Works (17)
Updated: November 20th, 2024 15:20
2022 journal article
Hands-on immunology: Engaging learners of all ages through tactile teaching tools
FRONTIERS IN MICROBIOLOGY, 13.
author keywords: tactile teaching tool-guided inquiry learning; antibody; epitope; MHC; haplotype; universal design for learning; inclusive teaching; active learning
TL;DR:
Two TTT-GIL activities are reported here designed to engage diverse learners from middle schoolers to masters students in exploring molecular interactions within the immune system and can be adapted for use with learners of different levels and educational backgrounds.
(via Semantic Scholar)
open access via www.frontiersin.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
4. Quality Education
(Web of Science)
Sources: ORCID, Web Of Science, NC State University Libraries
Added: October 25, 2022
2021 article
Editorial: Research Topic Tools, Techniques, and Strategies for Teaching in a Real-World Context With Microbiology
Gordy, C. L., Ramirez, M. V., Vandegrift, M., & Goller, C. C. (2021, October 13). FRONTIERS IN MICROBIOLOGY, Vol. 12.
Contributors: n , M. Ramirez n , M. Vandegrift n & C. Goller n
author keywords: microbiology; bioinformatics; educational studies; open education; undergraduate learning; sharing; quantitative skills
Sources: Web Of Science, NC State University Libraries, ORCID
Added: November 15, 2021
2021 journal article
Sugar‐seeking insects as a source of diverse bread‐making yeasts with enhanced attributes
Yeast, 39(1-2), 108–127.
Contributors: A. Madden n, C. Lahue n, n , J. Little n , L. Nichols n , M. Calvert n, R. Dunn n , C. Heil n
author keywords: baking; bioprospecting; bread; Lachancea; non-conventional yeasts; Saccharomyces
MeSH headings : Animals; Bread; Fermentation; Insecta; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sugars / metabolism; Yeasts
TL;DR:
The results suggest that non‐conventional yeasts have high potential for baking and, more generally, showcase the success of bioprospecting in insects for identifying yeasts relevant for industrial uses.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
13. Climate Action
(Web of Science)
Sources: Web Of Science, NC State University Libraries, ORCID, Crossref
Added: November 17, 2021
2020 journal article
Building the lac Operon: A Guided-Inquiry Activity Using 3D-Printed Models
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION, 21(1).
TL;DR:
Encouraging preliminary data suggest that TTTs with guided-inquiry learning disproportionately benefit disadvantaged student populations and could serve as a tool in leveling the playing field when teaching abstract biological concepts in diverse educational settings.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 30, 2020
2020 article
Building the lac operon: A guided-inquiry activity using 3D-printed models
Gordy, C. L., Sandefur, C. I., Lacara, T., Harris, F. R., & Ramirez, M. V. (2020, January). Journal of Microbiology & Biology Education, Vol. 21, p. 60.
UN Sustainable Development Goal Categories
4. Quality Education
(OpenAlex)
Source: ORCID
Added: August 24, 2021
2020 journal article
STEM BUILD: An Online Community To Decrease Barriers to Implementation of Inclusive Tactile Teaching Tools
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION, 21(1).
TL;DR:
The strengths and weaknesses of common strategies for employing physical models in undergraduate biology courses are outlined and a novel strategy that is developed to pair 3D-printed models with guided inquiry learning to create inclusive and interactive learning experiences are described.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: November 30, 2020
2020 journal article
Using Metabolic Engineering to Connect Molecular Biology Techniques to Societal Challenges
Frontiers in Microbiology, 11.
Contributors: n & C. Goller n
author keywords: metabolic engineering; yeast; sustainability; case study; molecular biology; group work; agency; ownership
TL;DR:
An 8-week laboratory module for upper-division undergraduates and graduate students that builds upon students’ basic understanding of GMOs to introduce them to the techniques used to sustainably produce commercially valuable products in yeast through metabolic engineering, and an individual sustainability project assignment created for this course.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
4. Quality Education
(Web of Science)
Sources: ORCID, Crossref, NC State University Libraries
Added: December 30, 2020
2019 journal article
Systematic analysis of F-box proteins reveals a new branch of the yeast mating pathway
JOURNAL OF BIOLOGICAL CHEMISTRY, 294(40), 14717–14731.
