Caroline Laplante
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Works (18)
Updated: April 3rd, 2024 19:58
2023 journal article
Actin-Microtubule Crosstalk Imparts Stiffness to the Contractile Ring in Fission Yeast
CELLS, 12(6).
author keywords: cytokinesis; mitosis; microtubules; mechanical properties; contractile ring; quantitative microscopy
MeSH headings : Actins; Schizosaccharomyces; Microtubules; Cytoskeleton; Cell Division
TL;DR:
It is proposed that the post-anaphase array of microtubules exploit the contractile ring for their assembly and function during cell division, while the contractiles ring may receive no benefit from these interactions.
(via Semantic Scholar)
www.mdpi.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: April 11, 2023
2023 journal article
Microtubule competition and cell growth recenter the nucleus after anaphase in fission yeast
MOLECULAR BIOLOGY OF THE CELL, 34(8).
TL;DR:
This work underlines how intrinsic properties of microtubules differently impact nuclear positioning according to microtubule network organization and cell size.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 28, 2023
2022 journal article
Imp2p forms actin-dependent clusters and imparts stiffness to the contractile ring
MOLECULAR BIOLOGY OF THE CELL, 33(14).
MeSH headings : Actin Cytoskeleton / metabolism; Actins / metabolism; Cytokinesis; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
It is found that similarly to Cdc15p, Imp2p contributes to the stiffness of the contractile ring and assembles into protein clusters, indicating that the two proteins influence each other during cytokinesis, which may partially explain their similar phenotypes.
(via Semantic Scholar)
Source: Web Of Science
Added: January 3, 2023
2022 journal article
Laser ablation reveals the impact of Cdc15p on the stiffness of the contractile ring
MOLECULAR BIOLOGY OF THE CELL, 33(6).
MeSH headings : Actin Cytoskeleton / metabolism; Cytokinesis; Laser Therapy; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
This work shows that the severed constricting contractile ring recoils to a finite point leaving a gap that can heal if less than ∼1 µm, and proposes that Cdc15p impacts the stiffness of the contractiles ring more than the viscous drag.
(via Semantic Scholar)
Sources: Web Of Science, ORCID
Added: June 6, 2022
2021 journal article
Host-Pathogen Interactions of Chlamydia trachomatis in Porcine Oviduct Epithelial Cells
PATHOGENS, 10(10).
author keywords: Chlamydia trachomatis; porcine oviduct epithelial cell; developmental cycle; innate immune response; claudin-4; tight junctions
TL;DR:
It is shown that primary pOECs represent an excellent in vitro model for research into Ct pathogenesis, cell biology and immunity and induces an immune response to Ct similar to human cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID
Added: October 6, 2021
2021 journal article
Molecular organization of cytokinesis node predicts the constriction rate of the contractile ring
JOURNAL OF CELL BIOLOGY, 220(3).
MeSH headings : Acetyltransferases / metabolism; Actin Cytoskeleton / metabolism; Actins / metabolism; Cytokinesis; Models, Biological; Mutation / genetics; Schizosaccharomyces / cytology; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / genetics; Schizosaccharomyces pombe Proteins / metabolism; Time Factors
TL;DR:
This work leveraged the Δmid1 contractile ring assembly mechanism to determine how two distinct molecular organizations, nodes versus strands, can yield functional contractile rings and establishes a predictive correlation between the molecular organization of nodes and the behavior of the contractiles ring.
(via Semantic Scholar)
Source: Web Of Science
Added: March 29, 2021
2018 journal article
Building the contractile ring from the ground up: a lesson in perseverance and scientific creativity
Biophysical Reviews, 10(6), 1491–1497.
TL;DR:
This contribution to the Festschrift for Professor Thomas (Tom) D. Pollard focuses on his work on the elucidation of the protein organization within the cytokinetic nodes, protein assemblies, precursors to the contractile ring.
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2018 article
Resolving single-actin filaments within the contractile ring of fission yeast
Laplante, C. (2018, February 13). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol. 115, pp. 1403–1405.
MeSH headings : Actin Cytoskeleton; Actins; Cytokinesis; Schizosaccharomyces; Schizosaccharomyces pombe Proteins
TL;DR:
There are still many aspects of the general mechanisms of contractile ring assembly, constriction, and disassembly that the authors do not understand and one remaining enigma about cytokinesis is the how the network of actin filaments is structured during constriction.
(via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018
2017 journal article
Response to Zambon et al.
Current Biology, 27(3), R101–R102.
MeSH headings : Constriction; Myosin Heavy Chains; Myosin Type II; Myosins; Schizosaccharomyces; Schizosaccharomyces pombe Proteins
TL;DR:
It is concluded that Myo2p is the major motor involved in ring contraction in S. pombe and most of the differences observed by Zambon et al. can be attributed to their use of the Rlc1p-3GFP marker, which genetically interacts with myo2-E1.
(via Semantic Scholar)
Source: Crossref
Added: February 21, 2020
2016 journal article
Molecular organization of cytokinesis nodes and contractile rings by super-resolution fluorescence microscopy of live fission yeast
Proceedings of the National Academy of Sciences, 113(40), E5876–E5885.
author keywords: super resolution; cytokinesis; cytokinetic nodes; contractile ring; fission yeast
MeSH headings : Actin Cytoskeleton / metabolism; Actins / metabolism; Cytokinesis; Interphase; Microscopy, Fluorescence / methods; Models, Molecular; Phenotype; Schizosaccharomyces / cytology; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
It is shown that nodes, protein assembly precursors to the contractile ring, are discrete structural units with stoichiometric ratios and distinct distributions of constituent proteins, which establish the organization of the proteins in the functional units of a cytokinetic contractiles ring.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Three Myosins Contribute Uniquely to the Assembly and Constriction of the Fission Yeast Cytokinetic Contractile Ring
Current Biology, 25(15), 1955–1965.
