@misc{korn_thieme_alves_yeakey_borba_capuzzi_fecho_bizon_edwards_chirkova_et al._2022, title={Defining clinical outcome pathways}, volume={27}, ISSN={["1878-5832"]}, DOI={10.1016/j.drudis.2022.02.008}, abstractNote={Here, we propose a broad concept of 'Clinical Outcome Pathways' (COPs), which are defined as a series of key molecular and cellular events that underlie therapeutic effects of drug molecules. We formalize COPs as a chain of the following events: molecular initiating event (MIE) → intermediate event(s) → clinical outcome. We illustrate the concept with COP examples both for primary and alternative (i.e., drug repurposing) therapeutic applications. We also describe the elucidation of COPs for several drugs of interest using the publicly accessible Reasoning Over Biomedical Objects linked in Knowledge-Oriented Pathways (ROBOKOP) biomedical knowledge graph-mining tool. We propose that broader use of COP uncovered with the help of biomedical knowledge graph mining will likely accelerate drug discovery and repurposing efforts.}, number={6}, journal={DRUG DISCOVERY TODAY}, author={Korn, Daniel and Thieme, Andrew J. and Alves, Vinicius M. and Yeakey, Michael and Borba, Joyce V. V. B. and Capuzzi, Stephen J. and Fecho, Karamarie and Bizon, Chris and Edwards, Stephen W. and Chirkova, Rada and et al.}, year={2022}, month={Jun}, pages={1671–1678} }