Wiegers, C. Mattingly, M. Leung*

author keywords: Cannabis; Pesticide; Database; Regulation; Seizure; Contaminant
Sources: Web Of Science, ORCID
Added: January 3, 2022

2020 review

Beyond the looking glass: recent advances in understanding the impact of environmental exposures on neuropsychiatric disease

[Review of ]. NEUROPSYCHOPHARMACOLOGY, 45(7), 1086–1096.

By: J. Hollander*, D. Cory-Slechta*, F. Jacka*, S. Szabo*, T. Guilarte*, S. Bilbo*, C. Mattingly, S. Moy* ...

Sources: Web Of Science, ORCID
Added: March 30, 2020

2020 journal article

Leveraging the Comparative Toxicogenomics Database to Fill in Knowledge Gaps for Environmental Health: A Test Case for Air Pollution-induced Cardiovascular Disease

TOXICOLOGICAL SCIENCES, 177(2), 392–404.

author keywords: environmental health; chemical-induced pathways; air pollution; cardiovascular disease; database
Sources: Web Of Science, ORCID
Added: December 14, 2020

2019 journal article

The Comparative Toxicogenomics Database: update 2019

NUCLEIC ACIDS RESEARCH, 47(D1), D948–D954.

Sources: Web Of Science, ORCID
Added: April 9, 2019

2018 journal article

Accessing an Expanded Exposure Science Module at the Comparative Toxicogenomics Database

ENVIRONMENTAL HEALTH PERSPECTIVES, 126(1).

By: C. Grondin, A. Davis, T. Wiegers, J. Wiegers & C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2018 journal article

Cadmium exposure increases the risk of juvenile obesity: a human and zebrafish comparative study

International Journal of Obesity, 42(7), 1285–1295.

By: A. Green n, C. Hoyo, C. Mattingly, Y. Luo n, J. Tzeng, S. Murphy*, D. Buchwalter, A. Planchart

Sources: Crossref, ORCID
Added: August 7, 2019

2018 journal article

Chemical-Induced Phenotypes at CTD Help Inform the Predisease State and Construct Adverse Outcome Pathways

TOXICOLOGICAL SCIENCES, 165(1), 145–156.

By: A. Davis, T. Wiegers, J. Wiegers, R. Johnson, D. Sciaky, C. Grondin*, C. Mattingly

author keywords: phenotype; database; curation; chemical; disease; adverse outcome pathway
Sources: Web Of Science, ORCID
Added: October 16, 2018

2018 journal article

Heavy Metal Exposure and Metabolic Syndrome: Evidence from Human and Model System Studies

Current Environmental Health Reports, 5(1), 110–124.

By: A. Planchart, A. Green n, C. Hoyo & C. Mattingly

author keywords: Metabolic syndrome; Diabetes; Heavy metals; Cadmium; Pb; Mercury
Sources: Crossref, ORCID
Added: August 7, 2019

2017 review

Applying evolutionary genetics to developmental toxicology and risk assessment

[Review of ]. REPRODUCTIVE TOXICOLOGY, 69, 174–186.

By: M. Leung*, A. Procter, J. Goldstone*, J. Foox*, R. DeSalle*, C. Mattingly, M. Siddall*, A. Timme-Laragy*

author keywords: Evolutionary genetics; Developmental toxicology; Systems toxicology; Birth defects; Signaling pathways; High-throughput screening; Evo-Devo
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 article

Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health

ANNUAL REVIEW OF PUBLIC HEALTH, VOL 38, Vol. 38, pp. 279–294.

By: A. Manrai*, Y. Cui*, P. Bushel*, M. Hall*, S. Karakitsios*, C. Mattingly, M. Ritchie*, C. Schmitt* ...

author keywords: exposures; bioinformatics; genomics; environment-wide association studies; data standards
Sources: Web Of Science, ORCID
Added: August 6, 2018

2017 journal article

The Comparative Toxicogenomics Database: update 2017

NUCLEIC ACIDS RESEARCH, 45(D1), D972–D978.

