Crystal Lynn Pace

College of Sciences

Works (5)

Updated: July 28th, 2023 21:15

2021 article

Mass Spectrometry Imaging of N-Linked Glycans in a Formalin-Fixed Paraffin-Embedded Human Prostate by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization

Pace, C. L., Angel, P. M., Drake, R. R., & Muddiman, D. C. (2021, December 3). Journal of Proteome Research, Vol. 1.

By: C. Pace n, P. Angel *, R. Drake * & D. Muddiman n 

author keywords: IR-MALDESI; N-linked glycans; mass spectrometry imaging; prostate cancer
MeSH headings : Formaldehyde / chemistry; Humans; Lasers; Male; Paraffin Embedding; Polysaccharides / chemistry; Prostate / chemistry; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Glycosylation and Glycoproteins Research; Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications
TL;DR: This work demonstrates the first steps in N-linked glycan imaging of biological tissues by IR-MALDESI MSI, a hybrid ionization technique commonly used for mass spectrometry imaging (MSI) applications. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: February 7, 2022

2021 article

Multimodal Mass Spectrometry Imaging of Rat Brain Using IR-MALDESI and NanoPOTS-LC-MS/MS

Pace, C. L., Simmons, J., Kelly, R. T., & Muddiman, D. C. (2021, December 3). Journal of Proteome Research, Vol. 3.

By: C. Pace n, J. Simmons *, R. Kelly * & D. Muddiman n 

author keywords: multimodal mass spectrometry imaging; multiomic analyses; IR-MALDESI; nanoPOTS-LC-MS/MS
MeSH headings : Animals; Brain / diagnostic imaging; Chromatography, Liquid / methods; Proteome; Proteomics; Rats; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods; Tandem Mass Spectrometry
topics (OpenAlex): Metabolomics and Mass Spectrometry Studies; Mass Spectrometry Techniques and Applications; Advanced Proteomics Techniques and Applications
TL;DR: A multiomic pathway integration showed a strong correlation between the two data sets when comparing average abundances of metabolites and corresponding enzymes in each brain region, and the first steps in the creation of a multimodal MSI technique that combines two highly sensitive and complementary imaging platforms are demonstrated. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: May 2, 2022

2020 article

Analysis of neurotransmitters in rat placenta exposed to flame retardants using IR-MALDESI mass spectrometry imaging

Pace, C. L., Horman, B., Patisaul, H., & Muddiman, D. C. (2020, April 16). Analytical and Bioanalytical Chemistry, Vol. 412, pp. 3745–3752.

By: C. Pace n, B. Horman n, H. Patisaul n  & D. Muddiman n 

author keywords: IR-MALDESI; Mass spectrometry imaging; Neurotransmitters; Exposomics
MeSH headings : Animals; Female; Flame Retardants / adverse effects; Infrared Rays; Neurotransmitter Agents / analysis; Optical Imaging / instrumentation; Optical Imaging / methods; Placenta / chemistry; Placenta / diagnostic imaging; Pregnancy; Rats; Rats, Wistar; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / instrumentation; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Toxic Organic Pollutants Impact; Metabolomics and Mass Spectrometry Studies
TL;DR: Changes in the abundance and spatial distribution of neurotransmitters in rat placenta following chemical exposure could be determined using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: June 1, 2020

2020 article

Direct Analysis of Native N-Linked Glycans by IR-MALDESI

Pace, C. L., & Muddiman, D. C. (2020, June 30). Journal of the American Society for Mass Spectrometry, Vol. 31, pp. 1759–1762.

By: C. Pace n & D. Muddiman n 

author keywords: IR-MALDESI; N-linked glycans; glycomics; direct analysis
topics (OpenAlex): Glycosylation and Glycoproteins Research; Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography
TL;DR: This study sought to demonstrate infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) as a novel approach for the direct analysis of N-linked glycans. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

2020 article

Infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI) mass spectrometry imaging analysis of endogenous metabolites in cherry tomatoes

Bagley, M. C., Pace, C. L., Ekelöf, M., & Muddiman, D. C. (2020, January 1). The Analyst, Vol. 145, pp. 5516–5523.

By: M. Bagley*, C. Pace*, M. Ekelöf* & D. Muddiman n 

MeSH headings : Lasers; Lipids; Solanum lycopersicum; Spectrometry, Mass, Electrospray Ionization; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
topics (OpenAlex): Mass Spectrometry Techniques and Applications; Metabolomics and Mass Spectrometry Studies; Analytical Chemistry and Chromatography
TL;DR: The spatially resolved metabolic profiling of cherry tomatoes using infrared matrix-assisted laser desorption electrospray ionization (IR-MALDESI), a mass spectrometry imaging technique that operates at ambient conditions and requires no sample derivatization, finds endogenous carotenoid hydrocarbons ionized as radical cations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 31, 2020

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