author keywords: G protein; mitogen-activated protein kinase (MAPK); yeast; ubiquitin; protein sorting; F-box; fungal mating; pheromone signaling
MeSH headings : Adaptor Proteins, Signal Transducing / genetics; Cell Cycle / genetics; Class III Phosphatidylinositol 3-Kinases / genetics; Endosomes / genetics; F-Box Proteins / chemistry; F-Box Proteins / genetics; GTP-Binding Protein alpha Subunits, Gq-G11 / genetics; GTP-Binding Protein beta Subunits / chemistry; GTP-Binding Protein beta Subunits / genetics; GTP-Binding Protein gamma Subunits / chemistry; GTP-Binding Protein gamma Subunits / genetics; Genes, Mating Type, Fungal / genetics; Morphogenesis / genetics; Pheromones / genetics; Pheromones / metabolism; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / physiology; Saccharomyces cerevisiae Proteins / genetics; Sequence Deletion / genetics; Signal Transduction; Transcription, Genetic; Vacuoles / genetics; Vacuoles / metabolism; cdc42 GTP-Binding Protein / genetics
TL;DR:
These findings point to the existence of a new and distinct branch of the pheromone-signaling pathway, one that likely leads to vacuolar engulfment of cytoplasmic proteins and recycling of cellular contents in preparation for mating.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: December 9, 2019
2016 journal article
Undergraduate journal club as an intervention to improve student development in applying the scientific process.
Journal of College Science Teaching. https://europepmc.org/articles/PMC4874504
Source: ORCID
Added: August 24, 2021
2014 journal article
c-FLIP Protects Eosinophils from TNF-α-Mediated Cell Death In Vivo
PLoS ONE, 9(10), e107724.
Ed(s): H. Nakano
MeSH headings : Animals; Apoptosis / drug effects; Bone Marrow Cells / cytology; Bone Marrow Transplantation; CASP8 and FADD-Like Apoptosis Regulating Protein / genetics; CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism; Cells, Cultured; Chromosomes, Artificial, Bacterial / genetics; Eosinophils / cytology; Eosinophils / drug effects; Eosinophils / metabolism; Genotype; Mice; Mice, Transgenic; NF-kappa B / metabolism; Tumor Necrosis Factor-alpha / pharmacology; Up-Regulation / drug effects
TL;DR:
It is shown for the first time that eosinophils express the caspase 8-inhibitory protein c- FLIP, and c-FLIP expression is upregulated upon TNF-α stimulation, and this suggests c-FlIP as a potential therapeutic target for the treatment of eOSinophil-mediated disease.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 24, 2021
2013 journal article
Participation of c-FLIP in NLRP3 and AIM2 inflammasome activation
Cell Death & Differentiation, 21(3), 451–461.
author keywords: c-FLIP; inflammasome; IL-1 beta; caspase-1; caspase-8; macrophages
MeSH headings : Animals; CASP8 and FADD-Like Apoptosis Regulating Protein / metabolism; Carrier Proteins / genetics; Carrier Proteins / metabolism; DNA-Binding Proteins / genetics; DNA-Binding Proteins / metabolism; Down-Regulation; HEK293 Cells; Humans; Inflammasomes / metabolism; Interleukin-1beta / metabolism; Macrophages / metabolism; Mice; NLR Family, Pyrin Domain-Containing 3 Protein; Peptides; Signal Transduction
TL;DR:
It is demonstrated that c-FLIPL is an unexpected contributor to canonical inflammasome activation for the generation of caspase-1 and active IL-1β and suggest that c -FLIP could be a valid target for treatment of inflammatory diseases caused by over-activation of inflamMASomes.
(via Semantic Scholar)
Source: ORCID
Added: August 24, 2021
2012 journal article
The crosstalk between autophagy and apoptosis: where does this lead?
Protein & Cell, 3(1), 17–27.
author keywords: autophagy; apoptosis; Beclin-1; lymphocytes
MeSH headings : Animals; Apoptosis / physiology; Apoptosis Regulatory Proteins / metabolism; Autophagy / physiology; Humans; Neoplasms / metabolism; Neoplasms / pathology; Neoplasms / therapy; Proteolysis; Signal Transduction
TL;DR:
Investigation of the interactions between Beclin-1 and Bcl-2/Bcl-xL and between FADD and Atg5, caspase- and calpain-mediated cleavage of autophagy-related proteins, and autophagic degradation of caspases is necessary to elucidate the mechanisms controlling the balance between survival and death both under normal conditions and in diseases including cancer.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
Source: ORCID
Added: August 24, 2021
2012 journal article
Transfer of CD8+ T cell memory using bcl-2 as a marker
Journal of Immunology, 190(3), 940–947.