By: A. Davis, C. Grondin, R. Johnson, D. Sciaky, B. King*, R. McMorran*, J. Wiegers, T. Wiegers, C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

Environmental Health Perspectives, 124(10), 1592–1599.

By: C. Grondin, A. Davis, T. Wiegers, B. King*, J. Wiegers, D. Reif, J. Hoppin, C. Mattingly

Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Advancing toxicology research using in vivo high throughput toxicology with small fish models

Altex-Alternatives to Animal Experimentation, 33(4), 435–452.

By: A. Planchart, C. Mattingly, D. Allen, P. Ceger, W. Casey, D. Hinton, J. Kanungo, S. Kullman ...

Source: NC State University Libraries
Added: August 6, 2018

2016 journal article

Assessing the state of the art in biomedical relation extraction: overview of the BioCreative V chemical-disease relation (CDR) task

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: C. Wei*, Y. Peng*, R. Leaman*, A. Davis, C. Mattingly, J. Li*, T. Wiegers, Z. Lu*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

BioCreative V CDR task corpus: a resource for chemical disease relation extraction

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: J. Li*, Y. Sun*, R. Johnson, D. Sciaky, C. Wei*, R. Leaman*, A. Davis, C. Mattingly ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

From the Cover: Embryonic Exposure to TCDD Impacts Osteogenesis of the Axial Skeleton in Japanese medaka,Oryzias latipes

Toxicological Sciences, 155(2), 485–496.

By: A. Watson, A. Planchart, C. Mattingly, C. Winkler, D. Reif & S. Kullman

author keywords: receptor, aryl hydrocarbon; gene expression/regulation, bone; transgenic models; methods, developmental/teratology; reproductive and developmental toxicology
Sources: Web Of Science, ORCID, Crossref
Added: August 6, 2018

2016 journal article

Generating Gene Ontology-Disease Inferences to Explore Mechanisms of Human Disease at the Comparative Toxicogenomics Database

PLOS ONE, 11(5).

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 review

Laying a Community-Based Foundation for Data-Driven Semantic Standards in Environmental Health Sciences

[Review of ]. ENVIRONMENTAL HEALTH PERSPECTIVES, 124(8), 1136–1140.

By: C. Mattingly, R. Boyles*, C. Lawler*, A. Haugen*, A. Dearry* & M. Haendel*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2016 journal article

ToxEvaluator: an integrated computational platform to aid the interpretation of toxicology study-related findings

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: D. Pelletier*, T. Wiegers, A. Enayetallah*, C. Kibbey*, M. Gosink*, P. Koza-Taylor*, C. Mattingly, M. Lawton*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2015 conference paper

Integrating literature-based curated data to predict mechanisms of toxicity

Presented at the OpenTox USA 2015, Baltimore, MD.

By: C. Mattingly

Event: OpenTox USA 2015 at Baltimore, MD on February 10-12, 2015

Source: NC State University Libraries
Added: August 10, 2019

2015 journal article

The Comparative Toxicogenomics Database's 10th year anniversary: update 2015

NUCLEIC ACIDS RESEARCH, 43(D1), D914–D920.

By: A. Davis, C. Grondin, K. Lennon-Hopkins, C. Saraceni-Richards n, D. Sciaky, B. King*, T. Wiegers, C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

BioC interoperability track overview

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: D. Comeau*, R. Batista-Navarro*, H. Dai*, R. Dogan*, A. Yepes*, R. Khare*, Z. Lu*, H. Marques* ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2014 journal article

Web services-based text-mining demonstrates broad impacts for interoperability and process simplification

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: T. Wiegers, A. Davis & C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

A CTD-Pfizer collaboration: manual curation of 88 000 scientific articles text mined for drug-disease and drug-phenotype interactions

DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: A. Davis, T. Wiegers, P. Roberts, B. King, J. Lay, K. Lennon-Hopkins, D. Sciaky, R. Johnson ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2013 journal article

Text Mining Effectively Scores and Ranks the Literature for Improving Chemical-Gene-Disease Curation at the Comparative Toxicogenomics Database

PLOS ONE, 8(4).