MeSH headings : Cell Cycle; Cell Division; Cytokinesis; Mutation; Myosin Heavy Chains / genetics; Myosin Heavy Chains / metabolism; Myosin Type II / genetics; Myosin Type II / metabolism; Myosins / genetics; Myosins / metabolism; Schizosaccharomyces / cytology; Schizosaccharomyces / genetics; Schizosaccharomyces / physiology; Schizosaccharomyces pombe Proteins / genetics; Schizosaccharomyces pombe Proteins / metabolism; Spindle Pole Bodies / metabolism
TL;DR:
Three myosins function in a hierarchal, complementary manner to accomplish cytokinesis, with Myo2 and Myo51 taking the lead during contractile ring assembly and Myp2 making the greatest contribution to constriction.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2015 journal article
Video-Rate Super Resolution Microscopy in Living Cells
Biophysical Journal, 108(2), 475a.
TL;DR:
A set of specially designed methods that characterize an sCMOS camera for the first time and allow for unbiased and precise localization analysis are presented and demonstrate localization-based super-resolution microscopy in live cells by monitoring dynamics of protein clusters, vesicles and organelles at a temporal resolution from 2 to 30 frames per second.
(via Semantic Scholar)
Source: Crossref
Added: February 24, 2020
2014 journal article
Experimental Measurement and Simulations of the Cytokinetic Ring Tension in Fission Yeast
Biophysical Journal, 106(2), 177a.
TL;DR:
The first measurements of contractile ring tension in fission yeast are reported, using micropipette aspiration of protoplast cell membranes and optical microscopy analysis of membrane deformation by the tense ring as it constricts.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2014 journal article
Mechanism of Cytokinetic Contractile Ring Constriction in Fission Yeast
Developmental Cell, 29(5), 547–561.
MeSH headings : Actin Cytoskeleton / metabolism; Actomyosin / metabolism; Computer Simulation; Cytokinesis / physiology; Myosin Type II / metabolism; Polymerization; Schizosaccharomyces / cytology; Schizosaccharomyces / metabolism; Schizosaccharomyces pombe Proteins / metabolism
TL;DR:
Computer simulations based on the amounts and biochemical properties of the key proteins showed that they spontaneously self-organize into a tension-generating bundle, revealing that the ring operates close to conditions of isometric tension.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2012 journal article
The Role of the Contractile Ring during Cytokinesis
Biophysical Journal, 102(3), 219a.
Source: Crossref
Added: August 28, 2020
2011 journal article
Asymmetric distribution of Echinoid defines the epidermal leading edge during Drosophila dorsal closure
The Journal of Cell Biology, 192(2), 335–348.
MeSH headings : Actins / metabolism; Actomyosin / metabolism; Amino Acid Motifs; Animals; Cell Adhesion; Cell Adhesion Molecules / chemistry; Cell Adhesion Molecules / metabolism; Cell Movement; Cell Polarity; Drosophila Proteins / chemistry; Drosophila Proteins / metabolism; Drosophila melanogaster / embryology; Drosophila melanogaster / metabolism; Epidermal Cells; Epidermis / metabolism; Intracellular Signaling Peptides and Proteins / metabolism; Protein Structure, Tertiary; Repressor Proteins / chemistry; Repressor Proteins / metabolism
TL;DR:
Upon loss of a binding partner in apposed tissue, the homophilic cell adhesion protein Echinoid adopts a planar polarization localization, which promotes the planar polarized localization of thePlanar cell polarity protein Bazooka/Par-3 and targets actomyosin cable assembly to the epidermal leading edge, thus establishing the migration direction of the developing epidermis.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2011 journal article
Mechanisms of Cytokinetic Ring Constriction in Fission Yeast
Biophysical Journal, 100(3), 443a.
TL;DR:
This work combined mathematical modeling and experiment to study ring constriction in fission yeast, a model organism as many ring components have been identified and their concentrations measured, and showed ring tension requires actin anchoring and is maximized when the barbed ends are anchored.
(via Semantic Scholar)
Source: Crossref
Added: August 28, 2020
2010 journal article
Echinoid regulates tracheal morphology and fusion cell fate in Drosophila
Developmental Dynamics, 239(9), 2509–2519.
author keywords: Drosophila; Echinoid; trachea; morphogenesis; cellular junctions; branch fusion; anastomosis
MeSH headings : Amidohydrolases / genetics; Amidohydrolases / metabolism; Animals; Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Cell Fusion; Drosophila Proteins / genetics; Drosophila Proteins / metabolism; Drosophila melanogaster / anatomy & histology; Drosophila melanogaster / embryology; Embryo, Nonmammalian / anatomy & histology; Embryo, Nonmammalian / physiology; Morphogenesis / physiology; Phenotype; Repressor Proteins / genetics; Repressor Proteins / metabolism; Trachea / anatomy & histology; Trachea / embryology; Wnt1 Protein / metabolism
Source: Crossref
Added: August 28, 2020
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