Contributors: A. Dunkle*, I. Dzhagalov *, * & Y. He*
MeSH headings : Adoptive Transfer; Animals; Bacterial Proteins / analysis; Bacterial Proteins / biosynthesis; Bacterial Proteins / genetics; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / transplantation; Chromosomes, Artificial, Bacterial; Genes, Reporter; Genes, bcl-2; Humans; Hybridomas / immunology; Immunologic Memory / immunology; Listeria monocytogenes / immunology; Listeriosis / immunology; Luminescent Proteins / analysis; Luminescent Proteins / biosynthesis; Luminescent Proteins / genetics; Mice; Mice, Inbred C57BL; Mice, Transgenic; Ovalbumin / genetics; Ovalbumin / immunology; Proto-Oncogene Proteins c-bcl-2 / biosynthesis; Proto-Oncogene Proteins c-bcl-2 / genetics; Proto-Oncogene Proteins c-bcl-2 / physiology; Recombinant Fusion Proteins / analysis; Recombinant Fusion Proteins / immunology; Spleen / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / transplantation; Transgenes
TL;DR:
A novel Bcl-2 reporter mouse model is presented and it is shown for the first time that a distinct subset of effector T cells, and also a subset within the CD127hiKLRG1lo memory precursor effector cell population, retains high B cl-2 expression at the peak of the CD8+ T cell response to Listeria monocytogenes.
(via Semantic Scholar)
Source: ORCID
Added: August 24, 2021
2011 journal article
Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing
Cellular and Molecular Immunology, 9(1), 5–6.
TL;DR:
Endocytosis by target cells: an essential means for perforin- and granzyme-mediated killing and its applications in apoptosis and cell reprograming.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger
(OpenAlex)
Source: ORCID
Added: August 24, 2021
2010 journal article
Regulation of steady-state neutrophil homeostasis by macrophages
Blood, 117(2), 618–629.
Contributors: * , Y. He, H. Pua & G. Sempowski *
MeSH headings : Animals; Bone Marrow Cells / cytology; Bone Marrow Cells / immunology; Bone Marrow Cells / metabolism; CASP8 and FADD-Like Apoptosis Regulating Protein / deficiency; CASP8 and FADD-Like Apoptosis Regulating Protein / genetics; Cell Survival; Gene Knock-In Techniques; Granulocyte Colony-Stimulating Factor / metabolism; Hematopoiesis / genetics; Hematopoiesis / immunology; Homeostasis / genetics; Homeostasis / immunology; Inflammation / genetics; Inflammation / immunology; Macrophages / immunology; Macrophages / metabolism; Mice; Mice, Knockout; Neutrophils / immunology; Neutrophils / metabolism; Spleen / cytology; Spleen / immunology; Spleen / metabolism
TL;DR:
By conditionally deleting the antiapoptotic gene cellular FLICE-like inhibitory protein (C-FLIP) in myeloid cells, a novel mouse model deficient in marginal zone and bone marrow stromal macrophages is generated, suggesting that a G-CSF-dependent, IL-1β-independent pathway plays a role in promoting neutrophil production in mice with defective clearance of apoptotic cells.
(via Semantic Scholar)
Source: ORCID
Added: August 24, 2021
2008 journal article
Regulation of CD8+ T cell functions by RARγ
Seminars in Immunology, 21(1), 2–7.
author keywords: Retinoic acid receptor gamma; CD8(+) T lymphocytes
MeSH headings : Animals; Antineoplastic Agents / immunology; Antineoplastic Agents / metabolism; Apoptosis / physiology; CD8-Positive T-Lymphocytes / immunology; CD8-Positive T-Lymphocytes / metabolism; Gastrointestinal Tract / immunology; Gastrointestinal Tract / metabolism; Humans; Receptors, Retinoic Acid / immunology; Receptors, Retinoic Acid / metabolism; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism; Tretinoin / immunology; Tretinoin / metabolism
TL;DR:
Emerging data suggest that RARalpha and RARgamma function differently in thymocyte development and that R ARgamma is required for both primary and secondary CD8(+) T cell immune responses.
(via Semantic Scholar)
Source: ORCID
Added: August 24, 2021
2004 journal article
Visualization of Antigen Presentation by Actin-Mediated Targeting of Glycolipid-Enriched Membrane Domains to the Immune Synapse of B Cell APCs
Journal of Immunology, 172(4), 2030–2038. http://www.scopus.com/inward/record.url?eid=2-s2.0-0842343443&partnerID=MN8TOARS
Source: ORCID
Added: August 24, 2021
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