By: A. Davis, T. Wiegers, R. Johnson*, J. Lay*, K. Lennon-Hopkins*, C. Saraceni-Richards*, D. Sciaky*, C. Murphy n, C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Aquatic models, genomics and chemical risk management

Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology, 155(1), 169–173.

By: K. Cheng*, D. Hinton*, C. Mattingly & A. Planchart

author keywords: Aquatic toxicology; Phenome project; Zebrafish; Genomics; Atlas
Sources: Crossref, ORCID
Added: August 7, 2019

2012 article

BioCreative-2012 Virtual Issue

Wu, C. H., Arighi, C. N., Cohen, K. B., Hirschman, L., Krallinger, M., Lu, Z. Y., … al. (2012, December 5). DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION.

By: C. Wu*, C. Arighi*, K. Cohen*, L. Hirschman*, M. Krallinger*, Z. Lu*, C. Mattingly, A. Valencia* ...

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Collaborative biocuration--text-mining development task for document prioritization for curation

Database, 2012(0), bas037–bas037.

By: T. Wiegers, A. Davis n & C. Mattingly

Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2012 journal article

Computation of Neutron Multiplicity Statistics Using Deterministic Transport

IEEE TRANSACTIONS ON NUCLEAR SCIENCE, 59(2), 314–322.

By: J. Mattingly n

author keywords: Coincidence techniques; neutron detectors; inverse problems; simulation
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Disease model curation improvements at Mouse Genome Informatics

Database, 2012(0), bar063–bar063.

By: S. Bello*, J. Richardson*, A. Davis*, T. Wiegers*, C. Mattingly, M. Dolan*, C. Smith*, J. Blake*, J. Eppig*

Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

MEDIC: a practical disease vocabulary used at the Comparative Toxicogenomics Database

Database, 2012(0), bar065–bar065.

By: A. Davis, T. Wiegers, M. Rosenstein & C. Mattingly

Sources: Crossref, ORCID
Added: August 7, 2019

2012 journal article

Providing the Missing Link: the Exposure Science Ontology ExO

ENVIRONMENTAL SCIENCE & TECHNOLOGY, 46(6), 3046–3053.

By: C. Mattingly, T. McKone*, M. Callahan*, J. Blake* & E. Hubal*

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Ranking Transitive Chemical-Disease Inferences Using Local Network Topology in the Comparative Toxicogenomics Database

PLOS ONE, 7(11).

By: B. King*, A. Davis, M. Rosenstein*, T. Wiegers & C. Mattingly

Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Targeted journal curation as a method to improve data currency at the Comparative Toxicogenomics Database

Database-The Journal of Biological Databases and Curation.

By: A. Davis, R. Johnson, K. Lennon-Hopkins, D. Sciaky, M. Rosenstein, T. Wiegers, C. Mattingly

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

The Comparative Toxicogenomics Database: update 2013

Nucleic Acids Research, 41(D1), D1104–D1114.

By: A. Davis, C. Murphy n, R. Johnson n, J. Lay n, K. Lennon-Hopkins n, C. Saraceni-Richards n, D. Sciaky n, B. King n ...

Sources: Crossref, ORCID, Web Of Science
Added: August 6, 2018

2011 journal article

DiseaseComps: a metric that discovers similar diseases based upon common toxicogenomic profiles at CTD

Bioinformation, 7(4), 154–156.

By: A. Davis*, M. Rosenstein, T. Wiegers & C. Mattingly

Sources: Crossref, ORCID
Added: August 7, 2019

2011 journal article

The curation paradigm and application tool used for manual curation of the scientific literature at the Comparative Toxicogenomics Database

Database, 2011(0), bar034–bar034.

By: A. Davis*, T. Wiegers*, C. Murphy* & C. Mattingly

Sources: Crossref, ORCID
Added: August 7, 2019

2010 journal article

2,3,7,8-Tetrachlorodibenzo-p-dioxin Upregulates FoxQ1b in Zebrafish Jaw Primordium

Chemical Research in Toxicology, 23(3), 480–487.

By: A. Planchart & C. Mattingly

Sources: Crossref, ORCID
Added: August 10, 2019

2010 journal article

The Comparative Toxicogenomics Database: update 2011

Nucleic Acids Research, 39(Database), D1067–D1072.

By: A. Davis*, B. King*, S. Mockus*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers*, C. Mattingly

Sources: Crossref, ORCID
Added: August 7, 2019

2010 chapter

Understanding environment-disease connections: An introduction to the comparative toxicogenomics database (ctd)

In Nature Pathway Interaction Database.

By: C. Mattingly

Source: NC State University Libraries
Added: August 10, 2019

2009 journal article

Chemical databases for environmental health and clinical research

Toxicology Letters, 186(1), 62–65.

By: C. Mattingly

author keywords: Chemical; Drug; Database; Toxicogenomics
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks

Nucleic Acids Research, 37(Database), D786–D792.

By: A. Davis*, C. Murphy*, C. Saraceni-Richards*, M. Rosenstein*, T. Wiegers* & C. Mattingly

Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

GeneComps and ChemComps: a new CTD metric to identify genes and chemicals with shared toxicogenomic profiles

Bioinformation, 4(4), 173–174.

By: A. Davis*, C. Murphy, C. Saraceni-Richards, M. Rosenstein, T. Wiegers, T. Hampton, C. Mattingly

author keywords: gene; chemical; toxicogenomic; database; curation
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Genetic and environmental pathways to complex diseases

BMC Systems Biology, 3(1), 46.

By: J. Gohlke*, R. Thomas*, Y. Zhang*, M. Rosenstein*, A. Davis*, C. Murphy*, K. Becker*, C. Mattingly, C. Portier*

Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Perturbation of Defense Pathways by Low-Dose Arsenic Exposure in Zebrafish Embryos

Environmental Health Perspectives, 117(6), 981–987.

By: C. Mattingly, T. Hampton, K. Brothers, N. Griffin & A. Planchart

author keywords: arsenic; Comparative Toxicogenomics Database; embryonic development; gene regulatory networks; immunity; microarray; toxicogenomics; transcriptional profiling; zebrafish
Sources: Crossref, ORCID
Added: August 10, 2019

2009 journal article

Text mining and manual curation of chemical-gene-disease networks for the Comparative Toxicogenomics Database (CTD)

BMC Bioinformatics, 10(1).

By: T. Wiegers*, A. Davis*, K. Cohen*, L. Hirschman* & C. Mattingly

Sources: Crossref, ORCID
Added: August 10, 2019

2008 journal article

An Evaluation of Information Content as a Metric for the Inference of Putative Conserved Noncoding Regions in DNA Sequences Using a Genetic Algorithms Approach

IEEE/ACM Transactions on Computational Biology and Bioinformatics, 5(1), 1–14.

By: C. Bates Congdon*, J. Aman*, G. Nava*, H. Gaskins* & C. Mattingly

author keywords: evolutionary computing; genetic algorithms; biology; genetics
Sources: Crossref, ORCID
Added: August 10, 2019

2008 journal article

The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

BMC Medical Genomics, 1(1).

By: A. Davis*, C. Murphy*, M. Rosenstein*, T. Wiegers* & C. Mattingly

Sources: Crossref, ORCID
Added: August 10, 2019

2007 conference paper

Towards Interactive Visualization for Exploring Conserved Motifs in Noncoding DNA Sequence

2007 Frontiers in the Convergence of Bioscience and Information Technologies. Presented at the 2007 Frontiers in the Convergence of Bioscience and Information Technologies.

By: C. Congdon*, H. Gaskins*, G. Nava* & C. Mattingly

Event: 2007 Frontiers in the Convergence of Bioscience and Information Technologies

Sources: Crossref, ORCID
Added: August 10, 2019

2006 journal article

The Comparative Toxicogenomics Database (CTD): a resource for comparative toxicological studies

Journal of Experimental Zoology Part A: Comparative Experimental Biology, 305A(9), 689–692.

By: C. Mattingly, M. Rosenstein*, G. Colby*, J. Forrest Jr & J. Boyer*

Sources: Crossref, ORCID
Added: August 10, 2019

2006 journal article

The Comparative Toxicogenomics Database: A Cross-Species Resource for Building Chemical-Gene Interaction Networks

Toxicological Sciences, 92(2), 587–595.

By: C. Mattingly, M. Rosenstein, A. Davis, G. Colby, J. Forrest & J. Boyer

author keywords: CTD; chemicals; environment; GO; toxicology; pathways; interactions
Sources: Crossref, ORCID
Added: August 10, 2019

2005 conference paper

Preliminary Results for GAMI: A Genetic Algorithms Approach to Motif Inference

2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology. Presented at the 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology.

By: C. Congdon*, C. Fizer*, N. Smith*, H. Gaskins*, J. Aman*, G. Nava*, C. Mattingly

Event: 2005 IEEE Symposium on Computational Intelligence in Bioinformatics and Computational Biology

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Cell and Molecular Biology of Marine Elasmobranchs: Squalus acanthias and Raja erinacea

Zebrafish, 1(2), 111–120.

By: C. Mattingly, A. Parton*, L. Dowell*, J. Rafferty* & D. Barnes*

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Marine Organism Cell Biology and Regulatory Sequence Discoveryin Comparative Functional Genomics

Cytotechnology, 46(2-3), 123–137.

By: D. Barnes*, C. Mattingly, A. Parton*, L. Dowell*, C. Bayne* & J. Forrest*

Sources: Crossref, ORCID
Added: August 10, 2019

2004 journal article

Promoting comparative molecular studies in environmental health research: an overview of the comparative toxicogenomics database (CTD)

The Pharmacogenomics Journal, 4(1), 5–8.

By: C. Mattingly, G. Colby*, M. Rosenstein*, J. Forrest* & J. Boyer*

Sources: Crossref, ORCID
Added: August 10, 2019

2003 journal article

The Comparative Toxicogenomics Database (CTD).

Environmental Health Perspectives, 111(6), 793–795.

By: C. Mattingly, G. Colby, J. Forrest & J. Boyer

author keywords: aquatic; comparative; database; environmental health; fishes; genomic; health; toxicogenomics; toxicology
Sources: Crossref, ORCID
Added: August 10, 2019

2001 journal article

Green fluorescent protein (GFP) as a marker of aryl hydrocarbon receptor (AhR) function in developing zebrafish (Danio rerio).

Environmental Health Perspectives, 109(8), 845–849.

By: C. Mattingly, J. McLachlan* & W. Toscano*

Sources: Crossref, ORCID
Added: August 10, 2019

2001 journal article

Posttranscriptional silencing of cytochrome P4501A1 (CYP1A1) during zebrafish (Danio rerio) development

Developmental Dynamics, 222(4), 645–654.

By: C. Mattingly & W. Toscano*

author keywords: cytochrome P450; monooxygenase; zebrafish; Ah receptor; dioxin
Sources: Crossref, ORCID
Added: August 10, 2019

1999 journal article

Estrogen Receptor Reduces CYP1A1 Induction in Cultured Human Endometrial Cells

Journal of Biological Chemistry, 274(6), 3430–3438.

By: M. Ricci*, D. Toscano*, C. Mattingly & W. Toscano*

Sources: Crossref, ORCID
Added: August 10, 2019

Employment

Updated: September 9th, 2019 21:21

2019 - present

NC State University Raleigh, NC, US
Professor Biological Sciences

2018 - present

NC State University Raleigh, NC, US
Interim Head Biological Sciences

2012 - 2019

NC State University Raleigh, NC, US
Associate Professor Biological Sciences